Acta medica Indonesiana最新文献

{"title":"Validation of Spleen Stiffness Measurement for Screening of High-risk Esophageal Varices Among Cirrhotic Patients in Indonesia: A Single-Center Cross-sectional Study.","authors":"Saut Horas Hatoguan Nababan, Gita Aprilicia, Pitt Akbar, Kemal Fariz Kalista, Chyntia Olivia Maurine Jasirwan, Juferdy Kurniawan, Cosmas Rinaldi A Lesmana, Andri Sanityoso Sulaiman, Irsan Hasan, Rino Alvani Gani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Spleen stiffness measurement (SSM) is a recently developed non-invasive method for predicting clinically significant portal hypertension and esophageal varices in compensated advanced liver disease or cirrhosis. This study aims to validate the accuracy of SSM for screening high-risk esophageal varices among cirrhotic patients in Indonesia.</p><p><strong>Methods: </strong>This is a single-center, cross-sectional study. Patients with liver cirrhosis who underwent endoscopy at Cipto Mangunkusumo Hospital, Jakarta were included. Clinical data and data from laboratory tests, endoscopy, liver, and spleen stiffness measurement by transient elastography (TE) were collected. A 100 Hz spleen-dedicated TE probe was used for SSM.</p><p><strong>Results: </strong>Of 86 patients, 52 had high-risk esophageal varices. The median (IQR) value of SSM were significantly higher in patients with high-risk varices [36.1 kPa (IQR 21.5-59.1) vs. 70.3 kPa (IQR (52.2-86.0); p<0.001). SSM with a low cutoff value of 20 kPa had sensitivity and negative predictive value of 98.1% and 87.5%, respectively. The high cutoff value of 70 kPa had specificity and positive predictive value of 82.4% and 81.3%, respectively.</p><p><strong>Conclusion: </strong>SSM is useful for screening high-risk esophageal varices. Furthermore, the new dual cutoff value can help rule-in and rule-out high-risk esophageal varices among cirrhotic patients in Indonesia.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 3","pages":"276-281"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with the Colonization of Multidrug-Resistant Gram-Negative Bacteria Upon Admission to the Intensive Care Unit: A Cross-sectional Study.","authors":"Nina Sania, Yulia Rosa Saharman, Delly Chipta Lestari, Dita Aditianingsih, Andi Yasmon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Multidrug-resistant Gram-negative bacteria (MDR-GNB) are prevalent in intensive care units (ICUs), leading to increased morbidity and mortality. Limited data on MDR-GNB in Indonesia prompted this study to determine the prevalence and risk factors associated with MDR-GNB colonization, enhancing screening strategies, and acquiring phenotypic and genotypic data on these bacteria.</p><p><strong>Methods: </strong>This analytical cross-sectional observational study included participants who met the criteria and were admitted to the ICU at Dr. Cipto Mangunkusumo Hospital from January to December 2022. We used multivariate analysis on the findings from rectal swab screening, sociodemographic, clinical, and microbiological examinations.</p><p><strong>Results: </strong>Out of 108 participants, 172 cultures comprised 165 Gram-negative isolates, four yeasts, and three with no growth. The prevalence of patients colonized with MDR-GNB was 51.85% (56/108), and the prevalence of MDR-GNB isolates was 39.53% (68/172), with the most common MDR-GNB being Escherichia coli (29.65%) and Klebsiella pneumoniae (19.44%). The most resistant gene found in ESBL was CTX-M (75%), and the carbapenemase producer gene was NDM (5.88%). Risk factors associated with MDR-GNB colonization were the length of stay before admission to the ICU (p = 0.003) and a history of previous antibiotic therapy (p = 0.036).</p><p><strong>Conclusion: </strong>In this study, two risk factors were associated with the occurrence of MDR-GNB colonization, with the prevalence of MDR-GNB colonization in patients initially admitted to the ICU still quite high. Therefore, selecting screening patients based on risk factors at the time of initial admission to the ICU is crucial for infection control programs.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 3","pages":"330-340"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between COVID-19 History and Arterial Vascular Elasticity Measured Using Accelerated Photoplethysmograph Analyzer in Medical Students.","authors":"Tasya Zuhriya Putri, Nurfitri Bustamam, Tri Faranita, Agneta Irmarahayu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 is a global health issue that can affect the cardiovascular system at various levels and cause damage to the endothelium, leading to decreased arterial elasticity and vascular dysfunction. This study investigates the relationship between COVID-19 history and arterial vascular elasticity in medical students.</p><p><strong>Methods: </strong>This study used a case-control design and a purposive random sampling technique. Data on COVID-19 history and characteristics of the subjects were collected using questionnaires, while arterial vascular elasticity was measured using the accelerated photoplethysmograph (APG) analyzer, SA-3000P. The sample consisted of 24 COVID-19 survivors (case) and 24 subjects without COVID-19 history (control).</p><p><strong>Results: </strong>This study found that three subjects (6.25%) had optimal arterial vascular elasticity, 28 subjects (58.3%) had normal elasticity, and 17 subjects (35.45%) had sub-optimal elasticity. No significant differences were found in age, gender, physical activity, dietary habits, body mass index, and family history of hypertension, diabetes mellitus, heart disease, and obesity between the case and control groups (p > 0.05). The Chi-square test results showed a significant relationship between COVID-19 history and arterial vascular elasticity (p = 0.003; OR = 9.8; CI = 2.2-42.0).</p><p><strong>Conclusion: </strong>COVID-19 survivors are nine times more likely to have sub-optimal arterial vascular elasticity compared to those who have not been infected with the virus. COVID-19 survivors are advised to adopt healthy lifestyles and undergo regular check-ups to mitigate the risk of developing vascular diseases.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 3","pages":"322-329"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Rupture of Abdominal Aorta Pseudoaneurysm: a Case Report.","authors":"Dono Antono, David Hutagaol, Nindya Pbs Utami, Jatmiko Gustinanda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pseudoaneurysms are false aneurysms that mostly occur at the site of arterial injury. Pseudoaneurysm is the most frequent complication after catheter-associated interventions and occurs because of an insufficient closure of the puncture site. However, there are several reported cases of patients with pseudoaneurysm without a prior history of vascular intervention. We described a case of ruptured giant abdominal aortic pseudoaneurysm in a patient with no prior history of vascular intervention, with an initial complaint of abdominal pain. The patient successfully received EVAR therapy using a kissing graft.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"206-209"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Genedrive in Point of Care Method For Hepatitis C Elimination in Hemodialysis Center.","authors":"Andri Sanityoso Sulaiman, Nuri Dyah Indrasari, Ni Made Hustrini, Desti Rachmani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Point of care is laboratory testing conducted close to the site of the patient. Point of care assessment is essential to detect and treat the hepatitis C virus in a single visit. The potential use of Genedrive extends to remote areas and key populations Therefore, there is a need for a simple, and cost-effective examination of methods, such as Genedrive. Genedrive is a rapid and low-cost diagnostic tool for the identification and treatment selection of infectious diseases. The World Health Organization targets to eliminate hepatitis by 2030, which decreases infections by 90%, and decreases deaths by 65%. Point of care could play a significant role in contributing to the elimination of hepatitis C. Chronic kidney disease (CKD) patients on hemodialysis are among the population at risk of hepatitis C due to nosocomial transmission. This study aimed to assess the role of Genedrive in measuring hepatitis C in chronic hepatitis C patients with chronic kidney disease on hemodialysis.</p><p><strong>Methods: </strong>This study used a cross-sectional design. There were 64 CKD on Hd patients in Cipto Mangunkusumo Hospital tested by Genedrive. ROC analysis was conducted to assess significant hepatitis C among chronic kidney disease on hemodialysis.</p><p><strong>Results: </strong>The calculated detection limit of Genedrive was 3.1x103 IU/mL. Genedrive HCV assay showed 90.6% sensitivity, 96.8% specificity, 92% negative predictive value, and 97% positive predictive value to detect HCV, 10.36 positive likelihood ratio, and 0.09 negative likelihood ratio.</p><p><strong>Conclusion: </strong>Genedrive could be a simple and reliable point of care method to detect hepatitis C with chronic kidney disease on hemodialysis.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"185-190"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotypic Analysis of Transmitted and Acquired HIV Drug Resistance in People Living with HIV/AIDS in Surabaya, Indonesia, from 2018 to 2019.","authors":"Brian Eka Rachman, Ni Luh Ayu Megasari, Siti Qamariyah Khairunisa, Tomohiro Kotaki, M Vitanata Arfijanto, Usman Hadi, Nasronudin Nasronudin, Masanori Kameoka","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of various effective antiretroviral (ARV) drugs, human immunodeficiency virus (HIV) infection has come with HIV drug resistance (HIVDR), which compromises its effectiveness in reducing HIV-related morbidity, mortality, and transmission. The emergence of transmitted (TDR) and acquired HIVDR (ADR) among antiretroviral therapy (ART)-naïve and experienced individuals have been reported in several Indonesian regions. Therefore, continuous HIVDR surveillance is needed in Indonesia, especially in Surabaya, which is identified as having the highest prevalence of HIV infection in East Java; thus, this study aimed to identify the emergence of TDR and ADR among people living with HIV/acquired immune deficiency syndrome (AIDS) (PLWHA).</p><p><strong>Methods: </strong>Fifty-eight PLWHA infected with HIV type 1 (HIV-1), comprising 21 and 37 ART-naïve and experienced individuals were enrolled in this study, respectively. Blood samples collected from study participants were subjected to genotypic analysis, mainly towards the pol gene encoding protease (PR gene) and reverse transcriptase (RT gene) of HIV-1.</p><p><strong>Results: </strong>Seventeen PR and 21 RT genes were successfully amplified and sequenced from 29 samples. HIV-1 subtyping revealed CRF01_AE as the most dominant subtype (24/29; 82.76%), followed by subtype B (3/29; 10.34%). Uncommon subtypes, including subtype D and a recombinant containing subtypes B and G genomic fragments, were also identified. TDR for PR inhibitors was not detected; however, TDR and ADR for RT inhibitors were identified in 11.11% and 41.67% of samples, respectively. Two amino acid insertions at position 69 of the RT gene (69ins), a previously never-reported mutation in Indonesia, were identified in this study.</p><p><strong>Conclusion: </strong>Both TDR and ADR have emerged among PLWHA residing in Surabaya, East Java, Indonesia. Uncommon drug-resistance mutations and subtypes were identified in this study. These situations might hamper ART efficacy and treatment success. Continuous surveillance of HIVDR is necessary to monitor both TDR and ADR in Indonesia.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"168-175"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kikuchi-Fujimoto Disease Preceding Overlap Syndrome of Sjögren's Syndrome and Systemic Lupus Erythematosus: Literature Review Based on a Case Report.","authors":"Cindy Cindy, Suryo Anggoro Kusumo Wibowo, Anna Ariane, Rudy Hidayat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting histiocytic necrotizing lymphadenitis systemic disorder with unknown etiology. KFD has been known for half a century, but difficulties in distinguishing it remain. Its diagnostic significance is related to the increasing prevalence of KFD with autoimmune diseases in various timeframes. Systemic lupus erythematosus (SLE) is the most prevalent autoimmune connective tissue disease (AICTD) appearing alongside KFD. An 18-year-old female presented with acute muscle weakness, shortness of breath, fever, and significant weight loss for 5 months before admission. Pain and morning joint stiffness had been felt for 9 months. One year ago, she lumped her right neck and was diagnosed with KFD from the excision biopsy and immunohistochemical staining (CD68). Creatine-kinase enzymes and C-Reactive protein were elevated with a high anti-Ku and anti-Jo-1 negative level. There was a low level of complements, high anti-nuclear antibody titer, with positive anti-SS-A. Sialometry and Schirmer test showed reduced salivary and lacrimal gland production. We diagnosed this patient as having an overlap syndrome preceded by KFD. The AICTD involved was Sjögren's syndrome and SLE. Although KFD is considered a self-limiting disease, its occurrence should be noticed regarding the possibility of other autoimmune conditions. KFD usually coincides with AICTD, although it could also precede or occur afterward. This case is reported to raise awareness of the overlap syndrome preceded by KFD.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"210-217"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Survival Analysis of COVID-19 Among Health Care Workers in West Jakarta Hospital.","authors":"Virmandiani Virmandiani, Asri C Adisasmita, Febby Elvanesa Sandra Dewi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The first two cases of Coronavirus Disease 2019 (COVID-19) were identified in Indonesia on March 2nd, 2020. Health Care workers (HCWs) are at risk of contracting COVID-19 infection. This study analyzed the risk factors, compared the prevalence rate of COVID-19 between HCWs and non-HCWs, and investigated survival analysis describing the time risk of COVID-19.</p><p><strong>Methods: </strong>This prospective cohort study retrieved data from the Hospital Surveillance Team (one of the largest hospitals in West Jakarta) which were analyzed using descriptive, bivariate analysis, Survival Analysis through the Kaplan-Meier method, and multivariate Cox analysis.</p><p><strong>Results: </strong>Observations were conducted on 1,080 employees from March 2021 to March 2022. There were 192 employees (17.78%) of 40±11 years tested positive for COVID-18, of which 126 cases (16.84%) were HCWs of ≤ 40 years of age, with females dominating. There was no difference between HCW and Non-HCW; ARR=1.08; [95% IK, 0.83-1.43]; p=0.591. Workers on shift work (> 38 hours in a week) were likely to be affected by COVID-19 with RR=1.37; [95% IK, 1.06-1.78]; p=0.018. Kaplan-Meier method and the log-rank test showed the difference between Shift and Non-shift groups HR=1.43; [95% IK 1.06-1.94]; p=0.019. Asthma or Chronic Obstructive Pulmonary Disease appeared as the independent factor of COVID-19 infection with RR=1.82; [95% IK, 1.10-3.02]; p=0.031.</p><p><strong>Conclusion: </strong>The probability of contracting COVID-19 was found equal to HCW and Non-HCW. Employees who are on shifts have a greater probability of contracting COVID-19. Survival analysis showed a statistically different Hazard Ratio between shifts with Non-shift workers.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"145-154"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Follicular Lymphoma: Complete Remission After Chemoimmunotherapy with Bendamustine-Rituximab.","authors":"Wulyo Rajabto, Agnes Stephanie Harahap, Handy Nugraha Putra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in Western countries after diffuse large B-cell lymphoma. Most patients with FL present with asymptomatic disease. Survival rates have been rising over time mainly due to advancing therapeutic strategiesA-51-year-old male with a history of well-controlled diabetes mellitus treated with insulin presented to the policlinic of hematology-medical oncology with worsening right inguinal lymphadenopathy for >3 months. He had no complaints of prolonged fever, night sweat, or weight loss. Initial physical examination revealed a healthy male with bulky right inguinal lymphadenopathy. The patient was then referred to a surgeon, and excisional biopsy of the enlarged right inguinal lymph nodes was performed. Therefore, stage II bulky symptomatic low-grade FL was established. We administered chemoimmunotherapy with rituximab and bendamustine every 3 weeks for six cycles. The patient tolerated the treatment well and completed six cycles of chemoimmunotherapy, and the follow-up FDG PET/CT showed complete remission of the disease.The patient achieved complete remission after series of chemoimmunotherapy with Bendamustine-Rituximab. Future assessment is still required for this patient to ensure the remission status of the lymphoma.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"249-252"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Corticosteroid as an Adjunct for Acute Respiratory Distress Syndrome in Non-Fatal Fresh Water Drowning: An Evidence-based Case Report.","authors":"Eric Daniel Tenda, Joshua Henrina, Andry Setiadharma, Ceva Wicaksono Pitoyo, Mira Yulianti, Raden Fidiaji Hiltono Santoso, Kuntjoro Harimurti, Czeresna Heriawan Soejono","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Acute lung injury or acute respiratory distress syndrome (ARDS) is one of the most common complications of non-fatal drowning. Although respiratory societies' guidelines endorse the role of systemic corticosteroids in ARDS, the evidence for systemic corticosteroid use in ARDS due to non-fatal drowning is limited.</p><p><strong>Methods: </strong>A search was conducted on Pubmed, OVID, and EuropePMC, assessing the clinical question using inclusion and exclusion criteria. The selected studies were critically appraised, and the results were summarized.</p><p><strong>Results: </strong>A total of six retrospective studies were selected and assessed, all studies showed poor validity and a high risk of bias. Out of six studies, only four informed us of steroid administration's effect on outcomes. In two studies, mortality associated with corticosteroid administration seemed to be higher. On the contrary, one study found no mortality in the corticosteroid group, but 100% mortality was observed in the control group. In another study, steroid therapy seemed to not affect hospital length of stay or mechanical ventilation rates.</p><p><strong>Conclusion: </strong>Corticosteroid administration for non-fatal drowning and its impact on clinical outcomes remains equivocal. Routine administration of corticosteroids is not indicated and should be done on a case-by-case basis.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"56 2","pages":"253-259"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}