Acta Neuropsychiatrica最新文献

The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration. 大麻二酚对长期服用氟哌啶醇诱导的行为和氧化应激参数的影响。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2022-11-04 DOI: 10.1017/neu.2022.29

Jaiyeola Abiola Kajero, Soraya Seedat, Jude U Ohaeri, Abidemi Akindele, Oluwagbemiga Aina

{"title":"The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration.","authors":"Jaiyeola Abiola Kajero, Soraya Seedat, Jude U Ohaeri, Abidemi Akindele, Oluwagbemiga Aina","doi":"10.1017/neu.2022.29","DOIUrl":"10.1017/neu.2022.29","url":null,"abstract":"Objectives: We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- and long-term administration of haloperidol in a rat model of tardive dyskinesia (TD).Methods: Haloperidol was administered either sub-chronically via the intraperitoneal (IP) route or chronically via the intramuscular (IM) route to six experimental groups only or in combination with CBD. VCM and oxidative stress parameters were assessed at different time points after the last dose of medication.Results: Oral CBD (5 mg/kg) attenuated the VCM produced by sub-chronic administration of haloperidol (5 mg/kg) but had minimal effects on the VCM produced by chronic administration of haloperidol (50 mg/kg). In both sub-chronic and chronic haloperidol groups, there were significant changes in brain antioxidant parameters compared with CBD only and the control groups. The sub-chronic haloperidol-only group had lower glutathione activity compared with sub-chronic haloperidol before CBD and the control groups; also, superoxide dismutase, catalase, and 2,2-diphenyl-1-picrylhydrazyl activities were increased in the sub-chronic (IP) haloperidol only group compared with the CBD only and control groups. Nitric oxide activity was increased in sub-chronic haloperidol-only group compared to the other groups; however, the chronic haloperidol group had increased malondialdehyde activity compared to the other groups.Conclusions: Our findings indicate that CBD ameliorated VCM in the sub-chronic haloperidol group before CBD, but marginally in the chronic haloperidol group before CBD. There was increased antioxidant activity in the sub-chronic group compared to the chronic group.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"265-275"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus. 大麻二酚可调节实验诱导的1型糖尿病动物的情境恐惧记忆巩固。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2023-02-20 DOI: 10.1017/neu.2023.13

Yane Costa Chaves, Ana Maria Raymundi, Ana Paula Farias Waltrick, José Alexandre de Souza Crippa, Cristina Aparecida Jark Stern, Joice Maria da Cunha, Janaína Menezes Zanoveli

{"title":"Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus.","authors":"Yane Costa Chaves, Ana Maria Raymundi, Ana Paula Farias Waltrick, José Alexandre de Souza Crippa, Cristina Aparecida Jark Stern, Joice Maria da Cunha, Janaína Menezes Zanoveli","doi":"10.1017/neu.2023.13","DOIUrl":"10.1017/neu.2023.13","url":null,"abstract":"Objectives: In view of the neuroprotective characteristic of cannabidiol (CBD) and its beneficial action on aversive memory in non-diabetic animals, we aimed to investigate in animals with experimentally induced type-1 diabetes mellitus (T1DM) whether CBD treatment would be able to impair the contextual fear memory consolidation, its generalisation and whether the effect would be lasting. We also investigated the CBD effect on anxiety-like responses.Methods: After T1DM induction, animals received single or more prolonged treatment with CBD and were submitted to the contextual fear conditioning test. As expression of activity-regulated cytoskeletal-associated (Arc) protein is necessary for memory consolidation, we evaluated its expression in the dorsal hippocampus (DH). For evaluating anxiety-related responses, animals were submitted to the elevated plus maze test (EPMT), in which the time and number of entries in the open arms were used as anxiety index.Results: A single injection of CBD impaired the contextual fear memory consolidation and its generalisation, which was evaluated by exposing the animal in a neutral context. This single injection was able to reduce the elevated expression of Arc in the DH from these animals. Interestingly, more prolonged treatment with CBD also impaired the persistence of context-conditioned fear memory and induced an anxiolytic-like effect, as the treated group spent more time in the open arms of the EPMT.Conclusion: CBD interferes with contextual fear memory and the dosage regimen of treatment seems to be important. Moreover, we cannot rule out the involvement of emotional aspects in these processes related to fear memory.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"276-286"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9089901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol negatively modulates adenosine A_2A receptor functioning in living cells. 大麻二酚能负向调节活细胞中腺苷 A2A 受体的功能。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2023-08-22 DOI: 10.1017/neu.2023.30

Nuria Sánchez-Fernández, Laura Gómez-Acero, Laura I Sarasola, Josep Argerich, Andy Chevigné, Kenneth A Jacobson, Francisco Ciruela, Víctor Fernández-Dueñas, Ester Aso

{"title":"Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells.","authors":"Nuria Sánchez-Fernández, Laura Gómez-Acero, Laura I Sarasola, Josep Argerich, Andy Chevigné, Kenneth A Jacobson, Francisco Ciruela, Víctor Fernández-Dueñas, Ester Aso","doi":"10.1017/neu.2023.30","DOIUrl":"10.1017/neu.2023.30","url":null,"abstract":"Objectives: Cannabidiol (CBD) is a phytocannabinoid with great potential in clinical applications. The mechanism(s) of action of CBD require further investigation. Previous studies suggested that adenosine A2A receptors (A2ARs) could play a role in CBD-induced effects. Here, we evaluated the ability of CBD to modify the function of A2AR.Methods: We used HEK-293T cells transfected with the cDNA encoding the human A2AR and Gαs protein, both modified to perform bioluminescence-based assays. We first assessed the effect of CBD on A2AR ligand binding using an A2AR NanoLuciferase sensor. Next, we evaluated whether CBD modified A2AR coupling to mini-Gαs proteins using the NanoBiT™ assay. Finally, we further assessed CBD effects on A2AR intrinsic activity by recording agonist-induced cAMP accumulation.Results: CBD did not bind orthosterically to A2AR but reduced the coupling of A2AR to Gαs protein and the subsequent generation of cAMP.Conclusion: CBD negatively modulates A2AR functioning.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"320-324"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours. T和B淋巴细胞大麻素1型和2型受体在重度抑郁症和自杀行为中的作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2023-09-08 DOI: 10.1017/neu.2023.35

Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Atapol Sughondhabirom, Abbas F Almulla, Pimpayao Sodsai

{"title":"Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours.","authors":"Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Atapol Sughondhabirom, Abbas F Almulla, Pimpayao Sodsai","doi":"10.1017/neu.2023.35","DOIUrl":"10.1017/neu.2023.35","url":null,"abstract":"Early flow cytometry studies revealed T cell activation in major depressive disorder (MDD). MDD is characterised by activation of the immune-inflammatory response system (IRS) and the compensatory immunoregulatory system (CIRS), including deficits in T regulatory (Treg) cells. This study examines the number of cannabinoid type 1 (CB1) and type 2 (CB2) receptor-bearing T/B lymphocytes in MDD, and the effects of in vitro cannabidiol (CBD) administration on CB1/CB2-bearing immunocytes. Using flow cytometry, we determined the percentage of CD20+CB2+, CD3+CB2+, CD4+CB2+, CD8+CB2+ and FoxP3+CB1+ cells in 19 healthy controls and 29 MDD patients in 5 conditions: baseline, stimulation with anti-CD3/CD28 with or without 0.1 µg/mL, 1.0 µg/mL, or 10.0 µg/mL CBD. CB2+ was significantly higher in CD20+ than CD3+ and CD4+ and CD 8+ cells. Stimulation with anti-CD3/CD8 increases the number of CB2-bearing CD3+, CD4+ and CD8+ cells, as well as CB1-bearing FoxP3+ cells. There was an inverse association between the number of reduced CD4+ CB2+ and IRS profiles, including M1 macrophage, T helper-(Th)-1 and Th-17 phenotypes. MDD is characterised by lowered basal FoxP3+ CB1+% and higher CD20+ CB2+%. 33.2% of the variance in the depression phenome (including severity of depression, anxiety and current suicidal behaviours) is explained by CD20+ CB2+ % (positively) and CD3+ CB2+% (inversely). All five immune cell populations were significantly increased by 10 µg/mL of CBD administration. Reductions in FoxP3+ CB1+% and CD3+ /CD4+ CB2+% contribute to deficits in immune homoeostasis in MDD, while increased CD20+CB2+% may contribute to the pathophysiology of MDD by activating T-independent humoral immunity.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"287-298"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort. SARS-Cov-2感染后的精神后遗症:澳大利亚纵向队列中的轨迹、预测因素和关联

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-08-01 Epub Date: 2023-09-08 DOI: 10.1017/neu.2023.45

Seetal Dodd, Mohammedreza Mohebbi, Josie O'Donohue, Gail Matthews, David R Darley, Michael Berk

{"title":"Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort.","authors":"Seetal Dodd, Mohammedreza Mohebbi, Josie O'Donohue, Gail Matthews, David R Darley, Michael Berk","doi":"10.1017/neu.2023.45","DOIUrl":"10.1017/neu.2023.45","url":null,"abstract":"A relationship between SARS-CoV-2 infection and psychiatric symptoms has been identified but is still being fully investigated. Neuropsychiatric sequalae have been reported for several infectious agents and are not unexpected for SARS-CoV-2 infection. This study follows for 12 months a sample (N = 144) of people who have had a confirmed infection of SARS-CoV-2. Medical and neuropsychiatric data and biological specimens are collected at 6 study visits. The 34-item SPHERE questionnaire, the Depression in the Medically Ill instrument, the EQ-5D-5L quality of life instrument and the visual analogue scale of fatigue were administered at multiple timepoints and associations with measures of illness and inflammatory biomarkers were investigated using the generalised estimating equation. Associations between inflammatory biomarkers and mental health measures of various effect sizes were identified. A robust inverse association was found between mental health outcomes and long covid status, but not between mental health outcomes and covid illness severity. This study suggests that long covid may be the strongest predictor of neuropsychiatric symptoms amongst people who have been infected with SARS-CoV-2.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"195-210"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The burden of major depressive disorder in the Middle East and North Africa region, 1990-2019. 1990年至2019年中东和北非地区重度抑郁症的负担。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2023-09-11 DOI: 10.1017/neu.2023.42

Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J M Sullman, Ali-Asghar Kolahi, Reza Shekarriz-Foumani

{"title":"The burden of major depressive disorder in the Middle East and North Africa region, 1990-2019.","authors":"Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J M Sullman, Ali-Asghar Kolahi, Reza Shekarriz-Foumani","doi":"10.1017/neu.2023.42","DOIUrl":"10.1017/neu.2023.42","url":null,"abstract":"Background: Major depressive disorder (MDD) is one of the leading causes of disability. We aimed to report the MDD-attributable prevalence, incidence and years lived with disability (YLDs) in the Middle East and North Africa (MENA) region from 1990 to 2019 by age, sex and socio-demographic index (SDI).Methods: Publicly available data on the burden of MDD were retrieved from the Global Burden of Disease (GBD) study 2019 for the 21 countries in MENA. The counts and age-standardised rates (per 100,000) were presented, along with their corresponding 95% uncertainty intervals.Results: In 2019, MDD had an age-standardised point prevalence of 3322.1 and an incidence rate of 4921.7 per 100,000 population in MENA. Furthermore, there were 4.1 million YLDs in 2019. However, there were no substantial changes in the MDD burden over the period 1990-2019. In 2019, Palestine had the highest burden of MDD. The highest prevalence, incidence and YLDs attributable to MDD were found in the 35-39 age group. In 2019, the YLD rate in MENA was higher than the global rate for almost all age groups. Furthermore, there was a broadly negative association between the YLD rate and SDI.Conclusion: The study highlights the need to prevent the disorder using a multidisciplinary approach and for the provision of cost-effective treatments for those affected, in order to increase their quality of life.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"139-152"},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring Dispositional Empathy in South African Children. 测量南非儿童的移情倾向。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-04-25 DOI: 10.1017/neu.2024.19

S. Malcolm-Smith, Lea-Ann Pileggi, Raphaella Lewis

{"title":"Measuring Dispositional Empathy in South African Children.","authors":"S. Malcolm-Smith, Lea-Ann Pileggi, Raphaella Lewis","doi":"10.1017/neu.2024.19","DOIUrl":"https://doi.org/10.1017/neu.2024.19","url":null,"abstract":"OBJECTIVE\u0000Empathy is a key factor to examine in development, because of its predictive associations with both aggression and successful prosocial behavior. However, established measures of empathy for Low-to-Middle Income Countries, including South Africa, are lacking. In children, parent-report measures are key. However, a local study examining empathy and aggression (Malcolm-Smith et al., 2015) found poor psychometric performance for a widely used parent-report measure of dispositional empathy, the Griffith Empathy Measure (GEM). We thus investigated which of two questionnaires measuring dispositional cognitive and affective empathy perform better in this context.\u0000\u0000\u0000METHOD\u0000We contrasted internal consistency reliability of a simplified version of the GEM (SGEM; n = 160) and a parent-report version of the Questionnaire of Cognitive and Affective Empathy (QCAE; n = 440) in a low-mid socio-economic status sample. Convergence between the measures and factor structure were also assessed.\u0000\u0000\u0000RESULTS\u0000The parent-report version of the QCAE performed well as a measure of child dispositional cognitive and affective empathy, with good reliability (overall α= .90 vs. SGEM α= .63), and confirmatory factor analysis supporting the two-factor structure. The SGEM's reliability and failure to correlate with QCAE indicated poor psychometric performance.\u0000\u0000\u0000CONCLUSION\u0000This is the first psychometric evaluation of the QCAE as a parent-report measure, and our results indicate that it should prove useful for future assessments of dispositional empathy in children across a variety of contexts.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":"6 9","pages":"1-22"},"PeriodicalIF":3.8,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective analysis of iv ketamine outcome on hospitalizations in an unselected psychiatric sample. 对未经选择的精神病样本中氯胺酮对住院治疗的影响进行回顾性分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-04-25 DOI: 10.1017/neu.2024.18

Karl Sandström, O. Kampman, Peter Asellus

{"title":"A retrospective analysis of iv ketamine outcome on hospitalizations in an unselected psychiatric sample.","authors":"Karl Sandström, O. Kampman, Peter Asellus","doi":"10.1017/neu.2024.18","DOIUrl":"https://doi.org/10.1017/neu.2024.18","url":null,"abstract":"OBJECTIVE\u0000This study aims to explore the outcome with iv ketamine treatment in a real-world clinical setting, primarily measured as posttreatment days hospitalized.\u0000\u0000\u0000METHODS\u0000The psychiatric medical records of 46 patients having received iv ketamine on a psychiatric treatment indication between 2015-2018 were retrospectively examined. Analysis comparing the number and duration of hospital admissions before and after ketamine treatment as well as logistic regression analysis to investigate clinical predictors of effectiveness, were performed. To assess patients' severity of depressed symptoms records were screened for MADRS-S scores.\u0000\u0000\u0000RESULTS\u0000No significant difference between pre- and posttreatment hospital days (p=0.170), or number of hospitalizations (p=0.740) were found. The response rate was 31% and remission rate 21%. None of the predictors showed statistical significance in the logistic model.\u0000\u0000\u0000CONCLUSION\u0000Iv ketamine treatment showed effectiveness in reducing depressive symptoms even with complex patients in a real-world clinical setting. However, this did not translate to a reduction in hospitalization. Highlighting the multifaceted challenges posed when implementing iv ketamine treatment in clinical practice.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":"77 12","pages":"1-21"},"PeriodicalIF":3.8,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphisms in ERBB4 and TACR1 associated with dry mouth in clozapine-treated patients ERBB4和TACR1的多态性与氯氮平治疗患者的口干有关

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-04-18 DOI: 10.1017/neu.2024.9

Hanna Puolakka, Anssi Solismaa, Leo-Pekka Lyytikäinen, Merja Viikki, Niko Seppälä, Nina Mononen, Terho Lehtimäki, Olli Kampman

{"title":"Polymorphisms in ERBB4 and TACR1 associated with dry mouth in clozapine-treated patients","authors":"Hanna Puolakka, Anssi Solismaa, Leo-Pekka Lyytikäinen, Merja Viikki, Niko Seppälä, Nina Mononen, Terho Lehtimäki, Olli Kampman","doi":"10.1017/neu.2024.9","DOIUrl":"https://doi.org/10.1017/neu.2024.9","url":null,"abstract":"Objective: Sialorrhea is a common and uncomfortable adverse effect of clozapine, and its severity varies between patients. The aim of the study was to select broadly genes related to the regulation of salivation and study associations between sialorrhea and dry mouth and polymorphisms in the selected genes. Methods: The study population consists of 237 clozapine-treated patients, of which 172 were genotyped. Associations between sialorrhea and dry mouth with age, sex, BMI, smoking, clozapine dose, clozapine and norclozapine serum levels, and other comedication were studied. Genetic associations were analyzed with linear and logistic regression models explaining sialorrhea and dry mouth with each SNP added separately to the model as coefficients. Results: Clozapine dose, clozapine or norclozapine concentration and their ratio were not associated with sialorrhea or dryness of mouth. Valproate use (p=0.013) and use of other antipsychotics (p=0.015) combined with clozapine were associated with excessive salivation. No associations were found between studied polymorphisms and sialorrhea. In analyses explaining dry mouth with logistic regression with age and sex as coefficients, two proxy-SNPs were associated with dry mouth: epidermal growth factor receptor 4 (ERBB4) rs3942465 (adjusted p=0.025) and tachykinin receptor 1 (TACR1) rs58933792 (adjusted p=0.029). Conclusion: Use of valproate or antipsychotic polypharmacy may increase the risk of sialorrhea. Genetic variations in ERBB4 and TACR1 might contribute to experienced dryness of mouth among patients treated with clozapine.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":"6 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Cortical Thickness or Surface Area and Divergent Thinking in Patients with Bipolar Disorder 双相情感障碍患者皮质厚度或表面积与发散性思维之间的关系

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-04-16 DOI: 10.1017/neu.2024.17

Pei-Chi Tu, Wan-Chen Chang, Yi-Hsuan Kuan, Mu-Hong Chen, Tung-Ping Su

{"title":"Association Between Cortical Thickness or Surface Area and Divergent Thinking in Patients with Bipolar Disorder","authors":"Pei-Chi Tu, Wan-Chen Chang, Yi-Hsuan Kuan, Mu-Hong Chen, Tung-Ping Su","doi":"10.1017/neu.2024.17","DOIUrl":"https://doi.org/10.1017/neu.2024.17","url":null,"abstract":"Objective: Divergent thinking is a critical creative cognitive process. Its neural mechanisms have been well-studied through structural and functional imaging in healthy individuals but are less explored in patients with bipolar disorder (BD). Because of the traditional link between creativity and BD, this study investigated the structural correlates of divergent thinking in patients with BD through surface-based morphometry. Methods: Fifty-nine patients diagnosed with BD I or BD II (35.3 ± 8.5 years) and 56 age- and sex-matched controls (33.9 ± 7.4 years) were recruited. The participants underwent structural magnetic resonance imaging and an evaluation of divergent thinking by using the Chinese version of the Abbreviated Torrance Test for Adults (ATTA). FreeSurfer 7.0 was used to generate thickness and surface area maps for each participant. Brainwise regression of the association between cortical thickness or surface area and ATTA performance was conducted using general linear models. Results: Divergent thinking performance did not differ significantly between the patients with BD and the healthy controls. In these patients, total ATTA score was negatively correlated with cortical thickness in the right middle frontal gyrus, right occipital, and left precuneus but positively correlated with the surface area of the right superior frontal gyrus. By contrast, total ATTA scores and cortical thickness or surface area were not significantly correlated among the controls. Conclusion: The findings indicate that divergent thinking involves cerebral structures for executive control, mental imagery, and visual processing in patients with BD, and the right prefrontal cortex might be the most crucial of these structures.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":"56 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0