结核病研究(英文)最新文献_第2页

The Role of Pyridoxine in the Prevention and Treatment of Neuropathy and Neurotoxicity Associated with Rifampicin-Resistant Tuberculosis Treatment Regimens: A Topic Review 吡哆醇在预防和治疗与利福平耐药结核病治疗方案相关的神经病变和神经毒性中的作用:主题综述

结核病研究(英文) Pub Date : 2023-01-01 DOI: 10.4236/jtr.2023.112004

Joseph G. Kariuki, S. Kariuki, Phuti Angel

引用次数: 0

Pleural Fluid Alkaline Phosphate Levels to Differentiate between Tuberculosis and Malignant Pleural Effusion a Tertiary Care Experience 胸膜液碱性磷酸盐水平鉴别结核和恶性胸腔积液的三级护理经验

结核病研究(英文) Pub Date : 2023-01-01 DOI: 10.4236/jtr.2023.112009

S. Waheed, Afshan Nisar, Amanullah Lail, G. Lail, Muhammad Imran, Javid Ali, Mahboob Ali, K. Khan, N. Rizvi

引用次数: 0

Sensorineural Hearing Loss in Multidrug-Resistant Tuberculosis Patients in Kinshasa (Democratic Republic of Congo): Prospective Cohort Study of Therapeutic Regimen with Aminoglycoside versus Bedaquiline 金沙萨(刚果民主共和国)耐多药结核病患者的感音神经性听力损失:氨基糖苷与贝达喹啉治疗方案的前瞻性队列研究

结核病研究(英文) Pub Date : 2023-01-01 DOI: 10.4236/jtr.2023.113011

Mireille A. Mpwate, Eddy M. Mbambu, Christian N. Matanda, G. Lema, M. Kaswa, M. Aloni, Nicole Anshambi, Fabrice M. Matuta, Luc L. Lukasu, D. Mupepe, Serge K. Mpwate, P. Akilimali, Z. Kashongwe, R. Matanda

引用次数: 1

Knowledge on tuberculosis, services of TB control programme and associated socio-demographic inequity among rural participants of Jaipur, Rajasthan, India: A cross sectional study 印度拉贾斯坦邦斋浦尔农村参与者的结核病知识、结核病控制规划服务和相关的社会人口不平等:一项横断面研究

结核病研究(英文) Pub Date : 2022-12-20 DOI: 10.1101/2022.12.19.22283674

P. K. Anand, V. Dhikav, M. Rathore, G. Toteja, M. Singh, B. Singh, C. Meena, A. Jangid, M. Devanda, M. Mathur

{"title":"Knowledge on tuberculosis, services of TB control programme and associated socio-demographic inequity among rural participants of Jaipur, Rajasthan, India: A cross sectional study","authors":"P. K. Anand, V. Dhikav, M. Rathore, G. Toteja, M. Singh, B. Singh, C. Meena, A. Jangid, M. Devanda, M. Mathur","doi":"10.1101/2022.12.19.22283674","DOIUrl":"https://doi.org/10.1101/2022.12.19.22283674","url":null,"abstract":"Introduction: Tuberculosis (TB) is one of the top 10 causes of deaths worldwide. India is still a highest TB burden country. There is scarcity of data on TB knowledge from Rajasthan state of India. Materials & Methods: Cross-sectional community based study was carried out at Model Rural Health Research Unit, Jaipur, an unit of Department of Health Research, Ministry of Health & Family Welfare, Government of India. Results: Study reports the result from 1993 adult participants from 10 villages of 2 sub-districts of district Jaipur. About 88.9% of studied participants knew that TB is an infectious disease and it spreads from TB patient to healthy person in close contact. Only 22.3% of participants knew DOTS is the name of treatment for TB. While, only 58.9% knew sputum is used for diagnosis of TB at health centres. Scheduled castes, scheduled tribes and backward classes social groups knew less than the mainstream General social group. The observed difference was statistically significant (p<0.05). Logistic regression analysis estimated the relative contribution in knowledge status. Discussion: The knowledge of study participants on transmission of tuberculosis was similar to the knowledge of population in country wide study. They poorly knew that sputum is used for diagnosing the tuberculosis disease; socio-demographic inequity exists in this knowledge too. People from older age groups, underprivileged social groups and minority need extra educational activities.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42744056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Management Problem of Miliary Tuberculosis in the Service of Pneumo-Phtisiology at the National References University Teaching Hospital of N’Djamena (Chad): About 103 Cases 乍得恩贾梅纳国立参考大学教学医院肺生理科军人结核病管理问题:约103例

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.103012

Mahamat Ali Bolti, R. Ngakoutou, Abdoulaye Ahmet, Mad-Toingue Joseph, Dluida Dieudonné, Lodoum Mbainadji, J. Toralta, Meurde Nemian, L. Allawaye, Koboye Bonté Adjougoulta, Yusra Aboulbachar, Hamit Mahamat Alio

引用次数: 0

Interim Outcomes and Adverse Events among Drug-Resistant Tuberculosis Patients Treated with Bedaquiline in the Philippines 菲律宾贝达喹啉治疗耐药结核病患者的中期结局和不良事件

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.102005

V. Lofranco, Maria Rhoda A. Torres-Cervas, Katherine A. Asence, Khrizza Marianne A. Del Mundo, V. Balanag, M. Santiago, Anna Marie Celina G. Garfin

{"title":"Interim Outcomes and Adverse Events among Drug-Resistant Tuberculosis Patients Treated with Bedaquiline in the Philippines","authors":"V. Lofranco, Maria Rhoda A. Torres-Cervas, Katherine A. Asence, Khrizza Marianne A. Del Mundo, V. Balanag, M. Santiago, Anna Marie Celina G. Garfin","doi":"10.4236/jtr.2022.102005","DOIUrl":"https://doi.org/10.4236/jtr.2022.102005","url":null,"abstract":"Objectives: This study aimed to assess the interim outcomes for drug-resistant tuberculosis (DR-TB) patients treated with bedaquiline regimen under the operational research conditions compared to DR-TB patients treated without bedaquiline in their regimen, and to describe the adverse events that occurred among patients treated with bedaquiline in the Philippines. Design: Patients who were treated with a bedaquiline-containing regimen from June 2016 to May 2017 were included in this study as the intervention group, while patients who were treated without bedaquiline regimen from January 2013 to May 2016 were included as the comparison group. The interim treatment outcomes were compared using Chi-square test. The analysis of time to culture conversion within 6 months of treatment was conducted. A Cox proportional hazard model was constructed to identify the variables associated with a favorable interim treatment outcome. The R program was used for statistical analysis. Results: On the 6th month of treatment, the culture conversion for patients treated with a bedaquiline-containing regimen was significantly higher than with the comparison group [63/75 (84.0%) vs 84/117 (71.8%), p =","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70459580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DOST Model’ for DR-TB Patients, New Delhi: Perspectives of Healthcare Providers 多斯特模型'耐药结核病患者，新德里:医疗保健提供者的观点

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.104014

Vindhya Vatsyayan, T. Pattery, Khasim Sayyad, Jason Williams, Arnab Pal, Vikas Panibatla, A. Khanna

{"title":"DOST Model’ for DR-TB Patients, New Delhi: Perspectives of Healthcare Providers","authors":"Vindhya Vatsyayan, T. Pattery, Khasim Sayyad, Jason Williams, Arnab Pal, Vikas Panibatla, A. Khanna","doi":"10.4236/jtr.2022.104014","DOIUrl":"https://doi.org/10.4236/jtr.2022.104014","url":null,"abstract":"Introduction: In India, tuberculosis continues to be a major public health problem and there is a growing concern about drug-resistant tuberculosis as most of the patients are from private sector. The National TB Elimination Programme (NTEP) in collaboration with TB Alert, India (TBAI) and Clin-ton Health Association of India (CHAI) had implemented a collaborative project to strengthen the network between the private practitioners and public healthcare facilities in New Delhi during 2019 and 2020. Methods: A study was conducted to understand the enablers and challenges encountered by them during the implementation of the project. This is a qualitative exploration of the “healthcare providers” on a project linking DR-TB patients in private sector with government health facilities. The process of data collection involved face-to-face in-depth interviews of healthcare providers, the Doctors mainly from private and public health facilities, the paramedical workers from general health system and paramedical from the project using an inter-view guide administered through a trained researcher. Results: The study findings revealed that all healthcare providers were completely aware of the DOST project in the health system, the model led to early diagnosis and initiation of quality treatment. There were no major challenges to the implementation of the project. The healthcare providers wish to have this project implemented for a longer duration. Conclusion: The perspectives of healthcare providers towards the “DOST” project were optimistic and call for re-initiating the project in the area.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70459594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competing Risk Model for Time to Development of Tuberculosis among Adults on Combination Antiretroviral Treatment 联合抗逆转录病毒治疗成人结核发病时间的竞争风险模型

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.103011

Lame Sharon Simon, L. Gabaitiri, S. Moyo, Kgalemelo Rodnie Mafa

{"title":"Competing Risk Model for Time to Development of Tuberculosis among Adults on Combination Antiretroviral Treatment","authors":"Lame Sharon Simon, L. Gabaitiri, S. Moyo, Kgalemelo Rodnie Mafa","doi":"10.4236/jtr.2022.103011","DOIUrl":"https://doi.org/10.4236/jtr.2022.103011","url":null,"abstract":"The purpose of this study was to identify factors affecting the time to development of tuberculosis in the presence of competing risks. In this case death before developing tuberculosis was deemed a competing risk because it al-tered the occurrence of the outcome of interest being time to development of tuberculosis from baseline. We used data from a randomized longitudinal clinical trial study called the “Tshepo” study. The “Tshepo” study was a 3-year randomized clinical study following 650 ART-naïve adults (69.4% female) from Botswana who initiated first-line NNRTI-based ART. Participants were assigned in equal proportions (in an open-label, unblinded fashion) to one of 6 initial treatment arms and one of two adherence arms using permuted block randomization. Randomization was stratified by CD4+ cell count (less than 200 cells/mm 3 , 201 - 350 cells/mm 3 ) and by whether the participants had an adherence assistant. Classical methods such as the Kaplan-Meier method and standard Cox proportional hazards regression were used to analyze survival data ignoring the competing event(s) which may have been in-appropriate in the presence of competing risks. The idea was to use competing risk models to investigate how different treatment regimens affect the time to the development of TB and compare the results to those obtained using the classical survival CD4, Hemoglobin and gender. Similarly, after accounting for competing risks the hazard ratio for treatment C was about 1.89 implying that the risk of developing TB amongst those taking treatment C was about 89% higher as compared to those taking treatment A. From the obtained results it was thus concluded that the standard Cox model of time to event data in the presence of competing risks underestimated the hazard ratios hence when dealing with data with multiple failure events it is important to account for competing events.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70459414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Covid-19 Pandemic on the Detection of Tuberculosis in Armenia 2019冠状病毒病大流行对亚美尼亚结核病检测的影响

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.104015

N. Khachatryan, H. Atshemyan, A. Manukyan, A. Khachatryan, K. Poghosyan

引用次数: 0

Effectiveness and Safety of 9-Month Treatment Regimen for Multidrug-Resistant Tuberculosis in the Philippines 菲律宾耐多药结核病9个月治疗方案的有效性和安全性

结核病研究(英文) Pub Date : 2022-01-01 DOI: 10.4236/jtr.2022.102006

V. Lofranco, VINCENT M. BALANAG JR, Lawrence O. Raymond, N. Macalalad, A. Golubkov, Mary Rosary T. Santiago, Anna Marie Celina G. Garfin

{"title":"Effectiveness and Safety of 9-Month Treatment Regimen for Multidrug-Resistant Tuberculosis in the Philippines","authors":"V. Lofranco, VINCENT M. BALANAG JR, Lawrence O. Raymond, N. Macalalad, A. Golubkov, Mary Rosary T. Santiago, Anna Marie Celina G. Garfin","doi":"10.4236/jtr.2022.102006","DOIUrl":"https://doi.org/10.4236/jtr.2022.102006","url":null,"abstract":"Background: The Philippines has a burden of drug-resistant tuberculosis (DR-TB). One of the key challenges in the programmatic management of DR-TB (PMDT) is the high rate of loss to follow-up (38% in the 2010 cohort). An urgent need for a shorter, more tolerable, less expensive treatment regimen exists. The aim of the operational study is to determine the efficacy and safety of the short treatment regimen among drug resistant TB. Methods: This is a prospective single-arm cohort study evaluating the effectiveness and safety of a shorter 9 - 11-month treatment regimen (9MTR) for rifampi-cin-resistant/multi-drug resistant TB (RR/MDR-TB) in 10 PMDT facilities. All eligible consenting adult patients with rifampicin-resistant TB were enrolled and received the standardized 9-month treatment regimen (9MTR), including injectables, with a follow-up after 12 months of treatment completion. Results: A total of 329 patients were enrolled from July 2015 to December 2016. At the 6th month post-enrollment, 256 (77.8%) of them had cul-ture-negative months of treatment. Conclusion: The 9-month treatment regimen had a high treatment success rate with a favorable safety profile. The loss to fol-low-up was reduced; however, it was still a challenge. The introduction of the 9MTR via operational research had a major impact on building national capacity and infrastructure for the programmatic adoption of a new regimen. Ten PMDT centers received training and experience, created diagnostic pathways, and active drug safety monitoring and management were built.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70459148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1