TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307006
Zhu Shao, Shuxiong Bi
{"title":"Trends in research on osteoarthritis of the knee in conventional medicine: a bibliometric analysis based on big data from 1990–2022","authors":"Zhu Shao, Shuxiong Bi","doi":"10.53388/tmrim202307006","DOIUrl":"https://doi.org/10.53388/tmrim202307006","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307022
Min Wang, Jian-Lin Li, Yu Qin, Jiangling Huang, Yunyi Shi
{"title":"Meta-analysis of ear acupoint therapy to treat sleep disorders in hemodialysis patients","authors":"Min Wang, Jian-Lin Li, Yu Qin, Jiangling Huang, Yunyi Shi","doi":"10.53388/tmrim202307022","DOIUrl":"https://doi.org/10.53388/tmrim202307022","url":null,"abstract":"Background: To evaluate the therapeutic effect of auricular therapy on sleep disorders in hemodialysis patients using meta-analysis methods, and to provide evidence-based support for clinical practice. Methods: PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, China Journal Full-text Database, Chinese Science and Technology Journal Full-text Database, and Wanfang Resource Database were searched up to February 2023. Randomized controlled trials of auricular therapy for sleep disorders in hemodialysis patients were collected and included in the study. Meta-analysis was performed using RevMan 5.3 software. Results: 587 patients from 7 randomized controlled trial studies were included. The auricular therapy group had better sleep conditions than the conventional care group, as evaluated by the Pittsburgh Sleep Quality Index, in terms of total Pittsburgh Sleep Quality Index score (mean difference (MD) = –5.11, 95% confidence interval (CI) (–5.25, –4.96), P < 0.00001), subjective sleep quality (MD = –0.64, 95% CI (–0.72, –0.56), P < 0.00001), falling asleep time (MD = –0.37, 95% CI (–0.49, –0.26), P < 0.00001), sleep time (MD = –0.38, 95% CI (0.44, –0.32), P < 0.00001), sleep efficiency (MD = –0.15, 95% CI (–0.23, –0.07), P < 0.0001), sleep disturbances (MD = –0.18, 95% CI (–0.28, –0.09), P = 0.0002), daytime dysfunction (MD = –0.89, 95% CI (–1.18, –0.6), P < 0.00001), and hypnotic medication (MD = –0.22, 95% CI (–0.4, –0.03), P = 0.02). Conclusion: Auricular therapy is an effective method for improving sleep quality in hemodialysis patients, providing evidence-based support for clinical practice.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307019
Yukun Shi, Xiaojing Yan, Li-Ya Zhu, Min Lin, Deke Lyu, Jia-Bao Liao, F. Chen
{"title":"Mechanic study of Qushi Kaiyu decoction on non-alcoholic fatty liver disease model rats based on the inhibition of TLR4/NF-ĸB pathway","authors":"Yukun Shi, Xiaojing Yan, Li-Ya Zhu, Min Lin, Deke Lyu, Jia-Bao Liao, F. Chen","doi":"10.53388/tmrim202307019","DOIUrl":"https://doi.org/10.53388/tmrim202307019","url":null,"abstract":"Background: The objective of this research was to examine the impact of the Chinese herbal formula Qushi Kaiyu (QSKY) on rats with non-alcoholic fatty liver disease (NAFLD) and its inhibitory effect on the TLR4/NF-ĸB pathway. Methods: NAFLD model rats was constructed through high-fat diet. Meanwhile, rats were treated with QSKY (6.4 g/kg) by gavage. The therapeutic effect of QSKY on NAFLD was assessed by testing body weight change, the liver index, lipid concentrations in blood, and antioxidant and inflammatory levels; assessing liver function; and performing pathological staining including hematoxylin-eosin and Oil Red O. The protein levels of key factors in the TLR4/NF-ĸB pathway (TLR4, MyD88, p65 and IKB) in rat liver tissue were determined using western blotting in order to explore the mechanism responsible for the therapeutic effects of QSKY in rats with NAFLD. Results: QSKY significantly reduced the liver index and body weight value; reduced triglyceride, cholesterol, alanine aminotransferase, and aspartate aminotransferase levels in NAFLD rats; improved the pathological changes, such as ballooning degeneration, fat accumulation, necrosis, and inflammation; elevated GSH-Px and superoxide dismutase activities and lowered malondialdehyde levels, indicating that QSKY enhanced the antioxidant capacity; and reduced inflammatory cytokine (IL-6, IL-1β, and TNF-α) levels. Western blotting results showed that QSKY significantly reduced TLR4, MyD88, and decreased the phosphorylation of IKB and p65 protein levels in the livers of rats with NAFLD. Conclusions: QSKY showed therapeutic effects on NAFLD and can alleviate oxidative stress and inflammation. This mechanism may be related to an improvement in TLR4/NF-ĸB pathway.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of complementary and alternative medicine used in cancer care: challenges and prospects","authors":"Samson Seyi Enitan, G. Avwioro, Esther Ngozi Adejumo, Oluwakemi Anike Ladipo, Chinenye Alaezi Okorochi, Gideon Taiwo Oluwaloye, Damilola Christianah Ademola-Kemiki","doi":"10.53388/tmrim202307021","DOIUrl":"https://doi.org/10.53388/tmrim202307021","url":null,"abstract":"Cancer is a leading cause of death globally, and most patients with cancers frequently seek for complementary and alternative medicine (CAM) to ameliorate their condition. Some of the available CAM care include: acupuncture, aromatherapy, Ayurvedic medicinal drug, cannabis, chelation remedy, homeopathy, hypnotherapy, massage therapy, naturopathic medication, and conventional Chinese remedy amongst others. Despite the growing use of CAM, the evidence-base for its efficacy and safety is limited. Major challenges confronting the efficient deployment of CAM is lack of standardization and regulation; as well as the demand for more extensive studies to validate their safety and efficacy. Integrative oncology which is the combination of CAM and conventional cancer care is likewise complicated through the potential adverse interactions between CAM options and most cancers drugs. The article serves as a guide for healthcare providers and patients to determine how CAM can be safely integrated into the cancer care paradigm. Taking into account safety concerns, however, more studies need to be conducted to properly evaluate its efficacy. Ultimately, CAM can help cancer patients in achieving greater health and well-being.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Yan-Xin Wang’s medication experience and regularity in treating Insomnia from the liver based on data mining","authors":"Yanyan Chen, Yan-Xin Wang, Man-xia Wen, Zheng Yu, Jing-Jing Wu","doi":"10.53388/tmrim202307017","DOIUrl":"https://doi.org/10.53388/tmrim202307017","url":null,"abstract":"Backgroun d: Professor Yan-Xin Wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years, and has achieved excellent clinical results. In order to better inherit Yan-Xin Wang’s academic thoughts. The purpose of this study is to use clinical data to explore the clinical experience of Prof. Yan-Xin Wang in the application of Chinese medicine to treat insomnia patients from the liver, explore the compatibility and medication rules of traditional Chinese medicine, and give more clinical treatment ideas for insomnia. Methods: The general data and prescription information of insomnia patients treated with Chinese herbal medicine by Prof. Yan-Xin Wang from January 1, 2021, to December 31, 2021, were summarized according to the inclusion and exclusion criteria, and the data were subjected to frequency statistics and drug association rules, complex network diagram analysis and cluster analysis. Results: A total of 159 patients and prescriptions were included in the study, of which 81.1% were women and 18.9% were men, containing 128 herbs; the highest frequency of use was 91.8% for Bupleuri Radix . Six Chinese herbs were used more than 70% of the time, namely Bupleuri Radix , Scutellariae Radix , oyster shell, Glycyrrhizae Radix , Os Draconis, and Ziziphi Spinosae Semen . The top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi, five flavours, and their attributions. The four Qi were mainly calm and warm, the five flavours were mainly bitter and acrid, followed by sweet, and the attributions were mainly to the liver, spleen, and heart meridians. The Chinese medicine association rules set the confidence level > 80% and the support level > 10%, resulting in 10 two-herb and three-herb associations with the highest confidence level, such as Os Draconis is associated with oyster shell, Platycodonis Radix is associated with Achyranthis Bidentatae Radix , Scutellariae Radix is associated with Bupleuri Radix , Os Draconis, Bupleuri Radix is associated with oyster shell, Os Draconis, Scutellariae Radix is associated with oyster shell, etc. Cluster analysis yielded 3 classes of drug formulas. The complex network diagram shows that the core prescription drugs are composed of Bupleuri Radix , Chuanxiong Rhizoma , Pseudostellariae Radix , Jujubae Fructus , Os Draconis, Coptidis Rhizoma , Scutellariae Radix , Ziziphi Spinosae Semen , Smilacis Glabrae Rhizoma , Cinnamomi Cortex , White Moutan Cortex , Atractylodis Rhizoma , Glycyrrhizae Radix , oyster shell, Rehmanniae Radix Praeparata , Tritici Levis Fructus , Pinelliae Rhizoma Praeparatum , and Cinnamomi Ramulus . Conclusion: Prof. Yan-Xin Wang believes that the main treatment for patients with insomnia is based on the liver, by tonifying the deficiency and supporting the righteousness, mutually regulating the liver and spleen, and calming the mind and nourishing the heart, while adding and subtracting appropriate herbs accordi","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307009
Hai-Yang Xing
{"title":"Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine","authors":"Hai-Yang Xing","doi":"10.53388/tmrim202307009","DOIUrl":"https://doi.org/10.53388/tmrim202307009","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307014
Dong-Kai Tang, Zi-Bin Lu
{"title":"Recent advances in the antiviral activity of Forsythiae Fructus","authors":"Dong-Kai Tang, Zi-Bin Lu","doi":"10.53388/tmrim202307014","DOIUrl":"https://doi.org/10.53388/tmrim202307014","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TMR整合医学Pub Date : 2023-01-01DOI: 10.53388/tmrim202307012
Die Qian, Chenghu He, Qing Zhang, Xiao-Ting Huang, Junhong Zhao, Chi Xu, Hong Zhang
{"title":"Research of the molecular mechanism of Hai Honghua medicinal liquor in the treatment of fracture based on network pharmacology combined with molecular docking","authors":"Die Qian, Chenghu He, Qing Zhang, Xiao-Ting Huang, Junhong Zhao, Chi Xu, Hong Zhang","doi":"10.53388/tmrim202307012","DOIUrl":"https://doi.org/10.53388/tmrim202307012","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}