Acta Cytologica最新文献_第9页

Ongoing Challenges in Maintaining the Diagnostic Quality of Cervical Cytopathology: Is It Possible to Minimize Differences in Morphological Interpretations? 保持宫颈细胞病理学诊断质量的持续挑战。是否有可能尽量减少形态学解释的差异？

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-11-21 DOI: 10.1159/000542618

Adhemar Longatto-Filho, Fernando C Schmitt

{"title":"Ongoing Challenges in Maintaining the Diagnostic Quality of Cervical Cytopathology: Is It Possible to Minimize Differences in Morphological Interpretations?","authors":"Adhemar Longatto-Filho, Fernando C Schmitt","doi":"10.1159/000542618","DOIUrl":"10.1159/000542618","url":null,"abstract":"Background: The efficiency of the cytological test largely depends on the control and quality assurance of laboratory procedures, to avoid false results. The objectives of this descriptive review were to point out and discuss the main mechanisms for controlling and ensuring the quality of cytological diagnosis.Summary: A critical revision was performed to identify the principal challenges involved in the processes of all the main issues related to the morphological alterations that characterize a true-related lesion in the daily routine of the Pap test examination. Principles of QC and QA are already being implemented worldwide, and the positive aspects and limitations of these are discussed as well as proposing alternatives when pertinent. Most of the articles evaluated highlighted the necessity of implementing audit mechanisms to control the performance of the professionals involved with the cytology evaluation.Key message: Promising data from the new image-based technological arsenal appear to be a remarkable tool for improving cytological evaluation, reducing errors of interpretation and serving as a powerful arm for cytology teaching.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Message from the International Academy of Cytology. 来自国际细胞学学会的信息。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-11-20 DOI: 10.1159/000542747

引用次数: 0

Message from the International Academy of Cytology. 来自国际细胞学学会的信息。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-11-20 DOI: 10.1159/000542745

引用次数: 0

Diagnostic Accuracy of the Second Edition of the Paris System for Reporting High-Grade Urothelial Carcinoma in Urinary Cytology. 用于报告尿液细胞学高级别尿路上皮癌的巴黎系统第二版的诊断准确性。

IF 1.8 4区医学

Acta Cytologica Pub Date : 2024-09-18 DOI: 10.1159/000541504

Anu Singh,Adil Aziz Khan,Charanjeet Ahluwalia,Sana Ahuja,Sunil Ranga

{"title":"Diagnostic Accuracy of the Second Edition of the Paris System for Reporting High-Grade Urothelial Carcinoma in Urinary Cytology.","authors":"Anu Singh,Adil Aziz Khan,Charanjeet Ahluwalia,Sana Ahuja,Sunil Ranga","doi":"10.1159/000541504","DOIUrl":"https://doi.org/10.1159/000541504","url":null,"abstract":"Background Urinary cytology, a non-invasive screening tool, is essential for detecting high-grade urothelial neoplasms. The Paris System (TPS) standardizes reporting practices to improve diagnostic accuracy. TPS 2.0, introduced in 2022, categorizes samples into six diagnostic groups, emphasizing high-grade urothelial carcinoma (HGUC). Materials and Methods This retrospective study analyzed urine cytology samples from June 2023 to May 2024, correlating with histopathology when available. Samples were classified under TPS 2.0 categories, and statistical metrics including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for three groups based on malignancy criteria. Results Out of 180 samples, the distribution was: ND (3.9%), NHGUC (65.6%), AUC (10%), SHGUC (11.7%), and HGUC (8.9%). Histopathological correlation was available for 30.6% of cases. ROM values were: ND (33.3%), NHGUC (29.4%), AUC (66.7%), SHGUC (94.1%), and HGUC (100%). Group A showed the highest sensitivity (86.49%) and diagnostic accuracy (84.62%), while Group C had 100% specificity and PPV. Conclusion The study confirms TPS 2.0's efficacy in improving diagnostic accuracy for HGUC, with high specificity and sensitivity. Compared to TPS 1.0, TPS 2.0 offers clearer diagnostic criteria, enhancing clinical decision-making and patient outcomes. The findings support the continued use of TPS 2.0 in clinical practice, ensuring reliable identification of high-grade urothelial carcinomas.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":"3 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meeting Report: The Kymi Odyssey Honorary Ceremony and the Future G.N. Papanicolaou Museum. 会议报告：Kymi Odyssey 荣誉仪式和未来的 G.N. Papanicolaou 博物馆。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1159/000535445

Kari J Syrjänen

引用次数: 0

Using the DNA Integrity Number to Analyze DNA Quality in Specimens Collected from Liquid-Based Cytology after Fine-Needle Aspiration of Breast Tumors and Lesions. 使用 DNA 完整性编号 (DIN) 分析乳腺肿瘤和病变细针穿刺后液基细胞学样本中的 DNA 质量。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-03-29 DOI: 10.1159/000538071

Akiyoshi Hoshino, Yoshiyasu Oana, Yasuyo Ohi, Yukari Maeda, Masako Omori, Yuki Takada, Tadashi Ikeda, Keiichi Sotome, Hinako Maeda, Takako Yanagisawa, Osamu Takeuchi, Satoshi Kuronuma, Takafumi Sangai, Yukiko Shibahara, Yoshiki Murakumo, Makoto Saegusa, Naoki Kanomata, Satoi Nagasawa, Rin Yamaguchi, Masayuki Yoshida, Yuji Kozuka, Hiroshi Matsumoto, Koichiro Tsugawa, Ichiro Maeda

{"title":"Using the DNA Integrity Number to Analyze DNA Quality in Specimens Collected from Liquid-Based Cytology after Fine-Needle Aspiration of Breast Tumors and Lesions.","authors":"Akiyoshi Hoshino, Yoshiyasu Oana, Yasuyo Ohi, Yukari Maeda, Masako Omori, Yuki Takada, Tadashi Ikeda, Keiichi Sotome, Hinako Maeda, Takako Yanagisawa, Osamu Takeuchi, Satoshi Kuronuma, Takafumi Sangai, Yukiko Shibahara, Yoshiki Murakumo, Makoto Saegusa, Naoki Kanomata, Satoi Nagasawa, Rin Yamaguchi, Masayuki Yoshida, Yuji Kozuka, Hiroshi Matsumoto, Koichiro Tsugawa, Ichiro Maeda","doi":"10.1159/000538071","DOIUrl":"10.1159/000538071","url":null,"abstract":"Introduction: Cancer genome analysis using next-generation sequencing requires adequate and high-quality DNA samples. Genomic analyses were conventionally performed using formalin-fixed paraffin-embedded sections rather than cytology samples such as cell block or smear specimens. Specimens collected from liquid-based cytology (LBC) have the potential to be sources of high-quality DNA suitable for genetic analysis even after long-term storage.Methods: We collected breast tumor/lesion fractions from 92 residual LBC specimens using fine-needle aspiration (FNA) biopsy, including breast carcinoma (1 invasive carcinoma and 4 ductal carcinomas in situ), papillomatous lesion (5 intraductal papillomas), and fibroepithelial lesion (19 phyllodes tumors and 53 fibroadenomas) samples, and others (1 ductal adenoma, 1 hamartoma, 1 fibrocystic disease, and 7 unknown). DNA was extracted from all samples and subjected to DNA integrity number (DIN) score analysis.Results: Average DIN score collected from 92 LBC specimens was significantly higher score. In addition, high-quality DNA with high DIN values (7.39 ± 0.80) was successfully extracted more than 12 months after storage of residual LBC specimens.Conclusion: Residual LBC specimens collected from FNA of the breast were verified to carry high-quality DNA and could serve as an alternate source for genetic analysis.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"145-152"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Langerhans Cell Histiocytosis: Diagnosis in Bronchoalveolar Lavage Liquid-Based Cytology Samples. 肺朗格汉斯细胞组织细胞增生症：基于支气管肺泡灌洗液的细胞学样本诊断。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI: 10.1159/000540011

Anjali Gupta, Parikshaa Gupta, Nalini Gupta, Sahajal Dhooria, Pankaj C Vaidya, Nidhi Prabhakar, Amanjit Bal, Joseph L Mathew

{"title":"Pulmonary Langerhans Cell Histiocytosis: Diagnosis in Bronchoalveolar Lavage Liquid-Based Cytology Samples.","authors":"Anjali Gupta, Parikshaa Gupta, Nalini Gupta, Sahajal Dhooria, Pankaj C Vaidya, Nidhi Prabhakar, Amanjit Bal, Joseph L Mathew","doi":"10.1159/000540011","DOIUrl":"10.1159/000540011","url":null,"abstract":"Introduction: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease characterized by the accumulation of Langerhans cells within the lung tissue. The diagnosis of PLCH traditionally involves clinical, radiological, and lung biopsy histopathological evaluations.Case presentation: We present 2 cases where the diagnosis of PLCH was confirmed through the analysis of bronchoalveolar lavage (BAL) fluid cytology using immunoperoxidase technique, highlighting the significance of this minimally invasive technique in the diagnostic process. Clinical and radiological examination suggested advanced interstitial lung disease characterized by a fibrocystic pattern in both cases. The cytologic analysis of the BAL fluid revealed typical histiocytes with longitudinal grooves and eosinophils, which was better seen on liquid-based cytology (LBC) smears. ICC with CD1a, Langerin, and S-100 confirmed the diagnosis of PLCH.Conclusion: Detecting PLCH through the examination of BAL cytology poses challenges, yet it is achievable, particularly with the assistance of LBC and ICC.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"379-383"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pitfalls in Cytopathology. 细胞病理学中的陷阱。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1159/000539418

Helen J Trihia, Philippe Vielh

引用次数: 0

Utility of Pipet Curet Cytology and Biopsy as a Diagnostic Method for Endometrial Endometrioid Carcinoma. Pipet Curet 细胞学和活组织切片检查作为子宫内膜样癌诊断方法的实用性。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI: 10.1159/000541279

Makiko Kurata, Takuma Tajiri, Masataka Ueda, Chie Inomoto, Tomoko Sugiyama, Hirotaka Fujita, Nozomi Nomura, Tomohisa Machida, Tetsuji Iida, Ippei Ooiwa, Yoshihiro Nishijima, Hiroshi Kajiwara, Toshinari Muramatsu, Naoya Nakamura

{"title":"Utility of Pipet Curet Cytology and Biopsy as a Diagnostic Method for Endometrial Endometrioid Carcinoma.","authors":"Makiko Kurata, Takuma Tajiri, Masataka Ueda, Chie Inomoto, Tomoko Sugiyama, Hirotaka Fujita, Nozomi Nomura, Tomohisa Machida, Tetsuji Iida, Ippei Ooiwa, Yoshihiro Nishijima, Hiroshi Kajiwara, Toshinari Muramatsu, Naoya Nakamura","doi":"10.1159/000541279","DOIUrl":"10.1159/000541279","url":null,"abstract":"Introduction: We aimed to determine the utility of Pipet Curet cytology (PCC) and Pipet Curet biopsy (PCB) for diagnosing uterine endometrial endometrioid carcinoma (EEC).Methods: We divided 77 patients with EEC into two groups per Federation of Gynecology and Obstetrics (FIGO) grades: G1 (n = 44) and G2/3 (n = 33) and compared the diagnostic sensitivity of PCC, PCB, and PCC and PCB combined, retrospectively. Next, we investigated any diagnostic discordance between PCC-based and PCB-based diagnoses per FIGO grade group.Results: The diagnostic sensitivity of PCC, PCB, and the two modalities combined was significantly higher for G2/3 EECs than for G1 EECs (72.7% vs. 45.5%, p = 0.0209; 84.8% vs. 63.6%, p = 0.0434; and 93.9% vs. 65.9%, p = 0.0046, respectively), likely due to more friable cancer cells in higher grade EEC cases. Among our 77 EEC patients, there were 4 patients (5.19%) with PCC-based concordant but PCB-based discordant results against EEC, in the G2/3 group predominantly. Diagnostic sensitivity of all cases increased from 72.7% (56/77) by PCB alone to 77.9% (60/77) by use of both modalities combined.Conclusion: Cytologic evaluation can reduce the number of false-negative histologic diagnoses. By providing complementary information, the two modalities combined from the Pipet Curet procedure would be valuable as a diagnostic method for EEC.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"413-422"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytopathology of a Newly Described Salivary Gland Neoplasm: A Case Report of Microsecretory Adenocarcinoma Presenting in the Parotid Gland. 一种新描述的唾液腺肿瘤的细胞病理学。腮腺微分泌性腺癌病例报告。

IF 1.6 4区医学

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-10-14 DOI: 10.1159/000541997

Rubina Razack, Justin A Bishop, Julandi Alwan, Liezel Coetzee, Daniel Rudolph De Wet, Wasim Mahomed, Marc Merven, Pawel Tomasz Schubert, Amir Afrogheh

{"title":"Cytopathology of a Newly Described Salivary Gland Neoplasm: A Case Report of Microsecretory Adenocarcinoma Presenting in the Parotid Gland.","authors":"Rubina Razack, Justin A Bishop, Julandi Alwan, Liezel Coetzee, Daniel Rudolph De Wet, Wasim Mahomed, Marc Merven, Pawel Tomasz Schubert, Amir Afrogheh","doi":"10.1159/000541997","DOIUrl":"10.1159/000541997","url":null,"abstract":"Introduction: Microsecretory adenocarcinoma (MSA) is a novel entity defined by distinctive histology, a specific immunophenotype, and unique molecular fusion MEF2C::SS18. It occurs mainly in intra-oral minor salivary glands and the skin, with only one reported case affecting the parotid gland. To the best of our knowledge, no cytomorphological features of MSA have been published to date. We report the first case of fine-needle aspiration biopsy (FNAB) cytology of MSA diagnosed in the parotid gland.Case presentation: A 48-year-old man presented with a 3.5 × 2.5-cm parotid mass. FNAB of the tumour revealed a cellular smear comprising a predominantly epithelial cell population showing luminal differentiation with secretory features and a distinctive background matrix with both myxoid and mucinous qualities. Scattered, but conspicuous multinucleated giant cells were present, a feature not commonly observed in salivary gland aspirates. Histology of the excised tumour revealed classic features of MSA with supportive immunohistochemistry and SS18 break apart fusion detected by fluorescence in situ hybridisation (FISH). Next-generation sequencing confirmed a MEF2C::SS18 gene fusion.Conclusion: MSA is a rare neoplasm and should be considered in the cytological differential diagnosis of low-grade salivary gland neoplasms. Its unique cytomorphological features should raise the possibility of MSA in salivary gland FNABs. The diagnosis can be established on cellular cell block preparations using immunohistochemistry and FISH or PCR.","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"516-524"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0