中华整形外科杂志最新文献

{"title":"[Isolation, culture and characterization of infantile hemangioma stem cell].","authors":"Dongze Lyu,&nbsp;Hanru Ying,&nbsp;Lei Chang,&nbsp;Gang Ma,&nbsp;Xiaoxi Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To establish a reliable method of isolation and culture of infantile hemangioma stem cells (HemSCs).</p><p><strong>Methods: </strong>Proliferating infantile hemangioma specimens were digested with collagenase to form a single cell suspension. The HemSCs were isolated with anti-CD133 MicroBeads, and were incubated in fibronectin coated 96-well plates with EBM-2 (10％ FBS). HemSCs were identified by morphological characteristics, flow cytometry, cell tubule formation assay, osteoinductive and adipogenic differentiation assay, and subcutaneous tumor formation assay.</p><p><strong>Results: </strong>This method enables the rapid isolation of HemSCs which demonstrated typical mesenchymal stem cell morphology in culture.CD133 (+) HemSCs expressed CD29 (99.5％),CD44 (97.9％),CD90 (87.6％) and CD105 (98.5％),but barely expressed CD31 (0.2％),CD34 (0.1％),CD45 (0.1％) and CD144 (0.1％).These cells could differentiate into osteoblasts and adipocytes,and could form vascular wall like structure in vitro. When implanted into subcutaneous of the nude mice, the cells can develop into hemangioma like lesion histologically.</p><p><strong>Conclusions: </strong>This technique can effectively isolate HemSCs from the proliferative hemangioma. These cells could be further used to reveal the charaeteristics of HemSCs, as well as for further study of widespread application.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 4","pages":"293-8"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36343380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anatomical study and clinical application of the sensory perforator flap from the ulnar palmar digtal artery of the little finger].","authors":"Yaopeng Huang,&nbsp;Xuanliang Fang,&nbsp;Shanqin Yin,&nbsp;Jiadong Pan,&nbsp;Xin Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study the anatomical basis of the sensory perforator flap from the ulnar palmar digtal artery of the little finger and its application in reconstruction of soft tissue defect on the finger pulp.</p><p><strong>Methods: </strong>The origins and distributions of the blood vessels and nerves of the hypothenar region were observed in 6 fresh cadavers whose upper limbs were perfused with red latex. From September 2013 to November 2015,13 cases with soft tissue defects on the finger pulp were treated. All patients received the sensory perforator flap from the ulnar palmar digtal artery of the little finger. The donor site was sutured directly.</p><p><strong>Results: </strong>Through anatomical study, we found that the ulnar palmar digital artery of the little finger gives off constant cutaneous perforarter to nourish the skin of the hypothenar region, so do the ulnar palmar digital nerve of the little finger. The diameter of the artey is about 1.28 mm and suitable for microvascular anastomosis. All the 13 flaps survived. The patients were followed up for 3 months to 15 months. All the flaps had a good appearance. The sensation of the flaps recovered to S3 and two-point discrimination was 8-9 mmm. All the fingers had good function. There was only one linear scar on the hypothenar region without any discomfort.</p><p><strong>Conclusions: </strong>The ulnar palm digital artery of the little finger contains constant branches to nourish the skin of the hypothenar region, so do the ulnar palrnar digital nerve of the little finger. So we can design a flap with sensory nerve on the hypothenar region. It is an effective method to repair soft tissue defect of the finger pulp with the free sensory perforator flap from the ulnar palmar digtal artery of the little finger.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 4","pages":"264-7"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36341447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Repair of soft tissue defects in lower extremities by latissimus dorsi myocutaneous flap with T type of vascular pedicle].","authors":"Shunhong Gao,&nbsp;Gang Zhao,&nbsp;Ming Zhou,&nbsp;Chao Chen,&nbsp;Zhiliang Yu,&nbsp;Wenlong Zhang,&nbsp;Hongyu Hu,&nbsp;Huishuang Dong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the Application of latissimus dorsi myocutaneous flap with T type of vascular pedicle in repairing soft tissue defects at lower extremities.</p><p><strong>Methods: </strong>Between January 2003 and August 2013,16 patients with skin and soft tissue defects at lower extremities were treated with T type vascular pedicled latissimus dorsi myocutaneous flap through bridge transplantation. There were 13 male and 3 female patients with an average age of 36.2 years(range,17-54 years).Skin and soft tissue defects in the lower extremities ranged from 18 cm × 13 cm to 32 cm × 15 cm. The T-configuration vascular anastomosis was formed by anastomosing the subscapular and circumflex scapular vessels to the proximal and distal ends of the posterior tibial vessel broken in the normal leg respectively in an end-to-end manner. The latissimus dorsi myocutaneous flap was used to cover the defect at damaged leg where vascular pedicle was wrapped by tube flap from the normal leg. External fixators was used to immobilize the bilateral lower legs postoperatively.</p><p><strong>Results: </strong>Vascular crisis occurred in 3 cases. Vascular crisis was relieved after exploring the vessel.2 cases developed infection at the distal end of flap and cured by debridement. Primary healing was obtained in 11 cases after 2 weeks,and the total survival rate was 100％.The follow-up period lasted for 6 months to 5 years with an average of 3.4 years. The flap appearance was satisfactory and extremity function was restored to normal.</p><p><strong>Conclusions: </strong>The application of the T type of vascular pedicled latissimus dorsi myocutaneous flap by bridge transplantation is an effective method for repair skin and soft tissue defects in lower extremity without damaging for main blood vessels at contralateral limb, when affected extremities have no available vessel for anastomosis.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36340917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combining eyebrow and inferior palpebral margin incision for the facial rejuvenation in the upper eyelid and midface region].","authors":"Ming Li,&nbsp;Yide Xie,&nbsp;Mingkun Zhan,&nbsp;Yakuan Zhou,&nbsp;Chushan Huang,&nbsp;Yanru Chen,&nbsp;Limin Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate a simple, minimally invasive and effective operative method for the facial rejuvenation in the upper eyelid and midface region.</p><p><strong>Methods: </strong>Blepharoplasty was combined with suspending orbicularis oculi muscle flap and fixing it on the periosteum underneath the eyebrow through eyebrow incision. Meanwhile, for midface rejuvenation, inferior palpebral margin incision was performed and prezygomatic interspace was separated completely under the orbicularis oculi muscle. The under-eye puffiness and tear trough deformity were corrected through releasing orbital fat, reposition and fastening orbital septum, and transposition of orbicularis oculi muscle flap. And the deep sulci nasolabialis and cheek anetoderma were relieved by dual lifting of malar fat pad and orbicularis oculi muscle flap. Follow-up was taken at the 1 week,3 months,6 months,1 year,2years and 3 years after operation. Each case was evaluated with postoperative effect, reprocessing time and postoperative complications and underwent photography.</p><p><strong>Results: </strong>From Feb.2010 to Oct.2014,190 patients (9 male,181 female, an average age of 49.03 ± 5.67 years) underwent this operation. Obvious improvement on the upper eyelid and midface region was achieved in all the patients after operation without serious or irreversible complication</p><p><strong>Conclusions: </strong>Combining eyebrow and inferior palpebral margin incision, through suspending the malar fat pad and orbicularis oculi muscle flap at the same time, as a simple, minimally invasive and reliable method, can strengthen the effect of the facial rejuvenation in the upper eyelid and midface region markedly.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"166-70"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36342301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Purse-string suture of imbrication of SMAS and malar fat pad technique for midface and lower face lift].","authors":"Zhihong Zhan,&nbsp;Wenzhi Li,&nbsp;Jiaqi Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To discuss the rhytidectomy technical improvements and clinical efficacy and safety, using the purse-string imbrication suture in midface and lower face lift.</p><p><strong>Methods: </strong>The absorbable purse-string suture was used in a pure antigravitational direction for correction of the aging middle and lower parts of the face. The volume of cheeks and jowls was repositioned in a cranial direction with a first, slightly oblique purse-string suture on SMAS. To correct the nasolabial fold, the face-lift was performed by adding a second malar vertical purse-string suture between the paracantbal area and the malar fat pad.</p><p><strong>Results: </strong>From July 2009 to May 2014,52 patients underwent this technique for facial rejuvenation with obvious effect and high satisfactory rate. There was only two minor complication of hematoma.</p><p><strong>Conclusions: </strong>The Purse-string imbrication suture in the rhytidectomy produces a natural face lifting through a better correction of the sagging tissue and restoration of the volume of the face. This is a simple technique with good results, short down-time, and high patient satisfactory rate.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"174-8"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36342300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of PDGF-C on biological characters of human dermal papilla cells in vitro].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of platelet-derived growth factor-C (PDGF-C) on biological characters of human hair dermal papilla cells cultured in vitro.</p><p><strong>Methods: </strong>The human dermal papilla cells(HDPCs) were isolated from human hair skin obtained from rhytidectomy procedure and then cultured in vitro. Cell counting and CCK-8 assay were used to detect the effects of PDGF-C (0,10,20,30 and 40ng/ml) on the proliferation of HDPCs at 0,1 d,2d,3d,4d,5d,6d.Under the optimal concentration, flow cytometry was used to detect cell phases. Transwell assay and cell scratch test were performed to detect cell migration. Alkaline Phosphatase Activity Assay kit was used to detect the inductive activity of HDPCs.</p><p><strong>Results: </strong>PDGF-C significantly induced the proliferation of HDPCs. PDGF-C of 30ng/mL promoted the HDPCs proliferation at a summit and increased the percentage of the cells arrested at S phase (P ＜ 0.05).PDGF-C also increased the migration populations of cultured HDPCs. The cell number in lower side of the transwell insert membrane of 30ng/ml PDGF-C treated group was (361.3 ± 24.95)while the control was (246.8 ± 7.525),showing significant difference (P ＜ 0.05).The alkaline phosphate activity of cultured HDPCs was increased comparing to the control group, the difference was significant (P ＜ 0.05).</p><p><strong>Conclusions: </strong>PDGF-C can promote the proliferation, migration and inductive activity of cultured human dermal papilla cells, which might be beneficial to promote the cultivation of human dermal papilla cells in vitro.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"215-20"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36340916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Induced cleft palat by Retinoic acid through altering the cell proliferation and apoptosis at the key stages of palatal development].","authors":"Xiao Hu,&nbsp;Yeyang Li,&nbsp;Min Liang,&nbsp;Weihua Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of retinoic acid (RA) on the proliferation and apoptosis of mesenchyme and epithelium at the key stages of palatal development, and to determine the embryonic alterations associated with cleft palate.</p><p><strong>Methods: </strong>100 pregnant C57 females (E12) were equally divided into two groups. The experimental group was administered RA once (70 mg/kg) while the control group was administered corn oil only, and the heads of the embryos at E13.5-17.5 were collected and processed to paraffin. Sections were stained with hematoxylin and eosin for the morphological assessment of anterior,posterior, left and right palate, and BrdU and TUNEL assays for the detection of proliferation and survival of palatal mesenchyme and epithelium.</p><p><strong>Results: </strong>Simple treatment of RA at 70 mg/kg caused an incidence of 100％ cleft palate. During E13.5-15.5,cell proliferation was significantly promoted on the anterior palatal mesenchyme in the RA group, while no difference for the posterior palatal mesenchyme. Besides, the cell proliferation on anterior and posterior epithelium was comparable between the control and RA group. Less apoptotic cells were observed on epithelium during El3.5-14.5 in the RA group.</p><p><strong>Conclusions: </strong>RA induces excessive cell proliferation of palatal mesenchyme, causing abnormal vertical palatal growth and failure of palatal shelves contact and fusion, which finally lead to cleft palate. RA also increases epithelium apoptosis.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"220-4"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36340918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical application of the free anterolateral thigh myocutaneous flap with the tensor fascia lata for one-stage repair of soft tissues defects at the dorsum of hands (feets)].","authors":"Hui Sheng,&nbsp;Hengjin Tian,&nbsp;Shulin Jing,&nbsp;Zhiyong Wang,&nbsp;Zhijia Zhang,&nbsp;Debao Li,&nbsp;Zhenxing Sha,&nbsp;Manyi Cui","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the method and the therapeutic effect of the free anterolateral thigh myocutaneous flap with the tensor fascia lata for one-stage repair of soft tissues defects at the dorsum of hands (feets).</p><p><strong>Method: </strong>Between Jan.2010 and Dec.014,8 patients with finger (toe) extensor tendon and dorsal foot defect were treated with anterolateral thigh myocutaneous flap. The defect area ranged from 6 cm ×5cm to 18 cm× 10cm.All of the soft tissues defects at the dorsum of hands (feets) combined with tendon colobomam. The free anterolateral thigh myocutaneous flap (ranged from 8 cm × 7cm to 20 cm × 12cm) were applied for one-stage repair of the soft tissues defects. The anterolateral thigh flap was used to repair defect and fascia lata was used to bridge two ends of digitorum longus tendon. The defects at donor sites were sutured directly or repaired with the split-thickness skin graft.2-3 months after the surgery, tenolysis for tendon was performed, and fascia lata was split into tendon-like shape and the finger (toe) functional exercises were done.</p><p><strong>Results: </strong>All flaps survived completely after the first stage.Postoperative follow-up time was 6-12 months (average,8 months).Except 4 flaps with somewhat swelling, the other flaps had satisfactory appearance with soft texture. During the follow-up, part of the dorsiflexion function of hand recovered in 3 patients (5°-40°),and flexion function was normal;5 patients with soft tissues defects at the dorsum of foots could walk normally with no toe ptosis.</p><p><strong>Conclusions: </strong>Application of the free anterolateral thigh myocutaneous flap with the tensor fascia lata can repair soft tissues defects at the dorsum of hands (feets) combined with tendon colobomam. It can repair soft tissues defect combined with finger (toe) extensor tendon defects. Excellent clinical results can be achieved with short treatment time and less damage to the donor site.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"196-8"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36342085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sagittal split ramus osteotomy combined with intraoral distraction osteogenesis for hemifacial microsomia].","authors":"Yude Ding,&nbsp;Bin Yang,&nbsp;Jian Ni,&nbsp;Binghang Li,&nbsp;Yilin Cao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of sagittal split ramus osteotomy(SSRO) combined with distraction osteogenesis(DO) for hemifacial microsomia (HFM).</p><p><strong>Methods: </strong>From January 2013 to September 2015,7 cases of unilateral HFM were included in the study. The 3-dimensional reconstruction images were used for the operation design. The location of the germs and inferior alveolar nerve was marked to avoid injury. The distractor was fixed after SSRO. The distractor was distracted 2-4 mm intraoperatively and began enlongation 3-5 days after operation,1-2 mm every day until the pre-designed length attained. The patients were followed up for 3-D CT and measurement of the height of bilateral ramus.</p><p><strong>Results: </strong>The enlongation length was 7 mm to 20 mm(mean,14.6 mm).The facial symmetry and occlusion plane was improved a lot. No complication occurred. The mean follow-up period was 22 months (range 17-32 months) with almost symmetrical appearance and occlusion function.</p><p><strong>Conclusions: </strong>SSRO combined with DO has a good therapeutic effect and low complication for patients with HFM. The distraction rate is relatively high with a short treatment period. The ramus width, even thickness, are not decreased, or even can be increased after DO.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"161-5"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36342298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the bacteria spectrum and clinical treatment of topical skin infection during soft tissue expander implantation].","authors":"Hong Chang,&nbsp;Bifeng Zhou,&nbsp;Xin Cui,&nbsp;Yingjun Su,&nbsp;Xianjie Ma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the identification and antibiotics susceptibility of infectious bacteria obtained from the topic skin infection during soft tissue expander implantation.</p><p><strong>Methods: </strong>A retrospective analysis of 121 cases with local infections during soft tissue expander implantation between 2003 to 2012 in Department of Plastic and Reconstructive Surgery, Xijing Hospital was performed. The efficacy of clinical management of local infection was evaluated. Laboratory examination on exudates bacterial pathogen and antibiotic susceptibility were performed. .</p><p><strong>Results: </strong>Based on the severity of wound infection, change of dressings, wound debridement, exudates drainage and intravenous antibiotics administration were applied. All infections were successfully controlled although the expanders were removed in 16 cases with severe infections. Total success rate of expansion in this cohort was 89.33％.Twenty-nine exudates samples collected from either skin rupture wounds or skin outlets of connector tubes of externally placed infusion ports in 29 patients underwent bacterial culture and antibiotic susceptibility test. The 23 samples showed positive while the rest 6 samples showed negative on bacterial identification in the bacterial culture test.Staphylococcus aureus strain was found in 20 samples (86.96％),Staphylococcus epidermidis in 1 sample, Klinefelter Citrobacter in 1 sample, and Aeromonas hydrophila in 1 sample. More than 80％ of the pathogens were susceptive to cefazolin, oxacillin, and levofloxacin.</p><p><strong>Conclusions: </strong>Staphylococcus aureus is the main pathogen of infection at expander implantation site. The local dressing change,surgical debridement, continuous infusion drainage, and the use intravenous antibiotics are the effective managements</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 3","pages":"191-5"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36342084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}