Acta pharmacologica et toxicologica最新文献_第9页

Methods using tissue preparations and isolated biomolecules. 方法采用组织制剂和分离的生物分子。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02688.x

E Heilbronn

引用次数: 1

Acute toxicity testing in cultures of mouse neuroblastoma cells. 小鼠神经母细胞瘤细胞急性毒性试验。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02686.x

E Walum, A Peterson

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引用次数: 9

Methodological aspects of acute toxicity testing particularly LD50 determinations present use in development of new drugs. 急性毒性试验的方法学方面，特别是LD50的测定目前在新药开发中使用。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02681.x

J S Fowler, D A Rutty

引用次数: 10

LD50 - its value for the pharmaceutical industry in safety evaluation of drugs. LD50 -它在制药行业药物安全性评价中的价值。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02692.x

T Malmfors, A Teiling

{"title":"LD50 - its value for the pharmaceutical industry in safety evaluation of drugs.","authors":"T Malmfors, A Teiling","doi":"10.1111/j.1600-0773.1983.tb02692.x","DOIUrl":"https://doi.org/10.1111/j.1600-0773.1983.tb02692.x","url":null,"abstract":"Does the pharmaceutical industry perform LD50-determinations in animals just because it is required by the authorities or are there any scientific benefits from counting dead animals and calculating and index of lethal toxicity? This is an important question when discussing LD50 and possible alternatives. We will try to answer this question by presenting data and some views collected during almost ten years at a Swedish pharmaceutical company. We will describe how we have made use of the LD50-values in the safety evaluation process. We will compare LD50-values with the dose levels used in longterm toxicity both after single or repeated administration and with therapeutical dose levels in man for different classes of drugs. These data will enable us to demonstrate the value of the LD50-determinations. As we are of the opinion that the LD50-value itself has a limited value for the total safety evaluation of drugs we will look into the possibility of replacing the LD50-determination with something else as an indication of lethal toxicity. In order to minimize the number of animals used and the number of animals dying because of dosing in studies on lethal toxicity we will try to support a proposal to use the maximal nonlethal dose (MNLD) as an indication of lethal toxicity in small animals.","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"52 Suppl 2 ","pages":"229-46"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1983.tb02692.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17202746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Today's requirements in food, drug and chemical control. 当今在食品、药品和化学品控制方面的要求。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01 DOI: 10.1111/j.1600-0773.1983.tb02691.x

R E Osterberg

引用次数: 2

Abstracts: Joint meeting of the Scandinavian Pharmacological Society and the Italian Pharmacological Society. Taormina, Italy, April 25-28, 1983. 摘要:斯堪的纳维亚药理学会和意大利药理学会联合会议。陶尔米纳，意大利，1983年4月25日至28日。

Acta pharmacologica et toxicologica Pub Date : 1983-01-01