H Priebe, H Dugstad, M Gacek, E Hagen, O M Homestad, A Larsen, C E Sjogren, T Thomassen
{"title":"碘二醇的合成与表征。","authors":"H Priebe, H Dugstad, M Gacek, E Hagen, O M Homestad, A Larsen, C E Sjogren, T Thomassen","doi":"10.1177/0284185195036s39903","DOIUrl":null,"url":null,"abstract":"<p><p>Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.</p>","PeriodicalId":7159,"journal":{"name":"Acta radiologica. Supplementum","volume":"399 ","pages":"21-31"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0284185195036s39903","citationCount":"10","resultStr":"{\"title\":\"Synthesis and characterization of iodixanol.\",\"authors\":\"H Priebe, H Dugstad, M Gacek, E Hagen, O M Homestad, A Larsen, C E Sjogren, T Thomassen\",\"doi\":\"10.1177/0284185195036s39903\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.</p>\",\"PeriodicalId\":7159,\"journal\":{\"name\":\"Acta radiologica. Supplementum\",\"volume\":\"399 \",\"pages\":\"21-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/0284185195036s39903\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta radiologica. Supplementum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/0284185195036s39903\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/0284185195036s39903","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.
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