A retrospective analysis of iv ketamine outcome on hospitalizations in an unselected psychiatric sample.

IF 3.8 4区医学 Q1 Medicine

Acta Neuropsychiatrica Pub Date : 2024-04-25 DOI:10.1017/neu.2024.18

Karl Sandström, O. Kampman, Peter Asellus

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Abstract

OBJECTIVE This study aims to explore the outcome with iv ketamine treatment in a real-world clinical setting, primarily measured as posttreatment days hospitalized. METHODS The psychiatric medical records of 46 patients having received iv ketamine on a psychiatric treatment indication between 2015-2018 were retrospectively examined. Analysis comparing the number and duration of hospital admissions before and after ketamine treatment as well as logistic regression analysis to investigate clinical predictors of effectiveness, were performed. To assess patients' severity of depressed symptoms records were screened for MADRS-S scores. RESULTS No significant difference between pre- and posttreatment hospital days (p=0.170), or number of hospitalizations (p=0.740) were found. The response rate was 31% and remission rate 21%. None of the predictors showed statistical significance in the logistic model. CONCLUSION Iv ketamine treatment showed effectiveness in reducing depressive symptoms even with complex patients in a real-world clinical setting. However, this did not translate to a reduction in hospitalization. Highlighting the multifaceted challenges posed when implementing iv ketamine treatment in clinical practice.

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对未经选择的精神病样本中氯胺酮对住院治疗的影响进行回顾性分析。

目的本研究旨在探讨在真实世界临床环境中使用氯胺酮静脉注射治疗的效果，主要以治疗后住院天数为衡量标准。方法回顾性研究了2015-2018年间46名接受氯胺酮静脉注射治疗的精神科患者的病历。分析比较了氯胺酮治疗前后的入院次数和持续时间，并进行了逻辑回归分析，以调查有效性的临床预测因素。为了评估患者抑郁症状的严重程度，对病历进行了MADRS-S评分筛查。结果未发现治疗前后住院天数（P=0.170）或住院次数（P=0.740）有显著差异。应答率为 31%，缓解率为 21%。结论在真实世界的临床环境中，氯胺酮治疗即使对病情复杂的患者也能有效减轻抑郁症状。然而，这并没有降低住院率。这凸显了在临床实践中实施静脉氯胺酮治疗所面临的多方面挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica 医学-精神病学

CiteScore

8.50

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.