Acta Biotheoretica最新文献_第8页

Optimal Control Strategies and Sensitivity Analysis of an HIV/AIDS-Resistant Model with Behavior Change 具有行为变化的HIV/ aids抵抗模型的最优控制策略及灵敏度分析

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-07-30 DOI: 10.1007/s10441-021-09421-3

Musa Rabiu, Robert Willie, Nabendra Parumasur

{"title":"Optimal Control Strategies and Sensitivity Analysis of an HIV/AIDS-Resistant Model with Behavior Change","authors":"Musa Rabiu, Robert Willie, Nabendra Parumasur","doi":"10.1007/s10441-021-09421-3","DOIUrl":"10.1007/s10441-021-09421-3","url":null,"abstract":"<div>Despite several research on HIV/AIDS, it is still incumbent to investigate more effective control measures to mitigate its infection level. Therefore, we introduce an HIV/AIDS-resistant model with behavior change and study its basic properties. In order to determine the most sensitive parameters that are responsible for disease transmission with respect to the basic reproduction number and those responsible for disease prevalence with respect to the endemic equilibrium, the sensitivity analysis was established and it was confirmed that the influx rate of people into the infected population and total abstinence from all risk practices and endemic areas are some of the most sensitive parameters for disease spread and disease eradication, respectively. Furthermore, by considering controls (u_1) denoting the government’s intervention in promoting and encouraging behavior change, (u_2) representing intake of balanced nutritional supplementation, and (u_3) connoting antiretroviral therapy (ART), an optimal control problem was developed and analyzed. Before the establishment of the necessary conditions of the optimal control using Pontryagin’s Maximum Principle, we proved the existence of the optimal control triplet ((u_1(t),u_2(t),u_3(t)in Phi ,) where (Phi) is the control set at time t,) which has been neglected by many researchers in recent years. Using the Runge–Kutta scheme, the optimal control problem was solved to understand the best combination of control strategies. Using the demographic and epidemiological data for South Africa on HIV/AIDS, a numerical simulation was carried out and results are presented on 3D surface plots. The obtained results suggested that the combination of all the considered control measures is the best method to ensure disease eradication.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"543 - 589"},"PeriodicalIF":1.3,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09421-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39263110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Organic Codes: A Unifying Concept for Life 有机密码:生命的统一概念

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-07-30 DOI: 10.1007/s10441-021-09422-2

Savio Torres de Farias, Francisco Prosdocimi, Gustavo Caponi

{"title":"Organic Codes: A Unifying Concept for Life","authors":"Savio Torres de Farias, Francisco Prosdocimi, Gustavo Caponi","doi":"10.1007/s10441-021-09422-2","DOIUrl":"10.1007/s10441-021-09422-2","url":null,"abstract":"<div>Although the knowledge about biological systems has advanced exponentially in recent decades, it is surprising to realize that the very definition of Life keeps presenting theoretical challenges. Even if several lines of reasoning seek to identify the essence of life phenomenon, most of these thoughts contain fundamental problem in their basic conceptual structure. Most concepts fail to identify either necessary or sufficient features to define life. Here, we analyzed the main conceptual frameworks regarding theoretical aspects that have been supporting the most accepted concepts of life, such as (i) the physical, (ii) the cellular and (iii) the molecular approaches. Based on an ontological analysis, we propose that Life should not be positioned under the ontological category of Matter. Yet, life should be better understood under the top-level ontology of “Process”. Exercising an epistemological approach, we propose that the essential characteristic that pervades each and every living being is the presence of organic codes. Therefore, we explore theories in biosemiotics and code biology in order to propose a clear concept of life as a macrocode composed by multiple inter-related coding layers. This way, as life is a sort of metaphysical process of encoding, the living beings became the molecular materialization of that process. From the proposed concept, we show that the evolutionary process is a fundamental characteristic for life’s maintenance but it is not necessary to define life, as many organisms are clearly alive but they do not participate in the evolutionary process (such as infertile hybrids). The current proposition opens a fertile field of debate in astrobiology, epistemology, biosemiotics, code biology and robotics.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"769 - 782"},"PeriodicalIF":1.3,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09422-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Factors in Protobiomonomer Selection for the Origin of the Standard Genetic Code 标准遗传密码起源的原生物单体选择因素

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-07-20 DOI: 10.1007/s10441-021-09420-4

Alexander I. Saralov

{"title":"Factors in Protobiomonomer Selection for the Origin of the Standard Genetic Code","authors":"Alexander I. Saralov","doi":"10.1007/s10441-021-09420-4","DOIUrl":"10.1007/s10441-021-09420-4","url":null,"abstract":"<div>Natural selection of specific protobiomonomers during abiogenic development of the prototype genetic code is hindered by the diversity of structural, spatial, and rotational isomers that have identical elemental composition and molecular mass (M), but can vary significantly in their physicochemical characteristics, such as the melting temperature Tm, the Tm:M ratio, and the solubility in water, due to different positions of atoms in the molecule. These parameters differ between cis- and trans-isomers of dicarboxylic acids, spatial monosaccharide isomers, and structural isomers of α-, β-, and γ-amino acids. The stable planar heterocyclic molecules of the major nucleobases comprise four (C, H, N, O) or three (C, H, N) elements and contain a single –C=C bond and two nitrogen atoms in each heterocycle involved in C–N and C=N bonds. They exist as isomeric resonance hybrids of single and double bonds and as a mixture of tautomer forms due to the presence of –C=O and/or –NH2 side groups. They are thermostable, insoluble in water, and exhibit solid-state stability, which is of central importance for DNA molecules as carriers of genetic information. In M–Tm diagrams, proteinogenic amino acids and the corresponding codons are distributed fairly regularly relative to the distinct clusters of purine and pyrimidine bases, reflecting the correspondence between codons and amino acids that was established in different periods of genetic code development. The body of data on the evolution of the genetic code system indicates that the elemental composition and molecular structure of protobiomonomers, and their M, Tm, photostability, and aqueous solubility determined their selection in the emergence of the standard genetic code.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"745 - 767"},"PeriodicalIF":1.3,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09420-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39201496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is Causal Specificity About, and What is it Good for in Philosophy of Biology? 因果专一性是什么，对生物学哲学有什么好处?

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-07-12 DOI: 10.1007/s10441-021-09419-x

María Ferreira Ruiz

引用次数: 0

A Human-Bovine Schistosomiasis Mathematical Model with Treatment and Mollusciciding 人牛血吸虫病的数学模型与治疗和杀螺

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-06-30 DOI: 10.1007/s10441-021-09416-0

Solomon Kadaleka, Shirley Abelman, Jean M. Tchuenche

{"title":"A Human-Bovine Schistosomiasis Mathematical Model with Treatment and Mollusciciding","authors":"Solomon Kadaleka, Shirley Abelman, Jean M. Tchuenche","doi":"10.1007/s10441-021-09416-0","DOIUrl":"10.1007/s10441-021-09416-0","url":null,"abstract":"<div>To mitigate the spread of schistosomiasis, a deterministic human-bovine mathematical model of its transmission dynamics accounting for contaminated water reservoirs, including treatment of bovines and humans and mollusciciding is formulated and theoretically analyzed. The disease-free equilibrium is locally and globally asymptotically stable whenever the basic reproduction number (R_0<1), while global stability of the endemic equilibrium is investigated by constructing a suitable Lyapunov function. To support the analytical results, parameter values from published literature are used for numerical simulations and where applicable, uncertainty analysis on the non-dimensional system parameters is performed using the Latin Hypercube Sampling and Partial Rank Correlation Coefficient techniques. Sensitivity analysis to determine the relative importance of model parameters to disease transmission shows that the environment-related parameters namely, (varepsilon _s) (snails shedding rate of cercariae), (p_s) (probability that cercariae shed by snails survive), c (fraction of the contaminated environment sprayed by molluscicides) and (mu _c) (mortality rate of cercariae) are the most significant to mitigate the spread of schistosomiasis. Mollusciciding, which directly impacts the contaminated environment as a single control strategy is more effective compared to treatment. However, concurrently applying mollusciciding and treatment will yield a better outcome.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"511 - 541"},"PeriodicalIF":1.3,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09416-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39122894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Do Trees Grow in Girth? Controversy on the Role of Cellular Events in the Vascular Cambium 树木的周长是如何增长的?关于维管形成层中细胞事件作用的争论

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-06-21 DOI: 10.1007/s10441-021-09418-y

Anna Wilczek-Ponce, Wiesław Włoch, Muhammad Iqbal

{"title":"How Do Trees Grow in Girth? Controversy on the Role of Cellular Events in the Vascular Cambium","authors":"Anna Wilczek-Ponce, Wiesław Włoch, Muhammad Iqbal","doi":"10.1007/s10441-021-09418-y","DOIUrl":"10.1007/s10441-021-09418-y","url":null,"abstract":"<div>Radial growth has long been a subject of interest in tree biology research. Recent studies have brought a significant change in the understanding of some basic processes characteristic to the vascular cambium, a meristem that produces secondary vascular tissues (phloem and xylem) in woody plants. A new hypothesis regarding the mechanism of intrusive growth of the cambial initials, which has been ratified by studies of the arrangement of cambial cells, negates the influence of this apical cell growth on the expansion of the cambial circumference. Instead, it suggests that the tip of the elongating cambial initial intrudes between the tangential (periclinal) walls, rather than the radial (anticlinal) walls, of the initial(s) and its(their) derivative(s) lying ahead of the elongating cell tip. The new concept also explains the hitherto obscure mechanism of the cell event called ‘elimination of initials’. This article evaluates these new concepts of the cambial cell dynamics and offers a new interpretation for some curious events occurring in the cambial meristem in relation to the radial growth in woody plants.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"643 - 670"},"PeriodicalIF":1.3,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09418-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39251752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effect of Mitochondrial DNA Half-Life on Deletion Mutation Proliferation in Long Lived Cells 线粒体DNA半衰期对长寿细胞中缺失突变增殖的影响

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-06-15 DOI: 10.1007/s10441-021-09417-z

Alan G. Holt, Adrian M. Davies

{"title":"The Effect of Mitochondrial DNA Half-Life on Deletion Mutation Proliferation in Long Lived Cells","authors":"Alan G. Holt, Adrian M. Davies","doi":"10.1007/s10441-021-09417-z","DOIUrl":"10.1007/s10441-021-09417-z","url":null,"abstract":"<div>The proliferation of mitochondrial DNA (mtDNA) with deletion mutations has been linked to aging and age related neurodegenerative conditions. In this study we model the effect of mtDNA half-life on mtDNA competition and selection. It has been proposed that mutation deletions ((text {mtDNA}_{del})) have a replicative advantage over wild-type ((text {mtDNA}_{wild})) and that this is detrimental to the host cell, especially in post-mitotic cells. An individual cell can be viewed as forming a closed ecosystem containing a large population of independently replicating mtDNA. Within this enclosed environment a selfishly replicating (text {mtDNA}_{del}) would compete with the (text {mtDNA}_{wild}) for space and resources to the detriment of the host cell. In this paper, we use a computer simulation to model cell survival in an environment where (text {mtDNA}_{wild}) compete with (text {mtDNA}_{del}) such that the cell expires upon (text {mtDNA}_{wild}) extinction. We focus on the survival time for long lived post-mitotic cells, such as neurons. We confirm previous observations that (text {mtDNA}_{del}) do have a replicative advantage over (text {mtDNA}_{wild}). As expected, cell survival times diminished with increased mutation probabilities, however, the relationship between survival time and mutation rate was non-linear, that is, a ten-fold increase in mutation probability only halved the survival time. The results of our model also showed that a modest increase in half-life had a profound affect on extending cell survival time, thereby, mitigating the replicative advantage of (text {mtDNA}_{del}). Given the relevance of mitochondrial dysfunction to various neurodegenerative conditions, we propose that therapies to increase mtDNA half-life could significantly delay their onset.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"671 - 695"},"PeriodicalIF":1.3,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09417-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39234655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Correction to: Biology and Pragmatism: The Organism-Environment Bond 更正:生物学与实用主义:生物与环境的结合

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-06-01 DOI: 10.1007/s10441-021-09414-2

David Depew

引用次数: 0

Memory in Ion Channel Kinetics 离子通道动力学中的记忆

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-05-27 DOI: 10.1007/s10441-021-09415-1

M. P. Silva, C. G. Rodrigues, W. A. Varanda, R. A. Nogueira

{"title":"Memory in Ion Channel Kinetics","authors":"M. P. Silva, C. G. Rodrigues, W. A. Varanda, R. A. Nogueira","doi":"10.1007/s10441-021-09415-1","DOIUrl":"10.1007/s10441-021-09415-1","url":null,"abstract":"<div>Ion channels are transport proteins present in the lipid bilayers of biological membranes. They are involved in many physiological processes, such as the generation of nerve impulses, hormonal secretion, and heartbeat. Conformational changes in the ion channel-forming protein allow the opening or closing of pores to control the ionic flux through the cell membranes. The opening and closing of the ion channel have been classically treated as a random kinetic process, known as a Markov process. Here the time the channel remains in a given state is assumed to be independent of the condition it had in the previous state. More recently, however, several studies have shown that this process is not random but a deterministic one, where both the open and closed dwell-times and the ionic current flowing through the channel are history-dependent. This property is called long memory or long-range correlation. However, there is still much controversy regarding how this memory originates, which region of the channel is responsible for this property, and which models could best reproduce the memory effect. In this article, we provide a review of what is, where it is, its possible origin, and the mathematical methods used to analyze the long-term memory present in the kinetic process of ion channels.</div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 4","pages":"697 - 722"},"PeriodicalIF":1.3,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-021-09415-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39022954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

On Predation–Commensalism Processes as Models of Bi-stability and Constructive Role of Systemic Extinctions 捕食-共生过程作为系统灭绝双稳定性和建设性作用的模型

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-05-13 DOI: 10.1007/s10441-021-09413-3

E. Sanchez-Palencia, J.-P. Françoise

引用次数: 2