世界胃肠病理生理学杂志(电子版)(英文版)最新文献

{"title":"Colorectal cancer tumor phenotypes associated with <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> hot-spot mutations.","authors":"Omer Abdelgadir, Yong-Fang Kuo, M Firoze Khan, Anthony O Okorodudu, Yu-Wei O Cheng, Jianli Dong","doi":"10.4291/wjgp.v16.i3.107954","DOIUrl":"10.4291/wjgp.v16.i3.107954","url":null,"abstract":"<p><strong>Background: </strong>Kirsten rat sarcoma viral oncogene homolog (<i>KRAS</i>), neuroblastoma RAS viral oncogene homolog (<i>NRAS</i>), and v-raf murine sarcoma viral oncogene homolog B1 (<i>BRAF</i>) nucleotide variants may generate quantitatively or qualitatively various protein activities, which may be reflected in their differential association with tumor characteristics.</p><p><strong>Aim: </strong>To examine the association between these mutations and colorectal cancer (CRC) progression stages.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 799 patients with CRC, whose tumor samples were examined for mutations in the hot-spots of the <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> genes at the University of Texas Medical Branch, spanning from January 2016 to July 2023. Statistical analyses were performed to assess the association of specific nucleotide changes with tumor, nodes, and metastasis stages.</p><p><strong>Results: </strong><i>KRAS</i> mutations were found in 39.5% of cases, <i>NRAS</i> mutations in 4.4%, and <i>BRAF</i> mutations in 6.0%. The <i>KRAS</i> p.Gly12Val and p.Gly13Asp mutations were positively associated with pathological stage 4 tumors. Additionally, the <i>KRAS</i> p.Gly12Asp and p.Gly12Val mutations were linked to an increased risk of distant metastasis. Meanwhile, the <i>BRAF</i> Val600Glu mutation was associated with a higher likelihood of lymph node involvement.</p><p><strong>Conclusion: </strong>Our findings support the potential prognostic utility of specific <i>KRAS</i> (p.Gly12Val, p.Gly12Asp, and p.Gly13Asp) and <i>BRAF</i> p.Val600Glu mutations in CRC. These results are preliminary and require validation through larger, multi-center studies before they can be considered reliable in clinical practice.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"107954"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-session endoscopic ultrasound-guided gallbladder drainage and biopsy in pancreatic cancer, obstructive jaundice, and acute cholecystitis: A case report.","authors":"Filippo Antonini, Durante Donnarumma, Tiziana Buono, Salomone Di Saverio, Andrea Gardini","doi":"10.4291/wjgp.v16.i3.106014","DOIUrl":"10.4291/wjgp.v16.i3.106014","url":null,"abstract":"<p><strong>Background: </strong>An 81-year-old patient presented to our center with pancreatic head cancer, obstructive jaundice, and acute cholecystitis. Due to duodenal tumor infiltration, both endoscopic retrograde cholangiopancreatography and endoscopic ultrasound (EUS)-guided choledochoduodenostomy were technically challenging.</p><p><strong>Case summary: </strong>An EUS-guided gallbladder drainage along with an EUS-guided fine needle biopsy were performed, resulting in a diagnosis of pancreatic cancer resolution of jaundice and improvement in acute cholecystitis, all in a safe and effective single endoscopic session.</p><p><strong>Conclusion: </strong>This case demonstrated the successful use of EUS-guided gallbladder drainage and EUS-guided fine needle biopsy in a patient with pancreatic cancer invading the duodenal wall.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"106014"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jejunal diverticular disease: A gastrointestinal bleeding enigma.","authors":"Roberto Anaya-Prado, Victor J Avalos-Herrera, Aldo A Silva-Esparza, Maria J Alvarez-Silva, Daniela Salazar-Hernandez, Roberto Anaya-Fernández, Ivan F Garcia-Ramirez, Michelle Marie Anaya-Fernandez, Consuelo C Azcona-Ramirez, Jean C Orendain-Luna, Norma L Anaya-Romero, Boris Derechin-Finkel, Jose E Alcocer-Escobar","doi":"10.4291/wjgp.v16.i3.109103","DOIUrl":"10.4291/wjgp.v16.i3.109103","url":null,"abstract":"<p><p>Diverticular disease (DD) represents a prevalent clinical challenge, especially in the aging population. The sigmoid colon is the most frequently affected area. However, the presence of DD in the upper gastrointestinal tract, including the duodenum and jejunum, underscores the need for comprehensive understanding and management. In this minireview we analyzed the epidemiology, pathogenesis, clinical presentation, diagnosis, and management of DD with a specific focus on jejunal diverticulosis. Although the incidence of gastrointestinal DD increases with age, the male and female prevalence is the same. Clinical presentation is either asymptomatic or with unclear abdominal symptoms. However, complications such as perforation and bleeding can occur in a subset of patients and demand urgent diagnosis and surgical treatment. Imaging alternatives, including CT and enteroscopy, play key roles in diagnosis. Surgical management is warranted in cases with persistent bleeding or more complicated acute abdomen. Jejunal diverticulosis (JD) is a less common condition and poses a unique diagnostic and therapeutic challenge. Bleeding has been reported as the most important complication in JD. Therefore, early diagnosis and management are critical to improve patient outcomes and reduce morbidity and mortality. This article highlighted the importance of considering JD in the differential diagnosis of gastrointestinal bleeding, especially in patients with concurrent colon diverticulosis in which the bleeding source remains unidentified. Therefore, current challenges in JD are better understanding the etiopathology and optimal management strategies.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"109103"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of tissue and fecal microbiota in active Crohn's disease and their ability to predict disease state.","authors":"Amit K Dutta, Dilip Abraham, Ira Praharaj, Blossom Benny, Karthikeyan Govindan, Zayina Zondervenni, A J Joseph","doi":"10.4291/wjgp.v16.i3.108058","DOIUrl":"10.4291/wjgp.v16.i3.108058","url":null,"abstract":"<p><strong>Background: </strong>Simultaneous assessment of gut microbiota in stool and tissue samples is crucial for a better understanding of their role in Crohn's disease (CD), yet most reports have focused on fecal microbiota alone. Additionally, gut microbiota may serve as a clinically useful diagnostic biomarker of CD although data on this is limited.</p><p><strong>Aim: </strong>To evaluate gut microbiota in tissue and stool samples in patients with active CD to understand the structure and function compared to healthy controls (HC). We also assessed their utility as a diagnostic biomarker of CD.</p><p><strong>Methods: </strong>Adult patients with active CD and HC were prospectively recruited for this study. The clinical and investigation details were recorded. Rectal mucosal biopsy and stool samples were obtained to assess the bacterial population. DNA was extracted, the V3-V4 region of the 16S rRNA gene was amplified, and library preparation was done and sequenced on the Illumina MiSeq platform. The bacterial diversity, composition, dysbiosis, predicted function, and predictors of disease state were estimated using the QIIME 2 pipeline and R packages.</p><p><strong>Results: </strong>We recruited 66 patients with CD (age 39.7 ± 11.1 years, 65.2% males) and 69 HC. Comparison of tissue with fecal microbiota in active CD showed significant differences in composition and predicted function. Both tissue and fecal microbiota from active CD showed reduced microbial diversity and compositional differences compared to HC, and disease state was a key determinant of bacterial population. Differences (CD <i>vs</i> HC) were noted in the abundance of several predicted synthetic and degradation pathways in both tissue and stool bacteria. Tissue microbiota was a superior predictor of active CD than stool (area under receiver operating characteristic curve 0.8 <i>vs</i> 0.62).</p><p><strong>Conclusion: </strong>Gut microbial characteristics revealed significant structural and functional differences between CD and HC in both tissue and stool. Tissue bacteria performed well as a microbial biomarker for clinical diagnosis of CD.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"108058"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering a new paradigm: Gut microbiota as a central modulator of sexual health.","authors":"Giuseppe Marano, Maria B Anesini, Miriam Milintenda, Mariateresa Acanfora, Claudia d'Abate, Francesco M Lisci, Ilaria Pirona, Gianandrea Traversi, Roberto Pola, Eleonora Gaetani, Marianna Mazza","doi":"10.4291/wjgp.v16.i3.107823","DOIUrl":"10.4291/wjgp.v16.i3.107823","url":null,"abstract":"<p><p>The gut microbiota plays a pivotal role in human health, influencing diverse physiological processes, including those related to sexual health. Emerging evidence suggests a bidirectional relationship between the gut microbiota and sexual health, mediated by its impact on systemic inflammation, hormonal regulation, and immune function. A balanced gut microbiota supports optimal levels of sex hormones, such as estrogen and testosterone, which are critical for sexual function and reproductive health. Additionally, gut-derived metabolites such as short-chain fatty acids contribute to maintaining mucosal barrier integrity and regulating immune responses, which are essential for protecting against infections that may impair sexual health. Conversely, dysbiosis, an imbalance in gut microbial composition, has been linked to conditions such as erectile dysfunction, polycystic ovary syndrome, and reduced libido, emphasizing its role in sexual dysfunction. Lifestyle factors, including diet, stress, and antibiotic use, can modulate the gut microbiota and, consequently, sexual health outcomes. Recent therapeutic approaches, such as probiotics, prebiotics, and fecal microbiota transplantation, offer potential for restoring gut balance and improving sexual health. This review highlights the central role of the gut microbiota in sexual health, emphasizing its importance as a target for therapeutic interventions to enhance overall well-being.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"107823"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrett's esophagus: A review.","authors":"Harleen Kaur Chela, Mustafa Gandhi, Mohammad Hazique, Hamza Ertugrul, Karthik Gangu, Ebubekir Daglilar","doi":"10.4291/wjgp.v16.i3.107273","DOIUrl":"10.4291/wjgp.v16.i3.107273","url":null,"abstract":"<p><p>Barrett's esophagus is a pathological process where the inflammatory milieu created within the esophagus leads to progressive changes over time that can lead eventually to frank malignancy. It is a pre-malignant condition and involves a metaplastic transformation of the distal epithelium of the esophagus. There is a conversion of the normal type of squamous epithelium into the columnar type of epithelium. There are several risk factors associated with this condition and it is typically diagnosed endoscopically. This review article provides a brief overview of this condition.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"107273"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management.","authors":"Suprabhat Giri, Sidharth Harindranath, Akshay Kulkarni, Jiten Kumar Sahoo, Harshad Joshi, Preetam Nath, Manoj Kumar Sahu","doi":"10.4291/wjgp.v16.i3.107573","DOIUrl":"10.4291/wjgp.v16.i3.107573","url":null,"abstract":"<p><p>Fatigue is a prevalent and often debilitating symptom in individuals with inflammatory bowel disease (IBD), affecting a substantial proportion of patients, even during periods of disease remission. The prevalence of fatigue in IBD remains high, affecting around half of the IBD patients and being more common in patients with active disease than those in remission. Several risk factors contribute to fatigue in IBD, including active disease and pro-inflammatory state, nutritional deficiencies and anemia, sleep disturbances, psychological comorbidities, microbiota changes and the gut-brain axis, muscle dysfunction, sarcopenia, and physical inactivity. Assessing fatigue in IBD is challenging due to its subjective nature and the lack of a uniformly quantifiable method. Fatigue significantly impacts the quality of life, affecting physical functioning, psychological and emotional well-being, and social and relational consequences. The management of fatigue in IBD requires a comprehensive, multidisciplinary approach. This includes addressing disease activity through conventional drug treatment, biologicals and small molecules, and surgical treatment. Psychological interventions such as cognitive behavioral therapy, problem-solving therapy, solution-focused therapy, mindfulness-based cognitive therapy, and brief behavioral therapy have shown promise in improving fatigue. Nutritional interventions, including treating deficiencies and supplementation, and lifestyle interventions, such as physical exercise, aromatherapy, and sleep interventions, are also important components of fatigue management. Pharmacological interventions like modafinil and bupropion may be considered in refractory cases. This review aims to summarize the current evidence on fatigue in IBD, including its prevalence, risk factors, assessment methods, outcomes, and management strategies.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"107573"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas9 gene editing in gastric cancer: Mechanisms, advances, and therapeutic potential.","authors":"Grigorios Christodoulidis, Dimitra Bartzi, Kyriaki Tsagkidou, Alexandra Dimaki, Lydia Lazaridou, Kalliopi Vakalou, Konstantinos E Koumarelas, Dimitrios Schizas","doi":"10.4291/wjgp.v16.i3.107834","DOIUrl":"10.4291/wjgp.v16.i3.107834","url":null,"abstract":"<p><p>Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative approaches for its diagnosis and treatment. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), a revolutionary gene-editing technology, has emerged as a powerful tool for unraveling the molecular mechanisms underlying GC and for advancing precision medicine strategies. This review explores the current applications of CRISPR/Cas9 in GC research, including the identification of oncogenes and tumor suppressors, modeling tumor microenvironment interactions, and developing gene-based therapies. We highlight recent breakthroughs in genome editing that have enhanced our understanding of GC pathogenesis and resistance mechanisms to conventional therapies. Additionally, we discuss the potential of CRISPR/Cas9 for therapeutic gene editing in GC, addressing challenges such as off-target effects, delivery methods, and ethical considerations. By summarizing the progress and limitations of CRISPR/Cas9 in GC, this review aims to provide a comprehensive perspective on how this transformative technology could shape future strategies for the prevention, diagnosis, and treatment of GC.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"107834"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-skin axis: Emerging insights for gastroenterologists-a narrative review.","authors":"Neeraj Singla, Khayati Singla, Mohamed Attauabi, Dhruv Aggarwal","doi":"10.4291/wjgp.v16.i3.108952","DOIUrl":"10.4291/wjgp.v16.i3.108952","url":null,"abstract":"<p><p>The gut-skin axis (GSA) embodies a complex, bidirectional interaction between the gastrointestinal (GI) system and skin, driven by immune modulation, systemic inflammation, and gut microbiota dynamics. Disruptions in gut homeostasis, including dysbiosis and increased intestinal permeability, are increasingly recognized as contributing factors to dermatological conditions such as acne, psoriasis, and atopic dermatitis. For gastroenterologists, appreciating this interplay is essential, as diseases and their treatments frequently present with cutaneous manifestations, offering diagnostic and therapeutic insights. This review explores the underlying mechanisms of the GSA, focusing on the microbiome and its metabolites as key regulators of inflammation and immunity. It underscores the clinical importance of microbiome-targeted therapies, such as probiotics, prebiotics, and dietary modifications, in addressing both GI and dermatological disorders. Furthermore, the review examines the influence of GI conditions, including inflammatory bowel disease and celiac disease on skin health. This article seeks to equip gastroenterologists with practical insights for identifying, diagnosing, and managing skin conditions associated with GI health. The article also highlights the current limitations in knowledge regarding the GSA. The GSA represents a promising avenue for therapeutic advancements, encouraging interdisciplinary collaboration between gastroenterology and dermatology to optimize patient care.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"108952"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with refractory ascites and spontaneous bacterial peritonitis in a predominantly Hispanic population: A retrospective analysis.","authors":"Shivangini Duggal, Mutaz Kalas, Alan Jurado, Edwin Mendoza, Swati Mahapatra, Keith Garrison, Marc J Zuckerman, Alejandro Robles","doi":"10.4291/wjgp.v16.i3.108842","DOIUrl":"10.4291/wjgp.v16.i3.108842","url":null,"abstract":"<p><strong>Background: </strong>Refractory ascites (RA) and spontaneous bacterial peritonitis (SBP) are severe complications of decompensated cirrhosis, contributing to high morbidity and mortality. RA develops when ascites persists despite maximum diuretic therapy, while SBP arises from bacterial translocation and immune dysfunction in cirrhotic patients with ascites. Identifying key risk factors associated with these conditions is crucial for early intervention and improved patient outcomes.</p><p><strong>Aim: </strong>To assess clinical and biochemical predictors of RA and SBP in a cohort of hospitalized patients with cirrhotic ascites.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on patients with cirrhotic ascites diagnosed with RA or SBP at University Medical Center, El Paso, from July 1, 2013 to December 31, 2023. Patient demographics, clinical history, laboratory parameters, ascitic fluid analysis, and cirrhosis severity scores [Model for End-Stage Liver Disease-Sodium (MELD-Na) and Child-Pugh] were recorded. Statistical analyses, including multivariate logistic regression, were performed to identify independent predictors of RA and SBP, with a significance threshold of <i>P</i> < 0.05.</p><p><strong>Results: </strong>A total of 179 patients were included, with a mean age of 59.08 ± 13.04 years, predominantly male (55.9%) and Hispanic (98.3%). The most common etiology of cirrhosis was alcohol-related liver disease (45.3%), and most patients had Grade III ascites (95.5%). Among them, 115 (64.2%) had RA, and 57 (31.8%) had SBP. RA was significantly associated with abnormal serum potassium levels [odds ratio (OR) = 2.27, 95%CI: 1.06-4.84, <i>P</i> = 0.034], while SBP was independently predicted by gastrointestinal bleeding (OR = 2.59, 95%CI: 1.18-5.64, <i>P</i> = 0.017) and thrombocytopenia (platelet count < 50000; OR = 3.27, 95%CI: 1.08-9.88, <i>P</i> = 0.035).</p><p><strong>Conclusion: </strong>RA and SBP are major complications of cirrhosis, with electrolyte imbalances and coagulopathy playing key roles in their development. Our study confirms that abnormal potassium levels significantly predict RA, while gastrointestinal bleeding and thrombocytopenia are strong predictors of SBP. These findings emphasize the need for early risk stratification and targeted management strategies to improve outcomes in high-risk cirrhotic patients, particularly in minority populations with limited healthcare access. Further prospective studies are warranted to validate these results and explore potential interventions to reduce RA and SBP incidence.</p>","PeriodicalId":68755,"journal":{"name":"世界胃肠病理生理学杂志(电子版)(英文版)","volume":"16 3","pages":"108842"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}