海军军医大学学报最新文献

{"title":"Hand,foot and mouth disease in Yangpu District of Shanghai:an analysis of epidemiologic characteristics in 2009-2013","authors":"Peng Qiao, Jing-jing Hu, Min Liu, Fei Li, Lin Wang, Hongwei Zhang, Rong Zhang","doi":"10.3724/SP.J.1008.2015.00044","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00044","url":null,"abstract":"Objective To analyze the etiological and epidemiological characteristics of hand,foot and mouth disease(HFMD)in Yangpu District of Shanghai from 2009 to 2013,providing evidence for its prevention and control.Methods HFMD surveillance and report were done using the National Disease Supervision Information Management System.Descriptive epidemiological method was used to analyze the 2009-2013 epidemiologic characters and etiological characters(partial patients)of HFMD in Yangpu District,Shanghai.Nucleic acid of enterovirus(EV)genome was detected by real-time PCR in some patients.Results A total of 4 974 cases of HFMD were reported during 2009-2013 in Yangpu District,Shanghai,with the average annual incidence rate of 755.3per million,with no death cases and 9(0.18%)severe cases.The peak incidence was observed in the period of April to July.The epidemic peak had an increasing tendency and could be delayed.The incidence rates of HFMD were increased at an annual basis(Ptrend0.05)in all communities and were significantly different between different communities(P0.05).Most of the cases were less than 5-year-old scattered and childcare children.The main epidemic strains were EV71 and Cox A16 in 2010,and other enterovirus and Cox A16 in 2011-2013.The proportions of other enterovirus strains were increased,with overlapping phenomenon found in the pathogenic spectrum curves before and after the epidemic peak.Conclusion The 2009-2013 epidemiology of HFMD in Yangpu District of Shanghai had prominent seasonal,regional and population characteristics.Epidemic superiority strains vary annually and influence the epidemic trend and severity.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69842301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small bronchoscopic biopsy specimens for detecting EGFRgene mutations in advanced lung adenocarcinoma","authors":"Yunqiang Nie, Cui-yun Li, Na Li, Xiaoying Zhang, Hui Wang, Da-cai Guo, P. Han, Xin Lü, Shulan Liu, Changzheng Wang, Xinyi Xu","doi":"10.3724/SP.J.1008.2015.00049","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00049","url":null,"abstract":"Objective To examine epidermal growth factor receptor(EGFR)gene mutations in small bronchoscopic biopsy specimens,so as to provide guidance for clinical targeted therapy.Methods Fifty-six female patients with advancedstage Ⅲ B-Ⅳ lung adenocarcinoma underwent endoscopic endobronchial biopsy of tumor tissues or transbronchial needle aspiration of mediastinal and hilar lymph nodes.Under the endoscope,20 patients underwent only bronchial biopsy,28 underwent only transbronchial needle aspiration(TBNA)lymph node biopsy,and 8underwent both endobronchial biopsy and TBNA biopsy of mediastinal and hilar lymph nodes.A total of 64 specimens were collected and were subjected to detection of EGFR gene mutations after confirmation of lung adenocarcinoma.The specimens were then divided into endobronchial metastasis group and lymph node metastasis group,and the mutations of exons 19 and 21were detected and the clinical efficacy of targeted therapy was analyzed.Results Exon 19 had higher positive rate in the endobronchial metastasis group(χ2=4.304,P=0.038),and exon 21 had higher positive rate in lymph node metastasis group(χ2=18.727,P=0.000).A total of 24 cases were included for the clinical efficacy assessments:10had endobronchial metastasis(exon 19 mutations in 8cases,21 exon in 2cases),with the disease control rate being 90%(9/10)and median progression-free survival period being 14.8 months;14patients had lymph node metastasis(19exon 3cases,21 exon 11cases),with the disease control rate being 78.57%(11/14)and the median progression-free survival period being 9.2 months;the disease control rates were not significantly different between the two groups(P0.05)and the median progression-free survival periods were significantly different between the two groups(χ2= 4.134,P=0.042).Conclusion Mutations of different EGFRexons might relate to the metastasis forms of female advanced lung adenocarcinoma,with exon 19 prone to endobronchial metastasis and exon 21 to lymph node metastasis.Targeted therapy for patients with endobronchial metastasis has a better outcome than that for patients with lymph node metastasis.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"49"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69842917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual roles of Nemo-like kinase in tumor development and progression","authors":"Jian He, Wei Zhang","doi":"10.3724/SP.J.1008.2015.00069","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00069","url":null,"abstract":"Nemo-like kinase(NLK)is an evolutionarily conserved mitogen activated protein kinase-like kinase,belonging to serine/threonine protein kinase superfamily.By participating in Wnt,Notch,FoxO and other pathways,NLK can regulate cell proliferation,differentiation,morphological changes,early embryonic development of vertebrate nervous system,and other biological processes.NLK is also a key molecule in tumor regulation and its roles vary in different tumors.In prostate cancer,non-small cell lung cancer,ovarian cancer,and breast cancer,NLK plays an inhibitory role,while it plays opposite roles in oral squamous cell carcinoma,hepatocellular carcinoma,and the bile duct tumors.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"69"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69843501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death and potential years of life lost of residents living in Yubei District of Chongqing City in 2012: an analysis on the main causes","authors":"W. Huang, Wen Wang, Wei Feng, Ling-li Hang, Yu Chen","doi":"10.3724/SP.J.1008.2015.00095","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00095","url":null,"abstract":"Objective To understand the main causes of death and the potential years of life lost(PYLL)of residents living in Yubei District of Chongqing,so as to provide evidence for disease control and health promotion.Methods The data of the death cases were classified according to ICD-10 method and were subjected to analysis by DeathReg2005 software.The characteristics of death of our population were analyzed using the following parameters:the crude mortality,proportions of death due to different reasons,order of death causes and the PYLL,etc.Results The crude death rate of residents in our study was 605.02 per 100 000 in 2012,with the standardized death rate being 440.72 per 100 000;and the mortality was higher in males than in females(χ2=227.87,P0.001).The top five causes of deaths in order were:circular system diseases,malignant tumors,respiratory system diseases,injury and poisoning,and digestive system diseases;these 5causes contributed to 95.15%of all death causes.The top six causes of PYLL in order were:malignant tumors,injury and poisoning,circular system diseases,respiratory system diseases,perinatal system diseases,and digestive system diseases.The main causes of death among different ages have their own characteristics.Conclusion The predominant causes of death among residents in our study include chronic non-infectious diseases(circular system diseases and malignant tumors);injuries and poisoning,especially death due to traffic accident,are the major causes among young adults.Appropriate preventive and interventional measures should be taken based on the death causes of residents.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69843546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doubled dose rosuvastatin or rosuvastatin combined with probucol for treatment of patients with coronary artery disease and hypercholesterolemia: a comparison of effectiveness","authors":"Yang Lu, Mingxing Lei, Miao Xu, Xianxian Zhao, Song-hua Li","doi":"10.3724/SP.J.1008.2015.00083","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00083","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69843919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of vascular adhesion protein-1 in severe hemorrhagic shock and resuscitation in rats","authors":"Jun-Yan Yao, Wei Yi, Z. Ya, C. Qian, Zhi Hu","doi":"10.3724/SP.J.1008.2015.00124","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00124","url":null,"abstract":"Objective To observe the expression and activity changes of vascular adhesion protein-1(VAP-1)in the small intestine and serum of rats during severe hemorrhagic shock and resuscitation,and to study its influence on shock prognosis.Methods Fifty rats were evenly randomized into sham group,hemorrhagic shock group,shock resuscitation group,control recovery group and the experimental recovery group.Rat models of severe hemorrhagic shock and resuscitation were established.Before shock,1hour after shock and 1hour after resuscitation,the expressions of VAP-1protein and mRNA in the intestinal tissues of rats were examined by Western blotting analysis and real-time RT-PCR,respectively;and the serum levels of VAP-1and its activities were determined by ELISA kit.Rats in the experimental recovery group was resuscitated by injection of 20mg/kg2-bromoethylamine and those in the control recovery group were given 1 mL/kg normal saline,and then the blood pressure,intestinal mucosa injury(Chiu's score),small intestinal epithelial cell apoptosis(TUNEL detection)and 24-hour survival rates were compared between the two recovery groups.Results The intestinal VAP-1protein and mRNA expressions and the serum VAP-1and its activities in the severe hemorrhagic shock group were significantly higher than those in the sham shock group(P0.05).Compared with the shock group,the above parameters were decreased in the recovery group,but were still higher than those in the sham group.Compared with the saline control group,20mg/kg 2-bromoethylamine significantly increased the blood pressure of animals 1hand 24 hafter recovery(P=0.010,0.039),significantly improved the Chiu's score and apoptosis index of small intestinal epithelial cells(P=0.022,P=0.002),and improved the 24-hour survival rates of rats(90%to 60%).Conclusion The levels of VAP-1and its activities are increased in severe hemorrhagic shock rats,and fluid resuscitation can inhibit this increase.Inhibition of VAP-1activities can improve the low blood pressure,intestinal mucosa injury and apoptosis of small intestinal mucosa cells after the severe hemorrhagic shock and resuscitation,improving the 24-hour survival rates of rats.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"124"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of mathematics model for differentiating benign and malignant solitary pulmonary nodules","authors":"Juanjuan Yang, Xuewei Sun, Guobin Lai, Hui-zhen Yu, Qiang Li, Yi-ping Han","doi":"10.3724/SP.J.1008.2015.00407","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00407","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"407"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69846578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment for basilar tip aneurysms associated with moyamoya disease","authors":"Yan Chen, Dai Dongwei, Yibin Fang, Qinghai Huang, Wen-yuan Zhao, Jianmin Liu","doi":"10.3724/SP.J.1008.2015.00330","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00330","url":null,"abstract":"Objective To assess the safety and efficacy of endovascular treatment for basilar tip aneurysms associated with moyamoya disease.Methods Seven patients with basilar tip aneurysms associated with moyamoya disease were treated by endovascular embolization in our department between Oct.2006 and Jul.2013.Two patients were treated by pure coiling and the others were treated by stent-assisted coiling.The immediate angiographic result was evaluated by Raymond scale.Postoperative angiographic and clinical follow-ups were obtained in all the 7cases,and the clinical outcomes were evaluated by the modified Rankin score(mRS).Results All the 7 patients successfully received endovascular embolization without procedure-related complications.Immediate angiographic results showed complete occlusion in 3cases,neck residual in 2,and partial occlusion in 2.Postoperative angiographic follow-ups were obtained for a mean of(10.4±3.5)months,with complete occlusion found in 6patients and stable in 1patient.No progressive thrombosis or in-stent occlusion were detected by follow-up angiograms in the stent group.Clinical follow-ups were obtained for a mean of(21.1±15.8)months and all the patients reported good outcomes(mRS 0-2).Conclusion Our data suggest that endovascular embolization is a safe and efficient treatment for basilar tip aneurysms associated with moyamoya disease.Stent-assistance might be a safe and effective option for the large or wide-necked aneurysms,though the long-term safety still remains to be confirmed.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"330"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69845298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of hepatitis B virus mutation, somatic mutations of hosts and related immune genetics in liver cirrhosis and hepatocellular carcinoma","authors":"Zi-xiong Li, R. Pu, Yan Du, G. Cao","doi":"10.3724/SP.J.1008.2015.00367","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00367","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"367"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69845616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of anatomic liver resection on prognosis of patients with hepatocellular carcinoma","authors":"Jin-long Huang, Qing Wang, Yong Yu, Xiaoqing Jiang, Xiang-ji Luo","doi":"10.3724/SP.J.1008.2015.00492","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00492","url":null,"abstract":"Objective To explore the effect of anatomic liver resection(AR) and non-anatomic liver resection(NAR) on the prognosis of patients with hepatocellular carcinoma(HCC).Methods The clinical data of 721 HCC patients,who were treated between July 2008 to July 2009,were collected from Eastern Hepatobiliary Surgery Hospital; the patients included 317 undergoing AR and 404 undergoing NAR.The prognosis of the patients was compared between the two groups by using the Kaplan-Meier method and log-rank test.The influence factors of the prognosis were analyzed by using the Cox proportional hazards regression model.The propensity score matching method was used to eliminate the selection bias in clinical and pathological features.Results The 1-year,3-year and 5-year overall survival(OS) rates of the 721 patients were 85.9%,64.7% and 51.5%,respectively; and the 1-year,3-year and 5-year disease free survival(DFS) rates were 59.3%,34.0% and 25.5%,respectively.AR conferred better OS than NAR(93.1%,74.5% and 62.5% vs 80.2%,56.8% and 42.9%,P 0.001,respectively); the same was also true for DFS rates(69.3%,41.3% and 34.9% vs 51.4%,38.3% and 18.7%,P 0.001,respectively).After propensity matching,AR still achieved better prognosis than NAR(OS rates: 93.9%,73.3%,and 59.4% vs 86.0%,62.8%,52.8%,P = 0.010; DFS rates: 67.9%,37.5%and 31.3% vs 56.8%,33.1% and 22.6%,P = 0.024).The results of multivariate analysis showed that the tumor size,tumor number,capsule,liver cirrhosis,microvascular invasion,and method of liver resection were the independent risk factors of OS; and blood transfusion,tumor size,tumor number,capsule,liver cirrhosis,microvascular invasion,and method of liver resection were the independent risk factors of DFS.However,the OS and DFS rates were not significantly different between AR and NAR groups in patients with hepatocirrhosis(P = 0.767 and P = 0.638,respectively).AR group achieved better prognosis than NAR group in the HCC patients without cirrhosis(P 0.001).Conclusion AR can achieve better prognosis than NAR in HCC patients,but for patients with hepatocirrhosis NAR should be recommended in order to retain better liver function.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"492"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69847686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}