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Acta endocrinologica. Supplementum最新文献

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Thyroid cell MHC class II antigens: a perspective on the aetiology of autoimmune thyroid disease. 甲状腺细胞MHCⅱ类抗原:自身免疫性甲状腺疾病病因学的研究
Acta endocrinologica. Supplementum Pub Date : 1987-01-01
T F Davies, S H Roman, W A Mackenzie, N Goldsmith, S M Dower, L A Piccinini
{"title":"Thyroid cell MHC class II antigens: a perspective on the aetiology of autoimmune thyroid disease.","authors":"T F Davies,&nbsp;S H Roman,&nbsp;W A Mackenzie,&nbsp;N Goldsmith,&nbsp;S M Dower,&nbsp;L A Piccinini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An association exists between certain MHC polymorphisms and autoimmune thyroid disease in animals and humans. The observation of MHC class II antigen expression by the thyroid suggests that such associations may have mechanistic explanations at the level of the thyroid cell. Such class II antigen expression, rather than being a constitutive property of thyroid epithelium, appears to be primarily mediated by lymphokine secretion from intrathyroidal T lymphocytes and a variety of agents, for example TSh and TSH receptor antibodies, may amplify such lymphokine action. Thyroid cell class II antigens participate in activation and amplification of T cells and are involved in presentation of thyroid antigen to the immune system. The relationship between these local immune interactions and the initial events leading to the development of autoimmune thyroid disease requires a more fundamental understanding of the workings of the immune system at the site of antigenic stimulation.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14431321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment. 血小板聚集因子对GEJ细胞增殖和分化的控制。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s264
Y Abramovici, N Boucekkine, J J Rémy, J Salamero, J Charreire
{"title":"Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment.","authors":"Y Abramovici,&nbsp;N Boucekkine,&nbsp;J J Rémy,&nbsp;J Salamero,&nbsp;J Charreire","doi":"10.1530/acta.0.114s264","DOIUrl":"https://doi.org/10.1530/acta.0.114s264","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"264-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The specificity of autoantibodies in Graves' ophthalmopathy. Graves眼病自身抗体的特异性研究。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s330
P Kendall-Taylor, D Jones, S Atkinson
{"title":"The specificity of autoantibodies in Graves' ophthalmopathy.","authors":"P Kendall-Taylor,&nbsp;D Jones,&nbsp;S Atkinson","doi":"10.1530/acta.0.114s330","DOIUrl":"https://doi.org/10.1530/acta.0.114s330","url":null,"abstract":"<p><p>An autoantibody to orbital antigens is found in patients with Graves' ophthalmopathy. This autoantibody also binds to skeletal muscle antigen. Occasional positive responses have been seen in patients with Hashimoto's disease and with non-organ-specific autoimmune disease. Eye muscle has a higher innervation ratio than skeletal muscle and may be of different embryological origin, but it is nevertheless closely related to skeletal muscle and it is perhaps not surprising that the antibody should interact with both these types of muscle. What remains quite unexplained, is why the disease process apparently affects eye muscle only. The antigen appears to be distinct from thyroidal antigens, but further work with a larger patient population is necessary before one can be certain of this. To date it has been possible to exclude the cytoskeletal proteins, myosin and actin, and also the TSH receptor as possible candidates for the responsible antigens. Further studies are in progress to elucidate the nature of this muscle antigen.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"330-3"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Reduced intrathyroidal K-cell activity in Graves' disease. Graves病甲状腺内k细胞活性降低。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s096
U Bogner, H Schleusener
{"title":"Reduced intrathyroidal K-cell activity in Graves' disease.","authors":"U Bogner,&nbsp;H Schleusener","doi":"10.1530/acta.0.114s096","DOIUrl":"https://doi.org/10.1530/acta.0.114s096","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"96-8"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Properties of thyrotropin receptor on cloned hybrid human thyroid cells. 克隆杂交人甲状腺细胞促甲状腺素受体的性质。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s186
J J Rémy, J Salamero, J Charreire
{"title":"Properties of thyrotropin receptor on cloned hybrid human thyroid cells.","authors":"J J Rémy,&nbsp;J Salamero,&nbsp;J Charreire","doi":"10.1530/acta.0.114s186","DOIUrl":"https://doi.org/10.1530/acta.0.114s186","url":null,"abstract":"<p><p>Purification of the thyrotropin (TSH) binding sites from cloned human thyroid cells (GEJ) was performed after biosynthetic labelling of the cells, affinity chromatography on a human TSH-sepharose column and polyacrylamide gel electrophoresis in sodium dodecyl sulphate (PAGE-SDS). The relative molecular mass (Mr) of the GEJ cell TSH receptor (TSH-R) was approximately 48,000. This was confirmed by cross-linking [125I]TSH to GEJ binding sites with two homobifunctional agents: dimethyl suberimidate and disuccinimidyl suberate. Moreover, the absence of a dithiothreitol effect demonstrated that the TSH binding site on GEJ cells is formed by a single chain lacking disulphide bonds.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"186-92"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth. 桥本甲状腺炎体内与体外细胞生长后细胞浸润的比较。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s086
M Londei, B Grubeck-Loebenstein, C Greenall, M Turner, M Feldmann
{"title":"Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth.","authors":"M Londei,&nbsp;B Grubeck-Loebenstein,&nbsp;C Greenall,&nbsp;M Turner,&nbsp;M Feldmann","doi":"10.1530/acta.0.114s086","DOIUrl":"https://doi.org/10.1530/acta.0.114s086","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"86-8"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14620415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of interleukin-1 on the function of in vitro cultured human thyroid cells in monolayers. 白细胞介素-1对体外培养单层人甲状腺细胞功能的影响。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s093
A K Rasmussen, K Bech, U Feldt-Rasmussen, S Poulsen, K Siersbaek-Nielsen, T Friis, K Bendtzen
{"title":"The influence of interleukin-1 on the function of in vitro cultured human thyroid cells in monolayers.","authors":"A K Rasmussen,&nbsp;K Bech,&nbsp;U Feldt-Rasmussen,&nbsp;S Poulsen,&nbsp;K Siersbaek-Nielsen,&nbsp;T Friis,&nbsp;K Bendtzen","doi":"10.1530/acta.0.114s093","DOIUrl":"https://doi.org/10.1530/acta.0.114s093","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"93-5"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14620416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? hla - dr分型和tsh受体抗体的测定是否有助于预测抗甲状腺药物治疗后Graves甲状腺毒症的临床病程?
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s318
H Schleusener, J Schwander, G Holl, K Badenhoop, J Hensen, R Finke, G Schernthaner, W R Mayr, P Kotulla
{"title":"Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment?","authors":"H Schleusener,&nbsp;J Schwander,&nbsp;G Holl,&nbsp;K Badenhoop,&nbsp;J Hensen,&nbsp;R Finke,&nbsp;G Schernthaner,&nbsp;W R Mayr,&nbsp;P Kotulla","doi":"10.1530/acta.0.114s318","DOIUrl":"https://doi.org/10.1530/acta.0.114s318","url":null,"abstract":"<p><p>In patients with Graves' hyperthyroidism, the relapse rate after antithyroid drug treatment is in the range of about 30-70%. Different attempts have been made to obtain criteria for the prediction of the clinical outcome after drug therapy, especially HLA-DR typing and measurement of TSH receptor antibodies. So far, very conflicting results have been reported. This is not surprising in view of the many genetically controlled and environmental factors that play a role in the pathogenesis of this disease. Moreover, most reports are based on retrospective studies with a relatively small number of patients. Our own data, obtained in a prospective multicenter study, yield strong evidence against the relevance of HLA-DR3 typing (n = 187, sensitivity = 0.38, specificity = 0.67) or measurement of TSH receptor antibodies at the end of therapy (n = 269, sensitivity = 0.49, specificity = 0.72) for the prediction of the clinical course after drug treatment.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"318-24"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13588905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. 特发性黏液水肿患者血清中含有阻断tsh刺激的甲状腺腺苷酸环化酶的IgG。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s348
P Vitti, L Chiovato, A Lombardi, G Lopez, C Mammoli, F Santini, G F Fenzi, A Pinchera
{"title":"Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase.","authors":"P Vitti,&nbsp;L Chiovato,&nbsp;A Lombardi,&nbsp;G Lopez,&nbsp;C Mammoli,&nbsp;F Santini,&nbsp;G F Fenzi,&nbsp;A Pinchera","doi":"10.1530/acta.0.114s348","DOIUrl":"https://doi.org/10.1530/acta.0.114s348","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"348-51"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cellular localization of the microsomal antigen and the thyroid peroxidase antigen. 微粒体抗原和甲状腺过氧化物酶抗原的细胞定位。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s057
A Pinchera, S Mariotti, L Chiovato, P Vitti, G Lopez, A Lombardi, S Anelli, R Bechi, P Carayon
{"title":"Cellular localization of the microsomal antigen and the thyroid peroxidase antigen.","authors":"A Pinchera,&nbsp;S Mariotti,&nbsp;L Chiovato,&nbsp;P Vitti,&nbsp;G Lopez,&nbsp;A Lombardi,&nbsp;S Anelli,&nbsp;R Bechi,&nbsp;P Carayon","doi":"10.1530/acta.0.114s057","DOIUrl":"https://doi.org/10.1530/acta.0.114s057","url":null,"abstract":"<p><p>Evidence has been accumulated that human thyroid microsomal/microvillar autoantigen (M) is expressed both in the cytoplasm and on the surface of thyroid follicular cells. The availability of this autoantigen to the immune system, possibly associated with abnormally expressed HLA-DR antigens may be relevant both to the triggering and to maintenance of thyroid autoimmune reactions. Preliminary biochemical characterization of M suggested that it was a glycoprotein with a mol. wt. of about 100-110 kD. recent studies carried out in our laboratories taking advantage of monoclonal antibodies provided evidence that the structure presently referred as M-Ag is represented by thyroid peroxidase (TPO). The identity between TPO and M is further supported by four-layer immunofluorescence analysis showing a complete overlap of the two antigens both in the surface and in the cytoplasm of thyroid cells and by the observation that the expression of M and TPO is similarly modulated by TSH, possibly through a cAMP-dependent mechanism.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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