V. Lofranco, Maria Rhoda A. Torres-Cervas, Katherine A. Asence, Khrizza Marianne A. Del Mundo, V. Balanag, M. Santiago, Anna Marie Celina G. Garfin
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引用次数: 1
摘要
目的:本研究旨在评估在操作研究条件下接受贝达喹啉方案治疗的耐药结核病(DR-TB)患者与未接受贝达喹啉方案治疗的耐药结核病患者的中期结果,并描述在菲律宾接受贝达喹啉治疗的患者中发生的不良事件。设计:将2016年6月至2017年5月接受含贝达喹啉方案治疗的患者作为干预组,将2013年1月至2016年5月未接受贝达喹啉方案治疗的患者作为对照组。中期治疗结果比较采用卡方检验。对治疗6个月内的培养转化时间进行分析。构建Cox比例风险模型以确定与良好的中期治疗结果相关的变量。采用R程序进行统计分析。结果:治疗第6个月,含贝达喹啉方案组患者的培养转化率显著高于对照组[63/75 (84.0%)vs 84/117 (71.8%)], p =
Interim Outcomes and Adverse Events among Drug-Resistant Tuberculosis Patients Treated with Bedaquiline in the Philippines
Objectives: This study aimed to assess the interim outcomes for drug-resistant tuberculosis (DR-TB) patients treated with bedaquiline regimen under the operational research conditions compared to DR-TB patients treated without bedaquiline in their regimen, and to describe the adverse events that occurred among patients treated with bedaquiline in the Philippines. Design: Patients who were treated with a bedaquiline-containing regimen from June 2016 to May 2017 were included in this study as the intervention group, while patients who were treated without bedaquiline regimen from January 2013 to May 2016 were included as the comparison group. The interim treatment outcomes were compared using Chi-square test. The analysis of time to culture conversion within 6 months of treatment was conducted. A Cox proportional hazard model was constructed to identify the variables associated with a favorable interim treatment outcome. The R program was used for statistical analysis. Results: On the 6th month of treatment, the culture conversion for patients treated with a bedaquiline-containing regimen was significantly higher than with the comparison group [63/75 (84.0%) vs 84/117 (71.8%), p =