Acta Pharmaceutica Sinica. B最新文献

{"title":"Outer membrane vesicles: Versatile nanocarriers for therapeutic delivery and immune modulation","authors":"Jinlong Yang ,&nbsp;Tang Wang ,&nbsp;Yuekai Zheng ,&nbsp;Yuning Wei ,&nbsp;Juan Tao ,&nbsp;Zhongjian Chen ,&nbsp;Jianping Qi","doi":"10.1016/j.apsb.2026.01.033","DOIUrl":"10.1016/j.apsb.2026.01.033","url":null,"abstract":"<div><div>Outer membrane vesicles (OMVs) are nanoscale lipid-bilayer vesicles naturally released by Gram-negative bacteria. By packaging membrane proteins, lipopolysaccharide-derived pathogen-associated molecular patterns, nucleic acids, and metabolites, OMVs integrate intrinsic bioactivity with cargo capacity and have emerged as a versatile platform for therapeutic delivery and immune modulation. In this review, we summarize current understanding of OMV biogenesis, composition, and physicochemical features that shape biodistribution and immunogenicity. We then discuss engineering strategies ranging from genetic rewiring of parental strains and detoxification of lipid A to surface functionalization, hybrid membrane assembly, and stimuli-responsive formulations that enable controllable targeting, loading, and release. Recent progress is highlighted in anti-tumor therapy, nanovaccines for infectious diseases and cancer, and nucleic acid delivery for gene regulation. Finally, we analyze key barriers to clinical translation, including endotoxin-associated safety, batch-to-batch heterogeneity, scalable manufacturing, and standardization of quality attributes. Addressing these challenges through rational design and robust production pipelines will be essential to advance OMV-based therapeutics toward safe, effective, and manufacturable clinical products.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 1914-1942"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep eutectic solvents@enteric technology for orally delivering anticoagulant macromolecule drug","authors":"Xiaoke He ,&nbsp;Jiahui Zou ,&nbsp;Yuxin Jiang ,&nbsp;Runrui Liao ,&nbsp;Huiling Liao ,&nbsp;Yaping Liu ,&nbsp;Yueming Zhao ,&nbsp;Jing Yu ,&nbsp;Wei He","doi":"10.1016/j.apsb.2025.10.037","DOIUrl":"10.1016/j.apsb.2025.10.037","url":null,"abstract":"<div><div>Low-molecular-weight heparin (LMWH) is one of the most clinically used anticoagulants to improve venous circulation. However, LMWH requires repeated injections, leading to poor medication compliance. Herein, we developed a deep eutectic solvents (DESs)@enteric technology, an intestinal absorption promotion platform, for the oral administration of LMWH. DESs with geranic acid (Ge) and choline (Ch) were first synthesized and characterized. Then, the DES–LMWH complex was prepared with a DES_2:1 (Ge and Ch in a 2:1 molar ratio), demonstrating superior intestinal absorption and high biocompatibility. Finally, DES–LMWH was granulated and loaded into an enteric capsule. <em>In vitro,</em> DESs reversibly opened the tight junctions between intestinal epithelial cells, facilitating the paracellular transport of LMWH. <em>In vivo</em>, the DES–LMWH oral enteric capsule demonstrated an absolute bioavailability of 19.93%, reaching the venous thromboembolism (VTE) prophylaxis threshold and reducing the embolization area by 52.01% in a FeCl₃-induced rat femoral venous thrombosis model. In conclusion, DES@enteric technology effectively enhances the oral absorption of LMWH and holds promising translational potential.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2553-2569"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered bacteria reprogram tumor microenvironment via cell senescence and neutrophil extracellular traps degradation","authors":"Wanfa Dong ,&nbsp;Chenyang Li ,&nbsp;Jiqiang Lu ,&nbsp;Lin Weng ,&nbsp;Yicong Xu ,&nbsp;Min Xu ,&nbsp;Peiqi Li ,&nbsp;Yanhui Wu ,&nbsp;Zixuan Shan ,&nbsp;Pengyou Shang ,&nbsp;Liangliang Dai ,&nbsp;Tao Zhang ,&nbsp;Yanlong Jia ,&nbsp;Tianyun Wang ,&nbsp;Wenjie Ren ,&nbsp;Ping Lu ,&nbsp;Xiao Chen ,&nbsp;Zichun Hua","doi":"10.1016/j.apsb.2026.01.030","DOIUrl":"10.1016/j.apsb.2026.01.030","url":null,"abstract":"<div><div>Attenuated <em>Salmonella</em> VNP20009 (VNP) shows promising anti-cancer therapeutic potential. Limited understanding of its anti-tumor mechanism has hindered broader clinical application. Recent studies have reported cellular senescence is involved in tumor progression; however, its critical role in VNP therapy remains elusive. Our study revealed that VNP exerts anti-tumor growth and anti-angiogenesis effects by inducing cellular senescence in tumor cells and vascular endothelial cells. While VNP-induced senescence inhibits tumor growth, it concurrently promotes neutrophil extracellular traps (NETs), which paradoxically enhance tumor progression. To address this challenge, we engineered VNP-SNase, a novel variant capable of releasing the DNA-degrading enzyme <em>Staphylococcus aureus</em> nuclease directly within tumors. VNP-SNase significantly inhibited NETs formation across multiple tumor types, effectively promoted anti-tumor immunity, and exhibited improved tumor suppression effects with enhanced biosafety. Our findings elucidate the critical role of cellular senescence in VNP therapy and propose targeting NETs as a strategic approach to enhance the efficacy of VNP-based cancer treatments.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2332-2356"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author correction to “The crucial function of IDO1 in pulmonary fibrosis: from the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition” [Acta Pharmaceutica Sinica B 15 (2025) 3125–3148]","authors":"Lei Wang ,&nbsp;Shanchun Ge ,&nbsp;Ye Zhang ,&nbsp;Deqin Feng ,&nbsp;Ting Zhu ,&nbsp;Louqian Zhang ,&nbsp;Chaofeng Zhang","doi":"10.1016/j.apsb.2026.01.036","DOIUrl":"10.1016/j.apsb.2026.01.036","url":null,"abstract":"","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2598-2599"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications","authors":"Yue Yin ,&nbsp;Qiaoqiao Zhao ,&nbsp;Zihan Wang ,&nbsp;Zixuan Li ,&nbsp;Hening Liu ,&nbsp;Fatemeh Eghbalitabar ,&nbsp;Jing Shang ,&nbsp;Lu Tang ,&nbsp;Wei Wang","doi":"10.1016/j.apsb.2026.01.021","DOIUrl":"10.1016/j.apsb.2026.01.021","url":null,"abstract":"<div><div>Microneedles (MNs), as innovative biomedical devices, are undergoing a transformation from basic transdermal devices to intelligent and multifunctional systems. The advancement of intelligent MNs enhances tissue penetration and adhesion, triggers timely, on-demand and precise spatiotemporal controlled release, achieves sequential drug delivery and <em>in situ</em> monitoring, and enables close-loop theranostics <em>via</em> the integration of flexible electronics, wireless communication, and artificial intelligence. This review not only systematically highlights these cutting-edge breakthroughs, focusing on five major innovative advancements of conceptual design, including mimicking strategies, stimuli-responsive systems, innovative structural designs, living payload, and wearable integration, but also delineates the principal obstacles obstructing the advancement of intelligent MNs. We also emphasize that MN technology is fueling the evolution of next-generation medical paradigms based on its personalized, minimally invasive, and intelligent features through interdisciplinary integration, which is crucial for reshaping the future landscape of disease diagnosis and treatment.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 1804-1847"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIM: Discovery of novel RNA-targeting argonautes by self-iterative learning from scarce data","authors":"Shuze Peng ,&nbsp;Feiming Huang ,&nbsp;Nuolan Li ,&nbsp;Karl Luigi Loza Vidaurre ,&nbsp;Luer Chen ,&nbsp;Yu Yang ,&nbsp;Jiaying Hu ,&nbsp;Yanyu Kou ,&nbsp;Wei He ,&nbsp;Shiwei Wang ,&nbsp;Lei Shi ,&nbsp;Kehao Tao ,&nbsp;Bo Sun ,&nbsp;Xiaoxuan Song ,&nbsp;Hao Yang ,&nbsp;Hainan Zhang ,&nbsp;Lin Yang ,&nbsp;Zixin Deng ,&nbsp;Yanqiang Han ,&nbsp;Yan Feng ,&nbsp;Jinjin Li","doi":"10.1016/j.apsb.2026.01.009","DOIUrl":"10.1016/j.apsb.2026.01.009","url":null,"abstract":"<div><div>The limited repertoire of experimentally validated RNA-targeting nucleases has constrained both mechanistic studies and the efficient discovery of novel enzymes for RNA biotechnology. This challenge is particularly pronounced for prokaryotic Argonaute (Ago) proteins, where the scarcity of confirmed RNA-targeting members and a lack of clarity regarding RNA specificity determinants hinder systematic exploration. Although machine learning offers a potential solution, its application is often impeded by the scarcity of labeled training data in this field. To address these limitations, we developed the self-iterative hierarchical ensemble model (SIM), which integrates hierarchical ensemble learning with a self-training strategy. This approach bypasses the dependency on large-scale experimental datasets, allowing SIM to iteratively expand its predictive capability from minimal initial labeled data. When applied to prokaryotic Agos, SIM identified six high-confidence RNA-targeting candidates, five of which were experimentally validated (83% success rate). Notably, SIM identified three uncharacterized Agos harboring a novel N-terminal domain, defining a previously unrecognized subclass. Biochemical and <em>in vivo</em> validations of <em>Haloferax profundi</em> Ago (<em>Hp</em>Ago) confirmed its RNA cleavage activity and a distinctive RNA modification-sensing capability. We leveraged this latter finding to develop a rapid, cost-effective method for quantifying modified RNAs. Our study not only expands the repertoire of RNA-targeting tools but also establishes SIM as a generalizable framework for protein function prediction under data-scarce conditions. This work has broad implications for both RNA biotechnology and the application of machine learning in data-limited fields.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2282-2298"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in biomedical applications of lyotropic liquid crystals","authors":"Guojin Liu ,&nbsp;Yuanmei Yang ,&nbsp;Qing Wu ,&nbsp;Zhongjian Chen ,&nbsp;Nadia M. Hamdy ,&nbsp;Amr Amin ,&nbsp;Gang Chen ,&nbsp;Yi Lu","doi":"10.1016/j.apsb.2025.12.008","DOIUrl":"10.1016/j.apsb.2025.12.008","url":null,"abstract":"<div><div>Lyotropic liquid crystals (LLCs), formed through the self-assembly of amphiphilic molecules in polar solvents, offer thermodynamic stability and tunable mesophases (lamellar, hexagonal, and cubic), making them a versatile platform for biomedical applications. Their structural adaptability enables enhanced drug stability, improved bioavailability, and controlled release, which are advantageous for various therapeutic strategies. LLC-based systems have shown significant promise in drug delivery, long-acting therapies, anti-infective treatments, and wound healing. Their diverse formulation options, including gels, nanoparticles, and <em>in situ</em> forming precursors, support multiple routes of administration, such as oral, intravenous, dermal, ocular, and intranasal. This review summarizes recent advances in the design and functionalization of LLC systems, with a focus on their ability to overcome physiological barriers, enhance therapeutic efficacy, enable targeted delivery, and support prolonged treatment regimens. Challenges in clinical translation and future research directions are also discussed to facilitate the transition from bench to bedside.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2043-2067"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes","authors":"Yi Zhao ,&nbsp;Wei Ai ,&nbsp;Jieyu Zhao ,&nbsp;Xi Yang ,&nbsp;Wencheng Liu ,&nbsp;Yaru Ma ,&nbsp;Jianrui Mou ,&nbsp;Ao Hai ,&nbsp;Ran Ji ,&nbsp;Yu Gan ,&nbsp;Zhuang Miao ,&nbsp;Shilong Hu ,&nbsp;Zhenbo Huang ,&nbsp;Jin Liu ,&nbsp;Xianggen Liu ,&nbsp;Jun Yang ,&nbsp;Bowen Ke","doi":"10.1016/j.apsb.2026.01.008","DOIUrl":"10.1016/j.apsb.2026.01.008","url":null,"abstract":"<div><div>While transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety. Etomidate, introduced in the 1970s, remains favored for its minimal hemodynamic impact but is severely limited by sustained adrenal suppression, leading to higher mortality and poorer outcomes in critically ill patients. To address these challenges, we reframed our strategy from solely optimizing receptor specificity to enhancing metabolic efficiency, thereby reducing prolonged postoperative exposure and mitigating sustained adverse effects. Using a deep-learning based molecule optimization algorithm, we identified metabolically favorable lead compounds and synthesized 31 novel imidazole-based etomidate derivatives. Among these, ETO-4 emerged as the most promising candidate, retaining potent anesthetic activity while accelerating metabolic clearance and significantly diminishing adrenal suppression. Plasma cortisol assays confirmed the effect of ETO-4 on adrenal function is greatly reduced. These findings underscore a paradigm shift in anesthetic drug design, demonstrating that prioritizing enhanced metabolic profiles can yield safer, more effective agents that improve postoperative outcomes.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 2420-2443"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuproptosis-based nanomedicine in cancer metastasis synergistic therapy","authors":"Kan Zhou ,&nbsp;Zi-Zhan Li ,&nbsp;Yi Liu ,&nbsp;Lei-Ming Cao ,&nbsp;Han-Yue Luo ,&nbsp;Guang-Rui Wang ,&nbsp;Kang-Ning Wang ,&nbsp;Jinmei Wu ,&nbsp;Bing Liu ,&nbsp;Zhiyong Song ,&nbsp;Lin-Lin Bu","doi":"10.1016/j.apsb.2025.11.003","DOIUrl":"10.1016/j.apsb.2025.11.003","url":null,"abstract":"<div><div>Cancer metastasis is a critical indicator of cancer progression and serves as a major cause of cancer-related deaths. Cuproptosis is a novel form of regulated cell death proposed in 2022. Unlike ferroptosis and other known regulated cell deaths (RCDs), cuproptosis has a unique regulatory pathway, and its major biochemical features include copper overload, lipoylated tricarboxylic acid cycle protein aggregation, and the loss of iron-sulfur cluster protein. Cuproptosis-based nanomedicine provides novel therapeutic insights for metastatic cancer treatment. The close link between cuproptosis and cancer therapy has been explored, and several therapeutic strategies have been developed, including copper ionophores and drug delivery systems. Cuproptosis-based nanotherapeutic strategies may enable controlled and selective drug release, and through the multifaceted actions of copper metallocompounds, achieve multimodal theranostic modalities or organically synergize with other regulated RCD pathways. This integration enhances antitumor effects and biosafety, overcomes tumor resistance, and improves the tumor microenvironment. In this review, we systematically delineate the mechanisms of cuproptosis and its current therapeutic implications in metastatic malignancies. We further critically analyze these synergistic therapeutic approaches, prospect emerging applications of cuproptosis-based nanomedicine in metastatic oncology, and highlight their untapped therapeutic potential. Ultimately, we anticipate this exploration will inform innovative clinical management strategies for cancer patients with metastasis.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 4","pages":"Pages 1971-1990"},"PeriodicalIF":14.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147706335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling","authors":"Zhenhui Wu ,&nbsp;Yihao Wang ,&nbsp;Renjie Wang ,&nbsp;Rong Gao ,&nbsp;Shubei Li ,&nbsp;Bodan Tu ,&nbsp;Xiubing Yin ,&nbsp;Maoxing Li ,&nbsp;Wei Zhou ,&nbsp;Huanhua Xu ,&nbsp;Zhenfeng Wu ,&nbsp;Zengchun Ma ,&nbsp;Xianglin Tang ,&nbsp;Chengrong Xiao ,&nbsp;Yue Gao","doi":"10.1016/j.apsb.2025.12.024","DOIUrl":"10.1016/j.apsb.2025.12.024","url":null,"abstract":"<div><div>Hypobaric hypoxia-induced lung injury can exacerbate the incidence of plateau pulmonary edema, but relevant pharmacologic measures are relatively limited. Here, we investigate the possible role of paeoniflorin (Pae) in hypobaric hypoxia-induced lung injury. Through <em>in vivo</em> and <em>in vitro</em> experiments, we observed that Pae significantly ameliorated hypobaric hypoxia-triggered oxidative stress, inflammatory response, mitochondrial dysfunction and ferroptosis. Using limited proteolysis-mass spectrometry (LiP-MS), molecular docking, and molecular dynamics simulations, we identified that Pae directly binds to three amino acid residues (K101, D156, and S198) of the MEK2 protein. Knockdown of MEK2 expression <em>in vivo</em> and <em>in vitro</em> abrogated the protective effect of Pae. It was also observed that Pae promotes the binding of MEK2 and ERK2 and increases the phosphorylation level of ERK2, leading to its activation. This process induced upregulation of SGK1 and the protective effect of Pae against hypobaric hypoxic lung injury was dependent on SGK1. Collectively, these findings provide pharmacological evidence that Pae activates SGK1 by targeting MEK2 and mediating MEK2–ERK2 crosstalk, highlighting Pae’s potential as a promising therapeutic agent for hypoxic lung injury-related diseases.</div></div>","PeriodicalId":6906,"journal":{"name":"Acta Pharmaceutica Sinica. B","volume":"16 3","pages":"Pages 1466-1488"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147553439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}