Acta physiologica Hungarica最新文献_第3页

Examination of the interaction of different lighting conditions and chronic mild stress in animal model. 不同光照条件与慢性轻度应激动物模型相互作用的研究。

Acta physiologica Hungarica Pub Date : 2015-09-23 DOI: 10.1556/036.102.2015.3.8

A. Muller, N. Gal, J. Betlehem, N. Fullér, P. Acs, G. Kovacs, K. Fusz, R. Józsa, A. Oláh

{"title":"Examination of the interaction of different lighting conditions and chronic mild stress in animal model.","authors":"A. Muller, N. Gal, J. Betlehem, N. Fullér, P. Acs, G. Kovacs, K. Fusz, R. Józsa, A. Oláh","doi":"10.1556/036.102.2015.3.8","DOIUrl":"https://doi.org/10.1556/036.102.2015.3.8","url":null,"abstract":"We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one- and two-way analysis of variance, with a significance level defined at p < 0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases. 足细胞中TRPC6离子通道的调节-对局灶节段性肾小球硬化和获得性蛋白尿疾病的影响

Acta physiologica Hungarica Pub Date : 2015-09-23 DOI: 10.1556/036.102.2015.3.2

T. Szabó, L. Ambrus, N. Zákány, G. Balla, T. Bíró

{"title":"Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.","authors":"T. Szabó, L. Ambrus, N. Zákány, G. Balla, T. Bíró","doi":"10.1556/036.102.2015.3.2","DOIUrl":"https://doi.org/10.1556/036.102.2015.3.2","url":null,"abstract":"The glomerular filtration barrier is a highly specialized tri-layer structure with unique functional properties. Podocyte dysfunction and cytoskeletal disorganization leads to disruption of the slit diaphragma, and proteinuria. Inflammatory diseases involving the kidney as well as inherited podocytopathies or diabetic nephropathy cause injury of the podocyte network. Focal segmental glomerulosclerosis (FSGS) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children. Several causative genes have been identified in the pathogenesis of FSGS. Mutations of the transient receptor potential canonical-6 (TRPC6), a non-selective cation channel that is directly activated by diacylglycerol (DAG), cause a particularly aggressive form of FSGS. Angiotensin II, acting through its AT1 receptor, plays a critical role in generation of proteinuria and progression of kidney injury in a number of kidney diseases, including FSGS. Mounting evidence suggest the central role of TRPC6 and perhaps other TRPC channels in the pathogenesis of FSGS as well as of acquired forms of proteinuria such as diabetic nephropathy or hypertension. Identification of signaling pathways downstream of TRPC6 may provide novel targets for the treatment of proteinuria and prevent progression of podocyte injury.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.3.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A comparative study of the physical development and motor performance of mentally non-handicapped children and children with intellectual and development disabilities. 非智障儿童与智障儿童身体发育及运动表现的比较研究。

Acta physiologica Hungarica Pub Date : 2015-09-01 DOI: 10.1556/036.102.2015.3.9

E. Szabó, N. Erdei, S. Bene

{"title":"A comparative study of the physical development and motor performance of mentally non-handicapped children and children with intellectual and development disabilities.","authors":"E. Szabó, N. Erdei, S. Bene","doi":"10.1556/036.102.2015.3.9","DOIUrl":"https://doi.org/10.1556/036.102.2015.3.9","url":null,"abstract":"Several studies state that there might be a difference in the physical development and the motor performance of the mentally non-handicapped children and those with intellectual and development disabilities. The aim of our research was to compare the two groups from these aspects. The study included the assessment of the physical development and motor performance of altogether 225 primary school pupils (mentally non-handicapped and with intellectual and development disabilities) aged 8-11. The following indicators of physical development and build were examined: body height, body weight and body mass index (BMI), musculoskeletal plasticity index, biceps and triceps skinfold thickness. The motor tests included: 20 m dash, standing long jump, medicine-ball throwing, six minutes continuous running, obstacle race-test and a match test. We also examined the children's chronological (decimal) and morphological age. Data were analysed with SPSS programme. The differences between the averages were calculated with ANOVA and Fisher's LSD tests. The results show that the children with intellectual and development disabilities are in general less developed physically than non-handicapped children of the same age and sex. It is also concluded that in most motor tests the children with intellectual and development disabilities fall behind the non-handicapped ones.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.3.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Greetings to the Reader. 向读者问好。

Acta physiologica Hungarica Pub Date : 2015-09-01 DOI: 10.1556/036.102.2015.3.1

L. Rosivall

引用次数: 0

Mechanisms to dyspnoea and dynamic hyperinflation related exercise intolerance in COPD. COPD患者与运动不耐受相关的呼吸困难和动态恶性通货膨胀机制。

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.7

Janos Varga

引用次数: 22

Altered mitochondrial response to activation of T-cells in neonate. 新生儿线粒体对t细胞活化反应的改变。

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.12

G Mészáros, Cs Orbán, A Kaposi, G Toldi, B Gyarmati, T Tulassay, Barna Vásárhelyi

{"title":"Altered mitochondrial response to activation of T-cells in neonate.","authors":"G Mészáros, Cs Orbán, A Kaposi, G Toldi, B Gyarmati, T Tulassay, Barna Vásárhelyi","doi":"10.1556/036.102.2015.2.12","DOIUrl":"https://doi.org/10.1556/036.102.2015.2.12","url":null,"abstract":"Unlabelled: Mitochondrial functions have a major impact on T-cell functionality. In this study we characterized whether mitochondrial function in the neonatal T-cells differs from that in the adult T-cells during short T-cell activation.Methods: We used flow cytometry methods to test mitochondrial mass and to monitor mitochondrial Ca²⁺ levels, mitochondrial potential and superoxide generation in parallel with cytoplasmic Ca²⁺ levels during phythohaemagglutinine-induced activation of CD4+ and CD8+ T-cells of 12 term neonates and 11 healthy adults.Results: Baseline mitochondrial mass of CD4+ and CD8+ cells was lower in the neonate than in the adult. In comparison with the adult, neonatal resting CD4+ T-cells had lower cytoplasmic Ca²⁺ levels and this was associated with normal activation induced Ca²⁺-response. During short-term activation cytoplasmic Ca²⁺-response was lower in neonatal than in adult CD8+ T-cells. Mitochondrial Ca²⁺ uptake was increased in CD4+ neonatal T cells while it decreased in CD8+ T-cells. Mitochondrial depolarization was increased in CD4+ and decreased in CD8+ neonatal T-cells compared to adults. Superoxide generation was higher and equal in neonatal CD4+ and CD8+ cells, respectively, compared to the adult ones.Conclusion: Our data suggest that neonatal T-cells exhibit marked differences in mitochondrial function and superoxide generation compared to adult T-cells.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.2.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33410686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Coherence between tissue oxygen indexes in vastus lateralis and gastrocnemius in repetition of impulse exercise with high intensity. 股外侧肌和腓肠肌组织氧指数在重复高强度冲动性运动中的一致性。

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.9

T Yano, W Widjaja, K Shirakawa, C-S Lian, Z Xiao, T Yunoki

{"title":"Coherence between tissue oxygen indexes in vastus lateralis and gastrocnemius in repetition of impulse exercise with high intensity.","authors":"T Yano, W Widjaja, K Shirakawa, C-S Lian, Z Xiao, T Yunoki","doi":"10.1556/036.102.2015.2.9","DOIUrl":"https://doi.org/10.1556/036.102.2015.2.9","url":null,"abstract":"The purpose of this study was to determine whether tissue oxygen indices (TOIs) in two muscle groups oscillated and were synchronized in repetition of impulse exercise with high intensity. Five impulse exercises of 400 watts for 10 s were repeated with intervals of 6 min. During this period, TOI was determined by near-infrared spectroscopy in the vastus lateralis and gastrocnemius muscles. TOIs in the two muscles oscillated at rest. The TOIs rapidly decreased during each impulse exercise and then recovered and overshot after each impulse. The TOIs oscillated during each interval period. During this test period, coherent and phase differences were determined. There was high coherence between TOIs in the two muscles with a peak value at 0.019 Hz. There was a phase difference of -45 ± 32.4 degrees between TOIs in the two muscles. This phase difference corresponded to about 6 s in time scale. It seemed from this time delay that impulse exercise was not a trigger factor for the starting point of TOIs in the two muscles. It has been concluded that TOIs oscillate and are synchronized between two muscles in repetition of impulse exercise with high intensity. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.2.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33411253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects - Results from the MAGYAR-Healthy Study. 三维斑点跟踪超声心动图衍生的左心房功能参数与健康受试者主动脉硬度之间的相关性——magyar健康研究的结果

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.10

Attila Nemes, GyÁ Piros, P Domsik, A Kalapos, Cs Lengyel, A Orosz, T Forster

{"title":"Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects - Results from the MAGYAR-Healthy Study.","authors":"Attila Nemes, GyÁ Piros, P Domsik, A Kalapos, Cs Lengyel, A Orosz, T Forster","doi":"10.1556/036.102.2015.2.10","DOIUrl":"https://doi.org/10.1556/036.102.2015.2.10","url":null,"abstract":"Unlabelled: Left atrial (LA) distension has been demonstrated to be linked with aortic stiffness in different patient populations. Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be a promising tool for volumetric and functional evaluation of the LA. The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects. The study included 19 healthy volunteers (mean age: 37.9 ± 11.4 years, 11 men) who had undergone complete two-dimensional (2D) Doppler transthoracic echocardiography extended with the assessment of aortic elastic properties and 3DSTE.Results: None of LA volumes correlated with echocardiographic aortic elastic properties. Active atrial stroke volume correlated with aortic stiffness index (ASI, r = 0.45, p = 0.05). None of other volume-based functional properties significantly correlated with aortic stiffness parameters. Global peak 3D strain correlated with aortic strain (r = ‒0.46, p = 0.05). global radial pre-atrial contraction strain correlated with ASI (r = ‒0.49, p = 0.04) and AS (r = ‒0.50, p = 0.04).Conclusions: Correlations exist between 3DSTE-derived LA functional parameters and eschocardiographic aortic elastic properties in healthy subjects.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.2.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33411254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Positive effects of naringenin on near-surface membrane fluidity in human erythrocytes. 柚皮素对人红细胞近表面膜流动性的积极影响。

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.3

Vladimir Ajdžanović, V Jakovljević, D Milenković, A Konić-Ristić, J Živanović, I Jarić, V Milošević

{"title":"Positive effects of naringenin on near-surface membrane fluidity in human erythrocytes.","authors":"Vladimir Ajdžanović, V Jakovljević, D Milenković, A Konić-Ristić, J Živanović, I Jarić, V Milošević","doi":"10.1556/036.102.2015.2.3","DOIUrl":"https://doi.org/10.1556/036.102.2015.2.3","url":null,"abstract":"Purpose: Deformability/rheologic behavior of erythrocytes are related to near-surface membrane fluidity. Specific agents can increase erythrocyte membrane fluidity in order to adjust hemodynamics in cardiovascular diseases. Grapefruit flavanone naringenin has been proposed for potential use in an alternative therapy of cardiovascular conditions. In respect to this, we assessed here effects of two nutritionally relevant concentrations of naringenin (0.1 and 1 μg/ml) on near-surface membrane fluidity in human erythrocytes.Methods: We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 7-DS), the spectra of which are dependent on membrane fluidity.Results: The results showed a significant (p = 0.029) increase of membrane fluidity near the hydrophilic surface in erythrocytes treated with higher concentration of naringenin. In the deeper layer, just below the erythrocyte membrane phospholipid heads, both lower and higher concentration of naringenin significantly increased membrane fluidity (p = 0.036 and p = 0.028, respectively).Conclusions: These data document the positive and dose dependent effect of naringenin on near-surface membrane fluidity in human erythrocytes, recommending its use in the cardiovascular conditions characterized by disturbed hemodynamics.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.2.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33411247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prediction of myocardial tissue loss by quantitative densitometric myocardial blush parameters following ST-elevation myocardial infarction. st段抬高型心肌梗死后定量密度测量心肌红晕参数预测心肌组织损失。

Acta physiologica Hungarica Pub Date : 2015-06-01 DOI: 10.1556/036.102.2015.2.11

V Sasi, H Gavallér, A Kalapos, P Domsik, F T Nagy, T Ungi, I Ungi, T Forster, Attila Nemes

{"title":"Prediction of myocardial tissue loss by quantitative densitometric myocardial blush parameters following ST-elevation myocardial infarction.","authors":"V Sasi, H Gavallér, A Kalapos, P Domsik, F T Nagy, T Ungi, I Ungi, T Forster, Attila Nemes","doi":"10.1556/036.102.2015.2.11","DOIUrl":"https://doi.org/10.1556/036.102.2015.2.11","url":null,"abstract":"Unlabelled: Tissue level myocardial perfusion is one of the most important prognostic factors after successful recanalisation of the occluded coronary artery in patients suffering acute ST elevation myocardial infarction (STEMI). The primary objective of the present study was to examine the relationship between videodensitometric myocardial perfusion parameters as assessed on coronary angiograms directly following successful recanalization therapy and magnetic resonance imaging (MRI)-derived myocardial tissue loss late after STEMI. The study comprised 29 STEMI patients. Videodensitometric parameter G(max)/T(max) was calculated to characterize myocardial perfusion, derived from the plateau of grey-level intensity (G(max)), divided by the time-to-peak intensity (Tmax). Myocardial loss index (MLI) was assessed by cardiac MRI following 376 ± 254 days after PCI.Results: Significant correlations could be demonstrated between MLI and G(max) (r = 0.36, p = 0.05) and G(max)/T(max) (r = 0.40, p = 0.03) using vessel masking. Using receiver operating characteristic curve analysis, G(max)/T(max) < 2.17 predicted best MLI = 0.3, 0.4, 0.5 and 0.6 with good sensitivity and specificity data, while G(max)/T(max) < 3.25 proved to have a prognostic role in the prediction of MLI = 0.7.Conclusions: Selective myocardial tissue level perfusion quantitative measurement method is feasible and can serve as a good predictor of myocardial tissue loss following STEMI and revascularization therapy.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.2.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33410685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1