动物疾病(英文)最新文献

筛选
英文 中文
Identification of novel serological agents for porcine deltacoronavirus infection based on the immunogenic accessory protein NS6 基于免疫原性附属蛋白 NS6 鉴定猪三角锥病毒感染的新型血清制剂
动物疾病(英文) Pub Date : 2024-01-15 DOI: 10.1186/s44149-023-00109-4
Yali Li, Fangshu Shi, Lingxiang Cao, Qiankun Zheng, Yaoyu Feng, Bin Wang, Yaowei Huang
{"title":"Identification of novel serological agents for porcine deltacoronavirus infection based on the immunogenic accessory protein NS6","authors":"Yali Li, Fangshu Shi, Lingxiang Cao, Qiankun Zheng, Yaoyu Feng, Bin Wang, Yaowei Huang","doi":"10.1186/s44149-023-00109-4","DOIUrl":"https://doi.org/10.1186/s44149-023-00109-4","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomedical knowledge graph construction of Sus scrofa and its application in anti-PRRSV traditional Chinese medicine discovery 猪的生物医学知识图谱构建及其在抗PRRSV中药发现中的应用
动物疾病(英文) Pub Date : 2024-01-12 DOI: 10.1186/s44149-023-00106-7
Mingyang Cui, Zhigang Hao, Yanguang Liu, Bomin Lv, Hongyu Zhang, Yuan Quan, Li Qin
{"title":"Biomedical knowledge graph construction of Sus scrofa and its application in anti-PRRSV traditional Chinese medicine discovery","authors":"Mingyang Cui, Zhigang Hao, Yanguang Liu, Bomin Lv, Hongyu Zhang, Yuan Quan, Li Qin","doi":"10.1186/s44149-023-00106-7","DOIUrl":"https://doi.org/10.1186/s44149-023-00106-7","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular characterization of canine parvovirus type 2 (CPV2) reveals a high prevalence of the CPV2c genotype among dogs suffering from diarrhea 犬细小病毒 2 型 (CPV2) 的分子特征显示,CPV2c 基因型在腹泻犬中的流行率很高
动物疾病(英文) Pub Date : 2024-01-02 DOI: 10.1186/s44149-023-00107-6
Sajid Umar, Di Gao, Semin Kim, Yixi Cheng, Zhenkun Fang, Zhongqi Qiu, Weidong Yu, Benjamin D. Anderson
{"title":"Molecular characterization of canine parvovirus type 2 (CPV2) reveals a high prevalence of the CPV2c genotype among dogs suffering from diarrhea","authors":"Sajid Umar, Di Gao, Semin Kim, Yixi Cheng, Zhenkun Fang, Zhongqi Qiu, Weidong Yu, Benjamin D. Anderson","doi":"10.1186/s44149-023-00107-6","DOIUrl":"https://doi.org/10.1186/s44149-023-00107-6","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice 慢性社会挫败压力诱发的抑郁症通过促进小鼠调节性 T 细胞水平降低卡介苗疗效
动物疾病(英文) Pub Date : 2023-12-18 DOI: 10.1186/s44149-023-00102-x
Rohit Tyagi, Xi Chen, Atika Dhar, Bing Yang, Wei Zhou, Aikebaier Reheman, Yingying Lei, Gang Cao
{"title":"Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice","authors":"Rohit Tyagi, Xi Chen, Atika Dhar, Bing Yang, Wei Zhou, Aikebaier Reheman, Yingying Lei, Gang Cao","doi":"10.1186/s44149-023-00102-x","DOIUrl":"https://doi.org/10.1186/s44149-023-00102-x","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal distribution of foot-and-mouth disease in Nepal between 2019 and 2021 2019 年至 2021 年尼泊尔口蹄疫的时空分布情况
动物疾病(英文) Pub Date : 2023-11-28 DOI: 10.1186/s44149-023-00104-9
Sujeeta Pokharel Dhakal, Krishnaraj Pandey, Mukul Upadhyaya, Surendra Karki, Nira Ramdam, Sarah VanDyk, S. Premashthira
{"title":"Spatiotemporal distribution of foot-and-mouth disease in Nepal between 2019 and 2021","authors":"Sujeeta Pokharel Dhakal, Krishnaraj Pandey, Mukul Upadhyaya, Surendra Karki, Nira Ramdam, Sarah VanDyk, S. Premashthira","doi":"10.1186/s44149-023-00104-9","DOIUrl":"https://doi.org/10.1186/s44149-023-00104-9","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The generation of hemagglutinin monoclonal antibodies against H9N2 influenza virus 生成针对 H9N2 流感病毒的血凝素单克隆抗体
动物疾病(英文) Pub Date : 2023-11-27 DOI: 10.1186/s44149-023-00100-z
Yongcheng Duan, Qingli Guo, Shaoyu Tu, Jiahui Zou, Guohong Li, Cheng Liang, Yanqing Cheng, Yijie Zhou, Lin Chen, Yuanbao Zhou, Sizhu Suolang, Hongbo Zhou
{"title":"The generation of hemagglutinin monoclonal antibodies against H9N2 influenza virus","authors":"Yongcheng Duan, Qingli Guo, Shaoyu Tu, Jiahui Zou, Guohong Li, Cheng Liang, Yanqing Cheng, Yijie Zhou, Lin Chen, Yuanbao Zhou, Sizhu Suolang, Hongbo Zhou","doi":"10.1186/s44149-023-00100-z","DOIUrl":"https://doi.org/10.1186/s44149-023-00100-z","url":null,"abstract":"","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum 血清中存在钩端螺旋体、犬埃利希体和嗜吞噬细胞无原体的犬慢性肾病的临床特征
动物疾病(英文) Pub Date : 2023-11-06 DOI: 10.1186/s44149-023-00103-w
Claire A. Vázquez-Manzanilla, María F. Cárdenas-Marrufo, Eduardo Gutiérrez-Blanco, Matilde Jiménez-Coello, Nelly R. Pech-Sosa, Antonio Ortega-Pacheco
{"title":"Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum","authors":"Claire A. Vázquez-Manzanilla, María F. Cárdenas-Marrufo, Eduardo Gutiérrez-Blanco, Matilde Jiménez-Coello, Nelly R. Pech-Sosa, Antonio Ortega-Pacheco","doi":"10.1186/s44149-023-00103-w","DOIUrl":"https://doi.org/10.1186/s44149-023-00103-w","url":null,"abstract":"Abstract Chronic kidney disease is commonly diagnosed in dogs, and clinical signs may be aggravated when infected agents are involved. In this case report, 33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum . The seroprevalence for Leptospira spp. was 39.4%. The most frequent serovars found were Pyrogenes, Canicola, Bratislava and Australis, with serological titers between 1:100 to 1:800. Clinical signs included fever, depression, decreased body condition, vomiting and hematuria. Significant laboratory findings were anemia, leukocytosis, thrombocytopenia, increased liver enzymes, urea and creatinine, hyperbilirubinemia and hyperphosphatemia. All leptospira seronegative dogs were positive for one or both monitored homoparasites (i.e., E. canis and A. phagocytophilum ); only three leptospira seropositive dogs were positive for one or both hemoparasites. Findings also suggest that endemic hemoparasites of dogs should be monitored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production 固体脂基悬浮液的热熔乳化剪切法:从实验室规模到中试规模生产
动物疾病(英文) Pub Date : 2023-10-27 DOI: 10.1186/s44149-023-00098-4
Chao Li, Wenqing Xie, Liwen Yuan, Mubbashar Abbas, Dongmei Chen, Shuyu Xie
{"title":"Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production","authors":"Chao Li, Wenqing Xie, Liwen Yuan, Mubbashar Abbas, Dongmei Chen, Shuyu Xie","doi":"10.1186/s44149-023-00098-4","DOIUrl":"https://doi.org/10.1186/s44149-023-00098-4","url":null,"abstract":"Abstract The clinical application of solid lipid particles (SLPs) is hampered due to the need for advanced nano/micro-suspension production technology. This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment. The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles (SLPs). The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production. The process and formulation endured optimization through orthogonal or single-factor tests at various production steps: laboratory research, small-scale trial production, and pilot production. Quality standards for the product were determined, and key parameters were obtained at each stage. The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3% polyvinyl alcohol (PVA) per 1.0 g tilmicosin and 2.5 g carnauba wax (WAX). During small-scale production, modifications were made to the volume of the aqueous phase, emulsifier concentration, and emulsification strength, setting them to 16 mL, 5%, and 2200 r/min, respectively. In the pilot production stage, the shear time was considered optimal at eight min. The impurity, content, polydispersion coefficient (PDI), and size of the pilot product were < 3%, 5%, 0.385 and 2.64 μm, respectively. Among the several parameters studied, heating temperature, drug-lipid ratio, and emulsifier concentration were identified as the main factors affecting product quality, and they were regulated at 100℃, 1:3, and 5%, respectively. A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production. This innovation is expected to enhance solid lipid-based suspensions' industrial evolution extensively.","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese herbal extracts with antiviral activity: evaluation, mechanisms, and potential for preventing PRV, PEDV and PRRSV infections 具有抗病毒活性的中草药提取物:评估、机制和预防PRV、PEDV和PRRSV感染的潜力
动物疾病(英文) Pub Date : 2023-10-26 DOI: 10.1186/s44149-023-00091-x
Yumei Sun, Chang Li, Zhongzhu Liu, Wei Zeng, Muhammad Jamil Ahmad, Mengjia Zhang, Lina Liu, Shujun Zhang, Wentao Li, Qigai He
{"title":"Chinese herbal extracts with antiviral activity: evaluation, mechanisms, and potential for preventing PRV, PEDV and PRRSV infections","authors":"Yumei Sun, Chang Li, Zhongzhu Liu, Wei Zeng, Muhammad Jamil Ahmad, Mengjia Zhang, Lina Liu, Shujun Zhang, Wentao Li, Qigai He","doi":"10.1186/s44149-023-00091-x","DOIUrl":"https://doi.org/10.1186/s44149-023-00091-x","url":null,"abstract":"Abstract The rapid expansion of large-scale pig farming has brought about a surge in viral diseases with high morbidity rates and diverse manifestations. This widespread occurrence of multiple viral diseases in pig farms has inflicted severe economic losses on the global swine industry. Consequently, there is an urgent need for eco-friendly and efficient antiviral drugs that can effectively combat viruses and prevent diseases such as PEDV, PRRSV, PRV, and other viral infections. To this end, we conducted a study on the antiviral activity and cytotoxicity of eleven different Chinese herbal extracts (CHE) against PRV. In vitro testing of several extracts, namely, Echinacea, Ilex purpurea Hassk, Ganoderma lucidum Kars, Taraxacum mongolicum, and Ilex rotunda Thunb, exhibited remarkable inhibition of PRV infection without causing any cytotoxic effects. Specifically, their antiviral selectivity indexes were significantly higher, with values ranging from 6- to 144-fold. The antiviral efficacy of five CHEs was evaluated against other RNA viruses, including PRRSV and PEDV. The extracts showed substantial inhibition of PEDV and PRRSV proliferation. Echinacea and Ilex purpurea Hassk extracts exhibited the highest virus inhibitory effects. To understand the antiviral mechanisms underlying their potent activity, a time-of-addition experiment was conducted. The results indicated that these extracts effectively targeted the early infection and postinfection stages of PRV, PEDV, and PRRSV. The study found that the Chinese herbal extracts, Echinacea and Ilex purpurea Hassk, had both direct and indirect effects on virus particles and cellular targets, demonstrating broad-spectrum antiviral activity against multiple clinical strains of PRV and PEDV. These findings provide a strong foundation for the development of herbal medicines to prevent and treat infections caused by PRV, PEDV and PRRSV in the swine industry. The identified extracts show great promise for the formulation of effective and environmentally friendly antiviral interventions. Graphical Abstract","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134906841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management practices and technologies for efficient biological sample collection from domestic animals with special reference to Indian field conditions 家畜高效生物样本采集的管理实践和技术,特别参考印度的野外条件
动物疾病(英文) Pub Date : 2023-10-25 DOI: 10.1186/s44149-023-00096-6
Gokula Kannan Ragavan, Purushothaman Selvaraj, Dharman Murugesan, Tirumurugaan Krishnaswamy Gopalan, Soundararajan Chinnaiyan, Dhinakar Raj Gopal, Aravindh Babu Ramasamy Parthiban, Karthik Kumaragurubaran, Azhahianambi Palavesam
{"title":"Management practices and technologies for efficient biological sample collection from domestic animals with special reference to Indian field conditions","authors":"Gokula Kannan Ragavan, Purushothaman Selvaraj, Dharman Murugesan, Tirumurugaan Krishnaswamy Gopalan, Soundararajan Chinnaiyan, Dhinakar Raj Gopal, Aravindh Babu Ramasamy Parthiban, Karthik Kumaragurubaran, Azhahianambi Palavesam","doi":"10.1186/s44149-023-00096-6","DOIUrl":"https://doi.org/10.1186/s44149-023-00096-6","url":null,"abstract":"Abstract Management strategies and the use of advanced technologies are equally important for determining the sample number and sampling frame for successful field sampling for animal disease prevalence studies. The quality of the biological samples collected in the field has a direct bearing on the integrity of the data generated, prevalence estimates and subsequent policy decisions on disease control. Hence, compromising the quality of biological samples collected in the field could potentially undermine the priority setting principles in disease control strategies. Biological samples collected from domestic animals in the field are precious materials and require meticulous planning for sample collection, sample storage in the field, transportation, and storage in the laboratory. Poorly managed field sampling has a significant detrimental impact on the sample quality and quantity and directly affects the accuracy of disease prevalence data. A bad choice of sampling tools, containers, storage and transport all have a negative impact on the integrity of the sample and consequently have an impact on the outcome. Over the last two years, as part of our one health animal sampling work in India, we have observed challenges and opportunities in the field sampling of animals for disease prevalence studies. This paper aims to provide information on management practices and technologies for efficient biological sample collection from the field and ensure that good quality samples are available for testing.","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信