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Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing 多功能水凝胶与电刺激疗法相结合促进糖尿病伤口愈合
IF 9.9 2区 材料科学
Nano Research Pub Date : 2024-08-24 DOI: 10.1007/s12274-024-6943-4
Xiaoyan Zheng, Jiaxin Yao, Jialing Yao, Pan Wang, Wan Liu, Daidi Fan, Junfeng Hui
{"title":"Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing","authors":"Xiaoyan Zheng, Jiaxin Yao, Jialing Yao, Pan Wang, Wan Liu, Daidi Fan, Junfeng Hui","doi":"10.1007/s12274-024-6943-4","DOIUrl":"https://doi.org/10.1007/s12274-024-6943-4","url":null,"abstract":"<p>Diabetic wounds, as a complication of diabetes, are slow to heal and seriously affect the quality of life of patients. Functional hydrogel dressing is an effective approach to improve diabetic wound healing. Electrical stimulation (ES) therapy is conducive to promoting cell migration and wound healing. In this work, a multifunctional PPTZ hydrogel wound dressing was developed by freeze-thaw method with polyvinyl alcohol (PVA), phytic acid (PA), tannic acid (TA), and Zinc chloride. The obtained PPTZ hydrogel has good mechanical properties (stress and strain of 700.03 kPa and 575.08%), light transmittance (close to 100%) and antibacterial rate (over 75%). With good biocompatibility, antioxidant abilities and conductivity, the PPTZ hydrogel could effectively promote the healing of diabetic wounds with two weeks under the action of electric field, which provides an auxiliary treatment strategy for diabetic patients.</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"14 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of quantum dot photolithography patterning and direct photolithography application 量子点光刻图案化和直接光刻应用的研究进展
IF 9.9 2区 材料科学
Nano Research Pub Date : 2024-08-24 DOI: 10.1007/s12274-024-6896-7
Zhong Chen, Yu Li, Zhongwei Man, Aiwei Tang
{"title":"Research progress of quantum dot photolithography patterning and direct photolithography application","authors":"Zhong Chen, Yu Li, Zhongwei Man, Aiwei Tang","doi":"10.1007/s12274-024-6896-7","DOIUrl":"https://doi.org/10.1007/s12274-024-6896-7","url":null,"abstract":"<p>For the new display technology based on quantum dots (QDs), realizing high-precision arrays of red, green, and blue (RGB) pixels has been a significant research focus at present, aimed at achieving high-quality and high-resolution image displays. However, challenges such as material stability and the variability of process environments complicate the assurance of quality in high-precision patterns. The novel optical patterning technology, exemplified by direct photolithography, is considered a highly promising approach for achieving submicron-level, hyperfine patterning. On the technological level, this method produces patterned quantum dot light-emitting films through a photochemical reaction. Here, we provide a comprehensive review of various methods of QD photolithography patterning, including traditional photolithography, lift off, and direct photolithography, which mainly focused on direct photolithography. This review covers the classification of direct photolithography technologies, summarizes the latest research progress, and discusses future perspectives on the advancement of photolithography technology de-masking.\u0000</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"38 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Layer-controlled 2D Sn4P3 via space-confined topochemical transformation for enhanced lithium cycling performance 通过空间约束拓扑化学转化实现层控二维 Sn4P3,从而提高锂循环性能
IF 9.5 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6915-8
Jianan Gu, Yongzheng Zhang, Bingbing Fan, Yanlong Lv, Yanhong Wang, Ruohan Yu, Meicheng Li
{"title":"Layer-controlled 2D Sn4P3 via space-confined topochemical transformation for enhanced lithium cycling performance","authors":"Jianan Gu,&nbsp;Yongzheng Zhang,&nbsp;Bingbing Fan,&nbsp;Yanlong Lv,&nbsp;Yanhong Wang,&nbsp;Ruohan Yu,&nbsp;Meicheng Li","doi":"10.1007/s12274-024-6915-8","DOIUrl":"10.1007/s12274-024-6915-8","url":null,"abstract":"<div><p>Topochemical transformation has emerged as a promising method for fabricating two-dimensional (2D) materials with precise control over their composition and morphology. However, the large-scale synthesis of ultrathin 2D materials with controllable thickness remains a tremendous challenge. Herein, we adopt an efficient topochemical synthesis strategy, employing a confined reaction space to fabricate ultrathin 2D Sn<sub>4</sub>P<sub>3</sub> nanosheets in large-scale. By carefully adjusting the rolling number during the processing of Sn/Al foils, we have successfully fabricated Sn<sub>4</sub>P<sub>3</sub> nanosheets with varied layer thicknesses, achieving a remarkable minimum thickness of two layers (~ 2.2 nm). Remarkably, the bilayer Sn<sub>4</sub>P<sub>3</sub> nanosheets display an exceptional initial capacity of 1088 mAh·g<sup>−1</sup>, nearing the theoretical value of 1230 mAh·g<sup>−1</sup>. Furthermore, we reveal their high-rate property as well as outstanding cyclic stability, maintaining capacity without fading more than 3000 cycles. By precisely controlling the layer thickness and ensuring nanoscale uniformity, we enhance the lithium cycling performance of Sn<sub>4</sub>P<sub>3</sub>, marking a significant advancement in developing high-performance energy storage systems.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9697 - 9703"},"PeriodicalIF":9.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitive and environmental friendly sensor on porphyrin functionalized chitosan fiber membrane for Hg2+ 卟啉功能化壳聚糖纤维膜上的 Hg2+ 灵敏环保传感器
IF 9.9 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6890-0
Yafei Ma, Xinman Liu, Zhiping Fu, Lifen Zhang, Yuexin Guo, Hui Wang, Zhiqian Jia
{"title":"Sensitive and environmental friendly sensor on porphyrin functionalized chitosan fiber membrane for Hg2+","authors":"Yafei Ma, Xinman Liu, Zhiping Fu, Lifen Zhang, Yuexin Guo, Hui Wang, Zhiqian Jia","doi":"10.1007/s12274-024-6890-0","DOIUrl":"https://doi.org/10.1007/s12274-024-6890-0","url":null,"abstract":"<p>Mercury is the most toxic and harmful heavy metal pollutant, and it is essential to detect and remove mercury from beverages. Inducing the porphyrin molecules into the chitosan structure, a novel membrane sensor tetrakis(4-carboxyphenyl)porphyrin-grafted chitosan fiber membrane (TCPP-CS) was prepared by electrospinning method and applied to recognize Hg<sup>2+</sup> contaminant selectively. Compared with other common metal ions (Pb<sup>2+</sup>, Cu<sup>2+</sup>, Fe<sup>3+</sup>, Cr<sup>3+</sup>, Mg<sup>2+</sup>, and Zn<sup>2+</sup>), the colorimetric sensor has specific color development and sensitivity to Hg<sup>2+</sup> and the detection limit of the sensor reaches 1 × 10<sup>−5</sup> mol·L<sup>−1</sup>. The response time of the membrane is 5 s, and it can be specifically colored in various pH environments convenient for practical application. Hg<sup>2+</sup> resulted in a visual color change of the fiber membrane from brown to yellow-green, indicating a potential interaction between the porphyrin-functionalized chitosan fiber membrane and Hg<sup>2+</sup> ions, and the wavelength shift of the UV–visible spectrum can be observed. It has the advantages of simplicity, rapidity, high selectivity, and high sensitivity, providing a new method for removing and detecting heavy metals in traditional Chinese medicine and drinks.\u0000</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"63 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical study on anomalous thermal expansion of two AB2-type compounds 两种 AB2 型化合物的反常热膨胀理论研究
IF 9.5 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6878-9
Xin Chen, Yili Cao, Xianran Xing
{"title":"Theoretical study on anomalous thermal expansion of two AB2-type compounds","authors":"Xin Chen,&nbsp;Yili Cao,&nbsp;Xianran Xing","doi":"10.1007/s12274-024-6878-9","DOIUrl":"10.1007/s12274-024-6878-9","url":null,"abstract":"<div><p>Anomalous thermal expansion, or other words, negative thermal expansion (NTE), resulting from the lattice contraction upon temperature increasing, has been an enduring topic for material science and engineering. The variation of a lattice go with the temperature is straightly originated from its electronic structures and is inseparable from those physical properties. In the past several decades, many efforts have been made to searching new series of NTE compounds or control the thermal expansion performance in order to supply various demands of different extreme applications. These development of new NTE systems also dependences on the theoretical studies. Here, we carried out theoretical calculation on CrB<sub>2</sub> and FeZr<sub>2</sub> with anisotropic negative thermal expansion. Intriguingly, theoretical calculations reveal that the binding of either Cr-Cr pair or Fe-Fe pair is relatively small. The results reveal that the origin of NTE is the ordered magnetic state during the increasing of temperature. The localized electrons would prevent the lattice parameters increase with heating, which shows macroscopic NTE phenomenon.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9830 - 9833"},"PeriodicalIF":9.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-level anti-counterfeiting based on versatile luminescence of tri-doped double perovskites 基于三掺杂双过氧化物多功能发光的五级防伪技术
IF 9.9 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6918-5
Xingru Yang, Yuhang Sheng, Linglong Zhang, Lun Yang, Fangjian Xing, Yunsong Di, Cihui Liu, Fengrui Hu, Xifeng Yang, Guofeng Yang, Yushen Liu, Zhixing Gan
{"title":"Five-level anti-counterfeiting based on versatile luminescence of tri-doped double perovskites","authors":"Xingru Yang, Yuhang Sheng, Linglong Zhang, Lun Yang, Fangjian Xing, Yunsong Di, Cihui Liu, Fengrui Hu, Xifeng Yang, Guofeng Yang, Yushen Liu, Zhixing Gan","doi":"10.1007/s12274-024-6918-5","DOIUrl":"https://doi.org/10.1007/s12274-024-6918-5","url":null,"abstract":"<p>Luminescent materials with multi-emission features are difficult to be replicated, which are highly desirable for advanced anti-counterfeiting. Here, we report the pioneering synthesis of Mn<sup>2+</sup>/Yb<sup>3+</sup>/Er<sup>3+</sup> tri-doped Cs<sub>2</sub>Ag<sub>0.8</sub>Na<sub>0.2</sub>InCl<sub>6</sub> double perovskites (MYE-DP), which exhibit photoluminescence (PL) covering from visible to near-infrared (NIR). The PL colors under excitations of 254 and 365 nm are notably different due to the changed relative emission intensities of self-trapped excitons (STEs) and Mn<sup>2+</sup> d–d transition. Moreover, under the excitation of a NIR laser, the MYE-DP exhibits upconversion (UC) emissions of Mn<sup>2+</sup> and Er<sup>3+</sup>. After ceasing the excitation, the long-lived trapped electrons can be thermally released to Mn<sup>2+</sup> and Er<sup>3+</sup> ions, resulting in both visible and NIR afterglow. Based on multi-modal emissions of the MYE-DP, we demonstrate a five-level anti-counterfeiting strategy, which significantly increases the anti-counterfeiting security. In addition, this work provides valuable insights into the energy transfer between STEs, Mn<sup>2+</sup>, Ln<sup>3+</sup>, and traps, laying a solid foundation for future development of new lead-free perovskites.\u0000</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"59 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral metal nanocluster within nanoarchitecture of fullerene C60: Chirality transfer and improvement of nonlinear optical property 富勒烯 C60 纳米结构中的手性金属纳米团簇:手性转移和非线性光学特性的改善
IF 9.5 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6913-x
Jinrui Li, Yuting Bi, Ziyao Liu, Zhijie Yang, Xia Xin, Lei Feng, Hongguang Li, Jingcheng Hao
{"title":"Chiral metal nanocluster within nanoarchitecture of fullerene C60: Chirality transfer and improvement of nonlinear optical property","authors":"Jinrui Li,&nbsp;Yuting Bi,&nbsp;Ziyao Liu,&nbsp;Zhijie Yang,&nbsp;Xia Xin,&nbsp;Lei Feng,&nbsp;Hongguang Li,&nbsp;Jingcheng Hao","doi":"10.1007/s12274-024-6913-x","DOIUrl":"10.1007/s12274-024-6913-x","url":null,"abstract":"<div><p>Interaction between heterogeneous, nanometer-sized building blocks (NSBBs) is fascinating from viewpoints of both structures and functions. We report the co-assembly of fullerene C<sub>60</sub> and a chiral silver nanocluster (Ag<sub>6</sub>), which yields C<sub>60</sub> nanoarchitecture decorated with a small amount of Ag<sub>6</sub>. While Ag<sub>6</sub> exhibits circular dichroism (CD) signal mainly in the ultraviolet (UV) region, the signal of the C<sub>60</sub>-Ag<sub>6</sub> hybrid extends to visible region (over 700 nm). Up to five pairs of CD signals were distinguished, which match well with the absorption of the C<sub>60</sub> crystal. The successful chirality transfer from the guest of Ag<sub>6</sub> to C<sub>60</sub>-dominated supramolecular system indicates that the “sergeants and soldiers” effect is valid in architectonics of NSBBs. In addition, the doping of Ag<sub>6</sub> leads to pronounced nonlinear optical response, paving a new way for the development of chiral optical materials.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9255 - 9260"},"PeriodicalIF":9.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasmall high-entropy alloy nanoparticles on hierarchical N-doped carbon nanocages for tremendous electrocatalytic hydrogen evolution 分层掺杂 N 的碳纳米笼上的超小型高熵合金纳米粒子用于巨大的电催化氢进化
IF 9.5 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6924-7
Manman Jia, Jietao Jiang, Jingyi Tian, Xizhang Wang, Lijun Yang, Qiang Wu, Zheng Hu
{"title":"Ultrasmall high-entropy alloy nanoparticles on hierarchical N-doped carbon nanocages for tremendous electrocatalytic hydrogen evolution","authors":"Manman Jia,&nbsp;Jietao Jiang,&nbsp;Jingyi Tian,&nbsp;Xizhang Wang,&nbsp;Lijun Yang,&nbsp;Qiang Wu,&nbsp;Zheng Hu","doi":"10.1007/s12274-024-6924-7","DOIUrl":"10.1007/s12274-024-6924-7","url":null,"abstract":"<div><p>High-entropy alloys (HEAs) are promising candidates for the electrocatalyst of hydrogen evolution reaction (HER) due to their unique properties such as cocktail electronic effect and lattice distortion effect. Herein, the ultrasmall (sub-2 nm) nanoparticles of PtRuCoNiCu HEA with uniform element distribution are highly dispersed on hierarchical N-doped carbon nanocages (hNCNC) via low-temperature thermal reduction, denoted as us-HEA/hNCNC. The optimal us-HEA/hNCNC exhibits excellent HER performance in 0.5 M H<sub>2</sub>SO<sub>4</sub> solution, achieving an ultralow overpotential of 19 mV at 10 mA·cm<sup>−2</sup> (without <i>iR</i>-compensation), high mass activity of 13.1 A·mg<sub>noble metals</sub><sup>−1</sup> at −0.10 V and superb stability with a slight overpotential increase of 3 mV after 20,000 cycles of cyclic voltammetry scans, much superior to the commercial Pt/C (20 wt.%). The combined experimental and theoretical studies reveal that the Pt&amp;Ru serve as the main active sites for HER and the CoNiCu species modify the electron density of active sites to facilitate the H* adsorption and achieve an optimum M-H binding energy. The hierarchical pore structure and N-doping of hNCNC support also play a crucial role in the enhancement of HER activity and stability. This study demonstrates an effective strategy to greatly improve the HER performance of noble metals by developing the HEAs on the unique hNCNC support.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9518 - 9524"},"PeriodicalIF":9.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for flame-retardant polymer electrolytes for safe lithium-based batteries 用于安全锂电池的阻燃聚合物电解质战略
IF 9.5 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6902-4
Xiao Ma, Yang Lu, Yu Ou, Shuaishuai Yan, Wenhui Hou, Pan Zhou, Kai Liu
{"title":"Strategies for flame-retardant polymer electrolytes for safe lithium-based batteries","authors":"Xiao Ma,&nbsp;Yang Lu,&nbsp;Yu Ou,&nbsp;Shuaishuai Yan,&nbsp;Wenhui Hou,&nbsp;Pan Zhou,&nbsp;Kai Liu","doi":"10.1007/s12274-024-6902-4","DOIUrl":"10.1007/s12274-024-6902-4","url":null,"abstract":"<div><p>The advancement of lithium-based batteries has spurred anticipation for enhanced energy density, extended cycle life and reduced capacity degradation. However, these benefits are accompanied by potential risks, such as thermal runaway and explosions due to higher energy density. Currently, liquid organic electrolytes are the predominant choice for lithium batteries, despite their limitations in terms of mechanical strength and vulnerability to leakage. The development of polymer electrolytes, with their high Young’s modulus and enhanced safety features, offers a potential solution to the drawbacks of traditional liquid electrolytes. Despite these advantages, polymer electrolytes are still susceptible to burning and decomposition. To address this issue, researchers have conducted extensive studies to improve their flame-retardant properties from various perspectives. This review provides a concise overview of the thermal runaway mechanisms, flame-retardant mechanisms and electrochemical performance of polymer electrolytes. It also outlines the advancements in flame-retardant polymer electrolytes through the incorporation of various additives and the selection of inherently flame-retardant matrix. This review aims to offer a comprehensive understanding of flame-retardant polymer electrolytes and serve as a guide for future research in this field.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 10","pages":"8754 - 8771"},"PeriodicalIF":9.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142412980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foamed microemulsion nanodroplets loaded with chlorin e6 for epidermal-targeted treatment against psoriasis 装载氯素 e6 的泡沫微乳液纳米微滴用于表皮靶向治疗银屑病
IF 9.9 2区 材料科学
Nano Research Pub Date : 2024-08-22 DOI: 10.1007/s12274-024-6916-7
Xiaolu Ma, Qiong Bian, Yihua Xu, Jingyi Hu, Weitong Hu, Ruxuan Wang, Yunting Zhang, Yuxian Ye, Xiaoxia Sheng, Tianyuan Zhang, Jianqing Gao
{"title":"Foamed microemulsion nanodroplets loaded with chlorin e6 for epidermal-targeted treatment against psoriasis","authors":"Xiaolu Ma, Qiong Bian, Yihua Xu, Jingyi Hu, Weitong Hu, Ruxuan Wang, Yunting Zhang, Yuxian Ye, Xiaoxia Sheng, Tianyuan Zhang, Jianqing Gao","doi":"10.1007/s12274-024-6916-7","DOIUrl":"https://doi.org/10.1007/s12274-024-6916-7","url":null,"abstract":"<p>Psoriasis is a chronic skin disease characterized by the hyperproliferation of keratinocytes and an overactive autoimmune response. Photodynamic therapy (PDT) has been established as a promising intervention for alleviating psoriasis. However, the current transdermal delivery of photosensitizers is inefficient and imprecise. In this study, we developed a foamed microemulsion nanodroplets system containing chlorin e6 (Ce6 FM), exhibiting precise epidermal targeting and retention, which targeted the aberrantly proliferating epidermal cells at psoriatic skin lesions and avoided the damage to the normal cutaneous cells. Upon application in a psoriatic mouse model, Ce6 FM efficiently induced keratinocyte apoptosis by generating reactive oxygen species under laser. Furthermore, Ce6 FM-based PDT activated the cyclooxygenase-2-induced immunosuppressive pathway in keratinocytes, resulting in the amelioration of the autoimmune microenvironment in psoriatic skin. Additionally, Ce6 FM-based PDT did not induce skin damage or atrophy associated with non-targeted halometasone treatment. Overall, Ce6 FM-based PDT holds promise as an effective, safe and compliant strategy for psoriasis treatment.</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"29 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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