Acta histochemica. Supplementband最新文献_第4页

Histochemical and morphometric investigation of the pathogenesis of acute brain infarction in primates. 灵长类动物急性脑梗死发病机制的组织化学和形态计量学研究。

Acta histochemica. Supplementband Pub Date : 1992-01-01

W Meier-Ruge, A Bruder, D Theodore

引用次数: 0

Acceleration of nerve and muscle regeneration by administration of nucleotides--electroneurophysiological and morphometrical investigations. 通过给药核苷酸加速神经和肌肉再生——电子神经生理学和形态计量学研究。

Acta histochemica. Supplementband Pub Date : 1992-01-01

B Wattig, G Schalow, M Madauss, F Heydenreich, R Warzok, J Cervós-Navarro

{"title":"Acceleration of nerve and muscle regeneration by administration of nucleotides--electroneurophysiological and morphometrical investigations.","authors":"B Wattig, G Schalow, M Madauss, F Heydenreich, R Warzok, J Cervós-Navarro","doi":"","DOIUrl":"","url":null,"abstract":"The effect of nucleotide administration on the regeneration of myelinated nerve fibres following crush injury to the sciatic nerve of the rat was studied using morphometric techniques. In addition morphometrical investigations of peroneal and soleal muscles were performed at different times. After a localized crush lesion of the right sciatic nerve, rats were given nucleotides daily at a dosage of 3.0 mg/kg body wt uridine monophosphate (UM), 2.5 mg/kg body wt cytidine monophosphate (CMP) or 3.0 plus 2.5 mg/kg body wt UMP plus CMP, respectively. Observations were made after 20, 40 and 60 days of common peroneal nerve regeneration for comparison with age-matched crushed or nonoperated controls. Forty days after daily UMP/CMP administration the single fibre conduction velocity of all type II afferents was significantly accelerated. There was a trend towards increased mean fibre area related to increased myelin area. Mean diameter of type II muscle fibres was increased. After 60 days, there was a trend to increase of single afferent fibre conduction velocity in the UMP/CMP group. In the same group automated morphometry revealed a significant increase of nerve fibre area, myelin area and axon area. At this time an increase was found of type I and/or type II muscle fibres in all animal groups. The present results suggest that both axons (neurons) and myelin sheaths (Schwann cells) of regenerating nerve fibres and regenerating muscle fibres are influenced by nucleotide administration.","PeriodicalId":7002,"journal":{"name":"Acta histochemica. Supplementband","volume":"42 ","pages":"333-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12751712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The dopamine agonist, lisuride, in the therapy of Parkinson disease]. [治疗帕金森氏病的多巴胺激动剂利苏脲]。

Acta histochemica. Supplementband Pub Date : 1992-01-01

U D Madeja

引用次数: 0

Neuropathology and pathogenesis of HIV encephalopathies. HIV脑病的神经病理学和发病机制。

Acta histochemica. Supplementband Pub Date : 1992-01-01

O D Wiestler, S L Leib, O Brüstle, H Spiegel, P Kleihues

{"title":"Neuropathology and pathogenesis of HIV encephalopathies.","authors":"O D Wiestler, S L Leib, O Brüstle, H Spiegel, P Kleihues","doi":"","DOIUrl":"","url":null,"abstract":"The nervous system is frequently affected in patients with the acquired immune deficiency syndrome (AIDS). In addition to opportunistic CNS infections and cerebral lymphomas, approx. 20% of the patients develop HIV-associated encephalopathies. Two major histopathological manifestations are observed. HIV leukoencephalopathy (progressive diffuse leukoencephalopathy) is characterized by a diffuse loss of myelin in the deep white matter of the cerebral and cerebellar hemispheres, with scattered multinucleated giant cells and microglia but scarce or absent inflammatory reaction. HIV encephalitis (multinucleated giant cell encephalitis) is associated with accumulations of multinucleated giant cells, inflammatory reaction and often focal necroses. In some patients, both patterns may overlap. In order to identify the HIV genome in the CNS, brain tissue from 27 patients was analyzed for the presence of HIV gag sequences using the polymerase chain reaction (PCR) and primers encoding a 109 base pair segment of the gag gene. Amplification of HIV gag succeeded in all 5 patients with clinical and histopathological evidence for HIV encephalopathy but was negative in the 20 AIDS patients with opportunistic bacterial, parasitic and/or viral infections or with cerebral lymphomas. These results strongly suggest that the evolution of histopathologically recognizable HIV-encephalopathies closely correlates with the presence and/or tissue concentration of HIV. Since there were no cases with amplified HIV DNA in the absence of HIV-associated tissue lesions, we conclude that harboring and replication of HIV in the CNS rapidly causes corresponding clinical and morphological changes of HIV-associated encephalopathies. In two children with severe HIV encephalomyelitis, large amounts of HIV gag and env transcripts were detected in affected areas of the brain and spinal cord by in situ hybridization.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":7002,"journal":{"name":"Acta histochemica. Supplementband","volume":"42 ","pages":"107-14"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12752770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignancy in human brain tumors. 鸟氨酸脱羧酶(ODC)活性和多胺水平作为人脑肿瘤恶性程度的生化指标。

Acta histochemica. Supplementband Pub Date : 1992-01-01

R I Ernestus, G Röhn, R Schröder, N Klug, K A Hossmann, W Paschen

引用次数: 0

[Vascular etiopathogenesis and degenerative dementias--current state of knowledge]. [血管发病和退行性痴呆——目前的知识状况]。

Acta histochemica. Supplementband Pub Date : 1992-01-01

S Hoyer, K Pöhlmann, M Hügel

引用次数: 0

[The morphology of hemostasis failure in gliosal brain tumors]. [胶质性脑肿瘤止血失败的形态学]。

Acta histochemica. Supplementband Pub Date : 1992-01-01

U Engel