TMR整合医学最新文献

{"title":"Study on mechanisms and molecular verification of Buyang Huanwu decoction in treating ischemic stroke from the perspective of cuproptosis","authors":"Da-Yuan Zhong, Hui Cheng, Hong Luo, Quan Li, Lan-Hua Li, Huan Li, Chun-Guang Guan, De-liang Liu, Ping Liu, Jia-Rong Li, Xiang-bo Kong, Jia-qi Chen, Yiming Deng, Xuelan Ou","doi":"10.53388/tmrim202307013","DOIUrl":"https://doi.org/10.53388/tmrim202307013","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture therapies in combination with conservative treatments for postoperative ileus: a systematic review and network meta-analysis","authors":"Zi-Wen Chen, Zihan Yin, Tao Xu, Jian Xiong, F. Liang","doi":"10.53388/tmrim202307008","DOIUrl":"https://doi.org/10.53388/tmrim202307008","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network pharmacology analysis and in vitro cell experiments to reveal the mechanisms of Ligusticum chuanxiong Hort. in the treatment of non-alcoholic fatty liver disease","authors":"Lingling Wang, Chenghu He, Dan-dan Tang, Chunjie Wu, Shu‐Ting Zhao, X. Pu","doi":"10.53388/tmrim202307018","DOIUrl":"https://doi.org/10.53388/tmrim202307018","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disease of unknown etiology. A traditional Chinese medicine Ligusticum chuanxiong Hort. (CX), it has been used about 2,000 years. Until now, the mechanism of action of CX on NAFLD remains unclear. Method: We first tested the toxicity of CX to AML12 cells with CCK-8. In vitro cell models of NAFLD were made using free fatty acid, and used Oil Red O staining tested lipid droplets. Then the active compounds of CX were collected from TCMSP and literatures, and SwissTargetPrediction, Search Tool for Interacting Chemicals, Encyclopedia of Traditional Chinese Medicin, Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine database were used to predict the targets of the compounds. DRUGBANK, Online Mendelian Inheritance in Man, Therapeutic Target Database, DisGeNET and GeneCards database were used to predict the targets of NAFLD. Use Venn diagram to obtained the intersection targets by, and analyzed the protein-protein intersection network. Use Kyoto Encyclopedia of Genes and Genomes and Gene Ontology to forecast the function of intersection genes. Molecular docking was used to evaluate the interaction between hub gene and active ingredients. Finally, use western blotting to determine the effects of CX on PPARA, PPARG, IL1B and TNF proteins. Result: CX can reduce the production of AML12 cell lipid droplets. A total of 15 chemical components were identified from CX. Folic acid, chrysophanol and sitosterol were the main components of CX against NAFLD. ALB, TNF, PPARG and PPARA proteins were the main targets of CX in the treatment of NAFLD. PPAR signaling pathway and fatty acid degradation were closely related to anti-NAFLD. Molecular docking results shows that folic acid was the main active ingredient of CX for NAFLD treatment, and TNF is the main potential target. The cellular NAFLD model showed that CX up-regulated the expression of PPARA and PPARG protein and down-regulated inflammatory factor IL-1B and TNF expression. Conclusion: Our study suggests that CX has a therapeutic effect on NAFLDA, which may be related to the PPAR pathway and the reduction of inflammatory cytokines.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ercao Qinggan decoction regulates apoptosis of hepatocytes in mice with acute liver failure via the TLR4-mediated PI3K/Akt/GSK3β signal pathway","authors":"Qin Ouyang, Chun-ming Wu, Sanguang Liu, Li-Jia Wang, Jiaping Yao, Anran Zhao, Jin-Lian Zheng, Jianxiang Huang","doi":"10.53388/tmrim202307020","DOIUrl":"https://doi.org/10.53388/tmrim202307020","url":null,"abstract":"Background: To clarify the inhibitory effect of Ercao Qinggan decoction (EQD) on acute liver failure (ALF) and its related mechanisms. Methods: HL-7702 hepatocytes were pretreated with TLR4 inhibitor CLI-095, glycogen synthase kinase 3 β (GSK3 β) inhibitor LiCl and different doses of EQD for 2 hours, and lipopolysaccharide (LPS) (10 μg/mL) for 24 hours. Cell apoptosis, TNF-α and IL-6 and GSK3β were detected by flow cytometry, immunofluorescence, quantitative polymerase chain reaction. After mice were gavaged with different concentrations of EQD for 12 days, ALF mouse models were established intraperitoneal injection of D-Gal/LPS. After 24 hours, the mice were euthanized and the liver tissue was stained with hematoxylin and eosin. Liver cell apoptosis, the serum levels of aspartate aminotransferase, alanine aminotransferase, TNF-α and IL-β were detected by terminal transferase-mediated dUTP nick end-labelling, enzyme linked immunosorbent assay, quantitative polymerase chain reaction, and Western blotting, respectively. These methods were also used to test the mRNA expression of Bax, Bcl-2 and the protein expression of GSK3β, p-Akt/Akt in livers. Results: CLI-095, LiCl, and EQD significantly inhibited apoptosis induced by LPS, the mRNA expression of IL-6, TNF-α and the nuclear translocation of GSK3β in HL-7702 hepatocytes. EQD dose-dependently inhibited hepatocyte apoptosis, the serum concentration of aspartate aminotransferase and ALT, the expression of TNF-α and IL-β, the ratio of p-GSK3β/GSK3β, p-Akt/Akt in alanine aminotransferase mice. Conclusion: EQD can inhibit hepatocyte apoptosis in ALF mice through regulating TLR4/PI3K/Akt/GSK3β signaling pathway.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential: integrating traditional Chinese medicine and modern technology for enhanced cancer treatment strategies","authors":"San-Jun Shi","doi":"10.53388/tmrim202307025","DOIUrl":"https://doi.org/10.53388/tmrim202307025","url":null,"abstract":"Based on the unique therapeutic advantages of traditional Chinese medicine (TCM) and its integration with modern scientific technology, the exploration of more effective strategies for cancer treatment holds great significance. The utilization of TCM in modern applications and the selection of drugs and drug delivery systems for cancer treatment demonstrate promising potential. In accordance with TCM theory, a strong spleen and stomach support the overall well-being of the five zang organs. During cancer treatment, TCM often reinforces healthy Qi (Qi refers to the basic substance that constitutes the human body and maintains life activities, and is the unity of substance and function) to eliminate pathogenic factors, safeguard the spleen and stomach, and strengthen vital Qi. This approach aims to remove toxins and regulate and harmonize the balance of Qi, blood, Yin (in Chinese philosophy, the female, latent, passive principle, characterized by dark, cold, wetness, passivity, disintegration, etc.), Yang (in Chinese philosophy, the masculine, active and positive principle, characterized by light, warmth, dryness, activity, etc.), and organ functions. Many scholars have incorporated TCM into adjuvant chemotherapy regimens for cancer patients with the hope of effectively inhibiting tumor growth, promoting apoptosis of tumor cells, regulating patients’ immune responses, mitigating adverse effects of chemotherapy, and reducing the risk of tumor recurrence. Additionally, individualized TCM formulations, tailored to patients’ constitutional and disease characteristics, synergistically combine modern spectrum-based anticancer Chinese herbs. Reinforcement and elimination in combination and therapy with syndrome differentiation, these formulations stimulate positive factors within the body, enhance immune function, fortify the body’s resistance, and improve patients’ quality of life. In the context of modern medical advancements, an increasing number of active compounds from TCM have been identified for their potent anti-tumor activities. These compounds intervene in critical signaling pathways, exhibiting noticeable inhibitory effects on tumor progression. The selection of drug delivery systems is paramount in determining the efficacy of cancer treatment. Hydrogel systems, functioning as reservoirs for drugs, enable controlled and sustained drug release, enhance drug accumulation at target sites, minimize drug circulation, and reduce required drug dosages, thereby decreasing systemic exposure and toxicity. Hydrogels with superior mechanical characteristics and biocompatibility are more easily absorbed by the body. The application of hydrogel-based local drug delivery at tumor sites holds extensive promise. Numerous hydrogels with excellent biocompatibility and degradability have been widely utilized in tissue engineering, biomedicine, and other domains, displaying outstanding drug-loading capabilities and anticancer activities. Contemporary research under","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the anti-bacterial effect of Echinops persicus, Cardamine uliginosa and Vaccaria oxyodontha Boiss on Staphylococcus aureus and Escherichia coli bacteria in vitro","authors":"M. Soori, Bibi Zahra, Sedigheh Soleimani, Raheleh Bahrami, Seyedali Hossein, H. Abbaspour, H. Hashemi-moghaddam","doi":"10.53388/tmrim202206006","DOIUrl":"https://doi.org/10.53388/tmrim202206006","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the treatment of chronic bronchitis with Chinese and western medicine","authors":"Hui Zhang, Nana Ding","doi":"10.53388/tmrim202206011","DOIUrl":"https://doi.org/10.53388/tmrim202206011","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesbania grandiflora (L.) Pers. (Agati): its ethnobotanical knowledge, phytochemical studies, pharmacological aspects, and future prospects","authors":"Pratiksha Patil, Dr.Nishat Shah","doi":"10.53388/tmrim202206031","DOIUrl":"https://doi.org/10.53388/tmrim202206031","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70829083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of Xiaoxianxiong Decoction in the treatment of gastroesophageal reflux disease","authors":"Jing-wen Mu, Wenya Feng, Tao Yu","doi":"10.53388/tmrim202206009","DOIUrl":"https://doi.org/10.53388/tmrim202206009","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applied aspect of ayurvedic fumigation (Dhupana Karma) in epidemic era: a conceptual review","authors":"M. Lal, S. R., Y. Kaushik, N. Singh, U. Sahu","doi":"10.53388/tmrim202206003","DOIUrl":"https://doi.org/10.53388/tmrim202206003","url":null,"abstract":"Ayurveda has attached great importance to preventive medicine and has described several methods for disinfection. Today we are living in a world where we are constantly facing new diseases and surrounded by various types of pathogenic microorganisms in our daily lives, which make us their prey as soon as they get a chance. Some of these microorganisms are the ones that give rise to terrible types of infectious diseases, which have the potential to influence a large section of the population. The Epidemic is the occurrence of more cases of a disease than would be expected in a community or region during a time of period, a severe outbreak of a disease such as SARS. Epidemiological diseases have been described in Ayurveda regarding Janpadodhwansa. Vayu (Air), Desha (Land), Kala (Season), and Jala (Water) are the four factors that are contaminated during the epidemic, according to Ayurveda. Dhupana (fumigation) is the act by which considerable success can be achieved in the field of disinfecting contaminated air and surface. Therefore, because of the present circumstances, this article is an attempt by which to show the importance of Dhupana Karma (fumigation) for the process of disinfection.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}