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Acta pharmacologica et toxicologica最新文献

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The LD50 test. LD50测试。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02680.x
E Paget
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引用次数: 13
Correlation between cytotoxicity in vitro and LD50-values. 体外细胞毒性与ld50值的相关性。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02685.x
B Ekwall
{"title":"Correlation between cytotoxicity in vitro and LD50-values.","authors":"B Ekwall","doi":"10.1111/j.1600-0773.1983.tb02685.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02685.x","url":null,"abstract":"","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"80-99"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02685.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17931146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Shortcomings of alternative techniques for the assessment of acute toxicity. 评估急性毒性的替代技术的缺点。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02690.x
A Rowan
{"title":"Shortcomings of alternative techniques for the assessment of acute toxicity.","authors":"A Rowan","doi":"10.1111/j.1600-0773.1983.tb02690.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02690.x","url":null,"abstract":"<p><p>Relatively little work has been done on the development of cell culture and other models to assess the acute toxicity of chemicals. Many of the present shortcomings have already been addressed in earlier presentations but will be summarized by the author. The parameters necessary for an appropriate model of acute toxicity will be discussed and the difference between testing for specific and general effects will be highlighted. Some possible future research directions and research needs will be discussed.</p>","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"190-200"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02690.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17931320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiated cell and organ culture in toxicity testing. 毒性试验中的分化细胞和器官培养。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02687.x
M Balls, R Clothier
{"title":"Differentiated cell and organ culture in toxicity testing.","authors":"M Balls,&nbsp;R Clothier","doi":"10.1111/j.1600-0773.1983.tb02687.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02687.x","url":null,"abstract":"<p><p>The safety evaluation of new chemicals involves a range of investigations, including acute and sub-acute toxicity testing, long-term toxicity testing, studies on mutagenicity, carcinogenicity, and reproductive toxicity, and special investigations involving the interaction of the chemical under test with particular parts of the body, such as the skin or the nervous system. We shall consider the potential role of differentiated cell and organ culture in toxicity testing, and the criteria available for assessing cell viability, damage, and death, with a view to establishing whether such methods could be used for determining the relative acute toxicities of chemicals. We shall also consider methods for studying the effects of chemicals on general and specific aspects of cell structure and function, including liver cell and organ cultures both as primary targets themselves susceptible to damage and as providers of metabolically activated compounds able to affect other cells and tissues.</p>","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"115-37"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02687.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17931318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Symposium: Altered function of receptors caused by diseases and drugs. Abstracts. 专题讨论会:疾病和药物引起的受体功能改变。摘要。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01
{"title":"Symposium: Altered function of receptors caused by diseases and drugs. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"53 Suppl 1 ","pages":"3-18"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17381969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The LD50 test and in vitro toxicology strategies. LD50试验及体外毒理学策略。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02684.x
R M Nardone
{"title":"The LD50 test and in vitro toxicology strategies.","authors":"R M Nardone","doi":"10.1111/j.1600-0773.1983.tb02684.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02684.x","url":null,"abstract":"<p><p>In order for in vitro alternatives for acute toxicity testing to emerge, it will be necessary to stage a clearly-defined strategy. The strategy, with its intermediate objectives and proximal decision points, could serve as the basis for validation of the in vitro tests to be used as components of a test battery for assessment of general cytotoxicity and for the evaluation of impairment of differentiated function. An approach for the evaluation of potential neurotoxic agents is presented and could serve as a model for the evaluation of potential ocular, hepatic, and other toxins.</p>","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"65-79"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02684.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17931145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First CFN symposium: LD50 and possible alternatives. Proceedings of a symposium at Uppsala Bio-Medical Center, Sweden, September 15-16, 1981. 第一届CFN研讨会:LD50和可能的替代方案。1981年9月15日至16日，瑞典乌普萨拉生物医学中心研讨会论文集。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01
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引用次数: 0
Complete programme for acute toxicity testing - not only LD50 determination. 完整的急性毒性试验方案-不仅仅是LD50测定。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02682.x
A Dayan
{"title":"Complete programme for acute toxicity testing - not only LD50 determination.","authors":"A Dayan","doi":"10.1111/j.1600-0773.1983.tb02682.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02682.x","url":null,"abstract":"<p><p>The objective of any experimenter should be to obtain the maximum amount of useful information in the most economical manner possible. In this context, 'useful' means study both of the principal or anticipated actions of the compound under examination, and also detection of additional responses to it. For efficient evaluation, including greater statistical rigour, a continuous or graded response and quantitative measurement is preferable, although much can be done by simply analysis of the presence or absence of responses, even if these are complex or dependent upon subjective criteria. Consistency of experimental conditions, and of diagnostic criteria are essential, whether in single, exploratory or comparative tests. Acute toxicity tests, like other experiments, should be designed pragmatically, therefore, confirming to the properties of the substance under examination, but also with general or holistic coverage, albeit less specific, to detect unanticipated actions. Greater or lesser weight may be given to these two classes of method, depending on whether the test is done as part of a general screen of a previously unknown substance, or as a specific control measure done to assay one particular property. Extrapolation of the results to man or other species is only possible with the caution proper to any experiment done under restricted and highly artificial conditions, but the value of acute toxicity data has often been shown by experience gained in man.</p>","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"31-51"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02682.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17931325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Symposium: Pharmacology of arachidonic acid and its metabolites. Abstracts. 座谈会:花生四烯酸及其代谢物的药理学。摘要。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01
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引用次数: 0
Symposium: Psychotropic drugs: pharmacokinetic and neuroendocrine monitoring. Abstracts. 研讨会:精神药物:药代动力学和神经内分泌监测。摘要。
Acta pharmacologica et toxicologica Pub Date : 1983-01-01
{"title":"Symposium: Psychotropic drugs: pharmacokinetic and neuroendocrine monitoring. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"53 Suppl 1 ","pages":"59-212"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17721386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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