Acta Neurologica Scandinavica最新文献

{"title":"Candidate Selection for Implantation: Noninvasive Predictors of Seizure Onset Zone Focality and Surgical Outcome in People with Drug-Resistant Epilepsy Evaluated by Intracranial Video-EEG Monitoring—A Retrospective Cohort Study","authors":"Nicolas Jannone-Pedro,&nbsp;Kevin G. Hampel,&nbsp;Mercedes Garces-Sanchez,&nbsp;Rebeca Conde-Sardon,&nbsp;Antonio Gutierrez-Martin,&nbsp;Vicente Villanueva","doi":"10.1155/2023/3455061","DOIUrl":"10.1155/2023/3455061","url":null,"abstract":"<div>\u0000 <p><i>Objectives</i>. People with drug-resistant epilepsy are potential candidates for epilepsy surgery, a subset of whom requires intracranial video-EEG monitoring (IVEM) to determine the seizure onset zone (SOZ). The purpose of this study is to investigate noninvasive predictors of SOZ focality and surgical outcome in order to optimise case selection for this procedure. <i>Materials and Methods</i>. We performed a retrospective cohort study of patients who underwent IVEM at our centre from January 2006 to July 2021. We applied a multivariate logistic regression model to estimate the effect of potential noninvasive data as influencing factors for both SOZ focality and surgical outcome. A focal SOZ included a sublobar onset on IVEM, and a good surgical outcome was defined as Engel class I. <i>Results</i>. A total of 783 underwent a presurgical evaluation, 102 of them with IVEM. Ninety-seven patients were included in the SOZ focality analysis, and 64 were included in the surgical outcome analysis. The presence of focal to bilateral tonic-clonic seizures (<i>p</i> = 0.03) and generalised interictal epileptiform discharges (IEDs) during scalp EEG (<i>p</i> = 0.02) predicted a nonfocal SOZ. A weekly (<i>p</i> = 0.01) or daily seizure frequency (<i>p</i> &lt; 0.01), focal to bilateral tonic-clonic seizures (<i>p</i> = 0.01), nonlesional MRI (<i>p</i> &lt; 0.01), and multifocal (<i>p</i> = 0.02) or generalised IEDs (<i>p</i> &lt; 0.01) were associated with a poor surgical outcome. <i>Conclusions</i>. A high seizure frequency, positive history of focal to bilateral tonic-clonic seizures, nonlesional MRI, and generalised and multifocal IEDs are noninvasive factors that may aid in selecting candidates for IVEM.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/3455061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134885129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Hyperhomocysteinemia in Patients with Ischemic Stroke: A Proof-of-Concept Randomized Trial","authors":"Bing Luo,&nbsp;Yun Wang,&nbsp;Minjie Sun,&nbsp;Mei Feng,&nbsp;Wei Zhu,&nbsp;Sufang Xu","doi":"10.1155/2023/6642768","DOIUrl":"10.1155/2023/6642768","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. This study is aimed at investigating the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hyperhomocysteinemia (HHCY) in patients with ischemic stroke (IS). <i>Methods</i>. This study retrospectively analyzed the clinical data and laboratory results of 110 IS patients. According to the cut-off value of HCY = 15 <i>μ</i>mol/L, the included patients were divided into the normal HCY (NHCY, <i>n</i> = 69) and the high HCY (HHCY, <i>n</i> = 41) groups. The relationship between NLR, PLR, and HCY between these groups was then compared. <i>Results</i>. NLR and PLR levels in IS patients with HHCY were significantly higher than those in IS patients without HHCY (<i>P</i> &lt; 0.05). Correlation analysis showed that NLR and PLR were positively correlated with hs-CRP, RDW, N, L, and HCY (<i>P</i> &lt; 0.05). NLR and PLR were the largest predictors of IS-related HHCY, followed by WBC, hs-CRP, RDW, VLDL, and TG. Additionally, NLR and PLR were independent risk factors for IS-related HHCY. <i>Conclusions</i>. NLR and PLR may be fast, cheap, and easy-to-analyze biomarkers for predicting IS-related HHCY.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/6642768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135059280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine and Risk of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis","authors":"Dachen Tian,&nbsp;Xin Hui,&nbsp;Lijun Zhang,&nbsp;Ji Liu,&nbsp;Mengen Wang,&nbsp;Tongtong Zhang,&nbsp;Xianjun Wang","doi":"10.1155/2023/8887282","DOIUrl":"10.1155/2023/8887282","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Migraine is a frequently observed neurological disease in patients with systemic lupus erythematosus. However, the relationship between these two conditions is still a subject of controversy. <i>Objectives</i>. Our aim was to investigate the association between migraine and the risk of developing systemic lupus erythematosus through a meta-analysis of case-control studies. <i>Methods</i>. Following the Preferred Reporting Project for Systematic Reviews and Meta-Analysis statement, we conducted a comprehensive search of the following literature databases, including PubMed, Embase, and Web of Science, to identify relevant articles published up to June 2022 using the keywords “migraine” and “systemic lupus erythematosus” as subject headings. If heterogeneity was expected to be low (<i>I</i>² ≤ 50%), the pooled analysis was performed using a fixed-effects model calculated by the Mantel-Haenszel method. Analysis in this study was conducted using R software (http://www.r-project.org). <i>Results</i>. Six case-control experimental studies involving 908 participants were included in the meta-analysis. The overall combined relative risk of developing systemic lupus erythematosus in patients with migraine, compared to the control group, was 1.69 (95% confidence interval (CI): 1.26 to 2.27). The analysis revealed minimal evidence of heterogeneity and publication bias. <i>Conclusions</i>. Based on our meta-analysis, there is suggestive evidence that patients with migraine may have an elevated risk of developing systemic lupus erythematosus attacks.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/8887282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135825923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Basal Ganglia Hematoma Expansion Based on Radiomics and Clinical Characteristics: A Novel Multivariate Predictive Nomogram","authors":"Bin Luo,&nbsp;Lin Ma,&nbsp;Yubo Wang,&nbsp;Hecheng Ren,&nbsp;MingSheng Yu,&nbsp;YuXiang Ma,&nbsp;Long Yin,&nbsp;Ying Huang","doi":"10.1155/2023/3012996","DOIUrl":"10.1155/2023/3012996","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. This study is aimed at formulating and authenticating a pioneering nomogram integrating noncontrast computed tomography (NCCT) mean CT densities (m-CTD) of hematoma, morphological indicators from NCCT hematoma, and clinical manifestations to foresee hematoma expansion (HE) in patients suffering from spontaneous basal ganglia hemorrhage (BGH). <i>Methods</i>. A predictive model was constructed by retrospectively evaluating the data from 406 patients. This model was externally validated using an independent dataset of 174 patients. Multivariate logistic regression analysis was deployed to discern independent prognostic indicators and to generate a nomogram for HE prediction. Model calibration was examined using 1000 bootstrap samples for internal validation. <i>Results</i>. Multivariate logistic regression disclosed that m-CTD (odds ratio (OR) 0.846, 95% confidence interval (CI) 0.782-0.909), baseline hematoma volume (BHV) (OR 1.055, 95% CI 1.017-1.095), NCCT blend sign (BS) (OR 3.320, 95% CI 1.704-6.534), NCCT black hole sign (BHS) (OR 2.468, 95% CI 1.293-4.729), systolic blood pressure (SBP) (OR 1.027, 95% CI 1.014-1.040), and homocysteine (Hcy) (OR 1.075, 95% CI 1.038-1.114) were independent predictors of HE. The area under the curve (AUC) for the training and validation datasets yielded 0.874 and 0.883, respectively. The calibration curve for the nomogram closely approximated the optimal diagonal. The decision curve analysis (DCA) indicated that the prediction model offers substantial net benefits. <i>Conclusions</i>. The innovative predictive nomogram, leveraging radiomics and clinical traits of hematoma, presents a potent and noninvasive tool for HE risk stratification. The method of quantifying mean hematoma density holds significant prognostic value in forecasting HE.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/3012996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49387787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor Band Sign in Motor Neuron Diseases Using Magnetic Resonance Imaging: A Systematic Review","authors":"Sana Mohammadi,&nbsp;Sadegh Ghaderi","doi":"10.1155/2023/6677967","DOIUrl":"10.1155/2023/6677967","url":null,"abstract":"<div>\u0000 <p>Motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS) are progressive neurodegenerative disorders affecting upper and lower motor neurons (UMN and LMN). Magnetic resonance imaging (MRI) often reveals a “motor band sign” (MBS) of hypointensity along the precentral gyri in ALS, considered a radiologic hallmark. This review comprehensively summarizes the literature on MBS in ALS and related MNDs using multiple MRI techniques. A systematic search was conducted in the PubMed and Scopus databases to identify relevant studies on MBS in MNDs published until August 2023. Twelve studies were included. Most patients had UMN involvement at the onset. MBS was correlated with UMN impairment severity. Susceptibility-weighted imaging (SWI) detected MBS in the majority of MND patients. The use of SWI could be particularly useful in detecting MBS, and it should be considered as part of the routine clinical MRI protocols. Recent studies suggest that hypointensity and atrophy of the primary motor cortex (M1) and nearby regions can be used as MRI markers of UMN impairment in MNDs. Other MRI techniques like T2-weighted (T2-w), T2 ^∗-w, and fluid-attenuated inversion recovery (FLAIR) also showed characteristic changes. Furthermore, quantitative susceptibility mapping (QSM) is an advanced MRI technique that allows sensitive quantification of iron deposition and has shown promise for accurately detecting MBS in MNDs. The findings suggest that MR neuroimaging techniques can provide valuable insights into the pathophysiology of MND and can be used to detect biomarkers such as MBS. The review demonstrates that advanced MRI techniques can detect cortical and white matter changes reflecting upper motor neuron degeneration in MNDs like ALS. To find out how sensitive and suggestive the MBS is in MNDs and neurodegenerative movement disorders and how well it works as a prognostic indicator, we will need to do more research that combines comprehensive prospective and longitudinal research.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/6677967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49636984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Areas Predisposing to the Stroke-Related Epilepsy Development","authors":"Viktor Weiss,&nbsp;Pavel Říha,&nbsp;Irena Doležalová,&nbsp;Martin Kojan,&nbsp;Vladimír Červeňák,&nbsp;Julius Šimko,&nbsp;Roman Herzig,&nbsp;Ivan Rektor","doi":"10.1155/2023/1439121","DOIUrl":"10.1155/2023/1439121","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Stroke-related epilepsy (STRE) represents a significant health problem. We focused on identifying brain areas, which involvement in ischemia predisposes a patient to STRE development. <i>Methods</i>. We retrospectively identified a group of patients with STRE consisting of 33 subjects. Subsequently, age-, sex-, and territory-matched controls who underwent stroke but did not develop STRE (control group (CG)) were identified. The CG was composed of 37 patients. The total ischemia volume and distribution of ischemic changes were compared between STRE and CG. We also analyzed multivariate statistics to identify independent variables predisposing to STRE development. <i>Results</i>. The patients with STRE exhibited a bigger volume of ischemia than CG (average volume of ischemia in STRE 60.8 cm³, in CG 42.4 cm³, <i>p</i> = 0.029). When comparing STRE and CG, there were differences in the distribution of ischemic changes in the temporal lobe (transverse (Heschl’s) temporal gyri, superior temporal gyrus, and middle temporal gyrus) and parietooccipital region (postcentral gyrus, supramarginal gyrus, angular gyrus, parietal operculum, lingual gyrus, and superior occipital gyrus). The involvement of transverse temporal (Heschl’s) gyri (<i>p</i> = 0.0222, odds ratio 30.0767), age (<i>p</i> = 0.0110, odds ratio 1.0745), and SeLECT score (<i>p</i> = 0.0480, odds ratio 1.8682) were identified as independent predictors for STRE development. <i>Conclusion</i>. The higher volume of ischemia correlates with a higher risk of STRE development. Some areas, particularly in the temporal and parietal neocortex, predispose the brain to generate epilepsy after the stroke.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1439121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42924120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume and Visual Field Defects in Occipital Stroke: The NOR-OCCIP Study","authors":"Ane R. Tharaldsen,&nbsp;Kathinka D. Kurz,&nbsp;Martin W. Kurz,&nbsp;Anna Midelfart,&nbsp;Kristin M. Sand,&nbsp;Ingvild Dalen,&nbsp;Jana M. Hoff","doi":"10.1155/2023/3564863","DOIUrl":"10.1155/2023/3564863","url":null,"abstract":"<div>\u0000 <p><i>Introduction</i>. The majority of patients with occipital infarcts display homonymous visual field defects (VFD), with negative implications on activities of daily living and quality of life. To overcome the disability, better prognostic markers in the acute phase, as well as more targeted rehabilitation, would be useful. The aim of the current study was to present an overview of the topographic distribution of occipital infarcts and to investigate whether lesion volume can predict VFD at baseline and after six months. <i>Materials and Methods</i>. Multicenter, prospective study including patients with acute occipital infarcts (NOR-OCCIP project). All patients were examined by a neurologist in the acute phase, admitted to a stroke unit, and further assessed by an ophthalmologist within two weeks. Topographic and volumetric data from brain imaging in 72 patients were analyzed and computed by an experienced neuroradiologist. <i>Results</i>. A majority (81%) had occipital infarcts with involvement of the primary visual cortex, and VFD were detected on perimetry in 80% of the examined patients. Higher infarct volume led to more severe VFD at baseline (<i>p</i> = 0.019); this was more evident if the infarct was located on the right side (<i>p</i> = 0.001). The odds for VFD improvement after six months were higher the larger the infarcts were (<i>p</i> = 0.020). There was a statistically significant association between volume of infarcts and atrial fibrillation (<i>p</i> = 0.016), previous myocardial infarction (<i>p</i> = 0.023), and modified Rankin Scale at three months (<i>p</i> = 0.007). <i>Conclusion</i>. Higher infarct volumes led to more severe VFD at baseline. More than half of the patients (54%) experienced improvement of their VFD at six months; a higher grade of improvement was seen in patients with larger occipital infarcts. Large infarcts were more common in patients with cardiovascular disease, strengthening the argument for secondary prevention.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/3564863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45628458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis and Suicide Attempts: A Review including a Meta-Analysis of Prevalence","authors":"Trine Banke d’Andrade,&nbsp;Christina Petrea Larsen,&nbsp;Egon Stenager,&nbsp;Elsebeth Nylev Stenager,&nbsp;Erik Christiansen","doi":"10.1155/2023/1067257","DOIUrl":"10.1155/2023/1067257","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Multiple sclerosis is an autoimmune inflammatory demyelinating disorder, and persons diagnosed with multiple sclerosis have a shorter life expectancy than the general population. Recent meta-analyses have examined the association between MS and suicide and between MS and suicidal ideation. The objective of the present review was to examine if MS is associated with a higher risk of suicide attempt. We hypothesised that MS patients were at increased risk of suicide attempts. <i>Methods</i>. Four databases (PubMed including MEDLINE, EMBASE, Web of Science, and PsycINFO) were searched systematically for studies assessing the risk of attempted suicide in people with MS. Eligibility criteria were studies designed as cohort, case-control, or cross-sectional studies with attempted suicide as the outcome and published in English. Lifetime prevalence of suicide attempt was calculated through a meta-analysis, and the results were presented as a forest plot. Sensitivity analyses were used to investigate the heterogeneity among studies. <i>Results</i>. 13 studies were identified from 533 records, providing a total population of 50,004 participants of whom 599 had attempted suicide. The weighted overall prevalence of suicide attempts among people with MS was 0.04 (95% CI 0.02-0.06) with a Cochran’s <i>Q</i> value of 591.05, which rejected the null hypothesis of homogeneous studies. The performed sensitivity analysis resulted in an <i>I</i>² of 81% as the lowest possible value, which still indicated a high level of heterogeneity. <i>Conclusion</i>. To our knowledge, this is the first study to examine the association between MS and suicide attempts in a meta-analysis. The results suggest a significant association between MS and suicide attempts. However, the small number of the included studies and the heterogeneous nature of these studies indicate a need for more studies based on more homogeneous samples.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1067257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46931111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Cognition in Idiopathic Generalized Epilepsies and Nonlesional Temporal Lobe Epilepsy","authors":"Giulia Maria Tallarita,&nbsp;Roberta Ciuffini,&nbsp;Katherine Turner,&nbsp;Barbara Pucci,&nbsp;Annalisa Parente,&nbsp;Anna Rita Giovagnoli","doi":"10.1155/2023/9450272","DOIUrl":"10.1155/2023/9450272","url":null,"abstract":"<div>\u0000 <p><i>Objectives</i>. Social cognition (SC) is a multifaceted concept involving mental processes to understand, store, and apply information regarding social relationships. Brain lesions in key areas can impair critical components of SC, but seizures and epileptiform discharges could also be associated with deficits in SC. To verify this hypothesis, this study evaluated SC in persons with generalized or focal epilepsy without detectable brain lesion. <i>Materials and Methods</i>. Forty-eight adult persons with idiopathic generalized epilepsy (IGE) or temporal lobe epilepsy without brain lesion (cryptoTLE) and 24 healthy controls were evaluated by means of the Faux Pas Test (FPT), Social Situation Test (SST), Moral/Conventional Distinction Test (MCDT), and Empathy Questionnaire (EQ) which assess theory of mind (ToM), recognition of social behaviors and moral and conventional rules, and empathy. Clinical work-up included information on age at seizure onset, epilepsy duration, seizure symptoms and frequency, demographic characteristics, and the presence of comorbidities. <i>Results</i>. Compared to controls, persons with IGE or cryptoTLE were impaired in the understanding of existent faux pas on the FPT. On the SST, persons with cryptoTLE also showed significant deficits, whereas the IGE persons only were less accurate in recognizing normative behaviors. In cryptoTLE persons, the capacity to recognize cognitive and affective mental states correlated with seizure frequency and age, whereas, in IGE persons, the SST and MCDT scores correlated with schooling and age, respectively. <i>Conclusions</i>. CryptoTLE can cause extensive deficits in ToM and recognition of social situations, whereas IGE is only associated with deficits in fewer domains. Dysfunction of temporolimbic areas could be related to seizure frequency and associated with more severe SC impairment in cryptoTLE. Older age and poor education may be associated with SC deficits in focal or generalized epilepsy.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/9450272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49294385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodic Limb Movements during Sleep in Children, Adolescents, and Adults with Narcolepsy: A Cross-Sectional Study in China","authors":"Xianchao Zhao,&nbsp;Jiafeng Ren,&nbsp;Guoyan Chen,&nbsp;Jinxiang Cheng,&nbsp;Danqing Shang,&nbsp;Min Wu,&nbsp;Yiqing Yang,&nbsp;Junying Zhou,&nbsp;Changjun Su","doi":"10.1155/2023/1715371","DOIUrl":"10.1155/2023/1715371","url":null,"abstract":"<div>\u0000 <p><i>Objectives</i>. This study is aimed at determining the prevalence and effects of periodic limb movements during sleep (PLMS) on nighttime sleep and daytime sleepiness in children/adolescents and adults with narcolepsy. <i>Methods</i>. A total of 94 patients with narcolepsy were recruited in this study. They were classified into two groups including children/adolescents (&lt;18 years, <i>n</i> = 41) and adults (≥18 years, <i>n</i> = 53). All participants completed face-to-face interviews and underwent polysomnography assessment followed by multiple sleep latency test. Demographic, clinical, and sleep parameters were compared between narcoleptic patients with and without PLMS. Linear regression analysis was performed to determine the association between PLMS and sleep parameters. <i>Results</i>. Thirty-eight (40.4%) patients with narcolepsy were defined as having PLMS, and there was a higher prevalence of PLMS in the children/adolescents than in the adults with narcolepsy (56.1% vs. 28.3%, respectively, <i>P</i> = 0.006). Narcoleptic patients with PLMS had a significantly shorter total sleep time, lower sleep efficiency (SE), and more wakefulness after sleep onset (WASO) than those without PLMS in adults (all <i>P</i> &lt; 0.05). After adjusting for the potential confounders, PLMS was significantly associated with lower SE (adjusted <i>β</i> = −0.327; 95% CI: -0.608, 0.044; <i>P</i> = 0.025) and more WASO (adjusted <i>β</i> = 0.330; 95% CI: 0.038, 0.520; <i>P</i> = 0.028) in adults with narcolepsy. <i>Conclusions</i>. There is a high prevalence of PLMS in narcolepsy, especially in children and adolescent patients. PLMS is associated with nighttime sleep disturbance in adults with narcolepsy but is not a risk factor for daytime sleepiness both in children/adolescents and adults with narcolepsy.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1715371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41874888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}