进行性多灶性脑白质病艾滋病患者脑脊液中存在乳头状病毒颗粒。一项额外的“体内”诊断测试。

Acta neurologica Pub Date : 1993-10-01
G Orefice, G Campanella, S Cicciarello, A Chirianni, G Borgia, S Rubino, M Mainolfi, M Coppola, M Piazza
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引用次数: 0

摘要

进行性多灶性脑白质病(PML)是艾滋病患者的一种神经系统机会性病毒感染,只能通过脑活检进行体内诊断。为了鉴定病毒颗粒,我们用阴性染色技术对15例有局灶性神经系统症状的艾滋病患者的脑脊液进行了电镜检查。在临床和神经放射学推定诊断为PML的3例患者中,有2例脑脊液检查显示木瓜样病毒颗粒。我们的研究结果支持了一种假设,即严重的细胞介导的免疫缺陷重新激活了潜伏在大脑中的papovavirus,从而导致PML。因此,脑脊液阴性染色研究可能是PML“体内”诊断的有用测试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Presence of papova-like viral particles in cerebrospinal fluid of AIDS patients with progressive multifocal leukoencephalopathy. An additional test for "in vivo" diagnosis.

An "in vivo" diagnosis of progressive multifocal leukoencephalopathy (PML), a neurological opportunistic viral infection in AIDS patients, can be made only by brain biopsy. In order to identify viral particles, we examined the cerebrospinal fluid (CSF) of 15 AIDS patients with focal neurological signs by electron microscopy using negative staining technique. In 2 out of 3 patients with clinical and neuroradiological presumptive diagnosis of PML, the CSF examination revealed papova-like viral particles. Our results support the hypothesis that the severe cell-mediated immunodeficiency reactivates papovavirus from a latent state in the brain, leading to PML. Therefore, the CSF study by negative staining might be a useful test for an "in vivo" diagnosis of PML.

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