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Acta endocrinologica. Supplementum最新文献

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Pulsatile GnRH therapy for the induction of ovulation in hypogonadotropic hypogonadism. 促性腺激素功能低下的促性腺功能低下患者的促排卵搏动性GnRH治疗。
Acta endocrinologica. Supplementum Pub Date : 1988-01-01
S M Blunt, W R Butt
{"title":"Pulsatile GnRH therapy for the induction of ovulation in hypogonadotropic hypogonadism.","authors":"S M Blunt,&nbsp;W R Butt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-eight patients with hypogonadotropic hypogonadism resistant to clomiphene therapy were treated with pulsatile GnRH. All the patients ovulated and there were 20 pregnancies in 16 women. Administration of the GnRH sc was successful at inducing ovulation in 19 of 22 patients whereas the treatment was successful in all of the 17 patients treated iv. There was no difference between iv and sc therapy in the rate of ovulation. Treatment was stopped after ovulation and hCG given for luteal support. The follicular phase pulse frequency was usually 90 min. In one patient ovulation only occurred with frequencies of 60 min. Higher pulse doses were usually required with sc therapy for primary amenorrhoeic patients and for those with pituitary lesions. The additional use of clomiphene increased pituitary sensitivity to GnRH resulting in ovulatory cycles in patients refractory to treatment and in ovarian hyperstimulation in a normally responsive patient. Two of the 20 pregnancies were twin--the rest were singletons. None aborted. The median time to conception was 3 ovulatory cycles. Although there were no serious complications with iv or sc therapy, the iv route is now reserved for those patients unresponsive to sc treatment as the sc route is potentially safer and more acceptable to the patient. In correctly selected patients pulsatile GnRH is a highly effective and safe new treatment for the induction of ovulation.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"288 ","pages":"58-65"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14269444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Program of plenary sessions and advance abstracts of short communications. 32. Symposium Deutsche Gesellschaft für Endokrinologie. Hamburg, February 17-20, 1988. 全体会议计划和简短通讯的预先摘要。32. 德国<s:1>内分泌学协会研讨会。汉堡，1988年2月17日至20日。
Acta endocrinologica. Supplementum Pub Date : 1988-01-01
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引用次数: 0
The management of hyperthyroidism due to Graves' disease in Europe in 1986. Results of an international survey. 1986年欧洲Graves病致甲状腺机能亢进的治疗。一项国际调查的结果。
Acta endocrinologica. Supplementum Pub Date : 1987-12-01 DOI: 10.1530/ACTA.0.115S006
D. Glinoer, D. Hesch, R. Lagasse, P. Laurberg
{"title":"The management of hyperthyroidism due to Graves' disease in Europe in 1986. Results of an international survey.","authors":"D. Glinoer, D. Hesch, R. Lagasse, P. Laurberg","doi":"10.1530/ACTA.0.115S006","DOIUrl":"https://doi.org/10.1530/ACTA.0.115S006","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"29 1","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90433735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 141
Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. EGF对甲状腺滤泡cAMP形成的抑制作用是由细胞内ca2 ++介导的。
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/ACTA.0.114S267
W. Greil, G. Niedernhuber, D. Stübner, R. Gärtner
{"title":"Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++.","authors":"W. Greil, G. Niedernhuber, D. Stübner, R. Gärtner","doi":"10.1530/ACTA.0.114S267","DOIUrl":"https://doi.org/10.1530/ACTA.0.114S267","url":null,"abstract":"The mechanism of cAMP-inhibition by EGF was studied in isolated porcine thyroid follicles. EGF inhibited TSH-induced cAMP-formation maximally by 40%, this effect remained up to 1 h of pre-incubation. The calcium-ionophore A 23 187 also inhibited cAMP-formation, but its effect was relieved after 1 h. The phorbolester TPA had a biphasic influence on cAMP-formation, with a transient increase (5 min) before a sustained inhibition (60 min); the inhibitory effect was mimicked by the diacylglycerol 1-oleoyl-2-acetyl-glycerol. Exogenous arachidonic acid had only a small and transient inhibitory effect on cAMP-formation. We conclude, that EGF inhibits cAMP-formation by a raise of intracellular Ca++, as well as by the direct activation of proteinkinase C, indicating, that a phosphorylated product could be a mediator for the inhibition of adenylate cyclase.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"9 1","pages":"267-9"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80946941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Stimulation of Graves' thyroids in vitro. 格雷夫斯甲状腺的体外刺激。
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/ACTA.0.114S203
R. Hörmann, J. Kirner, B. Saller, K. Mann
{"title":"Stimulation of Graves' thyroids in vitro.","authors":"R. Hörmann, J. Kirner, B. Saller, K. Mann","doi":"10.1530/ACTA.0.114S203","DOIUrl":"https://doi.org/10.1530/ACTA.0.114S203","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"2 1","pages":"203-6"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89371962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of the immune system in obese strain chickens with Hashimoto-like thyroiditis: intrinsic and extrinsic mechanisms. 肥胖株鸡桥本样甲状腺炎的免疫系统失调:内在和外在机制。
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/acta.0.114S107
K. Schauenstein, R. Fässler, G. Krömer, G. Wick
{"title":"Dysregulation of the immune system in obese strain chickens with Hashimoto-like thyroiditis: intrinsic and extrinsic mechanisms.","authors":"K. Schauenstein, R. Fässler, G. Krömer, G. Wick","doi":"10.1530/acta.0.114S107","DOIUrl":"https://doi.org/10.1530/acta.0.114S107","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"1 1","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75278563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulation of thyroid cell growth by thyrotropin and epidermal growth factor in isolated porcine thyroid follicles. 促甲状腺素和表皮生长因子对猪离体甲状腺滤泡甲状腺细胞生长的刺激作用。
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/ACTA.0.114S270
H. Stracke, R. Bär, F. Müller, H. Schatz
{"title":"Stimulation of thyroid cell growth by thyrotropin and epidermal growth factor in isolated porcine thyroid follicles.","authors":"H. Stracke, R. Bär, F. Müller, H. Schatz","doi":"10.1530/ACTA.0.114S270","DOIUrl":"https://doi.org/10.1530/ACTA.0.114S270","url":null,"abstract":"[3H]thymidine incorporation during culture of thyroid follicles isolated from porcine glands (Schatz et al. 1983, 1986) can be taken for estimating thyroid growth stimulating immunoglobulins (TGI) (Drexhage et al. 1980; Chiovato et al. 1983; Valente et al. 1983). In this study we wanted to characterize our assay system in order to answer the question whether TSH itself was responsible for stimulation of [3H]thymidine incorporation observed when using TSH as standard in","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"819 1","pages":"270-2"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77012851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Paracrine interaction between thyrocytes and fibroblasts. 甲状腺细胞和成纤维细胞的旁分泌相互作用。
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/ACTA.0.114S225
R. Gärtner, G. Bechtner, D. Stübner, W. Greil
{"title":"Paracrine interaction between thyrocytes and fibroblasts.","authors":"R. Gärtner, G. Bechtner, D. Stübner, W. Greil","doi":"10.1530/ACTA.0.114S225","DOIUrl":"https://doi.org/10.1530/ACTA.0.114S225","url":null,"abstract":"Cell free supernatants (conditioned medium) of isolated porcine thyroid follicles, stimulated with EGF (5 ng/ml) or TSH (1-1000 microU/ml), were tested for a mitogenic activity for fibroblasts. Whereas TSH-conditioned medium dose-dependently stimulated [3H]thymidine incorporation into DNA of fibroblasts, only a weak stimulation was found with EGF. However, when the changes in cell number were determined, a significant increase was only found with EGF-conditioned medium from thyroid follicles. The cause of this discrepancy is a dose-dependent stimulation of [3H]thymidine incorporation into fibroblasts by cAMP and thyroid hormones. Cyclic AMP, however, does not stimulate growth of fibroblasts. IGF I production is stimulated in fibroblasts by basal as well as EGF stimulated conditioned medium of thyroid follicles. In contrast, TSH-conditioned medium inhibited IGF I production in fibroblasts. Conditioned medium itself is free of detectable IGF I. As IGF I stimulates not only growth of fibroblasts, but also of thyrocytes, we conclude, that conditioned medium from thyrocytes stimulates IGF I production in fibroblasts, which itself stimulates fibroblast and thyrocyte growth.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"237 1","pages":"225-30"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77781250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases. 人体内分泌组织移植到裸鼠:一种适合研究自身免疫性甲状腺疾病病理机制的体内模型
Acta endocrinologica. Supplementum Pub Date : 1987-08-01 DOI: 10.1530/acta.0.114S077
K. Usadel, J. Teuber, R. Paschke, M. Junker, U. Schwedes
{"title":"Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases.","authors":"K. Usadel, J. Teuber, R. Paschke, M. Junker, U. Schwedes","doi":"10.1530/acta.0.114S077","DOIUrl":"https://doi.org/10.1530/acta.0.114S077","url":null,"abstract":"After transplantation of human tissue to nu/nu mice the human lymphocytes disappear. In this context, interestingly, the DR-expression is not detectable anymore after transplantation of the tissues from patients with autoimmune thyrotoxicosis and cancer. Neopterin release was only demonstrable when T-lymphocytes from patients with autoimmune thyrotoxicosis or PHA-stimulated lymphocytes were added, independently of the presence of DR-expression in the used culture tissues. These results seem to exclude a functional role of DR-expression as a trigger mechanism of autoimmunity. It is supposed that DR-priming on epithelial cells is mediated by kinine production of activated T-lymphocytes or macrophages.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"116 1","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72588764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. EGF对甲状腺滤泡cAMP形成的抑制作用是由细胞内ca2 ++介导的。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01
W Greil, G Niedernhuber, D Stübner, R Gärtner
{"title":"Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++.","authors":"W Greil,&nbsp;G Niedernhuber,&nbsp;D Stübner,&nbsp;R Gärtner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanism of cAMP-inhibition by EGF was studied in isolated porcine thyroid follicles. EGF inhibited TSH-induced cAMP-formation maximally by 40%, this effect remained up to 1 h of pre-incubation. The calcium-ionophore A 23 187 also inhibited cAMP-formation, but its effect was relieved after 1 h. The phorbolester TPA had a biphasic influence on cAMP-formation, with a transient increase (5 min) before a sustained inhibition (60 min); the inhibitory effect was mimicked by the diacylglycerol 1-oleoyl-2-acetyl-glycerol. Exogenous arachidonic acid had only a small and transient inhibitory effect on cAMP-formation. We conclude, that EGF inhibits cAMP-formation by a raise of intracellular Ca++, as well as by the direct activation of proteinkinase C, indicating, that a phosphorylated product could be a mediator for the inhibition of adenylate cyclase.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"267-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14172291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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