Acta endocrinologica. Supplementum最新文献_第3页

TSH and biogenic amine signals in the regulation of thyroid function: independent regulation by protein kinase C and G proteins. TSH和生物胺信号在甲状腺功能调控中的作用:蛋白激酶C和G蛋白的独立调控。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s199

E F Grollman, E Bone, J Chan, D Corda, O Isozaki, C Marcocci, P Santisteban, L D Kohn

引用次数: 2

Thyrotoxic effect of high iodine doses on xenotransplanted autoimmune thyroid tissue in athymic nude mice. 高剂量碘对胸腺裸鼠异种移植自身免疫性甲状腺组织的甲状腺毒作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s118

P M Schumm-Draeger, K H Usadel, B O Böhm, F D Maul, H J Wenisch, R Senekowitsch, C R Pickardt, K Schöffling

引用次数: 9

Advance abstracts of papers. Scandinavian Society for the Study of Diabetes: 22nd annual meeting. May 28-30, 1987, Turku. 论文的提前摘要。斯堪的纳维亚糖尿病研究协会:第22届年会。1987年5月28日至30日，图尔库。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

引用次数: 0

Inhomogenous TSH-binding in functional and proliferative thyroid disorders: evidence for different membrane characteristics, TSH-receptor capping and TSH-receptor presentation on the inner surface of the follicular epithelium. 功能性和增生性甲状腺疾病中不均匀的tsh结合:滤泡上皮内表面不同膜特征、tsh受体封顶和tsh受体呈现的证据

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s193

H W Müller-Gärtner, C Schneider, V Bay, A Tadt, M Jessel

引用次数: 0

Clinical and pathophysiological aspects of somatostatin and the gastrointestinal tract. 生长抑素与胃肠道的临床和病理生理方面。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.115s019

C B Lamers

{"title":"Clinical and pathophysiological aspects of somatostatin and the gastrointestinal tract.","authors":"C B Lamers","doi":"10.1530/acta.0.115s019","DOIUrl":"https://doi.org/10.1530/acta.0.115s019","url":null,"abstract":"Somatostatin is present in the gastrointestinal tract in appreciable amounts. The highest concentrations of the polypeptide are found in the stomach, the upper small intestine, and the pancreas. Within the gastrointestinal tract, somatostatin inhibits various functions, including endocrine and exocrine secretion, motility, blood flow, absorption, and growth. The polypeptide regulates these functions by endocrine, paracrine, neurocrine or luminal mechanisms. Abnormalities of endogenous somatostatin have been implicated in several gastrointestinal disorders, including the somatostatinoma syndrome, antroduodenal D-cell hyperplasia, peptic ulcer, obesity, and liver cirrhosis. Because of its potent inhibitory effects, somatostatin or somatostatin-analogues have been used as therapeutic agents in various clinical conditions, such as upper gastrointestinal haemorrhage, endocrine pancreatic tumours, gastrointestinal and pancreatic fistulas, pancreatitis, secretory diarrhoea, and dumping syndrome. The recent availability of the synthetic long-acting somatostatin-analogue SMS 201-995 (Sandostatin) has greatly facilitated the therapeutical application of somatostatin-polypeptides.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"286 ","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.115s019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14027665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Growth factor receptors in thyroid follicle cells. 甲状腺滤泡细胞中的生长因子受体。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s252

K Westermark, M Lundqvist, G Hacker, A Karlsson, B Westermark

引用次数: 12

Adenylate cyclase stimulation and [3H]thymidine incorporation in human thyroid tissues and thyrocyte cultures: the effect of IgG preparation from patients with different thyroid disorders. 腺苷酸环化酶刺激和[3H]胸苷在人甲状腺组织和甲状腺细胞培养中的掺入:不同甲状腺疾病患者IgG制备的影响

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s281

P E Goretzki, M West, R Koob, C Koller, K Joseph, H D Röher

{"title":"Adenylate cyclase stimulation and [3H]thymidine incorporation in human thyroid tissues and thyrocyte cultures: the effect of IgG preparation from patients with different thyroid disorders.","authors":"P E Goretzki, M West, R Koob, C Koller, K Joseph, H D Röher","doi":"10.1530/acta.0.114s281","DOIUrl":"https://doi.org/10.1530/acta.0.114s281","url":null,"abstract":"Primary cell cultures of normal and adenomatous human thyroid tissues were incubated with TSH or ammonium sulphate precipited IGG fractions (1 mg/ml) of sera from patients with different thyroid diseases (Graves' disease: active n = 7 in remission n = 12; thyroid autonomy n = 39; simple euthyroid goitre n = 15) and were compared to controls (n = 26). [3H]thymidine incorporation in primary thyrocyte cultures demonstrated a typical bell shape curve after incubation with EGF and TSH with a maximal effect at 10-100 microIU/ml. This effect, however, was inconsistent and positive only in 2 of 7 primary cultures. Only TSH positive cultures were used for IgG studies. 16-28% of IGG fractions from sera of thyroid patients caused high (more than X + 5 SD of controls) stimulation of [3H]thymidine incorporation. Dose response curves of IgG fractions of 19 additional patients (Graves' disease in remission n = 15; thyroid autonomy n = 4) showed an increase in [3H]thymidine incorporation at 0.1 mg protein/ml for 10 patients and at low concentrations of 10-5 mg/ml for 5 patients. There was a good correlation (r = 0.72) (P less than 0.0001) between positive findings in TSH-binding inhibition (TBII) and AC-stimulation (TSI) IGG fractions but none between stimulation of [3H]thymidine incorporation and any other thyroid specific immunoglobulin nor thyroid function nor any other available data. Immunoglobulins stimulating [3H]thymidine incorporation differ therefore from TBII and TSI. The growth effect of these immunoglobulins, however, has yet to be determined.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"281-7"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Program of plenary sessions and advance abstracts of short communications. 31. Symposium Deutsche Gesellschaft für Endokrinologie. Münster, March 4-7, 1987. 全体会议计划和简短通讯的预先摘要。31. 德国<s:1>内分泌学协会研讨会。1987年3月4日至7日。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

引用次数: 0

Control of thyroid cell proliferation: the example of the dog thyrocyte. 甲状腺细胞增殖的控制:以犬甲状腺细胞为例。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s215

S Reuse, P Roger, F Lamy, F Foureau, C Gerard, J E Dumont

引用次数: 11

Near-normoglycemia and late diabetic complications. The Oslo Study. 接近正常血糖和晚期糖尿病并发症。奥斯陆研究。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

K Dahl-Jørgensen

{"title":"Near-normoglycemia and late diabetic complications. The Oslo Study.","authors":"K Dahl-Jørgensen","doi":"","DOIUrl":"","url":null,"abstract":"A fast and precise method for routine, large scale measurements of HbA1, with elimination of pre-Alc, was established. Near normal blood glucose levels were obtained during treatment with CSII and MI; significantly better than during conventional treatment with two daily injections of mixed regular/intermediate insulin. On most parameters of glycemic control, CSII was slightly better than MI (n.s.). The frequency of hypoglycemic coma was significantly reduced, but blood glucose values below 2.5 mmol/l were more frequent on CSII, compared to conventional treatment. The frequency on MI was similar to that of conventional treatment. CSII patients have an increased risk of developing ketoacidosis by accidental cessation of insulin infusion, and of developing cutaneous infections at the infusion site. Insulin antibodies increased during one year of CSII and MI, when compared to conventional treatment. Rapid tightening of blood glucose control may lead to transient deterioration of retinopathy, mainly by the occurrence of cotton wool spots. Patients who already have background retinopathy are at higher risk for such changes. A significant increase in the number of microaneurysms and haemorrhages was observed on conventional treatment whilst no significant change was found on CSII and MI. Less progression of retinopathy (elevated by fluorescein angiograms) was observed on CSII and MI (n.s.) when compared to conventional treatment. Thus long term near-normoglycemia may retard the progression of early retinopathy. Urinary albumin excretion was reduced during CSII and MI (n.s.), but no change was observed during conventional treatment. Glomerular hyperfiltration improved during intensified treatment. Motor nerve conduction velocity deteriorated on conventional treatment, but improved during CSII. No change occurred on MI.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"284 ","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14426386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0