Association of Maternal Diabetes and ADHD in Offspring: A Systematic Review and Meta-Analysis

Q3 Medicine

Acta medica Iranica Pub Date : 2023-10-13 DOI:10.18502/acta.v61i6.13829

Batool Okhovat Isfahani, Farzad Khodamoradi

引用次数: 0

Abstract

A systematic review and meta-analysis was conducted to determine the association between exposure to maternal diabetes and ADHD in the offspring. Major electronic databases, including Web of Science, PubMed, Scopus, Embase, and Proquest, were searched from inception until December 2018. The New Castle-Ottawa scale was used to assess the quality of the included studies. A fixed effects model was applied for analysis. Seven studies including a total of 5,658,871 individuals were retained. A significant association was found between maternal diabetes and ADHD [OR=1.23, 95% CI: 1.117, 1.345]. There was a significant heterogeneity (I^2=77.7, P<0.0001), while Egger’s and Begg’s test were not significant. This study showed a significant relationship between maternal diabetes and ADHD; however, more well-designed studies are needed to confirm the results.

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母亲糖尿病与后代ADHD的关联:一项系统综述和荟萃分析

进行了一项系统回顾和荟萃分析，以确定母体糖尿病暴露与后代ADHD之间的关系。主要的电子数据库，包括Web of Science, PubMed, Scopus, Embase和Proquest，从成立到2018年12月进行了检索。采用新堡-渥太华量表评估纳入研究的质量。采用固定效应模型进行分析。共有7项研究保留了5,658,871人。母亲糖尿病与ADHD之间存在显著关联[OR=1.23, 95% CI: 1.117, 1.345]。存在显著异质性(I^2=77.7, P<0.0001)，而Egger’s和Begg’s检验不显著。本研究显示母亲糖尿病与ADHD之间存在显著关系;然而，需要更多精心设计的研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica Iranica Medicine-Medicine (all)

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

18 weeks

期刊介绍： ACTA MEDICA IRANICA (p. ISSN 0044-6025; e. ISSN: 1735-9694) is the official journal of the Faculty of Medicine, Tehran University of Medical Sciences. The journal is the oldest scientific medical journal of the country, which has been published from 1960 onward in English language. Although it had been published quarterly in the past, the journal has been published bimonthly (6 issues per year) from the year 2004. Acta Medica Iranica it is an international journal with multidisciplinary scope which publishes original research papers, review articles, case reports, and letters to the editor from all over the world. The journal has a wide scope and allows scientists, clinicians, and academic members to publish their original works in this field.