Acta Obstetricia et Gynecologica Scandinavica最新文献

{"title":"Induction of labor versus cesarean section after 36 + 0 weeks in twin pregnancy: A review of maternal and neonatal outcomes","authors":"Joanna Gent,&nbsp;Evie Oliver,&nbsp;Grace Williams,&nbsp;Steven Lane,&nbsp;Kate Navaratnam,&nbsp;Andrew Sharp","doi":"10.1111/aogs.70271","DOIUrl":"10.1111/aogs.70271","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Our aim was to assess maternal and perinatal morbidity associated with induction of labor (IOL) and elective cesarean section (ECS) in uncomplicated twin pregnancies delivered &gt;36 weeks' gestation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A retrospective review of all twin pregnancies, irrespective of chorionicity, that underwent ECS and IOL at the Liverpool Women's Hospital (LWH) over a 10-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three hundred and eighty-two women underwent IOL and 326 had ECS between January 2010 and December 2020 at LWH. 71.2% (<i>n</i> = 272) achieved vaginal delivery of both babies in the IOL group, 4.2% (<i>n</i> = 16) required CS for the second twin. There was no difference in blood loss &gt;1500 mLs (7.4% vs. 6.8%, RR 0.92 (0.54–1.58), <i>p</i> = 0.77). Admission of one or both twins to the neonatal unit was higher following IOL than ECS (13.5% vs. 10%, RR 1.35 (1.01–1.81), <i>p</i> = 0.04 and 5.1% vs. 2.9%, RR 1.75 (1.03–2.97), <i>p</i> = 0.04, respectively). There was no impact of chorionicity on outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Existing consensus on mode of delivery of twins at term suggests both IOL and ECS are safe options. We found an association between increased neonatal admissions following IOL compared to ECS, which has also been observed in line with previous epidemiological studies. Our study broadens our knowledge and strengthens the case that this should be discussed when counseling women about intended mode of birth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"105 9","pages":"1742-1748"},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-specific validation of fetal weight formulas: Evidence from a multicenter near-delivery cohort","authors":"Sumito Nagasaki,&nbsp;Rio Suzuki,&nbsp;Fumio Sugo,&nbsp;Mayu Tachihara,&nbsp;Tsubasa Mori,&nbsp;Sena Shimizu,&nbsp;Junya Sakuma,&nbsp;Ayumu Ito,&nbsp;Mayumi Takano,&nbsp;Masahiko Nakata","doi":"10.1111/aogs.70278","DOIUrl":"10.1111/aogs.70278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Accurate ultrasound estimated fetal weight (EFW) supports key perinatal decisions. This study aimed to compare the accuracy of a population-specific formula with that of a widely used global model in pregnancies examined near delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This was a secondary analysis of a prospective Japanese cohort study to develop a new fetal ultrasound biometry reference chart. Fetal ultrasound measurements were obtained by Japan Society of Ultrasonics in Medicine-certified sonographers or under their supervision and submitted to the coordinating center, where EFW was calculated using the Shinozuka and Hadlock-3 formulas. Analyses were restricted to cases with EFW available from both formulas. The primary analysis included examinations within 7 days before delivery; a sensitivity analysis restricted the interval to ≤3 days. A subgroup analysis was performed in fetuses classified as small for gestational age (SGA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the primary analysis (<i>n</i> = 310), the median signed error was −75.8 g for Shinozuka and −223.3 g for Hadlock-3 (Wilcoxon <i>p</i> &lt; 0.001). The median absolute percentage signed error was 4.81% for Shinozuka and 7.93% for Hadlock-3 (Wilcoxon <i>p</i> &lt; 0.001). The proportion within ±10% of BW was 83.9% with Shinozuka versus 61.6% with Hadlock-3 (McNemar <i>p</i> &lt; 0.001). In the sensitivity analysis (<i>n</i> = 176), similar findings were observed. In the SGA subgroup (<i>n</i> = 40), the signed error and absolute percentage error were significantly lower with the Shinozuka formula than with Hadlock-3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this multicenter cohort examined near delivery, the population-specific Shinozuka formula produced EFW closer to BW and a higher proportion within ±10% than Hadlock-3, which showed greater systematic underestimation. These findings support the use of locally validated, population-specific EFW formulas when available, particularly for clinical decision-making near delivery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"105 9","pages":"1680-1688"},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility outcomes and ovarian function recovery after anti-NMDAR encephalitis: A retrospective cohort study","authors":"Jia Wang,&nbsp;Jie Ding,&nbsp;Han Cai,&nbsp;YingXiang Wang,&nbsp;HaoTian Wu","doi":"10.1111/aogs.70261","DOIUrl":"10.1111/aogs.70261","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Anti-<i>N</i>-methyl-D-aspartate receptor (anti-NMDAR) encephalitis predominantly affects women of reproductive age and is frequently associated with ovarian teratomas. While acute neurological outcomes are well described, the long-term impact on ovarian endocrine function and fertility—particularly in tumor-associated cases—remains poorly understood, creating significant uncertainty in survivorship counseling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study involving 106 women diagnosed with anti-NMDAR encephalitis at a tertiary academic hospital between 2015 and 2024. Primary outcomes included the recovery of ovarian endocrine function, measured by serial sex hormone levels and fertility outcomes. Secondary analyses assessed disease severity, tumor markers, and neuroimaging features between teratoma-associated cases and non-teratoma cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with teratoma-associated encephalitis (<i>n</i> = 23) exhibited greater acute disease severity, necessitating higher rates of ICU admission (<i>p</i> = 0.012) and mechanical ventilation (<i>p</i> = 0.021). During the acute phase of illness, 38% of all patients experienced HPO axis suppression, primarily manifesting as amenorrhea. However, longitudinal monitoring revealed substantial recovery, with significant improvements in both luteinizing hormone (<i>p</i> = 0.01) and estradiol levels (<i>p</i> = 0.01) during convalescence. Notably, pregnancy rates were comparable between the teratoma (80%) and non-teratoma (83.3%) groups (<i>p</i> = 0.68).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ovarian dysfunction in anti-NMDAR encephalitis is often reversible, and long-term fertility remains favorable even in teratoma-associated cases. These findings provide valuable guidance for fertility counseling and highlight the importance of incorporating reproductive health monitoring into the long-term care of young women with tumor-related autoimmune encephalitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"105 9","pages":"1823-1832"},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuum-assisted hemorrhage control device versus uterine balloon tamponade for refractory atonic postpartum hemorrhage in a protocol-driven care pathway-A retrospective cohort study.","authors":"Kelvin Z X Lee, Calista L S Por, Tak Yein Lim, Pradip Dashraath, Wei Wei Teo, Christopher King, Su Wei Bryan Ng, Harshaana Ramlal, Liang Shen, Arijit Biswas, Ganesh Acharya, Sabaratnam Arulkumaran, Mahesh Choolani, Sarah W L Li","doi":"10.1111/aogs.70334","DOIUrl":"10.1111/aogs.70334","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, 1 in 5 maternal deaths are attributable to major postpartum hemorrhage (PPH), despite widespread uterotonic use. Intrauterine tamponade is recommended as second-line therapy for refractory atonic PPH. Uterine balloon tamponade (UBT) achieves hemostasis through intrauterine pressure. Conversely, the vacuum-assisted hemorrhage-control device (VHD) promotes uterine contraction through negative pressure. Limited data compare these modalities. We compared the clinical effectiveness of UBT and VHD in refractory atonic PPH.</p><p><strong>Material and methods: </strong>This retrospective cohort study was conducted at the National University Hospital in Singapore and included all women treated for primary PPH with either the UBT or VHD between January 2020 and September 2025, during which ROTEM-guided transfusion and E-MOTIVE-aligned practices were implemented. The composite morbidity endpoint, comprising transfusion of ≥4 units of packed red blood cells (PRBC), plasma or cryoprecipitate administration, examination under anesthesia, high dependency or intensive care unit admission, or device failure was compared between groups with logistic regression adjusted for placenta previa major and cesarean delivery.</p><p><strong>Results: </strong>Fifty-three women met inclusion criteria (33 UBT, 20 VHD). The composite morbidity outcome occurred less frequently with VHD than UBT (45.0% versus 75.8%; unadjusted OR 0.26, 95% CI 0.08-0.86, p = 0.03); after adjusting for placenta previa major and cesarean delivery, this difference was no longer statistically significant (adjusted OR 0.38, 95% CI 0.10-1.41, p = 0.15). Baseline characteristics were similar except for higher rates of placenta previa (45.5% versus 5.0%) and cesarean delivery (78.8% versus 50.0%) in the UBT group. Median estimated blood loss at device insertion was comparable (1500 mL). Among secondary outcomes, VHD was associated with lower median PRBC transfusion (1 vs. 2 units, p = 0.009), fewer women receiving ≥4 PRBC units (5.0% versus 36.4%, p = 0.02), fewer plasma transfusions (5.0% versus 36.4%, p = 0.02), shorter device indwelling duration (10.1 versus 24.3 h, p < 0.001), shorter hospital stay (54 versus 72 h, p = 0.007), and fewer high-dependency admissions (45.0% versus 72.7%, p = 0.04).</p><p><strong>Conclusions: </strong>The VHD demonstrated outcomes comparable to balloon tamponade in managing refractory atonic PPH, with lower transfusion requirements and shorter hospitalization. VHD may be a useful component of standardized PPH protocols incorporating the E-MOTIVE bundle and ROTEM-guided transfusion, warranting further evaluation in broader clinical settings.</p>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicon dioxide vaginal gel and short-term high-risk human papillomavirus DNA detectability: A randomized controlled trial.","authors":"Julia M Hecken, Clemens B Tempfer, Katrin Klaus, Jan Scheich, Günther A Rezniczek","doi":"10.1111/aogs.70332","DOIUrl":"10.1111/aogs.70332","url":null,"abstract":"<p><strong>Introduction: </strong>Intravaginal products, including silicon dioxide-based gels, are marketed to support short-term high-risk human papillomavirus (hrHPV) clearance or loss of detectability, but independent randomized evidence testing these short-term claims against observation is limited. We evaluated whether daily intravaginal silicon dioxide-based gel treatment increases the proportion of women with no detectable cervical hrHPV DNA compared with observation alone.</p><p><strong>Material and methods: </strong>This prospective, single-center, parallel-group, randomized, open-label controlled trial included women with PCR-confirmed cervical hrHPV infection and no indication for immediate treatment. Participants were randomized 1:1 to 3 months of self-administered daily intravaginal gel treatment or observation alone. The primary outcome was absence of detectable cervical hrHPV DNA by PCR at 3 months. Secondary outcomes during the randomized study period were patient-reported satisfaction and adverse events.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT05509413, https://clinicaltrials.gov/study/NCT05509413.</p><p><strong>Results: </strong>Between November 2022 and January 2025, 242 women were randomized, with 121 allocated to each group. Primary-endpoint data were available for 208 women. At 3 months, hrHPV DNA was not detected in 18/99 women (18%) in the gel treatment group and 23/109 women (21%) in the observation group (absolute risk difference -2.9 percentage points, 95% CI -14 to 8; p = 0.60). A reduced post hoc adjusted sensitivity analysis did not materially change the interpretation of the primary comparison. Patient-reported adverse events were more frequent in the gel treatment group than in the observation group (32/99 [32%] vs. 2/106 [2%]; absolute risk difference 30 percentage points, 95% CI 21 to 40; p < 0.001). Satisfaction scores were high in both groups but lower with gel treatment.</p><p><strong>Conclusions: </strong>In this randomized trial, 3 months of daily intravaginal silicon dioxide-based gel treatment did not improve short-term loss of detectable cervical hrHPV DNA compared with observation alone. The trial did not reproduce the large short-term virologic benefit suggested by prior product-related studies. The findings do not support routine use of this intervention solely to promote short-term hrHPV non-detectability in women without an indication for immediate treatment, particularly given the higher frequency of local adverse events.</p>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality-of-life and late effects after transabdominal cerclage: A nationwide matched cohort study.","authors":"Lea Kirstine Hansen, Julie Glavind, Andrew H Shennan, Niels Uldbjerg, Stina Lou, Ulrik Schiøler Kesmodel, Pernille Tine Jensen","doi":"10.1111/aogs.70324","DOIUrl":"10.1111/aogs.70324","url":null,"abstract":"<p><strong>Introduction: </strong>A transabdominal cerclage is inserted to prevent recurrent midtrimester loss and spontaneous preterm birth. The transabdominal cerclage often remains as a permanent foreign body for years. Synthetic materials within the abdomen, cesarean birth, and prior adverse pregnancy outcomes have each been associated with long-term complications or poorer health-related quality-of-life. However, the long-term effects of a permanent transabdominal cerclage have not been investigated. We aimed to evaluate patient-reported late effects and health-related quality-of-life in Danish women who underwent transabdominal cerclage between 2004 and 2025.</p><p><strong>Material and methods: </strong>In this nationwide cohort study, women with a transabdominal cerclage were matched in a 1:1:1 ratio to two comparison groups: (1)women without transabdominal cerclage who had a cesarean birth, and (2)women without transabdominal cerclage who had a non-instrumental vaginal birth and no prior cesarean birth. Participants completed validated questionnaires assessing quality-of-life, anxiety and depression, bladder discomfort, pelvic pain and sexual health. The primary outcome was the General Health scale in SF-36. Domain- and total scale scores were compared between the groups using multiple linear regression. The study was pre-registered on clinicaltrials.gov (NCT06875401).</p><p><strong>Results: </strong>Two hundred three women with a transabdominal cerclage, 90 with a cesarean section, and 98 with a vaginal birth participated. The mean General Health score did not differ between groups by a predefined minimally important difference of 10 points. Adjusted mean differences were - 4.0 points (95% CI -9.5-1.4) for women with cesarean birth and -0.6 (95% -CI-6.2-4.9) for women with vaginal birth in comparison to the transabdominal cerclage group. Mental health, bladder discomfort, pelvic pain, and sexual health symptom burdens were similar between groups. Response rates were higher in the transabdominal cerclage group, which may have introduced selection bias. Cerclage-related complications leading to suture removal after completed pregnancies were rare (3/203 women, 1.5%). Quality-of-life scores tended to be higher with longer time since cerclage procedure.</p><p><strong>Conclusions: </strong>Permanent transabominal cerclage was not associated with poorer self-reported general health compared with women without transabominal cerclage, regardless of mode of birth. These findings support that a permanent transabominal cerclage does not appear to have long-term negative health effects.</p>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward risk-stratified management of placental site nodules with atypical features.","authors":"Tingting Xu, Shuhong Li","doi":"10.1111/aogs.70250","DOIUrl":"10.1111/aogs.70250","url":null,"abstract":"","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":"1640"},"PeriodicalIF":3.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with deep perineal wound dehiscence after second-degree perineal tears or episiotomy.","authors":"Denise Golmann, Josefin Hedström, Elisabeth Epstein, Ida Bergman","doi":"10.1111/aogs.70285","DOIUrl":"10.1111/aogs.70285","url":null,"abstract":"<p><strong>Introduction: </strong>Second-degree perineal tears and episiotomies, involving the bulbocavernosus and/or superficial transverse perineal muscles, are common after vaginal birth and may lead to wound dehiscence, infection, and long-term pelvic floor dysfunction. Despite this, risk factors for deep wound dehiscence involving perineal musculature remain insufficiently studied. This study aimed to identify risk factors for wound dehiscence in second-degree tears and episiotomies to inform potential use of antibiotic prophylaxis.</p><p><strong>Material and methods: </strong>A single-center case-control study (1:2 ratio) was conducted including 105 cases with 2nd degree perineal tears or episiotomies complicated by deep wound dehiscence, diagnosed within two weeks postpartum and 210 controls with second-degree tears or episiotomies without dehiscence. Exposure data were retrieved from medical records. Univariate analyses were performed on a priori selected exposure variables, using Mann-Whitney U and Fisher's exact tests. Variable selection used Lasso regression with leave-one-out cross-validation. Multivariate logistic regression generated adjusted odds ratios (aOR). Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>Women with wound dehiscence were more often vaginal primiparas (87% vs 69%, p < 0.001) and had higher rates of episiotomy (33% vs 7%, p < 0.001). Intrapartum antibiotics were administered less frequently among cases (7% vs 20%, p = 0.002). Cases had longer second stage of labor, more active pushing, and greater postpartum bleeding. After multivariate adjustment, only episiotomy (aOR 4.40, 95% CI 2.10-9.64) and intrapartum antibiotic administration (aOR 0.21, 95% CI 0.07-0.50) remained significantly associated with wound dehiscence.</p><p><strong>Conclusions: </strong>Episiotomy substantially increased the risk of deep perineal wound dehiscence compared with spontaneous second-degree perineal tears, while intrapartum antibiotics were protective. These findings support selective episiotomy use and suggest that antibiotic prophylaxis may reduce this risk in women with second-degree perineal tears or episiotomies.</p>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":"1623-1628"},"PeriodicalIF":3.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient education materials by ChatGPT: Real intention and interpretation.","authors":"Shigeki Matsubara","doi":"10.1111/aogs.70123","DOIUrl":"10.1111/aogs.70123","url":null,"abstract":"","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":"1636-1637"},"PeriodicalIF":3.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks of gynecological and breast cancers in women with endometriosis or adenomyosis: A nationwide cohort study.","authors":"Louise Moberg, Xinjun Li, Filip Herbst, Filip Jansåker, Arturas Dobilas, Kristina Sundquist, Christer Borgfeldt","doi":"10.1111/aogs.70223","DOIUrl":"10.1111/aogs.70223","url":null,"abstract":"<p><strong>Introduction: </strong>Endometriosis has been associated with several risk factors for cancer, and population-based research has shown that women with endometriosis have a higher risk of several types of cancer. The aim of this study was to examine the risks of gynecological and breast cancers among women diagnosed with endometriosis or adenomyosis.</p><p><strong>Material and methods: </strong>A nationwide cohort study was conducted between 1997 and 2018. All women diagnosed with endometriosis or adenomyosis (the first recorded diagnosis during the study period) in Sweden were followed for cancer diagnosis. The reference population was women not diagnosed with endometriosis or adenomyosis during the study period. Data were obtained from the National Patient Register (in patient and out patient specialist care settings), the Swedish Cancer Register, and the Total Population Register. Adjusted standardized incidence ratios with 95% confidence intervals were calculated for cancer. Women with prior gynecological organ removal or mastectomy were not excluded.</p><p><strong>Results: </strong>A total of 49 133 women were diagnosed with endometriosis or adenomyosis at a mean age of 42.7 years (standard deviation: 9.97 years). Of these, 1784 (3.6%) were diagnosed with gynecological or breast cancer. The overall standardized incidence ratio for gynecological and breast cancer in women with endometriosis or adenomyosis for the whole study period was 1.4 (95% confidence interval, 1.3-1.5) compared to those without. For cancers diagnosed in the same calendar year as endometriosis or adenomyosis (n = 370), the standardized incidence ratios were particularly high for endometrial cancer (standardized incidence ratio 47.0) and ovarian (standardized incidence ratio 39.6) cancer. For cancers diagnosed in subsequent calendar years (n = 1414), the standardized incidence ratios were 0.6 (0.5-0.8) for endometrial cancer, 0.7 (0.5-0.9) for cervical cancer, 1.2 (1.1-1.3) for breast cancer, and 1.9 (1.6-2.2) for epithelial ovarian cancers overall. When looking at ovarian cancer subtypes, the standardized incidence ratios were 1.5 (1.1-2.0), 2.8 (1.7-4.2), and 7.7 (5.4-10.6), for low-grade serous, endometrioid, and ovarian clear cell cancers, respectively.</p><p><strong>Conclusions: </strong>Women with endometriosis or adenomyosis have a higher subsequent risk of ovarian and breast cancers compared to women without. This may represent important information for clinicians and a foundation for further studies on prophylactic interventions.</p>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":" ","pages":"1607-1613"},"PeriodicalIF":3.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}