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Mesoglycan in treatment of patients with cerebral ischemia: effects on hemorheologic and hematochemical parameters. 中聚糖治疗脑缺血患者:对血液流变学和血液化学参数的影响。
Acta neurologica Pub Date : 1993-12-01
F Vecchio, G Zanchin, F Maggioni, C Santambrogio, L De Zanche
{"title":"Mesoglycan in treatment of patients with cerebral ischemia: effects on hemorheologic and hematochemical parameters.","authors":"F Vecchio,&nbsp;G Zanchin,&nbsp;F Maggioni,&nbsp;C Santambrogio,&nbsp;L De Zanche","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study evaluates the hematochemical and hemorheologic effects of mesoglycan, a preparation of natural glycosaminoglycans, administered by the intramuscular route to patients with a recent episode of cerebral ischemia. A total of twenty patients (13 males and 7 females), between the ages of 45 and 75, under observation for a cerebral ischemic episode occurring at least 2 months prior to enrollment, were treated with intramuscular mesoglycan (30 mg, twice daily), for 15 days. Blood samples were taken prior to and at the end of treatment to measure the investigated parameters. Following mesoglycan treatment we observed a statistically significant decrease in fibrinogen plasma concentration, total cholesterol and triglycerides, while HDL cholesterol was found to increase. In addition, erythrocytes filterability improved at the end of treatment. No changes were observed in coagulation parameters such as prothrombin time, partial thromboplastin time, or antithrombin III. The results of the present study demonstrate that a 15-days treatment of intramuscular mesoglycan in patients recovering from a cerebral ischemic episode produces significant changes in fibrinogen and lipid plasma levels with no apparent anticoagulant effect.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 6","pages":"449-56"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19151336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlations between abnormalities on brain SPECT scan and interictal EEG-foci in children with 'intractable' partial epilepsy. 顽固性部分性癫痫患儿脑SPECT扫描异常与间期脑电图灶的相关性
Acta neurologica Pub Date : 1993-10-01
A Spina, R Damato, R Losito, P L Marzocco, L Zizzo, V Damato
{"title":"Correlations between abnormalities on brain SPECT scan and interictal EEG-foci in children with 'intractable' partial epilepsy.","authors":"A Spina,&nbsp;R Damato,&nbsp;R Losito,&nbsp;P L Marzocco,&nbsp;L Zizzo,&nbsp;V Damato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>SPECT scanning with Tc99mHM-PAO was performed on 40 children with 'intractable' partial epilepsy; 27 patients had abnormalities on SPECT images consisting of areas of decreased cerebral blood flow. In 18 of these 27 subjects there was a good correlation between site of the abnormalities on SPECT scan and interictal EEG foci. 12 patients with regionally decreased CBF had also neuroimaging (C.T. and/or R.M.I.) abnormalities. The brain SPECT provides more precise detection of epileptogenic foci, when used to complement EEG, also in childhood-onset epilepsy.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"321-7"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological and structural basis of the central nervous system plasticity]. [中枢神经系统可塑性的生物学和结构基础]。
Acta neurologica Pub Date : 1993-10-01
G A Buscaino
{"title":"[Biological and structural basis of the central nervous system plasticity].","authors":"G A Buscaino","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"382-92"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute primary meningoencephalitis from entamoeba Naegleria Fowleri. Report of a clinical case with a favourable outcome. 福氏内阿米巴引起的急性原发性脑膜脑炎。报告一例临床病例，结果良好。
Acta neurologica Pub Date : 1993-10-01
F Loschiavo, T Ventura-Spagnolo, E Sessa, P Bramanti
{"title":"Acute primary meningoencephalitis from entamoeba Naegleria Fowleri. Report of a clinical case with a favourable outcome.","authors":"F Loschiavo,&nbsp;T Ventura-Spagnolo,&nbsp;E Sessa,&nbsp;P Bramanti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Authors describe a primary amoebic acute meningoencephalitis case from Naegleria Fowleri, where the parasite was found in the cerebrospinal fluid and in culture. The case had a favorable outcome after treatment with amphotericin B.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"333-40"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of papova-like viral particles in cerebrospinal fluid of AIDS patients with progressive multifocal leukoencephalopathy. An additional test for "in vivo" diagnosis. 进行性多灶性脑白质病艾滋病患者脑脊液中存在乳头状病毒颗粒。一项额外的“体内”诊断测试。
Acta neurologica Pub Date : 1993-10-01
G Orefice, G Campanella, S Cicciarello, A Chirianni, G Borgia, S Rubino, M Mainolfi, M Coppola, M Piazza
{"title":"Presence of papova-like viral particles in cerebrospinal fluid of AIDS patients with progressive multifocal leukoencephalopathy. An additional test for \"in vivo\" diagnosis.","authors":"G Orefice,&nbsp;G Campanella,&nbsp;S Cicciarello,&nbsp;A Chirianni,&nbsp;G Borgia,&nbsp;S Rubino,&nbsp;M Mainolfi,&nbsp;M Coppola,&nbsp;M Piazza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An \"in vivo\" diagnosis of progressive multifocal leukoencephalopathy (PML), a neurological opportunistic viral infection in AIDS patients, can be made only by brain biopsy. In order to identify viral particles, we examined the cerebrospinal fluid (CSF) of 15 AIDS patients with focal neurological signs by electron microscopy using negative staining technique. In 2 out of 3 patients with clinical and neuroradiological presumptive diagnosis of PML, the CSF examination revealed papova-like viral particles. Our results support the hypothesis that the severe cell-mediated immunodeficiency reactivates papovavirus from a latent state in the brain, leading to PML. Therefore, the CSF study by negative staining might be a useful test for an \"in vivo\" diagnosis of PML.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"328-32"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of viruses in the etiopathogenesis of multiple sclerosis. 病毒在多发性硬化发病机制中的作用。
Acta neurologica Pub Date : 1993-10-01
P Sarchielli, A Trequattrini, F Usai, D Murasecco, V Gallai
{"title":"Role of viruses in the etiopathogenesis of multiple sclerosis.","authors":"P Sarchielli,&nbsp;A Trequattrini,&nbsp;F Usai,&nbsp;D Murasecco,&nbsp;V Gallai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epidemiological studies performed to identify the possible cause of Multiple Sclerosis (MS) suggest that an environmental agent could be involved in its etiopathogenesis. For a long time it has been hypothesized that this agent was a virus, but until now no virus specific to MS has been consistently identified. Animal models indicate that the demyelination of the central nervous system can be induced by certain families of viruses, but the implication of this in the etiopathogenesis of MS has not been clearly demonstrated. Morbilliviruses were the most studied. Research on this subject arose from the observation of the similarity between the brain lesions occurring in MS and encephalitis caused by the measles virus (Subacute Sclerosing Panencephalitis). Antimeasles, antirubella, antiherpes zoster antibodies have been found in the blood and the cerebrospinal fluid of MS patients, but the relationship between this finding and the disease is not clear. It has recently been proposed that the pathogenetic immune response in the brain of MS patients might be directed predominantly towards antigens of a DNA virus, such as JCV. This preferentially infects glial cells and causes a demyelinating syndrome in immunodeficient subjects, called Progressive Multifocal Leucoencephalopathy. The target JC viral antigens in MS could be synthesized during transient viral reactivation. A recent hypothesis is that retroviruses may intervene in the etiopathogenesis of MS. Strong interest has been taken in HTLV-I after its identification in Tropical Spastic Paraparesis, a disease with certain similarities to MS. Serologic and polymerase chain reaction findings from various authors have suggested an association between this human retrovirus and MS. However more recent data are not consistent with this. Current experiments aimed at detecting retroviral particles in long-term cultured peripheral blood monocytes and cerebrospinal fluid mononuclear cells in MS could clarify whether these cells provide a reservoir for such viruses, with a latency of many years without expression at brain level.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"363-81"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute meningitis from Cryptococcus neoformans (Filobasidiella neoformans) in a patient suffering from AIDS. Report of a clinical case with a favourable outcome. 艾滋病患者由新生隐球菌引起的急性脑膜炎。报告一例临床病例，结果良好。
Acta neurologica Pub Date : 1993-10-01
F Loschiavo, T Ventura-Spagnolo, E Sessa, P Bramanti
{"title":"Acute meningitis from Cryptococcus neoformans (Filobasidiella neoformans) in a patient suffering from AIDS. Report of a clinical case with a favourable outcome.","authors":"F Loschiavo,&nbsp;T Ventura-Spagnolo,&nbsp;E Sessa,&nbsp;P Bramanti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Authors describe a case of acute meningitis from Cryptococcus neoformans, with the finding of the fungus in the cerebrospinal fluid and in culture in a young subject with AIDS. The case had a favourable outcome after fluconazole treatment.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"341-7"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prevalence study of carotid atherosclerotic disease in patients aged above 60. 60岁以上患者颈动脉粥样硬化性疾病的患病率研究。
Acta neurologica Pub Date : 1993-10-01
C Giraldi, M C Bianchi, F Bianchi, M C Masi, M Manetti, L Pasca, A Romanelli, M Mancino, A Martini
{"title":"A prevalence study of carotid atherosclerotic disease in patients aged above 60.","authors":"C Giraldi,&nbsp;M C Bianchi,&nbsp;F Bianchi,&nbsp;M C Masi,&nbsp;M Manetti,&nbsp;L Pasca,&nbsp;A Romanelli,&nbsp;M Mancino,&nbsp;A Martini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of Doppler sonography and the echotomographic evaluation of extracranial arteries performed on 139 asymptomatic patients aged above 60 are presented. Atheromatous lesions were found in 54 (38.85%) of the subjects, though most had no hemodynamic effects. Statistical analysis showed an increase in both number and gravity of lesions with advancing age in females alone. No significant association was found between risk factors and atheromatous lesions, except for smoking in males.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"348-56"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered EEG pattern in aromatic hydrocarbon intoxication. A case report. 芳香烃中毒的脑电图改变。一份病例报告。
Acta neurologica Pub Date : 1993-10-01
C Ottelio, M Giagheddu, F Marrosu
{"title":"Altered EEG pattern in aromatic hydrocarbon intoxication. A case report.","authors":"C Ottelio,&nbsp;M Giagheddu,&nbsp;F Marrosu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of acute intoxication after both cutaneous and inhalatory absorption of a mixture of organic solvents (toluene and benzene) is reported. The peculiarity of this case is represented by the abnormal EEG findings: paroxysmal slow waves at the beginning of the intoxication, persisting, although attenuated, days after the patient's complete recovery. Moreover, the fact that other investigations were normal gives further support to the significance of routine EEG recording in monitoring the involvement of CNS in cases of acute exposure to aromatic organic solvents.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 5","pages":"357-62"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19290330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The presence of anti-Borrelia burgdorferi antibodies in a group of multiple sclerosis patients in eastern Sicily. Preliminary data. 西西里岛东部一组多发性硬化症患者中存在抗伯氏疏螺旋体抗体。初步的数据。
Acta neurologica Pub Date : 1993-08-01
P di Bella, M L Calisto, S Calimeri, R Squeri, C Anzalone, D Lo Giudice, P Bramanti
{"title":"The presence of anti-Borrelia burgdorferi antibodies in a group of multiple sclerosis patients in eastern Sicily. Preliminary data.","authors":"P di Bella,&nbsp;M L Calisto,&nbsp;S Calimeri,&nbsp;R Squeri,&nbsp;C Anzalone,&nbsp;D Lo Giudice,&nbsp;P Bramanti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors evaluate the presence of anti-Borrelia burgdorferi antibodies in a group of polysclerotic patients of Eastern Sicily, in order to verify or dismiss a correlation between Borrelia infection and demyelinizing syndrome. 460 samples of serum were examined, of which 60 belonged to patients affected by definite multiple sclerosis; the other 400 were taken from a group of apparently healthy subjects. From the analysis of the data obtained it can be seen that of the 60 polysclerotic subjects examined, 12 equal to 20% were found to be positive for the presence of IgG anti-Borrelia burgdorferi, while in the control group 30 subjects were found to be positive, equal 7.5%.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"15 4","pages":"253-7"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19239150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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