世界胃肠病理生理学杂志(电子版)(英文版)最新文献_第3页

Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine. 缓激肽诱发豚鼠小肠粘膜氯离子分泌的神经生理机制。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.150

Mei-Hua Qu, Wan-Sheng Ji, Ting-kun Zhao, Chunyan Fang, Shu-Mei Mao, Zhiqin Gao

{"title":"Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine.","authors":"Mei-Hua Qu, Wan-Sheng Ji, Ting-kun Zhao, Chunyan Fang, Shu-Mei Mao, Zhiqin Gao","doi":"10.4291/wjgp.v7.i1.150","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.150","url":null,"abstract":"AIM\u0000To investigate the mechanism for bradykinin (BK) to stimulate intestinal secretomotor neurons and intestinal chloride secretion.\u0000\u0000\u0000METHODS\u0000Muscle-stripped guinea pig ileal preparations were mounted in Ussing flux chambers for the recording of short-circuit current (Isc). Basal Isc and Isc stimulated by BK when preincubated with the BK receptors antagonist and other chemicals were recorded using the Ussing chamber system. Prostaglandin E2 (PGE2) production in the intestine was determined by enzyme immunologic assay (EIA).\u0000\u0000\u0000RESULTS\u0000Application of BK or B2 receptor (B2R) agonist significantly increased the baseline Isc compared to the control. B2R antagonist, tetrodotoxin and scopolamine (blockade of muscarinic receptors) significantly suppressed the increase in Isc evoked by BK. The BK-evoked Isc was suppressed by cyclooxygenase (COX)-1 or COX-2 specific inhibitor as well as nonselective COX inhibitors. Preincubation of submucosa/mucosa preparations with BK for 10 min significantly increased PGE2 production and this was abolished by the COX-1 and COX-2 inhibitors. The BK-evoked Isc was suppressed by nonselective EP receptors and EP4 receptor antagonists, but selective EP1 receptor antagonist did not have a significant effect on the BK-evoked Isc. Inhibitors of PLC, PKC, calmodulin or CaMKII failed to suppress BK-induced PGE2 production.\u0000\u0000\u0000CONCLUSION\u0000The results suggest that BK stimulates neurogenic chloride secretion in the guinea pig ileum by activating B2R, through COX increasing PGE2 production. The post-receptor transduction cascade includes activation of PLC, PKC, CaMK, IP3 and MAPK.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Small bowel neuroendocrine tumors: From pathophysiology to clinical approach. 小肠神经内分泌肿瘤:从病理生理学到临床方法。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.117

S. Xavier, B. Rosa, J. Cotter

{"title":"Small bowel neuroendocrine tumors: From pathophysiology to clinical approach.","authors":"S. Xavier, B. Rosa, J. Cotter","doi":"10.4291/wjgp.v7.i1.117","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.117","url":null,"abstract":"Neuroendocrine tumors (NETs), defined as epithelial tumors with predominant neuroendocrine differentiation, are among the most frequent types of small bowel neoplasm. They represent a rare, slow-growing neoplasm with some characteristics common to all forms and others attributable to the organ of origin. The diagnosis of this subgroup of neoplasia is not usually straight-forward for several reasons. Being a rare form of neoplasm they are frequently not readily considered in the differential diagnosis. Also, clinical manifestations are nonspecific lending the clinician no clue that points directly to this entity. However, the annual incidence of NETs has risen in the last years to 40 to 50 cases per million probably not due to a real increase in incidence but rather due to better diagnostic tools that have become progressively available. Being a rare malignancy, investigation regarding its pathophysiology and efforts toward better understanding and classification of these tumors has been limited until recently. Clinical societies dedicated to this matter are emerging (NANETS, ENETS and UKINETS) and several guidelines were published in an effort to standardize the nomenclature, grading and staging systems as well as diagnosis and management of NETs. Also, some investigation on the genetic behavior of small bowel NETs has been recently released, shedding some light on the pathophysiology of these tumors, and pointing some new directions on the possible treating options. In this review we focus on the current status of the overall knowledge about small bowel NETs, focusing on recent breakthroughs and its potential application on clinical practice.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4291/wjgp.v7.i1.117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis. 一氧化氮在巴雷特相关癌变发病机制中的作用。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.131

G. Kusaka, K. Uno, K. Iijima, T. Shimosegawa

{"title":"Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis.","authors":"G. Kusaka, K. Uno, K. Iijima, T. Shimosegawa","doi":"10.4291/wjgp.v7.i1.131","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.131","url":null,"abstract":"Barrett's esophagus (BE), a premalignant condition to Barrett's adenocarcinoma (BAC), is closely associated with chronic inflammation due to gastro-esophageal reflux. Caudal type homeobox 2 (CDX2), a representative marker of BE, is increased during the metaplastic and neoplastic transformation of BE. Nitric oxide (NO) has been proposed to be a crucial mediator of Barrett's carcinogenesis. We previously demonstrated that CDX2 might be induced directly under stimulation of large amounts of NO generated around the gastro-esophageal junction (GEJ) by activating epithelial growth factor receptor in a ligand-independent manner. Thus, we reviewed recent developments on the role of NO in Barrett's carcinogenesis. Notably, recent studies have reported that microbial communities in the distal esophagus are significantly different among groups with a normal esophagus, reflux esophagitis, BE or BAC, despite there being no difference in the bacterial quantity. Considering that microorganism components can be one of the major sources of large amounts of NO, these studies suggest that the bacterial composition in the distal esophagus might play an important role in regulating NO production during the carcinogenic process. Controlling an inflammatory reaction due to gastro-esophageal reflux or bacterial composition around the GEJ might help prevent the progression of Barrett's carcinogenesis by inhibiting NO production.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Intra-abdominal pressure: Time ripe to revise management guidelines of acute pancreatitis? 腹内压：修订急性胰腺炎管理指南的时机是否成熟？

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.186

Jiten Jaipuria, Vimal Bhandari, Avneet Singh Chawla, Mohit Singh

{"title":"Intra-abdominal pressure: Time ripe to revise management guidelines of acute pancreatitis?","authors":"Jiten Jaipuria, Vimal Bhandari, Avneet Singh Chawla, Mohit Singh","doi":"10.4291/wjgp.v7.i1.186","DOIUrl":"10.4291/wjgp.v7.i1.186","url":null,"abstract":"Aim: To systematically review evidence on pathophysiology of intra-abdominal pressure (IAP) in acute pancreatitis (AP) with its clinical correlates.Methods: Systematic review of available evidence in English literature with relevant medical subject heading terms on PubMed, Medline and Scopus with further search from open access sources on internet as suggested by articles retrieved.Results: Intra-abdominal hypertension (IAH) is increasingly gaining recognition as a point of specific intervention with potential to alter disease outcome and improve mortality in AP. IAH can be expected in at least 17% of patients presenting with diagnosis of AP to a typical tertiary care hospital (prevalence increasing to 50% in those with severe disease). Abdominal compartment syndrome can be expected in at least 15% patients with severe disease. Recent guidelines on management of AP do not acknowledge utility of surveillance for IAP other than those by Japanese Society of Hepato-Biliary-Pancreatic Surgery. We further outline pathophysiologic mechanisms of IAH; understanding of which advances our knowledge and helps to coherently align common observed variations in management related conundrums (such as fluid therapy, nutrition and antibiotic prophylaxis) with potential to further individualize treatment in AP.Conclusion: We suggest that IAP be given its due place in future practice guidelines and that recommendations be formed with help of a broader panel with inclusion of clinicians experienced in management of IAH.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amniotic fluid: Source of trophic factors for the developing intestine. 羊水发育中肠道的营养因子来源

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.38

Soham Dasgupta, Shreyas Arya, Sanjeev Choudhary, Sunil K Jain

引用次数: 0

High rate of Helicobacter pylori reinfection in Lithuanian peptic ulcer patients. 立陶宛消化性溃疡患者幽门螺杆菌再感染率高。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.181

L. Jonaitis, G. Kiudelis, Paulius Slepavicius, L. Kupčinskas

{"title":"High rate of Helicobacter pylori reinfection in Lithuanian peptic ulcer patients.","authors":"L. Jonaitis, G. Kiudelis, Paulius Slepavicius, L. Kupčinskas","doi":"10.4291/wjgp.v7.i1.181","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.181","url":null,"abstract":"AIM\u0000To evaluate the frequency of Helicobacter pylori (H. pylori) reinfection in peptic ulcer patients during 9 years after H. pylori eradication.\u0000\u0000\u0000METHODS\u0000We invited 117 peptic ulcer patients in whom eradication of H. pylori was confirmed 1 year after eradication treatment both by histology and by rapid urease test. In total, 57 patients were available for the study procedures: 34 (59.6%) male, 23 (40.4%) female; mean age 52.3 ± 13.0 years. There were 45 (78.9%) patients with duodenal ulcer and 12 (21.1%) with gastric ulcer. H. pylori was diagnosed by a rapid urease test and histology if endoscopy was performed. If endoscopy was refused, H. pylori was diagnosed by the C14-urea breath test and serology. H. pylori was established if at least one of the tests was positive.\u0000\u0000\u0000RESULTS\u0000The mean follow-up was 8.9 ± 1.0 years (range, 6-12). H. pylori was established in 15 patients. In 2 H. pylori-negative patients, H. pylori was established during the follow-up period and eradicated. Therefore, we consider that reinfection occurred in 17 patients. In the per protocol analysis, reinfection was established in 17 of 57 (29.8%; 95%CI: 19.2-42.2) patients during the follow-up period. The annual rate of infection was 3.36%. If all non-responders were considered H. pylori-negative, reinfection would be 14.5% (17/117), the annual rate being 1.63%. The mean age of patients with reinfection was 51.8 ± 14.0 years, and without reinfection was 52.5 ± 13.0 years, P > 0.05; the mean body mass index of patients with reinfection was 27.2 ± 4.1 kg/m(2), and without reinfection was 25.7 ± 4.2 kg/m(2), P > 0.05. There were no differences in the reinfection rates according the location of the peptic ulcer, the eradication regimen used, and smoking status.\u0000\u0000\u0000CONCLUSION\u0000The reinfection rate of H. pylori is relatively high in Lithuania and probably related to the high prevalence of H. pylori, what may reflect differences in the socioeconomic status between Western and Eastern European countries.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Faecal incontinence: Current knowledges and perspectives. 大便失禁:当前的知识和观点。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.59

A. Benezech, M. Bouvier, V. Vitton

{"title":"Faecal incontinence: Current knowledges and perspectives.","authors":"A. Benezech, M. Bouvier, V. Vitton","doi":"10.4291/wjgp.v7.i1.59","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.59","url":null,"abstract":"Faecal incontinence (FI) is a disabling and frequent symptom since its prevalence can vary between 5% and 15% of the general population. It has a particular negative impact on quality of life. Many tools are currently available for the treatment of FI, from conservative measures to invasive surgical treatments. The conservative treatment may be dietetic measures, various pharmacological agents, anorectal rehabilitation, posterior tibial nerve stimulation, and transanal irrigation. If needed, patients may have miniinvasive approaches such as sacral nerve modulation or antegrade irrigation. In some cases, a surgical treatment is proposed, mainly external anal sphincter repair. Although these different therapeutic options are available, new techniques are arriving allowing new hopes for the patients. Moreover, most of them are non-invasive such as local application of an α1-adrenoceptor agonist, stem cell injections, rectal injection of botulinum toxin, acupuncture. New more invasive techniques with promising results are also coming such as anal magnetic sphincter and antropylorus transposition. This review reports the main current available treatments of FI and the developing therapeutics tools.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Esophageal testing: What we have so far. 食道测试:目前我们有什么。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.72

N. de Bortoli, I. Martinucci, L. Bertani, S. Russo, R. Franchi, M. Furnari, S. Tolone, G. Bodini, V. Bolognesi, M. Bellini, V. Savarino, S. Marchi, E. Savarino

{"title":"Esophageal testing: What we have so far.","authors":"N. de Bortoli, I. Martinucci, L. Bertani, S. Russo, R. Franchi, M. Furnari, S. Tolone, G. Bodini, V. Bolognesi, M. Bellini, V. Savarino, S. Marchi, E. Savarino","doi":"10.4291/wjgp.v7.i1.72","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.72","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry (HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h pH-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and pH monitoring can detect acid and non-acid reflux events. EndoFLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal pH-metry. Future studies are required of these techniques to evaluate their diagnostic accuracy and usefulness, although the available data are promising.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Mesenteric ischemia: Pathogenesis and challenging diagnostic and therapeutic modalities. 肠系膜缺血:发病机制和具有挑战性的诊断和治疗方式。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.125

A. Mastoraki, S. Mastoraki, Evgenia Tziava, Stavroula Touloumi, Nikolaos T Krinos, N. Danias, A. Lazaris, N. Arkadopoulos

{"title":"Mesenteric ischemia: Pathogenesis and challenging diagnostic and therapeutic modalities.","authors":"A. Mastoraki, S. Mastoraki, Evgenia Tziava, Stavroula Touloumi, Nikolaos T Krinos, N. Danias, A. Lazaris, N. Arkadopoulos","doi":"10.4291/wjgp.v7.i1.125","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.125","url":null,"abstract":"Mesenteric ischemia (MI) is an uncommon medical condition with high mortality rates. ΜΙ includes inadequate blood supply, inflammatory injury and eventually necrosis of the bowel wall. The disease can be divided into acute and chronic MI (CMI), with the first being subdivided into four categories. Therefore, acute MI (AMI) can occur as a result of arterial embolism, arterial thrombosis, mesenteric venous thrombosis and non-occlusive causes. Bowel damage is in proportion to the mesenteric blood flow decrease and may vary from minimum lesions, due to reversible ischemia, to transmural injury, with subsequent necrosis and perforation. CMI is associated to diffuse atherosclerotic disease in more than 95% of cases, with all major mesenteric arteries presenting stenosis or occlusion. Because of a lack of specific signs or due to its sometime quiet presentation, this condition is frequently diagnosed only at an advanced stage. Computed tomography (CT) imaging and CT angiography contribute to differential diagnosis and management of AMI. Angiography is also the criterion standard for CMI, with mesenteric duplex ultrasonography and magnetic resonance angiography also being of great importance. Therapeutic approach of MI includes both medical and surgical treatment. Surgical procedures include restoration of the blood flow with arteriotomy, endarterectomy or anterograde bypass, while resection of necrotic bowel is always implemented. The aim of this review was to evaluate the results of surgical treatment for MI and to present the recent literature in order to provide an update on the current concepts of surgical management of the disease. Mesh words selected include MI, diagnostic approach and therapeutic management.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4291/wjgp.v7.i1.125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 85

Adipose tissue-liver axis in alcoholic liver disease. 酒精性肝病的脂肪组织-肝轴。

世界胃肠病理生理学杂志(电子版)(英文版) Pub Date : 2016-02-15 DOI: 10.4291/wjgp.v7.i1.17

Zhigang Wang, Xiao-Bing Dou, Zhan-Xiang Zhou, Zhenyuan Song

{"title":"Adipose tissue-liver axis in alcoholic liver disease.","authors":"Zhigang Wang, Xiao-Bing Dou, Zhan-Xiang Zhou, Zhenyuan Song","doi":"10.4291/wjgp.v7.i1.17","DOIUrl":"https://doi.org/10.4291/wjgp.v7.i1.17","url":null,"abstract":"Alcoholic liver disease (ALD) remains an important health problem worldwide. The disease spectrum is featured by early steatosis, steatohepatitis (steatosis with inflammatory cells infiltration and necrosis), with some individuals ultimately progressing to fibrosis/cirrhosis. Although the disease progression is well characterized, no effective therapies are currently available for the treatment in humans. The mechanisms underlying the initiation and progression of ALD are multifactorial and complex. Emerging evidence supports that adipose tissue dysfunction contributes to the pathogenesis of ALD. In the first part of this review, we discuss the mechanisms whereby chronic alcohol exposure contributed to adipose tissue dysfunction, including cell death, inflammation and insulin resistance. It has been long known that aberrant hepatic methionine metabolism is a major metabolic abnormality induced by chronic alcohol exposure and plays an etiological role in the pathogenesis of ALD. The recent studies in our group documented the similar metabolic effect of chronic alcohol drinking on methionine in adipose tissue. In the second part of this review, we also briefly discuss the recent research progress in the field with a focus on how abnormal methionine metabolism in adipose tissue contributes to adipose tissue dysfunction and liver damage.","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71059358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23