Acta radiologica. Supplementum最新文献_第7页

Anatomical variations of the human vestibular aqueduct. Part II. A radioanatomical study. 人类前庭导水管的解剖学变异。第二部分。放射解剖学研究。

Acta radiologica. Supplementum Pub Date : 1996-01-01

P A Dimopoulos, O Smedby, H F Wilbrand

引用次数: 0

Cardioangiography and the hemodynamic effects of iodixanol. 碘二醇的心血管造影和血流动力学效应。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39911

N E Klow, E A Jacobsen, H Refsum

引用次数: 13

Cardiac effects of iodixanol compared to those of other nonionic and ionic contrast media on the isolated rat heart. 碘沙醇与其他非离子和离子造影剂对离体大鼠心脏的影响比较。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39917

J A Dunkel, J Bokenes, J O Karlsson, H Refsum

{"title":"Cardiac effects of iodixanol compared to those of other nonionic and ionic contrast media on the isolated rat heart.","authors":"J A Dunkel, J Bokenes, J O Karlsson, H Refsum","doi":"10.1177/0284185195036s39917","DOIUrl":"https://doi.org/10.1177/0284185195036s39917","url":null,"abstract":"This study was designed to compare the cardiac electrophysiology and mechanical effects of iodixanol to those of iotrolan, iopromide, ioxaglate and diatrizoate. Two consecutive injections of contrast media (CM) (0.3 g I/kg and 0.9 g I/kg b.w.) were given to spontaneously beating, Langendorff-perfused rat hearts. CM were given as a single, short-lasting bolus injection (i.e. over 2 and 5 s). Changes in aortic pressure, left ventricular pressures and ECG were continuously recorded during constant volume perfusion. The nonionic CM had less pronounced effects on aortic pressure than had the ionic media. The peak rate of isovolumetric contraction (LV dP/dt(max)) was slightly decreased by iodixanol and iotrolan, slightly more decreased by iopromide and markedly decreased by ioxaglate and diatrizoate. Similarly, the peak rate of pressure decline (LV dP/dt (min)) was only slightly decreased by iodixanol and iotrolan. Also, the 2 nonionic dimers had the smallest effects on the left ventricular end diastolic pressure (LVEDP) and heart rate. Ioxaglate lengthened the PQ-interval, but less so than diatrizoate. THe QT-interval was only slightly lengthened by iodixanol and iotrolan, as compared to the lenghthening caused by iopromide, ioxaglate and diatrizoate. Single ventricular extrasystoles were seen in all groups. Extrasystoles up to 3 coupled beats were registered after ioxaglate and diatrizoate. No episodes of ventricular fibrillation occurred with any CM. In conclusion, the nonionic dimers, and in particular iodixanol, induce only minor changes in cardiac function, whereas the ionic dimer ioxaglate and the ionic monomer diatrizoate induce pronounced effects.","PeriodicalId":7159,"journal":{"name":"Acta radiologica. Supplementum","volume":"399 ","pages":"142-54"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0284185195036s39917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19589393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Visipaque--a step forward. A historical review. Visipaque——向前迈进了一步。历史回顾。

Acta radiologica. Supplementum Pub Date : 1995-01-01

T Almen

引用次数: 0

Cardiac electrophysiology, arrhythmogenic mechanisms and roentgen contrast media. 心脏电生理学、心律失常机制和x线造影剂。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39913

E A Jacobsen, H K Pedersen, N E Klow, H Refsum

{"title":"Cardiac electrophysiology, arrhythmogenic mechanisms and roentgen contrast media.","authors":"E A Jacobsen, H K Pedersen, N E Klow, H Refsum","doi":"10.1177/0284185195036s39913","DOIUrl":"https://doi.org/10.1177/0284185195036s39913","url":null,"abstract":"Contrast media (CM) affect normal cardiac electrophysiology when injected into the coronary arteries. High-osmolality CM cause more pronounced electrophysiological effects than do low-osmolality CM. Further, both high- and low-osmolality ionic CM have more pronounced effects than the nonionic CM. The CM-induced electrophysiological effects involve regional disturbances of depolarization and repolarization, thereby causing disturbances of impulse conduction as well as dispersion of refractoriness. Recent experimental studies have demonstrated that the addition of sodium or a balanced electrolyte supplement to nonionic CM reduces the risk of ventricular fibrillation (VF), particularly when the CM is injected in a wedged catheter situation. The reduced risk of VF may be due to the small and transient lengthening of repolarization seen in the CM-perfused area of the myocardium. Iodixanol, which is an isotonic nonionic dimer supplemented with NaCl and CaCl(2), is as well tolerated as iohexol during free coronary flow. However, when flow is restricted, such as when CM is injected through a wedged catheter, the risk of VF is less with iodixanol than with iopamidol, iohexol and ioxaglate.","PeriodicalId":7159,"journal":{"name":"Acta radiologica. Supplementum","volume":"399 ","pages":"105-14"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0284185195036s39913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19589443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Reducing arrhythmogenic effects in the isolated heart enriching roentgen contrast media with electrolytes. Survey and present state. 减少离体心脏的致心律失常作用。调查和现状。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39914

J Besjakov, L Baath

引用次数: 4

Synthesis and characterization of iodixanol. 碘二醇的合成与表征。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39903

H Priebe, H Dugstad, M Gacek, E Hagen, O M Homestad, A Larsen, C E Sjogren, T Thomassen

引用次数: 10

Neural tolerability of iodixanol in mice and dogs after single and repeated intracisternal administration. 碘沙醇在小鼠和狗单次和多次腹腔内给药后的神经耐受性。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39929

L E Larsen, I F Heglund, R Fabian, P Walday, W F Blazak

{"title":"Neural tolerability of iodixanol in mice and dogs after single and repeated intracisternal administration.","authors":"L E Larsen, I F Heglund, R Fabian, P Walday, W F Blazak","doi":"10.1177/0284185195036s39929","DOIUrl":"https://doi.org/10.1177/0284185195036s39929","url":null,"abstract":"The neural tolerability of iodixanol has been assessed in studies in mice and dogs. The animals received up to 4 injections in the cisterna cerebellomedullaris while under light anesthesia. Iotrolan was included as a reference study in 1 study. The observations comprised assessment of clinical behavior, cerebrospinal fluid analysis, hematology, clinical chemistry and/or macroscopic and microscopic examination at necropsy. In addition, the repeated-dose dog study, urinalysis and opthalmoscopy were performed, electrocardiograms obtained, and respiratory rate, blood pressure and rectal temperature measured. Clinical signs and minor pathological changes caused by the injection procedures were seen in all studies in some animals treated with iodixanol as well as in control animals. Single (2.0 g I/kg) and repeated (0.960 g I/kg) intracisternal administration of iodixanol to mice caused no significant toxicological effects. Two dogs treated with a high dose of iodixanol (0.256 g I/kg; 0.8 ml/kg) had pathological changes (meningeal inflammation and/or necrosis) that were more severe than those observed in control dogs. Single and repeated intracisternal administration of 0.128 g I/kg (0.4 ml/kg) of iodixanol to dogs, however, caused no significant toxicological effects. Apart from the findings in the 2 dogs, the neurological and neuropathological changes elicited by iodixanol were similar to those induced by control or reference substances. The results from these intracisternal toxcity studies in mice and dogs indicate a significant margin of safety regarding the use of iodixanol in clinical intra-thecal indications.","PeriodicalId":7159,"journal":{"name":"Acta radiologica. Supplementum","volume":"399 ","pages":"238-43"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0284185195036s39929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19589452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Physicochemical properties of iodixanol. 碘二醇的物理化学性质。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39904

K Eivindvik, C E Sjogren

引用次数: 24

Renal effects of iodixanol in healthy volunteers and patients with severe renal failure. 碘沙醇对健康志愿者和严重肾功能衰竭患者肾脏的影响。

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI: 10.1177/0284185195036s39923

J A Jakobsen

{"title":"Renal effects of iodixanol in healthy volunteers and patients with severe renal failure.","authors":"J A Jakobsen","doi":"10.1177/0284185195036s39923","DOIUrl":"https://doi.org/10.1177/0284185195036s39923","url":null,"abstract":"Contrast medium- (CM) induced nephropathy may be evident from symptoms ranging from acute renal failure to minor changes in tubular function tests. While the incidence is usually low, it increases with the presence of risk factors and when arterial injections are made. The pathogenesis is not fully understood. No specific therapy exists, but in most cases it can be prevented by ensuring that the patient is well hydrated prior to injection of CM. The extended phase 1 study with iodixanol (Visipaque) included detailed investigations on its renal effects. No changes in glomerular filtration rate (GFR) were found. Even though enzymuria was less pronounced after injection of iodixanol than after various monomeric CM, a somewhat higher degree on intrarenal retention of CM was observed on CT examination of the kidneys after iodixanol. In nondiabetic patients suffering from severe renal failure, angiography with either iodixanol or iohexol caused no changes in GFR, or in urinary excretion of protein and enzymes. However, a higher degree of contrast retention than that seen in healthy volunteers was found.","PeriodicalId":7159,"journal":{"name":"Acta radiologica. Supplementum","volume":"399 ","pages":"191-5"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0284185195036s39923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19589399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25