Ferrocene-based compounds: promising anticancer and antimalarial agents in modern therapeutics

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Research Pub Date : 2025-04-16 DOI:10.1007/s00044-025-03408-2

Anchal Sharma, Rupali Rana, Nitish Kumar, Harmandeep kaur gulati, Jyoti, Aanchal Khanna, Sofia Sharma, Pooja, Jatinder Vir Singh, Preet Mohinder Singh Bedi

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Abstract

Ferrocene, owing to its inherent stability, favourable redox characteristics, and low toxicity, has emerged as a significant structural motif in the field of bioorganometallic chemistry. Two prominent examples of ferrocene’s impact on medicinal chemistry are ferroquine and ferrocifen, both demonstrating remarkable antimalarial and anticancer activities. The enhanced therapeutic properties observed in these drug candidates underscore the profound influence ferrocene can exert on the molecular and biological behaviour of bioactive compounds. This Perspective delves into the scope and limitations of incorporating ferrocene into organic molecules and natural products, examining how such modifications affect their mechanisms of action and overall biological activities. A detailed discussion is provided on the role of ferrocene derivatization in modulating the anticancer, antimalarial, and antimicrobial properties of diverse bioactive moieties. The ultimate goal is to provide insights that contribute to the design and development of safer and more effective ferrocene-based drugs and focusing on their potential to address the critical unmet needs in cancer and malaria treatment.

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二茂铁基化合物：现代治疗中有前途的抗癌和抗疟药物

二茂铁由于其固有的稳定性、良好的氧化还原特性和低毒性，已成为生物有机金属化学领域一个重要的结构基序。二茂铁对药物化学影响的两个突出例子是亚铁喹和西芬铁，两者都显示出显著的抗疟疾和抗癌活性。在这些候选药物中观察到的增强的治疗特性强调了二茂铁可以对生物活性化合物的分子和生物学行为产生深远影响。本展望深入探讨了将二茂铁纳入有机分子和天然产物的范围和局限性，研究了这种修饰如何影响其作用机制和整体生物活性。详细讨论了二茂铁衍生化在调节多种生物活性成分的抗癌、抗疟疾和抗菌特性中的作用。最终目标是提供有助于设计和开发更安全、更有效的二茂铁药物的见解，并关注它们在解决癌症和疟疾治疗中未得到满足的关键需求方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.