Acta Cirúrgica Brasileira最新文献_第5页

Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway 1 miR-134直接靶向NOS3调控PI3K/Akt通路对心肌缺氧/再氧化损伤的影响

Acta Cirúrgica Brasileira Pub Date : 2019-10-14 DOI: 10.1590/s0102-865020190080000002

Jian-Min Xiao, Ji-Jia Wang, Li-Li Sun

{"title":"Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway 1","authors":"Jian-Min Xiao, Ji-Jia Wang, Li-Li Sun","doi":"10.1590/s0102-865020190080000002","DOIUrl":"https://doi.org/10.1590/s0102-865020190080000002","url":null,"abstract":"Abstract Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH) assay, cell counting kit-8 (CCK-8), Hoechst 33342/PI double staining and flow cytometry assay were implemented in H9c2 cells, respectively. MiR-134 mimic/inhibitor was used to regulate miR-134 expression. Bioinformatic analysis and luciferase reporter assay were utilized to identify the interrelation between miR-134 and NOS3. Rescue experiments exhibited the role of NOS3. The involvement of PI3K/AKT was assessed by western blot analysis. Results MiR-134 was high regulated in the myocardial ischemia model, and miR-134 mimic/inhibitor transfection accelerated/impaired the speed of cell apoptosis and attenuated/exerted the cell proliferative prosperity induced by H/R regulating active status of PI3K/AKT signaling. LDH activity was also changed due to the different treatments. Moreover, miR-134 could target NOS3 directly and simultaneously attenuated the expression of NOS3. Co-transfection miR-134 inhibitor and pcDNA3.1-NOS3 highlighted the inhibitory effects of miR-134 on myocardial H/R injury. Conclusion This present work puts insights into the crucial effects of the miR-134/NOS3 axis in myocardial H/R injury, delivering a potential therapeutic technology in future.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83047168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure 1 丹参酮IIA对压力超负荷心力衰竭大鼠心室重构的缓解作用

Acta Cirúrgica Brasileira Pub Date : 2019-10-14 DOI: 10.1590/s0102-865020190080000007

Xu Li, Daokang Xiang, Y. Shu, Xiangjun Zeng, Yonghong Li

{"title":"Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure 1","authors":"Xu Li, Daokang Xiang, Y. Shu, Xiangjun Zeng, Yonghong Li","doi":"10.1590/s0102-865020190080000007","DOIUrl":"https://doi.org/10.1590/s0102-865020190080000007","url":null,"abstract":"Abstract Purpose To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 and 20 mg/kg TIIA groups. Ten rats receiving laparotomy excepting abdominal aortic coarctation were enrolled in sham-operated group. The 5, 10 and 20 mg/kg TIIA groups were treated with 5, 10 and 20 mg/kg TIIA, respectively, for 8 weeks. Results Compared with model group, in 20 mg/kg TIIA group the left ventricular ejection fraction, left ventricular fractional shortening, left ventricular systolic pressure, ±maximum left ventricular pressure rising and dropping rate, and myocardial B-cell lymphoma-2 and cleaved cysteinyl aspartate specific proteinase-3 protein levels were increased, respectively (P<0.05), and the left ventricular end diastolic diameter, left ventricular end systolic diameter, left ventricular end diastolic pressure, heart weight index, left ventricular weight index, serum B-type brain natriuretic peptide, interleukin 6 and C-reactive protein levels and myocardial B-cell lymphoma-2 associated X protein level were decreased, respectively (P<0.05). Conclusion TIIA may alleviate ventricular remodeling in rats with pressure overload-induced heart failure heart by reducing inflammatory response and cardiomyocyte apoptosis.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90731317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Effect of sevoflurane pretreatment in relieving liver ischemia/reperfusion-induced pulmonary and hepatic injury 1 七氟醚预处理对肝缺血/再灌注所致肺和肝损伤的缓解作用

Acta Cirúrgica Brasileira Pub Date : 2019-10-14 DOI: 10.1590/s0102-865020190080000005

Guiping Xu, Xiaoli Wang, Yuxiang Xiong, Xueping Ma, Liao Qu

{"title":"Effect of sevoflurane pretreatment in relieving liver ischemia/reperfusion-induced pulmonary and hepatic injury 1","authors":"Guiping Xu, Xiaoli Wang, Yuxiang Xiong, Xueping Ma, Liao Qu","doi":"10.1590/s0102-865020190080000005","DOIUrl":"https://doi.org/10.1590/s0102-865020190080000005","url":null,"abstract":"Abstract Purpose To investigate the effect of sevoflurane preconditioning on ischemia/reperfusion (I/R)-induced pulmonary/hepatic injury Methods Fifty-one Wistar rats were randomly grouped into sham, I/R, and sevoflurane groups. After reperfusion, the structural change of the lung was measured by Smith score, the wet and dry weights (W/D) were determined, malondialdehyde (MDA) myeloperoxidase (MPO) content was determined colorimetrically and by fluorescence, respectively, and matrix metalloprotein-9 (MMP-9) mRNA was quantified by RT-PCR. Biopsy and morphological analyses were performed on liver tissue, activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were determined, and tumor necrosis factor-alpha (TNF-α) level was determined. Results The sham group showed no changes in tissue structure. Structural lesions in the sevoflurane and I/R groups were mild and severe, respectively. Smith score, W/D, MDA, MPO, and MMP mRNA showed the same trend, and were increased in the I/R group and recovered in the sevoflurane group, compared with the sham group (both P<0.05). AST and ALT were significantly increased compared to the sham group (AST: 655±52.06 vs . 29±9.30 U/L; ALT: 693±75.56 vs . 37±6.71 U/L; P<0.05). In the sevoflurane group, AST and ALT levels were significantly decreased (464±47.71 and 516±78.84 U/L; P<0.001). TNF-α presented similar results. Conclusion The protection of lung and liver by sevoflurane may be mediated by inhibited leukocyte recruitment and MMP-9 secretion.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89819970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy 1 基于血小板的预后模型对肝恶性肿瘤TACE治疗后预后价值的比较

Acta Cirúrgica Brasileira Pub Date : 2019-09-16 DOI: 10.1590/s0102-865020190070000010

Qiancheng Du, C. Hu, Yan Yan Wang, Ying Zhou

{"title":"Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy 1","authors":"Qiancheng Du, C. Hu, Yan Yan Wang, Ying Zhou","doi":"10.1590/s0102-865020190070000010","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000010","url":null,"abstract":"Abstract Purpose: To investigate the prognostic value of 17 platelet-based prognostic scores in patients with malignant hepatic tumors after TACE therapy. Methods: In total, 92 patients were divided into death group and survival group according to long-term follow-up results. The AUC was calculated to determine the optimal cut-off values for predicting prognosis. To determine better prognostic models, platelet-based models were analyzed separately after being showed as binary according to cut-off values. Cumulative survival rates of malignant hepatic tumors were calculated using Kaplan-Meier curves and differences were analyzed by the log-rank test. Univariate and multivariate analyses were performed to identify platelet-based prognostic scores associated with overall survival. Results: Univariate analysis showed that APGA, APRI, FIB-4, FibroQ, GUCI, King's score, Lok index, PAPAS, cirrhosis, number of tumors, vascular cancer embolus, AFP, ALP and APTT were significantly related to prognosis. A multivariate analysis showed that the APGA, number of tumors, ALP and APTT were independently associated with overall survival. Conclusion: This study showed that the APGA, a platelet-based prognostic score, was an independent marker of prognosis in patients with malignant hepatic tumors after TACE and was superior to the other platelet-based prognostic scores in terms of prognostic ability.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"28 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82726237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New training model using chickens intestine for pediatric intestinal anastomosis 1 鸡肠用于小儿肠吻合术的新训练模式

Acta Cirúrgica Brasileira Pub Date : 2019-09-16 DOI: 10.1590/s0102-865020190070000009

D. Santos, Faustino Chaves Calvo, Daniel Haber Feijó, Nayara Pontes de Araújo, R. Teixeira, Edson Yuzur Yasojima

引用次数: 9

Splenic ischemic preconditioning attenuates oxidative stress induced by hepatic ischemia-reperfusion in rats 1 脾缺血预处理对大鼠肝缺血-再灌注氧化应激的影响[j]

Acta Cirúrgica Brasileira Pub Date : 2019-09-16 DOI: 10.1590/s0102-865020190070000007

C. Costa, Nathalia Gabay Pereira, A. Machado, M. Dórea, R. Cruz, Renata Cunha Silva, Robson José de Souza Domingues, Edson Yuzur Yasojima

{"title":"Splenic ischemic preconditioning attenuates oxidative stress induced by hepatic ischemia-reperfusion in rats 1","authors":"C. Costa, Nathalia Gabay Pereira, A. Machado, M. Dórea, R. Cruz, Renata Cunha Silva, Robson José de Souza Domingues, Edson Yuzur Yasojima","doi":"10.1590/s0102-865020190070000007","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000007","url":null,"abstract":"Abstract Purpose: To evaluate the effects of splenic ischemic preconditioning (sIPC) on oxidative stress induced by hepatic ischemia-reperfusion in rats. Methods: Fifteen male Wistar rats were equally divided into 3 groups: SHAM, IRI and sIPC. Animals from IRI group were subjected to 45 minutes of partial liver ischemia (70%). In the sIPC group, splenic artery was clamped in 2 cycles of 5 min of ischemia and 5 min of reperfusion (20 min total) prior to hepatic ischemia. SHAM group underwent the same surgical procedures as in the remaining groups, but no liver ischemia or sIPC were induced. After 1h, hepatic and splenic tissue samples were harvested for TBARS, CAT, GPx and GSH-Rd measurement. Results: sIPC treatment significantly decreased both hepatic and splenic levels of TBARS when compared to IRI group (p<0.01). Furthermore, the hepatic and splenic activities of CAT, GPx and GSH- Rd were significantly higher in sIPC group than in IRI group. Conclusion: sIPC was able to attenuate hepatic and splenic IRI-induced oxidative stress.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78208805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Botulinum toxin as a treatment for short bowel syndrome in rats 1 肉毒杆菌毒素治疗大鼠短肠综合征

Acta Cirúrgica Brasileira Pub Date : 2019-09-16 DOI: 10.1590/s0102-865020190070000005

I. Marques, S. B. Minto, Mariane Quaglio Marques, J. Ribeiro, P. Moraes, Lourenço Sbragia Neto, S. Garcia

{"title":"Botulinum toxin as a treatment for short bowel syndrome in rats 1","authors":"I. Marques, S. B. Minto, Mariane Quaglio Marques, J. Ribeiro, P. Moraes, Lourenço Sbragia Neto, S. Garcia","doi":"10.1590/s0102-865020190070000005","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000005","url":null,"abstract":"Abstract Purpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine. Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control). Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection. Conclusion: This may provide a new promising approach to the surgical treatment of SBS.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85677781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways 1 黄芪甲苷通过调节PI3K/AKT/GSK-3β信号通路减轻大鼠心肌缺血-再灌注损伤

Acta Cirúrgica Brasileira Pub Date : 2019-09-12 DOI: 10.1590/s0102-865020190070000008

Dajun Wei, Hongjie Xu, Xiaodong Gai, Ying Jiang

{"title":"Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways 1","authors":"Dajun Wei, Hongjie Xu, Xiaodong Gai, Ying Jiang","doi":"10.1590/s0102-865020190070000008","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000008","url":null,"abstract":"Abstract Purpose: To investigate the effect of astragaloside IV (As-IV) on myocardial ischemia-reperfusion (I/R) injury in rats and reltaed mechanisms. Methods: Sixty rats were randomly divided into sham-operated, control I/R and 2.5, 5 and 10 mg/kg As-IV groups, 12 rats in each group. The later three groups were intragastrically administered with As-IV for 7 days, with a dose of 2.5, 5 and 10 mg/kg, respectively. The myocardial I/R injury model was constructed in later four groups. At the end of reperfusion, the cardiac function indexes, serum lactate dehydrogenase (LDH) and creatine kinase (CK) levels, heart weight (HW)/body weight (BW) ratio and infarct size, and expressions of phosphatidylinositol-3 kinase/serine-threonine protein kinase (PI3K/AKT) and glycogen synthase kinase-3β (GSK-3β) proteins and the phosphorylated forms (p-AKT, p-GSK-3β) were determined. Results: Compared with control I/R group, in 5 and 10 mg/kg As-IV groups the left ventricular systolic pressure, fractional shortening and ejection fraction were increased, the left ventricular end-diastolic pressure was decreased, the serum LDH and CK levels were decreased, the HW/BW ratio and myocardial infarct size were decreased, and the p-Akt/Akt ratio and p-GSK-3β/GSK-3β ratio were increased (all P < 0.05). Conclusion: As-IV can alleviate the myocardial I/R injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78853552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats 1 白藜芦醇在大鼠颅骨骨缺损同种异体移植材料中的短期应用

Acta Cirúrgica Brasileira Pub Date : 2019-09-12 DOI: 10.1590/s0102-865020190070000004

N. Laçin, E. Deveci

{"title":"Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats 1","authors":"N. Laçin, E. Deveci","doi":"10.1590/s0102-865020190070000004","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000004","url":null,"abstract":"Abstract Purpose: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. Results: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. Conclusion: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72713019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats 1 火棘提取物对氯化镉致大鼠急性肾毒性的保护作用

Acta Cirúrgica Brasileira Pub Date : 2019-09-12 DOI: 10.1590/s0102-865020190070000006

Yixin Ke, Kaihang Yu, Weiliang Zeng, Guojun Lian

{"title":"Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats 1","authors":"Yixin Ke, Kaihang Yu, Weiliang Zeng, Guojun Lian","doi":"10.1590/s0102-865020190070000006","DOIUrl":"https://doi.org/10.1590/s0102-865020190070000006","url":null,"abstract":"Abstract Purpose: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl2) in rats. Methods: Rats were pretreated with PFE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days. Results: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl2 group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl2 treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl2 treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl2 treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl2 treatment. Conclusion: PFE could protect the kidney against acute renal toxicity induced by CdCl2.","PeriodicalId":6993,"journal":{"name":"Acta Cirúrgica Brasileira","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83961342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7