动物疾病(英文)最新文献

{"title":"Phenotypic and molecular characterizations of multidrug-resistant diarrheagenic E. coli of calf origin","authors":"Shan Yue, Ze-cai Zhang, Yu Liu, Yulong Zhou, Chenhua Wu, Wenjing Huang, Nannan Chen, Zhanbo Zhu","doi":"10.1186/s44149-021-00019-3","DOIUrl":"https://doi.org/10.1186/s44149-021-00019-3","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46594700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and preventive practices of livestock farmers on infectious causes of reproductive disorders in dairy cows in the Kembata Tambaro zone, southern Ethiopia","authors":"B. Ayele, S. Leta","doi":"10.1186/s44149-021-00014-8","DOIUrl":"https://doi.org/10.1186/s44149-021-00014-8","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41405778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dopamine receptor D4 regulates the proliferation of pulmonary arteries smooth muscle in broilers by downregulating AT1R","authors":"Xiaoqi Yang, Yang Fu, Lianfeng Wu, Antong Li, Luyao Ji, Hao Li, Yuxuan Peng, Jiabin Zhang, Donghai Zhou, Huiping Zhou","doi":"10.1186/s44149-021-00012-w","DOIUrl":"https://doi.org/10.1186/s44149-021-00012-w","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41548126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein","authors":"L. Yao, Chang Li, Junwei Wang, Yufang Cheng, Ahmed. H. Ghonaim, Qi Sun, Xuexiang Yu, Weijie Niu, S. Fan, Qigai He","doi":"10.1186/s44149-021-00015-7","DOIUrl":"https://doi.org/10.1186/s44149-021-00015-7","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s44149-021-00015-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42712670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of colistin-resistant Escherichia coli from pig farms in Central China","authors":"Zhong Peng, Xiaoxue Zhang, Xiaosong Li, Zizhe Hu, Zugang Li, Chaoying Jia, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang","doi":"10.1186/s44149-021-00009-5","DOIUrl":"https://doi.org/10.1186/s44149-021-00009-5","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s44149-021-00009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46176953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins","authors":"D. Hu, Shaowen Li, Rendong Fang, H. Ono","doi":"10.1186/s44149-021-00007-7","DOIUrl":"https://doi.org/10.1186/s44149-021-00007-7","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s44149-021-00007-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47126907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Icariin protects against cage layer osteoporosis by intervening in steroid biosynthesis and glycerophospholipid metabolism","authors":"Zhengwang Yu, Jie Huang, Zhongxin Zhou","doi":"10.1186/s44149-021-00001-z","DOIUrl":"https://doi.org/10.1186/s44149-021-00001-z","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s44149-021-00001-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis","authors":"G. Zhu, Jigang Yin, G. Cuny","doi":"10.1186/s44149-021-00002-y","DOIUrl":"https://doi.org/10.1186/s44149-021-00002-y","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s44149-021-00002-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49585067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inactivated Pseudomonas PE(ΔIII) exotoxin fused to neutralizing epitopes of PEDV S proteins produces a specific immune response in mice.","authors":"Leqiang Sun,&nbsp;Yajie Tang,&nbsp;Keji Yan,&nbsp;Huanchun Chen,&nbsp;Huawei Zhang","doi":"10.1186/s44149-021-00021-9","DOIUrl":"https://doi.org/10.1186/s44149-021-00021-9","url":null,"abstract":"<p><p>Porcine epidemic diarrhea (PED) caused by the porcine epidemic diarrhea virus (PEDV), is a severe infectious and devastating swine disease that leads to serious economic losses in the swine industry worldwide. An increased number of PED cases caused by variant PEDV have been reported in many countries since 2010. S protein is the main immunogenic protein containing some B-cell epitopes that can induce neutralizing antibodies of PEDV. In this study, the construction, expression and purification of Pseudomonas aeruginosa exotoxin A (PE) without domain III (PEΔIII) as a vector was performed for the delivery of PEDV S-A or S-B. PE(ΔIII) PEDV S-A and PE(ΔIII) PEDV S-B recombinant proteins were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis. The immunogenicity of PEDV S-A and PEDV S-B subunit vaccines were evaluated in mice. The results showed that PEDV-S-B vaccine could not only induce specific humoral and Th1 type-dominant cellular immune responses, but also stimulate PEDV-specific mucosal immune responses in mice. PEDV-S-B subunit vaccine is a novel candidate mucosal vaccine against PEDV infection.</p>","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39892154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationally designed <i>mariner</i> vectors for functional genomic analysis of <i>Actinobacillus pleuropneumoniae</i> and other <i>Pasteurellaceae</i> species by transposon-directed insertion-site sequencing (TraDIS).","authors":"Janine T Bossé,&nbsp;Yanwen Li,&nbsp;Leon G Leanse,&nbsp;Liqing Zhou,&nbsp;Roy R Chaudhuri,&nbsp;Sarah E Peters,&nbsp;Jinhong Wang,&nbsp;Gareth A Maglennon,&nbsp;Matthew T G Holden,&nbsp;Duncan J Maskell,&nbsp;Alexander W Tucker,&nbsp;Brendan W Wren,&nbsp;Andrew N Rycroft,&nbsp;Paul R Langford","doi":"10.1186/s44149-021-00026-4","DOIUrl":"https://doi.org/10.1186/s44149-021-00026-4","url":null,"abstract":"<p><p>Comprehensive identification of conditionally essential genes requires efficient tools for generating high-density transposon libraries that, ideally, can be analysed using next-generation sequencing methods such as Transposon Directed Insertion-site Sequencing (TraDIS). The <i>Himar1</i> (<i>mariner</i>) transposon is ideal for generating near-saturating mutant libraries, especially in AT-rich chromosomes, as the requirement for integration is a TA dinucleotide, and this transposon has been used for mutagenesis of a wide variety of bacteria. However, plasmids for <i>mariner</i> delivery do not necessarily work well in all bacteria. In particular, there are limited tools for functional genomic analysis of <i>Pasteurellaceae</i> species of major veterinary importance, such as swine and cattle pathogens, <i>Actinobacillus pleuropneumoniae</i> and <i>Pasteurella multocida</i>, respectively. Here, we developed plasmids, pTsodCPC9 and pTlacPC9 (differing only in the promoter driving expression of the transposase gene), that allow delivery of <i>mariner</i> into both these pathogens, but which should also be applicable to a wider range of bacteria. Using the pTlacPC9 vector, we have generated, for the first time, saturating <i>mariner</i> mutant libraries in both <i>A. pleuropneumoniae</i> and <i>P. multocida</i> that showed a near random distribution of insertions around the respective chromosomes as detected by TraDIS. A preliminary screen of 5000 mutants each identified 8 and 14 genes, respectively, that are required for growth under anaerobic conditions. Future high-throughput screening of the generated libraries will facilitate identification of mutants required for growth under different conditions, including <i>in vivo</i>, highlighting key virulence factors and pathways that can be exploited for development of novel therapeutics and vaccines.</p>","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}