Dual roles of Nemo-like kinase in tumor development and progression

Q4 Medicine

第二军医大学学报 Pub Date : 2015-01-01 DOI:10.3724/SP.J.1008.2015.00069

Jian He, Wei Zhang

引用次数: 0

Abstract

Nemo-like kinase(NLK)is an evolutionarily conserved mitogen activated protein kinase-like kinase,belonging to serine/threonine protein kinase superfamily.By participating in Wnt,Notch,FoxO and other pathways,NLK can regulate cell proliferation,differentiation,morphological changes,early embryonic development of vertebrate nervous system,and other biological processes.NLK is also a key molecule in tumor regulation and its roles vary in different tumors.In prostate cancer,non-small cell lung cancer,ovarian cancer,and breast cancer,NLK plays an inhibitory role,while it plays opposite roles in oral squamous cell carcinoma,hepatocellular carcinoma,and the bile duct tumors.

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nemo样激酶在肿瘤发生和发展中的双重作用

Nemo-like kinase(NLK)是一种进化保守的丝裂原活化蛋白激酶样激酶，属于丝氨酸/苏氨酸蛋白激酶超家族。NLK通过参与Wnt、Notch、FoxO等通路，调节细胞增殖、分化、形态改变、脊椎动物神经系统早期胚胎发育等生物学过程。NLK也是肿瘤调控的关键分子，其在不同肿瘤中的作用各不相同。在前列腺癌、非小细胞肺癌、卵巢癌和乳腺癌中，NLK发挥抑制作用，而在口腔鳞状细胞癌、肝细胞癌和胆管肿瘤中，NLK发挥相反的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

第二军医大学学报 Medicine-Medicine (all)

CiteScore

0.50

自引率

0.00%

发文量

14752

期刊介绍： Founded in 1980, Academic Journal of Second Military Medical University(AJSMMU) is sponsored by Second Military Medical University, a well-known medical university in China. AJSMMU is a peer-reviewed biomedical journal,published in Chinese with English abstracts.The journal aims to showcase outstanding research articles from all areas of biology and medicine,including basic medicine(such as biochemistry, microbiology, molecular biology, genetics, etc.),clinical medicine,public health and epidemiology, military medicine,pharmacology and Traditional Chinese Medicine),to publish significant case report, and to provide both perspectives on personal experiences in medicine and reviews of the current state of biology and medicine.