Study on Yan-Xin Wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

Abstract

Backgroun d: Professor Yan-Xin Wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years, and has achieved excellent clinical results. In order to better inherit Yan-Xin Wang’s academic thoughts. The purpose of this study is to use clinical data to explore the clinical experience of Prof. Yan-Xin Wang in the application of Chinese medicine to treat insomnia patients from the liver, explore the compatibility and medication rules of traditional Chinese medicine, and give more clinical treatment ideas for insomnia. Methods: The general data and prescription information of insomnia patients treated with Chinese herbal medicine by Prof. Yan-Xin Wang from January 1, 2021, to December 31, 2021, were summarized according to the inclusion and exclusion criteria, and the data were subjected to frequency statistics and drug association rules, complex network diagram analysis and cluster analysis. Results: A total of 159 patients and prescriptions were included in the study, of which 81.1% were women and 18.9% were men, containing 128 herbs; the highest frequency of use was 91.8% for Bupleuri Radix . Six Chinese herbs were used more than 70% of the time, namely Bupleuri Radix , Scutellariae Radix , oyster shell, Glycyrrhizae Radix , Os Draconis, and Ziziphi Spinosae Semen . The top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi, five flavours, and their attributions. The four Qi were mainly calm and warm, the five flavours were mainly bitter and acrid, followed by sweet, and the attributions were mainly to the liver, spleen, and heart meridians. The Chinese medicine association rules set the confidence level > 80% and the support level > 10%, resulting in 10 two-herb and three-herb associations with the highest confidence level, such as Os Draconis is associated with oyster shell, Platycodonis Radix is associated with Achyranthis Bidentatae Radix , Scutellariae Radix is associated with Bupleuri Radix , Os Draconis, Bupleuri Radix is associated with oyster shell, Os Draconis, Scutellariae Radix is associated with oyster shell, etc. Cluster analysis yielded 3 classes of drug formulas. The complex network diagram shows that the core prescription drugs are composed of Bupleuri Radix , Chuanxiong Rhizoma , Pseudostellariae Radix , Jujubae Fructus , Os Draconis, Coptidis Rhizoma , Scutellariae Radix , Ziziphi Spinosae Semen , Smilacis Glabrae Rhizoma , Cinnamomi Cortex , White Moutan Cortex , Atractylodis Rhizoma , Glycyrrhizae Radix , oyster shell, Rehmanniae Radix Praeparata , Tritici Levis Fructus , Pinelliae Rhizoma Praeparatum , and Cinnamomi Ramulus . Conclusion: Prof. Yan-Xin Wang believes that the main treatment for patients with insomnia is based on the liver, by tonifying the deficiency and supporting the righteousness, mutually regulating the liver and spleen, and calming the mind and nourishing the heart, while adding and subtracting appropriate herbs according to the patient’s co-morbidities, which can significantly improve the patient’s insomnia symptoms