Academic journal of gastroenterology & hepatology最新文献_第5页

Crohn’s Disease: A Curable Disease Held Hostage? 克罗恩病:一种可治愈的疾病?

Academic journal of gastroenterology & hepatology Pub Date : 2019-01-01 DOI: 10.33552/ajgh.2021.02.000549

G. Monif

引用次数: 0

The Combined Value of Faecal Haemoglobin and Calprotectin in Diagnosis of Colorectal Cancer in Symptomatic Patients Referred to Colonoscopy 粪便血红蛋白和钙保护蛋白在结肠镜检查有症状的结直肠癌患者中的联合诊断价值

Academic journal of gastroenterology & hepatology Pub Date : 2019-01-01 DOI: 10.33552/ajgh.2019.01.000514

R. Palmqvist

{"title":"The Combined Value of Faecal Haemoglobin and Calprotectin in Diagnosis of Colorectal Cancer in Symptomatic Patients Referred to Colonoscopy","authors":"R. Palmqvist","doi":"10.33552/ajgh.2019.01.000514","DOIUrl":"https://doi.org/10.33552/ajgh.2019.01.000514","url":null,"abstract":"Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and has a considerable impact on both the individual and the health care system. The majority of patients with CRC have their initial consultation in primary care [1]. However, the symptoms of CRC often present late. In addition, a vast majority of patients seeking primary care for symptoms associated with CRC (rectal bleeding, a change in bowel habits, diarrhoea, constipation and abdominal pain) are not diagnosed with CRC [2-4]. Therefore, general screening programs among individuals at average risk for CRC, along with guidelines for urgent referral, are implemented widely to reduce mortality of the disease [5,6]. However, there is still a need for improved screening strategies for CRC [4,7,3]. The recommended “gold standard” screening tool for CRC today is endoscopic examination, such as sigmoidoscopy or colonoscopy, but such examinations are resource-demanding, highly costly and inconvenient for the patients [8-11]. The most important factor in screening is patient adherence, and therefore annual faecal occult blood tests have been suggested as an alternative to endoscopy in CRC screening [7]. Analysis of faecal haemoglobin (F-Hb) using either guaiac-based (gFOBT) tests or, more recently, immunological (FIT) tests [12] is commonly used as a primary screening tool, since it requires no preparation, is cost-effective, and relatively convenient for the patient [13]. A positive F-Hb test is an indication of bleeding in the gastrointestinal (GI) tract, which could be caused *Corresponding author: Richard Palmqvist, Department of Medical Biosciences/ Pathology, Umeå University, Sweden. Received Date: September 12, 2019 Published Date: September 17, 2019 Scientific Journal of Gastroenterology & Hepatology Open Access","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69448609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Alcohol Fatty Liver Disease Goes Beyond the Liver 非酒精性脂肪肝不只是肝脏的问题

Academic journal of gastroenterology & hepatology Pub Date : 2018-12-13 DOI: 10.33552/AJGH.2018.01.000505

G. Koek

引用次数: 0

Microbiota of the Gut: Antibiotic-Induced Dysbiosis and the Adverse Effects on Human Health 肠道微生物群:抗生素引起的生态失调及其对人体健康的不良影响

Academic journal of gastroenterology & hepatology Pub Date : 2018-10-16 DOI: 10.33552/ajgh.2018.01.000504

Matthew T. F. Lamaudière, I. Morozov

{"title":"Microbiota of the Gut: Antibiotic-Induced Dysbiosis and the Adverse Effects on Human Health","authors":"Matthew T. F. Lamaudière, I. Morozov","doi":"10.33552/ajgh.2018.01.000504","DOIUrl":"https://doi.org/10.33552/ajgh.2018.01.000504","url":null,"abstract":"A healthy gut microbial community is essential for homeostasis in mammals. A symbiotic relationship between host and microbe is essential in developing the immune system, providing biomolecules and generating energy through utilisation of indigestible compounds. The diversity of the gut microbiota is altered following antibiotic treatments, the effect this has on the health and wellbeing of the host has long been underestimated and is now the subject of intense debate. Antibiotics facilitate the selection of energy harvesting microbes within the gut and hence heavily influence the gaining of weight and may be contributing more than we anticipated to the modern obesity epidemic. These changes to the bacterial composition of the gut, dysbiosis are caused by elevated oxygen levels within the gut that promotes the propagation of facultative anaerobic Proteobacteria, a condition associated with inflammation and cancer. Additionally, the altered oxygenated intestinal climate allows the growth of aerobic pathogens, conveying clinically relevant resistance genes on highly transmissible mobile elements between communities or acquiring them from commensal bacteria, in turn aiding the spread of antibiotic resistance. Here we discuss the indirect pleotropic effects antibiotics have on the microbial community and environment of the gut leading to hidden adverse implications to human health.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48690078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Viral Hepatitis B and C Need to be Approached as A Major Public Health Problem in Latin America 需要将乙型和丙型病毒性肝炎视为拉丁美洲的一个主要公共卫生问题

Academic journal of gastroenterology & hepatology Pub Date : 2018-09-25 DOI: 10.33552/AJGH.2018.01.000503

I. Machado

引用次数: 0

The Interleukin-1β (-511T/C) is Associated with Ulcerative Colitis 白细胞介素-1β（-511T/C）与溃疡性结肠炎的关系

Academic journal of gastroenterology & hepatology Pub Date : 2018-09-04 DOI: 10.33552/AJGH.2018.01.000502

M. Tavares, Camilla De Lima, V. Martinelli, M. Lucena, Francisco Lima, A. Telles, L. Brandão

{"title":"The Interleukin-1β (-511T/C) is Associated with Ulcerative Colitis","authors":"M. Tavares, Camilla De Lima, V. Martinelli, M. Lucena, Francisco Lima, A. Telles, L. Brandão","doi":"10.33552/AJGH.2018.01.000502","DOIUrl":"https://doi.org/10.33552/AJGH.2018.01.000502","url":null,"abstract":"Purpose: Inflammatory bowel disease (IBD) is a group of illnesses whose primary manifestation is inflammation. The most common typical phenotypes are ulcerative colitis (UC) and Crohn’s disease (CD). Although the precise etiology remains obscure, several reports have indicated that dysfunction of the mucosal immune system play an important role in its pathogenesis. This study aimed to analyzing the genes polymorphisms of immune response in Brazilian patients with IBD. Methods and results: 95 patients were analyzed for the caspase activation and recruitment domains 15/ NOD like receptor 2 (CARD15/NOD2) (rs2066844 and rs2066845), NOD like receptor – (NLRP1) (rs12150220), NLRP3 (rs35829419) and interleukin (IL)-1 (rs16944) genes polymorphisms. The anatomic-clinical form of CD predominant was both, fistulizing and inflammatory each (35.18%), followed by structuring (27.77%) and 1.85% structuring and fistulizing in the same patients. 91 healthy subjects composed the control group. The statistical analysis was performed using R program. NOD like receptor pyrin domain containing 1 and 3 and caspase activation and recruitment domains 15/ NOD like receptor 2 genes R702W and G908R variants were not associated to inflammatory bowel disease susceptibility. We found that AG genotype of interleukin-1beta was associated with the development of UC. Conclusion: Our findings suggest that the IL-1 single nucleotide polymorphism is involved with UC and may be contributing to pathogenesis in Brazilian population.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41603701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Integrated Gene Regulatory Networks for Hepatocellular Carcinoma 了解肝癌的整合基因调控网络

Academic journal of gastroenterology & hepatology Pub Date : 2018-07-27 DOI: 10.33552/AJGH.2018.01.000501

Long Gao

引用次数: 0