Medicinal Chemistry Research最新文献_第6页

Design, synthesis and investigating the in vitro and in silico HDAC8 inhibitory activities of derivatives of [6]-shogaol and [6]-gingerol isolated from ginger (Zingiber officinale) 姜中[6]-shogaol和[6]-gingerol衍生物的设计、合成及体外和体内抑制HDAC8活性的研究

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-06 DOI: 10.1007/s00044-024-03337-6

Thitiporn Kamloon, Pattamabhorn Worsawat, Chanokbhorn Phaosiri, Chiwarat Romsanthia, Puttima Pimphoklang, La-or Somsakeesit, Thanaset Senawong, Gulsiri Senawong, Narissara Namwan, Nopawit Khamto, Puracheth Rithchumpon, Pakit Kumboonma

{"title":"Design, synthesis and investigating the in vitro and in silico HDAC8 inhibitory activities of derivatives of [6]-shogaol and [6]-gingerol isolated from ginger (Zingiber officinale)","authors":"Thitiporn Kamloon, Pattamabhorn Worsawat, Chanokbhorn Phaosiri, Chiwarat Romsanthia, Puttima Pimphoklang, La-or Somsakeesit, Thanaset Senawong, Gulsiri Senawong, Narissara Namwan, Nopawit Khamto, Puracheth Rithchumpon, Pakit Kumboonma","doi":"10.1007/s00044-024-03337-6","DOIUrl":"10.1007/s00044-024-03337-6","url":null,"abstract":"<div><p>The main components, [6]-shogaol (<b>6</b>) and [6]-gingerol (<b>7</b>), were obtained from the rhizome of <i>Zingiber officinale</i>. Both natural phenolic compounds were modified at C<sub>4′</sub> position to get new sixteen derivatives. All derivatives were screened for their HDAC inhibitory activity at 50 µM using HeLa nuclear extract. Among the synthesized compounds, derivatives <b>6b</b>, <b>6e</b>, <b>6f</b> and <b>6g</b> were the most effective against HDACs with the IC<sub>50</sub> values as 44.60 ± 1.40 µM, 49.23 ± 1.13 µM, 50.55 ± 4.25 µM and 48.52 ± 1.52 µM, respectively. In addition, the selected derivatives were investigated against HDAC8 inhibitory activity. The results demonstrated that among them, <b>6b</b> was selective with HDAC8 (IC<sub>50</sub> = 23.19 ± 1.57 µM). The molecular docking study via MOE docking program also revealed that compound <b>6b</b> bound into the active pocket of HDAC8 with Δ<i>G</i> value as −6.92 kcal/mol. Moreover, the in vitro antiproliferative activity of four most potent compounds were evaluated against nine cancer cell lines with MTT assay. The results showed that all selected derivatives were most effective against lung (A549), colon (HCT116 and HT29) and human cervical (HeLa) cancer cell lines. Especially, compound <b>6g</b> was the most potent against A549 cancer cell line with the IC<sub>50</sub> value as 8.41 ± 0.04 µM. Therefore, compound <b>6b</b> and <b>6g</b> are considered as promising HDACs-inhibitor-anticancer agents.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"272 - 284"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturally occurring organosulfur for treating metabolic disorders and infectious diseases 天然存在的有机硫，用于治疗代谢紊乱和传染病

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-06 DOI: 10.1007/s00044-024-03326-9

Gautam Kumar

{"title":"Naturally occurring organosulfur for treating metabolic disorders and infectious diseases","authors":"Gautam Kumar","doi":"10.1007/s00044-024-03326-9","DOIUrl":"10.1007/s00044-024-03326-9","url":null,"abstract":"<div><p>Sulfur has been used as a medicinal agent by the Greeks since ancient times. Approximately 350 sulfur-containing compounds have been approved as drugs by the Food and Drug Administration (FDA). Generally, sulfur exists as organosulfur in plants and as glucosinolates and isothiocyanates. Metabolic disorders and infectious diseases are becoming worldwide public health problems, directly affecting individuals' quality of life and constitute a robust economic challenge to healthcare systems. Glucosinolates have been reported in several vegetables, bacteria, plants, fungi, and animals. In addition to organosulfur, glucosinolates, and their hydrolyzed products, isothiocyanates have immense therapeutic value. Several studies suggest glucosinolates have a potential role in treating metabolic disorders, including cancer, diabetes, and inflammation. Also, some of the glucosinolates had shown broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria and antifungal activity against fungal strains. This review discusses recently identified naturally occurring sulfur-containing compounds, including glucosinolates and organosulfur, and their therapeutic potential for treating metabolic disorders and infectious diseases.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"45 - 85"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual inhibition strategy addressing hyperuricemia and oxidative stress: design, biological evaluation and stability studies of febuxostat-probenecid mutual prodrug 针对高尿酸血症和氧化应激的双重抑制策略：非布司他-丙苯酸互前药的设计、生物学评价和稳定性研究

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-06 DOI: 10.1007/s00044-024-03317-w

Aya Y. Rashad, Hoda G. Daabees, Mohamed Elagawany, Mohamed Shahin, Ahmed E. Abdel Moneim, Maram Y. Marei, Sherif A. F. Rostom

{"title":"Dual inhibition strategy addressing hyperuricemia and oxidative stress: design, biological evaluation and stability studies of febuxostat-probenecid mutual prodrug","authors":"Aya Y. Rashad, Hoda G. Daabees, Mohamed Elagawany, Mohamed Shahin, Ahmed E. Abdel Moneim, Maram Y. Marei, Sherif A. F. Rostom","doi":"10.1007/s00044-024-03317-w","DOIUrl":"10.1007/s00044-024-03317-w","url":null,"abstract":"<div><p>The mutual prodrug approach appears as a promising strategy for developing candidates with great therapeutic effectiveness and enhanced safety profile. The present study addresses the assessment of merging the xanthine oxidase (XO) inhibitor febuxostat (FEB) with the URAT1 inhibitor probenecid (PRO) for managing hyperuricemia and gout associated with oxidative stress. Accordingly, FEB-PRO <b>(5)</b> prodrug was synthesized and proved to be a significant hypouricemic and free radical scavenging agent, when compared to its parents and the physical mixture. Moreover, <b>(5)</b> was found to remarkably decrease serum and hepatic XO as compared with the parent drugs and physical mixture. Inclusion of PRO imparted synergism and enhancement of the pharmacological profile of FEB. Additionally, the tested prodrug showed protective effect against hepatotoxicity caused by carbon tetrachloride, beside being non cytotoxic to normal breast cells. Also, RT-PCR analysis showed that the expression of antioxidant biomarkers CAT and SOD2 significantly increased in the group treated with FEB-PRO <b>(5)</b>. Being an ester, <b>(5)</b> displayed reduced aqueous solubility and increased lipophilicity relative to the parent medications.</p></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"33 12","pages":"2476 - 2490"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, molecular docking, and antibacterial activity of novel amide-linked tetrahydrobenzothienopyrimidinone derivatives as potential DNA gyrase and topoisomerase IV inhibitors 新型酰胺连接的四氢苯并噻吩嘧啶衍生物作为潜在的DNA回转酶和拓扑异构酶IV抑制剂的设计、合成、分子对接和抗菌活性

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-05 DOI: 10.1007/s00044-024-03325-w

Mamdouh F. A. Mohamed, Ahmed M. Soliman, Omar Alshazly, Ayman Nafady, Razium Ali Soomro

{"title":"Design, synthesis, molecular docking, and antibacterial activity of novel amide-linked tetrahydrobenzothienopyrimidinone derivatives as potential DNA gyrase and topoisomerase IV inhibitors","authors":"Mamdouh F. A. Mohamed, Ahmed M. Soliman, Omar Alshazly, Ayman Nafady, Razium Ali Soomro","doi":"10.1007/s00044-024-03325-w","DOIUrl":"10.1007/s00044-024-03325-w","url":null,"abstract":"<div><p>A series of tetrahydrobenzo [4, 5] thieno [2, 3-<i>d</i>] pyrimidinone derivatives <b>3a</b>–<b>j</b> and <b>4</b>–<b>6</b> was synthesized, and tested for their inhibitory activity against <i>E. coli</i> DNA gyrase in a supercoiling assay. The results showed that the five most promising compounds, <b>3d</b>, <b>3g</b>, <b>3h</b>, <b>3i</b> and <b>3j</b> were the most potent, therefore, they were selected for investigating their inhibitory activity against <i>E. coli</i> topoisomerase IV, <i>S. aureus</i> DNA gyrase, and <i>S. aureus</i> topoisomerase IV. The results revealed that compound <b>3j</b> was a more effective inhibitor of <i>E. coli</i> topoisomerase IV, <i>S. aureus</i> DNA gyrase and <i>S. aureus</i> topoisomerase IV, respectively. The molecular docking study of compound <b>3j</b> has revealed that it binds effectively in the active sites of <i>E. coli</i> DNA gyrase B and <i>E. coli</i> DNA topoisomerase. The hybrid <b>3j</b> particularly showed promise as a scaffold for designing and developing novel therapeutic antibacterial candidates.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"172 - 182"},"PeriodicalIF":2.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives 通过四氢化萘衍生物的多种治疗应用，塑造医学的未来

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-05 DOI: 10.1007/s00044-024-03331-y

Bhumi M. Shah, Radhika N. Kachhadiya

{"title":"Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives","authors":"Bhumi M. Shah, Radhika N. Kachhadiya","doi":"10.1007/s00044-024-03331-y","DOIUrl":"10.1007/s00044-024-03331-y","url":null,"abstract":"<div><p>Tetralin is an ortho-fused bicyclic hydrocarbon notable for its odour of a mixture of benzene and menthol and high boiling point. Its low vapor pressure has limited its study by far-infrared spectroscopy but vibrational data have been obtained through alternative methods such as single vibronic level fluorescence (SVLF) and high-temperature vapor-phase Raman spectra. Tetralin is of more than chemical interest because it is part of several biologically active compounds. Interestingly, tetralin is a structural element of the anthracycline antibiotics that are clinically applied in cancer chemotherapy owing to their DNA-intercalating activity. The tetralin ring is crucial in sertraline, an antidepressant, and other clinically relevant compounds, including antifungal, anti-Parkinsonian, and anti-inflammatory activity. A comprehensive overview of tetralin derivatives with their diverse biological activities and therapeutic potentials has been discussed in the review. It also encompasses the synthetic methodology for the synthesis of tetralin and its derivatives including hydrogenation, and cyclization through metal catalysts, and visible light. In addition, a green chemical synthetic technique such as supercritical fluid technology was discussed, which improves the production of tetralin. Apart from that, metabolic pathways and catabolism of tetralin in biological systems and drug delivery systems of tetralin have been discussed. The review underlines the importance of tetralin derivatives in medicinal chemistry and has future developmental potential in therapeutic applications.</p></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"86 - 113"},"PeriodicalIF":2.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antivirulence therapy: type IV pilus as a druggable target for bacterial infections 抗毒治疗：IV型菌毛可作为细菌感染的药物靶点

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-04 DOI: 10.1007/s00044-024-03338-5

Esra Basaran, Fatma Gizem Avci, Aslihan Ozcan, Ceyda Kula, Soumaya Ben Ali Hassine, Ozlem Keskin, Pemra Ozbek, Berna Sariyar Akbulut

{"title":"Antivirulence therapy: type IV pilus as a druggable target for bacterial infections","authors":"Esra Basaran, Fatma Gizem Avci, Aslihan Ozcan, Ceyda Kula, Soumaya Ben Ali Hassine, Ozlem Keskin, Pemra Ozbek, Berna Sariyar Akbulut","doi":"10.1007/s00044-024-03338-5","DOIUrl":"10.1007/s00044-024-03338-5","url":null,"abstract":"<div><p>Virulence is an organism’s ability to infect the host and cause disease, and this ability is determined by the presence of virulence factors. The “do not kill, neutralize” strategy used by antivirulence therapies is a novel approach to managing the increasing drug resistance. In this respect, type IV pilus is one druggable target among many virulence factors. The type IV pili (T4P) assembly systems with adaptable and flexible filaments are utilized by numerous pathogens for infection. The current work focuses on druggable targets of T4aP with specific emphasis on <i>Pseudomonas aeruginosa</i>, <i>Neisseria meningitidis</i>, and <i>Neisseria gonorrhoeae</i>. Additionally, available information on potential inhibitor molecules that attenuate T4P activities or impair pilus function and/or assembly in different pathogens is summarized. The structural organization of T4aP suggests that ATPases, pilins, tip-associated adhesins, and peptidases could be considered potential target sites. As the number of high-resolution structures of different T4P systems and the computational power to model T4P machineries increase, the pace in the identification of novel molecules and targets to attenuate the activities of T4P will accelerate. Artificial intelligence, which has already penetrated into our daily lives, will definitely have a prominent role in providing a framework for progress in this area.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 2","pages":"285 - 300"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and evaluation of antitumor activity of quinazoline derivatives containing different terminal segments of basic amine groups 含有不同碱胺末端的喹唑啉衍生物的设计、合成及抗肿瘤活性评价

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-04 DOI: 10.1007/s00044-024-03320-1

Shihao Wang, Zichen Yang, Dongling Gu, JiaHui Han, Hongjing Chen, Hao Wang, JiaXin Zheng, Hongmin Liu, Yu Ke, Qiurong Zhang

引用次数: 0

Synthesis and in vitro antiproliferative evaluation of novel drimane oxepinyl triazoles from labdane diterpene sclareol 唇丹二萜戊二醇新型驱动型氧苄基三唑的合成及体外抗增殖评价

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-11-01 DOI: 10.1007/s00044-024-03334-9

Gulzar Hussain, Manzoor Ahmed, Sundas Chowdhary, Sanket K. Shukla, Syed Khalid Yousuf

引用次数: 0

Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities 二苄基丁烷木脂素LCA衍生物的合成及其抗炎活性评价

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-10-31 DOI: 10.1007/s00044-024-03332-x

Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo, Yan Zou, Jishun Yang, Yan Song, Qingjie Zhao, Xiaoyun Chai

{"title":"Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities","authors":"Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo, Yan Zou, Jishun Yang, Yan Song, Qingjie Zhao, Xiaoyun Chai","doi":"10.1007/s00044-024-03332-x","DOIUrl":"10.1007/s00044-024-03332-x","url":null,"abstract":"<div><p>The roots of <i>Litsea cubeba</i> (Lour.) Pers have been used for the treatment of rheumatism. We previously extracted and isolated the natural product dibenzylbutane lignan LCA with anti-inflammatory activity. In the current study, using LCA as the lead compound, two series of LCA derivatives with an imide structure and butadiene structure were designed and synthesized. Among them, compounds <b>10c</b> and <b>16a</b> showed stronger inhibitory effects on LPS-induced NO and ROS production in RAW264.7 cells. Further study showed that compound <b>16a</b> not only reduced the levels of inflammatory cytokines, including IL-6, TNF-α, and IL-1β, but it also significantly reduced the expression of iNOS and COX-2. Preliminary mechanism of action studies suggested that <b>16a</b> exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway. Overall, our results suggest that compound <b>16a</b> may be used as a promising anti-inflammatory drug to enrich the compound library. Further study into compound <b>16a</b> could provide research ideas and methods for developing anti-inflammatory drugs.</p></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"228 - 239"},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New derivatives of dipicolinic acid as metallo-β-lactamase NDM-1 inhibitors 二吡啶酸衍生物作为金属β-内酰胺酶NDM-1抑制剂的研究

IF 2.6 4区医学

Medicinal Chemistry Research Pub Date : 2024-10-31 DOI: 10.1007/s00044-024-03330-z

Tatiana S. Shkuratova, Vitaly G. Grigorenko, Irina P. Andreeva, Valeria A. Litvinova, Natalia E. Grammatikova, Alexander S. Tikhomirov, Alexey M. Egorov, Andrey E. Shchekotikhin

{"title":"New derivatives of dipicolinic acid as metallo-β-lactamase NDM-1 inhibitors","authors":"Tatiana S. Shkuratova, Vitaly G. Grigorenko, Irina P. Andreeva, Valeria A. Litvinova, Natalia E. Grammatikova, Alexander S. Tikhomirov, Alexey M. Egorov, Andrey E. Shchekotikhin","doi":"10.1007/s00044-024-03330-z","DOIUrl":"10.1007/s00044-024-03330-z","url":null,"abstract":"<div><p>Resistance to β-lactam antibiotics caused by β-lactamases such as New-Delhi lactamase (NDM-1) has become one of the major challenges in the current antimicrobial therapy. Pyridine-2,6-dicarboxylic acid (DPA) derivatives have been demonstrated to inhibit NDM-1 in a due to the interactions with Zn ion and amino acid residues of the enzyme’s active site. In this study, a series of new 4-substituted DPA derivatives was synthesized. The SAR study has proven that the presence of a substituent at the 4-position of pyridine-2,6-dicarboxylic acid had a certain impact on the NDM-1 inhibitory. Some representatives, e.g., <b>4e</b> exhibited IC<sub>50</sub> values against NDM-1 close to the previously reported hit-compound 4-(3-aminophenyl)pyridine-2,6-dicarboxylic acid. The microdilution broth test confirmed an ability of derivative <b>4e</b> to increase susceptibility of NDM-1-producing <i>E. coli</i> strain and did not demonstrate cytotoxicity to eukaryotic cells. However, NDM-1 inhibition by 4-substituted derivatives dramatically dropped when Zn<sup>2+</sup> was added. We observed a strong complexation of 4-modified derivatives with Zn<sup>2+</sup> similar to unsubstituted pyridine-2,6-dicarboxylic acid. Taken together, a complexation mode of NDM-1 inhibition leading to potential off-target action on other metalloenzymes and low efficiency of structure optimization make DPA derivatives an unproductive scaffold for future development of clinically relevant metallo-β-lactamase inhibitors.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 1","pages":"219 - 227"},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0