Acta Clinica Belgica最新文献_第7页

Truth or dare: switching BRAF/MEK inhibitors after acute interstitial nephritis in a patient with metastatic melanoma - A case report and review of the literature. 真心话大冒险:转移性黑色素瘤患者急性间质性肾炎后切换BRAF/MEK抑制剂-一例报告和文献回顾

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2114684

Lore De Ryck, Sigurd Delanghe, Celine Jacobs, Sharareh Fadaei, Lieve Brochez, Michael Saerens

{"title":"Truth or dare: switching BRAF/MEK inhibitors after acute interstitial nephritis in a patient with metastatic melanoma - A case report and review of the literature.","authors":"Lore De Ryck, Sigurd Delanghe, Celine Jacobs, Sharareh Fadaei, Lieve Brochez, Michael Saerens","doi":"10.1080/17843286.2022.2114684","DOIUrl":"https://doi.org/10.1080/17843286.2022.2114684","url":null,"abstract":"Introduction: The introduction of BRAF/MEK inhibitors has significantly improved overall survival of patients with BRAF V600-mutant advanced or metastatic melanoma. Most patients treated with BRAF/MEK inhibitors will experience adverse events during the course of their treatment. Kidney impairment, however, was rarely reported in the pivotal trials. To date, there are only three cases of biopsy-proven acute interstitial nephritis associated with dabrafenib and trametinib reported in the literature.Case report: A 50-year-old man diagnosed with metastatic melanoma was hospitalized in August 2021, 5 months after treatment initiation with dabrafenib and trametinib. He presented with acute kidney injury, with serum creatinine of 3.34 mg/dL and eGFR of 20.3 mL/min/m². Kidney biopsy revealed acute interstitial nephritis.Management & outcome: He was treated with methylprednisolone 16 mg qd, and both dabrafenib and trametinib were permanently discontinued, with recuperation of his kidney function. Another BRAF/MEK inhibitor combination, encorafenib and binimetinib, was introduced, with preserved kidney function and excellent disease control.Discussion: We report the first case of biopsy-proven interstitial nephritis in a patient treated with dabrafenib and trametinib, with successful introduction of another BRAF/MEK inhibitor combination. Although rare, clinicians should be aware of the risk of renal adverse events associated with BRAF/MEK inhibitors. Renal biopsy is mandatory in the absence of a clear explanation or rapid recovery of renal failure. In case of proven interstitial nephritis, corticosteroids should be initiated. Switching to another BRAF/MEK inhibitor combination can be considered for patients with complete recovery of renal function and limited treatment options.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 3","pages":"215-222"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prediction parameters of left ventricular diastolic dysfunction improvement in patients after acute coronary syndrome. 急性冠脉综合征患者左室舒张功能改善的预测参数。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2114678

Marija Bjelobrk, Tatjana Miljković, Aleksandra Ilić, Aleksandra Milovančev, Snežana Tadić, Snežana Bjelić, Dragana Dabović, Milenko Čanković, Vladimir Ivanović, Andrej Preveden, Dejana Popović

{"title":"Prediction parameters of left ventricular diastolic dysfunction improvement in patients after acute coronary syndrome.","authors":"Marija Bjelobrk, Tatjana Miljković, Aleksandra Ilić, Aleksandra Milovančev, Snežana Tadić, Snežana Bjelić, Dragana Dabović, Milenko Čanković, Vladimir Ivanović, Andrej Preveden, Dejana Popović","doi":"10.1080/17843286.2022.2114678","DOIUrl":"https://doi.org/10.1080/17843286.2022.2114678","url":null,"abstract":"Objectives: The aim of this study was to examine the effects of comprehensive cardiac rehabilitation (CCR) in patients after acute coronary syndrome (ACS) resolved by percutaneous coronary intervention (PCI) on left ventricular diastolic dysfunction (LVDD) and to extract the parameters that have the greatest influence on LVDD improvement.Methods: The study included 85 subjects who were divided into intervention (N = 56) and control (N = 29) groups depending on CCR attendance. Initially and after 12 weeks, patients of both groups were subjected to echocardiography to assess LVDD, as well as CPET to assess improvement in functional capacity.Results: The study showed that 23 patients (27.1%) of both groups demonstrated the improvement of LVDD degree. The improvement of the LVDD degree in the intervention group was significant, whereas in the control group, it did not change (a one-degree improvement in 22 (39.3%) patients of the intervention group (p < 0.001) and only 1 (3.4%) (p > 0.05) in the control group). Multivariate binary logistic regression showed that key parameters in LVDD improvement were participation in the CCR, E/A ratio and haemoglobin value. We created a model, for prediction of LVDF improvement, with a cut-off value of 33 (area = 0.9, p < 0.0005), a sensitivity of 87.0% and a specificity of 85.5%.Conclusions: CCR can be used as an effective non-pharmacological measure to improve LVDD and functional capacity in patients after ACS. The statistical model may have practical application in prediction of clinical benefit in such a group of patients.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 3","pages":"206-214"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Peritoneal tuberculosis caused by intravesical instillation with Bacillus Calmette-Guérin (BCG) following nephroureterectomy in a patient with bladder and upper tract urothelial cancer: a case report. 膀胱和上尿路上皮癌患者肾输尿管切除术后膀胱内灌注卡介苗引起腹膜结核:1例报告。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2110688

Charlotte Allaeys, Pieter De Backer, Karel Decaestecker, Camille Berquin, Karen Decaestecker, Steven Callens, Charles Van Praet

引用次数: 1

Infections caused by hypervirulent Klebsiella pneumoniae in non-endemic countries: three case reports and review of the literature. 在非流行国家由高毒力肺炎克雷伯菌引起的感染:三个病例报告和文献综述。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2106705

Wannes Van Hooste, Marthe Vanrentergem, Eric Nulens, Christophe Snauwaert, Deborah De Geyter, Rembert Mertens, Jens T Van Praet

{"title":"Infections caused by hypervirulent Klebsiella pneumoniae in non-endemic countries: three case reports and review of the literature.","authors":"Wannes Van Hooste, Marthe Vanrentergem, Eric Nulens, Christophe Snauwaert, Deborah De Geyter, Rembert Mertens, Jens T Van Praet","doi":"10.1080/17843286.2022.2106705","DOIUrl":"https://doi.org/10.1080/17843286.2022.2106705","url":null,"abstract":"Objectives: Spontaneous liver abscess caused by a hypervirulent Klebsiella pneumoniae strain was first described several decades ago in Taiwan and has been an emerging clinical entity worldwide ever since. We aimed to describe the clinical and microbiological characteristics of this infection in a non-endemic setting.Methods: A narrative literature review was conducted in PubMed for European case reports of hypervirulent Klebsiella pneumoniae from 2016 to 2021.Results: Forty case reports were retrieved. Mean age of the patients was 59 years and 72% were male. Diabetes mellitus was present in 33%. Twenty percent of the patients originated from an endemic region. A liver abscess and bacteremia were observed in, respectively, 83% and 80% of the cases. The most frequent metastatic infections were found in the eye (28%) and the lungs (28%). The sensitivity of molecular capsular antigen detection and the string test was 87% and 92%, respectively. Sixty-three percent of the strains had a wildtype resistance.Conclusion: Hypervirulent Klebsiella pneumoniae infections in non-endemic countries are most frequently observed in middle-aged males. Clinicians should be vigilant for metastatic infections.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 3","pages":"229-233"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The prospective screening for SARS-CoV-2 S1/S2 antibodies delineates the factual incidence of COVID-19 and shows a sustained serological response post COVID-19 in kidney transplant recipients. SARS-CoV-2 S1/S2抗体的前瞻性筛查描绘了COVID-19的实际发病率，并显示肾移植受者在COVID-19后持续的血清学反应。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2108978

Louis Firket, Antoine Bouquegneau, Laurence Seidel, Catherine Bonvoisin, Stéphanie Grosch, Marie-Pierre Hayette, François Jouret, Laurent Weekers

{"title":"The prospective screening for SARS-CoV-2 S1/S2 antibodies delineates the factual incidence of COVID-19 and shows a sustained serological response post COVID-19 in kidney transplant recipients.","authors":"Louis Firket, Antoine Bouquegneau, Laurence Seidel, Catherine Bonvoisin, Stéphanie Grosch, Marie-Pierre Hayette, François Jouret, Laurent Weekers","doi":"10.1080/17843286.2022.2108978","DOIUrl":"https://doi.org/10.1080/17843286.2022.2108978","url":null,"abstract":"Background: The impact of immunosuppression on the occurrence of Coronavirus Disease 2019 (COVID-19) remains unclear.Methods: We conducted a prospective screening of anti-S1/S2 IgGs against SARS-CoV-2 Spike protein from March, 1 2020 to May, 15 2021 (prior to the vaccination campaign) in a cohort of 713 kidney transplant recipients (KTRs). In a first phase, the factual incidence and seroprevalence of COVID-19 was established in this cohort: cases diagnosed by serology were added to RT-PCR-based diagnoses to obtain the overall incidence of COVID-19 in both symptomatic and asymptomatic KTRs. In the second phase, the kinetics of the post-COVID-19 humoral response were studied, taking into account the severity of the disease defined by the need for oxygen therapy (group S, \"severe\") or not (group nS, \"not severe\").Results: The combined diagnostic approaches identified 138 COVID-19 cases (19.2%), with 37 diagnoses by serology (26.8%). The rate of asymptomatic KTRs reached 20.3% (28/138). Thirteen patients (9.4%) died from COVID-19. The seroconversion rate was 91.7% (99/108). The peak anti-S1/S2 IgG level was 85 [30-150] AU/ml and was similar between the S and nS groups (117 [38; 186] AU/ml versus 73 [23; 140] AU/ml). A high probability of persistence of anti-S1/S2 IgG post-COVID-19 was observed, with only 10.1% (7/69) of the patients having negated their serology during the 9-month follow-up.Conclusion: Our pragmatic serological screening combined with RT-PCR tests provides a better estimation of the real incidence of COVID-19 in KTRs. A significant proportion of KTRs develop humoral immunity post COVID-19, which most often persists beyond 9 months.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 3","pages":"200-205"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of clinical characteristics between old and oldest-old patients hospitalised for SARS-COV2. 老年与高龄SARS-COV2住院患者临床特征比较

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-06-01 DOI: 10.1080/17843286.2022.2102115

Sylwia Szklarzewska, Justine Vande Walle, Sandra De Breucker, Didier Schoevaerdts

{"title":"A comparison of clinical characteristics between old and oldest-old patients hospitalised for SARS-COV2.","authors":"Sylwia Szklarzewska, Justine Vande Walle, Sandra De Breucker, Didier Schoevaerdts","doi":"10.1080/17843286.2022.2102115","DOIUrl":"https://doi.org/10.1080/17843286.2022.2102115","url":null,"abstract":"Objectives: Oldest-old patients may have an unusual SARS-COV2 presentation that can jeopardise diagnosis and management. The aim of this study was to compare the clinical characteristics and outcomes of oldest-old (≥85 years) and old patients (75-85 years) admitted with COVID-19 to Belgian hospitals during the first wave of the pandemic.Methods: We conducted a multicentre, retrospective, observational study in ten Belgian hospitals. We reviewed the electronic clinical records of patients ≥75 years hospitalised with COVID-19 from March to June 2020.Results: A total of 986 patients were placed on the register (old group: n = 507; oldest-old group: n = 479). Before hospitalisation, the oldest-old (OO) group presented with more geriatric syndromes including comorbidities, frailty, falls, cognitive impairment, and incontinence. At admission, the OO group presented with less cough, less headache, and less fever but significantly more delirium than old (O) group. Members of the OO group were admitted less frequently to intensive care units (ICUs). A geriatrician was consulted to help in the decision-making process more often for the OO group. The global mortality of the cohort was 47%, with no difference between the two groups. Patients in the OO group were more often institutionalised after hospitalisation and less often referred for rehabilitation.Conclusions: The OO patients presented with more geriatric syndromes that make them vulnerable to dependence and institutionalisation after a hospital stay, without having a higher mortality rate than O patients. Geriatrician expertise is necessary in the management of frail older patients.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 3","pages":"192-199"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9381019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMI in (bi)ventricular pacing - do not discard the ECG. AMI(双心室起搏)-不要丢弃心电图。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-04-01 DOI: 10.1080/17843286.2022.2074711

T Versyck, D Devriese, S Smith, P Calle, C Borin

{"title":"AMI in (bi)ventricular pacing - do not discard the ECG.","authors":"T Versyck, D Devriese, S Smith, P Calle, C Borin","doi":"10.1080/17843286.2022.2074711","DOIUrl":"https://doi.org/10.1080/17843286.2022.2074711","url":null,"abstract":"Background: There is a growing number of patients with ventricular paced rhythm, who present to the emergency department with chest pain. The diagnosis of ST-segment elevation myocardial infarction (STEMI) and subsequent percutaneous coronary intervention (PCI) is often postponed, as the 12 leads-electrocardiogram (ECG) is discarded as not interpretable. There is a growing body of literature that suggests that Smith-modified Sgarbossa criteria can be applied for the diagnosis of STEMI in patients with paced rhythms. These criteria were originally developed for the interpretation of ECGs in patients with a left bundle branch block (LBBB) and chest pain, but have been expanded to paced ECGs.Methodology: We present three case reports with chest pain and right ventricular or biventricular pacing.Findings: In all three cases, the Smith-modified Sgarbossa was positive and the diagnosis of STEMI could have been made early on.Implications: It remains important to look for ST-segment deviations and to compare the symptomatic ECG with previous asymptomatic ECGs. As the number of patients with potential acute myocardial infarction (AMI) and paced rhythms is likely to rise in the future, these criteria should be known to emergency physicians and cardiologists.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 2","pages":"165-170"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10852452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical decision-making in older patients with cancer: a cross-sectional single-centre study to assess the impact of clinical judgement and patient preferences. 老年癌症患者的临床决策:一项评估临床判断和患者偏好影响的横断面单中心研究

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-04-01 DOI: 10.1080/17843286.2022.2074702

Annelies Deldycke, Hannelore Denys, Alexander Decruyenaere, Anja Velghe, Eline Naert

{"title":"Clinical decision-making in older patients with cancer: a cross-sectional single-centre study to assess the impact of clinical judgement and patient preferences.","authors":"Annelies Deldycke, Hannelore Denys, Alexander Decruyenaere, Anja Velghe, Eline Naert","doi":"10.1080/17843286.2022.2074702","DOIUrl":"https://doi.org/10.1080/17843286.2022.2074702","url":null,"abstract":"Objective: The heterogeneity in the population of older patients with cancer makes clinical decision-making difficult. We investigated the agreement between the G8 score and clinical judgment in frailty assessments, determined the impact of a life-expectancy calculator, and explored patient and caregiver preferences towards the treatment goal.Methods: Patients aged ≥75 years in need of new oncological treatment were prospectively enrolled between June 2020 and February 2021. Frailty was estimated by the oncologist and caregiver and compared to the G8 estimation. We examined whether the oncologist changed the fit/frail estimation based on life expectancy calculated using the ePrognosis tool. The main treatment goals, either longevity or quality of life (QoL), from the patient's and caregiver's perspective were noted and compared.Results: Forty-nine patients were included in the analysis. Comparison of the oncologist's and the caregiver's frailty estimation with the G8 assessment showed agreement and a Kappa coefficient of 58.3% (0.231) and 60% (0.255), respectively. The ePrognosis score and the odds of change in the frailty estimation by the oncologist showed no correlation. Regarding preferences, 28 (57.1%) and 17 (34.7%) patients and eighteen (47.3%) and seventeen (44.7%) caregivers chose longevity and QoL, respectively. The observed agreement and Kappa coefficient were 78.8% and 0.578.Conclusion: Compared to the G8 assessment, frailty was underestimated by both oncologists and caregivers. Most of the patients chose longevity over QoL, and the preferences between the patient and the caregiver matched in the majority of cases.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 2","pages":"103-111"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10857193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Body mass index and occupational accidents among health care workers in a large university hospital. 某大型大学医院医护人员身体质量指数与职业事故。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-04-01 DOI: 10.1080/17843286.2022.2084936

N Fraeyman, D De Bacquer, T Fiers, L Godderis, R Verhaeghe, K Eeckloo, P Gemmel, L Viaene, E Mortier

{"title":"Body mass index and occupational accidents among health care workers in a large university hospital.","authors":"N Fraeyman, D De Bacquer, T Fiers, L Godderis, R Verhaeghe, K Eeckloo, P Gemmel, L Viaene, E Mortier","doi":"10.1080/17843286.2022.2084936","DOIUrl":"https://doi.org/10.1080/17843286.2022.2084936","url":null,"abstract":"Introduction: Obesity is associated with a number of chronic diseases such as cardiovascular diseases and cancers. The association of obesity with occupational accidents has been suggested although the evidence is less convincing. The objective of the study is to analyse the relationship between BMI values and ergonomic accidents in a large University Hospital.Methods: The relationship between body mass index (BMI) and the incidence of ergonomic occupational accidents over a period of 8 years was investigated in a cohort of employees of a large University Hospital, covering almost 27,000 person-years of observation. This relationship was stratified according to the variables age, gender, functional status within the organization and work schedule (part-time or full time). Height and weight were objectively measured, demographic data were obtained from the human resource department and the registration of ergonomic accidents was carried out by the safety and prevention department of the hospital.Results: The number of ergonomic accidents, expressed as number/1000 person-years was higher for female employees compared to male employees, increased with age and markedly increased from functional class A (leading or expert function and higher educational level) to D (executive function in patient care and technical department). However, the incidence of ergonomic accidents accompanied by loss of working time was not significantly associated with BMI, independently of age and gender. In addition, the type of accident and the severity of the accidents expressed as the number of days absent from work were unrelated to BMI.Conclusion: No independent relationship between BMI and the incidence of ergonomic accidents could be identified in our cohort. Tailoring working conditions to individual BMI levels is not recommended.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 2","pages":"128-134"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preterm birth during the COVID-19 pandemic: more, less, or just the same? COVID-19大流行期间的早产:更多，更少，还是一样?

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-04-01 DOI: 10.1080/17843286.2022.2091321

Isabelle Dehaene, Caroline Van Holsbeke, Kristien Roelens, Noortje Nvh van Oostrum, Katrien Nulens, Koenraad Smets, Marie-Rose Van Hoestenberghe, Gunnar Naulaers, Roland Devlieger

{"title":"Preterm birth during the COVID-19 pandemic: more, less, or just the same?","authors":"Isabelle Dehaene, Caroline Van Holsbeke, Kristien Roelens, Noortje Nvh van Oostrum, Katrien Nulens, Koenraad Smets, Marie-Rose Van Hoestenberghe, Gunnar Naulaers, Roland Devlieger","doi":"10.1080/17843286.2022.2091321","DOIUrl":"https://doi.org/10.1080/17843286.2022.2091321","url":null,"abstract":"Objectives: Coronavirus disease (COVID-19) and its mitigation measures have been associated with changes in preterm birth (PTB) incidences. The objective of this paper is to summarize and comment on the literature on COVID-19 and PTB and to compare PTB incidence between 2019 (pre-COVID-19) and 2020 (COVID-19) in three Belgian tertiary care hospitals.Methods: A non-systematic review on COVID-19 and PTB was performed, and literature was summarized in a table. Preterm birth rates at Ghent University Hospital, Ziekenhuis Oost-Limburg, and University Hospital Leuven in 2019 and 2020 were compared. Chi-square and Fisher's exact tests were used to compare PTB rates between 2019 and 2020, and Kaplan Meier survival analysis was used to compare pregnancy duration. The mean outcome measure was PTB incidence in 2020 (COVID-19) compared with PTB incidence in 2019 (pre-COVID-19).Results: Some (parts of) countries report decreases in PTB rates, others report no differences in incidence, and a minority of countries report an increased incidence of PTB. Almost all studies only consider live-births. In three tertiary care hospitals in Flanders, there were no differences in PTB rates before and during the COVID-19 pandemic.Conclusion: The impact of the (mitigation measures during the) COVID-19 pandemic on PTB incidence is unclear and difficult to explore. To enable a correct interpretation, all conceptions before and during the pandemic should be taken into consideration, as well as all births, still or alive.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":"78 2","pages":"140-159"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9415997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1