Acta medica Iranica最新文献_第7页

Identification of Two Novel Mutations in ABCA4 Gene in a Patient With Stargardt Disease 一名Stargardt病患者ABCA4基因两种新突变的鉴定

Acta medica Iranica Pub Date : 2023-10-13 DOI: 10.18502/acta.v61i6.13832

Masoumeh Mohebbi, Matin Heidari, Mansour Heidari

引用次数: 0

Prolonged Intrauterine Fetal Bone Retention Following a Neglected Pregnancy: A Case Report 忽视妊娠后延长的宫内胎儿骨保留:1例报告

Acta medica Iranica Pub Date : 2023-10-13 DOI: 10.18502/acta.v61i6.13838

Maryam Hajihashemi, Fereshteh Mohammadizadeh, Behnoosh Mohamadi Jazi, Amirhossein Pezeshki, Leila Mousavi Seresht, Fedyeh Haghollahi

引用次数: 0

Associated Factors and Common Pathogens of Positive Cultures in Infants With Definitive Septicemia Admitted to NICU 新生儿重症监护病房确诊败血症婴儿培养阳性的相关因素和常见病原体

Acta medica Iranica Pub Date : 2023-10-13 DOI: 10.18502/acta.v61i6.13836

Mamak Shariat, Bolfazl Baghban Youssefkhani, Hosein Dalili, Negar Hajinasab, Nahid Farrokhzad, Zohreh Nozarian, Soufi Enayati Yasamin, Farima Raji

{"title":"Associated Factors and Common Pathogens of Positive Cultures in Infants With Definitive Septicemia Admitted to NICU","authors":"Mamak Shariat, Bolfazl Baghban Youssefkhani, Hosein Dalili, Negar Hajinasab, Nahid Farrokhzad, Zohreh Nozarian, Soufi Enayati Yasamin, Farima Raji","doi":"10.18502/acta.v61i6.13836","DOIUrl":"https://doi.org/10.18502/acta.v61i6.13836","url":null,"abstract":"   Immune system immaturity in newborns exposes them to infections, among which bloodstream infection is of great importance due to high mortality and morbidity and treatment costs. The aim of the present study was to evaluate common pathogens in blood culture positive cases and its determinants. This study was conducted in two phases, including a cross-sectional phase to collect the cases of definitive septicemia and a case-control phase on neonates admitted to the Neonatal Intensive Care Unit of Vali-e-Asr Hospital with clinical suspicion of sepsis during 2015-2019. The eligible cases were selected based on the study criteria. After extracting descriptive statistics, to evaluate causal relationships, culture-positive and culture negative cases were compared in terms of neonatal disease in the second phase. SPSS-22 was used for data analysis. The most common bacterial families were Staphylococcus (34.30%), Acinetobacter (10.46%), and Klebsiella (7.55%), among which coagulase negative Staphylococcus was the most common organism (13.08%). The most common antibiotics prescribed were ampicillin (75.1%), amikacin (58%), and gentamycin (44.8%). Factors that had a significant association were the occurrence of septicemia were gestational hypertension, premature rupture of membranes, conjunctivitis, TORCH infections, and low gestational age. The results of this study will be helpful in anticipation and management of neonatal septicemia through shedding light on some determinants of common blood culture pathogens like infections and obstetric complications in NICU admitted neonates.  ","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135918945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Misdiagnosis Due to Atypical Symptoms: A Case Report 新冠肺炎非典型症状误诊1例

Acta medica Iranica Pub Date : 2023-10-13 DOI: 10.18502/acta.v61i6.13839

Jalal Karimi, Zahra Montaseri, Hojatolah Najafi, Zahra Rahimi Asl

引用次数: 0

Association of Maternal Diabetes and ADHD in Offspring: A Systematic Review and Meta-Analysis 母亲糖尿病与后代ADHD的关联:一项系统综述和荟萃分析

Acta medica Iranica Pub Date : 2023-10-13 DOI: 10.18502/acta.v61i6.13829

Batool Okhovat Isfahani, Farzad Khodamoradi

引用次数: 0

Abnormal Promoter Methylation of Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Gene in the Pathogenesis of Crohn’s Disease 含有2核苷酸结合寡聚结构域(NOD2)基因的异常启动子甲基化在克罗恩病发病中的作用

Acta medica Iranica Pub Date : 2023-08-27 DOI: 10.18502/acta.v61i5.13480

G. Sanati, M. Noruzinia, D. Jafari, M. Ahmadvand, S. Teimourian, N. Daryani, N. Rezaei

{"title":"Abnormal Promoter Methylation of Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Gene in the Pathogenesis of Crohn’s Disease","authors":"G. Sanati, M. Noruzinia, D. Jafari, M. Ahmadvand, S. Teimourian, N. Daryani, N. Rezaei","doi":"10.18502/acta.v61i5.13480","DOIUrl":"https://doi.org/10.18502/acta.v61i5.13480","url":null,"abstract":"Changes in the expression of nucleotide-binding oligomerization domain containing 2 (NOD2) play an important role in the pathogenesis of several autoimmune diseases, such as inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). It seems that epigenetic modifications, including DNA methylation, have an important role in the suppression of gene activity. In this study, the relationship between DNA methylation patterns of the promoter region of the NOD2 gene and the pathogenesis of CD was assessed. Colonic mucosal samples were obtained from 15 Iranian patients with CD and 15 matched healthy controls with no history of autoimmune diseases. After bisulfite conversion of genomic DNA, the DNA methylation status of three CpG sites in the promoter region of the NOD2 gene was determined by the real-time quantitative multiplex methylation-specific PCR assay. Using this approach, we identified a decreased level of methylation of the NOD2 promoter in the colonic mucosa of patients with CD (0.128±0.093 vs. 0.025±0.016, unmethylated DNA in CD vs. healthy controls, respectively, P<0.000). According to our findings, promoter hypomethylation of the NOD2 gene in the colonic mucosa might contribute to the development and severity of CD.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46598940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Communication Skills Training: An Effective Tool to Improve the Caring Behaviors of ICU Nurses 治疗性沟通技巧训练:改善ICU护士关怀行为的有效工具

Acta medica Iranica Pub Date : 2023-08-27 DOI: 10.18502/acta.v61i5.13486

Farzane Zare, Jamileh Farokhzadian, Monirsadat Nematollahi, Sakineh Miri, Mohammad Ali Zakeri, Golnaz Foroughameri

{"title":"Therapeutic Communication Skills Training: An Effective Tool to Improve the Caring Behaviors of ICU Nurses","authors":"Farzane Zare, Jamileh Farokhzadian, Monirsadat Nematollahi, Sakineh Miri, Mohammad Ali Zakeri, Golnaz Foroughameri","doi":"10.18502/acta.v61i5.13486","DOIUrl":"https://doi.org/10.18502/acta.v61i5.13486","url":null,"abstract":"Caring behaviors are crucial in intensive care units (ICU) because patients in these wards require high levels of care. Effective communication with patients is one of the most important factors in the caring behaviors of nurses working in ICUs. This study aimed to evaluate the effect of therapeutic communication skills training on the caring behaviors of ICU nurses. This experimental pre-test/post-test study was carried out on 105 nurses working in ICUs of hospitals affiliated with Yazd University of Medical Sciences in Iran in 2019. Nurses were randomly assigned into control (52 nurses) and intervention (53 nurses) groups. A two-day therapeutic communication training workshop was conducted for the participants. Data were collected using a demographic information questionnaire and caring behaviors questionnaire before and one month after the intervention. The findings showed no significant difference between the control and intervention groups regarding the nurses' caring behaviors in the pretest (P=0.148). However, after the implementation of the training program, a significant difference was observed in the mean scores of caring behaviors between the two groups. In the control group, the mean scores of caring behaviors decreased significantly after the intervention (P=0.001); whereas, the mean scores of the intervention group increased significantly after the intervention (P=0.001). According to the results, ICU nurses' training in therapeutic communication skills had a positive effect on their caring behaviors. Therefore, we suggest the authorities prepare and implement educational packages of therapeutic communication skills as a coherent program for other nurses. As a result, the caring behaviors and the quality of care can be improved for patients.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135181746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 and Diabetes COVID-19与糖尿病

Acta medica Iranica Pub Date : 2023-08-27 DOI: 10.18502/acta.v61i5.13479

Vahid Asgharzadeh, Mir Reza Valiollahzadeh, Zahra Taghinejad, Mohammad Asgharzadeh, Jalil Rashedi, Behroz Mahdavi Poor, Hossein Jalaei Nobari, Ahmad Ali Khalili, Yousof Khairy, Amir Ali Mir Mazhari

{"title":"COVID-19 and Diabetes","authors":"Vahid Asgharzadeh, Mir Reza Valiollahzadeh, Zahra Taghinejad, Mohammad Asgharzadeh, Jalil Rashedi, Behroz Mahdavi Poor, Hossein Jalaei Nobari, Ahmad Ali Khalili, Yousof Khairy, Amir Ali Mir Mazhari","doi":"10.18502/acta.v61i5.13479","DOIUrl":"https://doi.org/10.18502/acta.v61i5.13479","url":null,"abstract":"Following the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, it has been transmitted to travelers through respiratory droplets and distributed worldwide. Viral, environmental, and host factors all play a role in getting infected with the virus and having severe forms of the disease named coronavirus disease 2019 (COVID-19). Diabetes is one of the most important host risk factors in the progression and severity of COVID-19. In diabetes, hyperglycemia and protein glycosylation increase pro-inflammatory cytokines levels and suppress innate and adaptive immune system by impairing the function of neutrophils, macrophages, and lymphocytes, especially regulatory T lymphocytes. The compromised immune system in diabetic patients makes them vulnerable to infectious diseases like COVID-19. Correspondingly, people with diabetes are usually treated with angiotensin-converting enzyme (ACE) inhibitors and angiotensin II Type-I receptor blockers (ARBs), which increase ACE2 expression as a receptor for SARS-CoV-2. Thus, diabetic patients are more likely to develop severe forms of COVID-19 and die due to chronic inflammation and impaired immune function.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135182624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Infantile Psychomotor Development Status in 6 and 12-Month-Old IUGR Infants: A Historical Cohort Study 6月和12月IUGR婴儿精神运动发展状况的评估:一项历史队列研究

Acta medica Iranica Pub Date : 2023-08-27 DOI: 10.18502/acta.v61i5.13483

F. Nayeri, S. Bahadoram, Z. Farahani, M. Shariat

{"title":"Assessment of Infantile Psychomotor Development Status in 6 and 12-Month-Old IUGR Infants: A Historical Cohort Study","authors":"F. Nayeri, S. Bahadoram, Z. Farahani, M. Shariat","doi":"10.18502/acta.v61i5.13483","DOIUrl":"https://doi.org/10.18502/acta.v61i5.13483","url":null,"abstract":"Intrauterine growth restriction (IUGR) is responsible for different post-natal adverse outcomes. This study aimed to evaluate the post-natal psychomotor development status in 6 and 12-month-old IUGR infants who received early preventive interventions. A historical cohort study was done at an Iranian Hospital (2019). The case group included one-year-old infants with a history of IUGR at birth. This group was visited every 2 months to evaluate their growth and neurodevelopmental status. Their parents had also received some training to improve their infant's sensory and motor skills. The control group comprised one-year-old healthy infants with a history of appropriate for gestational age (AGA) at birth. Data related to psychomotor developmental indices based on the ASQ questionnaire at 6 and 12-month for both groups was extracted from subjects' records. Infants' psychomotor development status was compared between groups. Forty-one infants with a history of IUGR and 43 healthy control infants were included in this study. There were significant differences between 2 groups associated with abnormalities in all evaluated psychomotor skills, including gross motor (P=0.014), problem-solving ability (P=0.049), communication (P=0.031), fine motor (P=0.016) and personal-social (P=0.016) at 6 months. After one year of family-based interventions for the case group, significant differences between groups were notable in only fine motor (P=0.016) and personal-social skills (P=0.031). At 12 months, the psychomotor disorders related to gross motor, problem-solving ability, and communication were significantly alleviated in the IUGR group. Early preventive family-based interventions can improve the neurodevelopmental outcomes in 12-month-old IUGR infants.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43184005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Foreign Bodies Ingestion in Children 儿童异物摄入的患病率

Acta medica Iranica Pub Date : 2023-08-27 DOI: 10.18502/acta.v61i5.13485

Omar Ajaj

{"title":"Prevalence of Foreign Bodies Ingestion in Children","authors":"Omar Ajaj","doi":"10.18502/acta.v61i5.13485","DOIUrl":"https://doi.org/10.18502/acta.v61i5.13485","url":null,"abstract":"Foreign body ingestion is one of the common pediatric emergency conditions and can lead to childhood morbidity, and mortality. We think that the results of this study will be of utmost usefulness for pediatric surgeons when considering foreign bodies' ingestion in children. We decided to study the age distribution, nature, the site of impaction, and fate of foreign body ingestion in children. This cross-sectional study was conducted on 77 children with foreign body ingestion, from February 2017 to July 2021(54 months). A total of 77 patients with foreign body ingestion were diagnosed during the study period. Forty percent were boys and 60% were girls. The maximum age of participants was 1-2 years, accounting for 55%. Batteries were the most common foreign bodies ingested accounting for 26% followed by magnets (13%), and coins 6.5%. The most common site of foreign body impaction was the stomach (34%), colon (26%), and small bowel (23%). Majorities of foreign bodies (72%) were passed through the gastrointestinal tract without complication, 18 % required extraction by the upper endoscope, and 10% were removed surgically. We conclude that increasing awareness among parents to check the quality and safety protocols of electronic toys that contain batteries and magnets.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43425625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0