生物材料与纳米技术(英文)最新文献_第2页

Fabrication and Characterization of Chitosan Based Injectable Thermosensitive Hydrogels Containing Silica/Calcium Phosphate Nanocomposite Particles 含二氧化硅/磷酸钙纳米复合颗粒的壳聚糖基注射用热敏水凝胶的制备与表征

生物材料与纳米技术(英文) Pub Date : 2021-05-28 DOI: 10.4236/jbnb.2021.123004

S. Latifi, Christina Tang, H. Donahue

{"title":"Fabrication and Characterization of Chitosan Based Injectable Thermosensitive Hydrogels Containing Silica/Calcium Phosphate Nanocomposite Particles","authors":"S. Latifi, Christina Tang, H. Donahue","doi":"10.4236/jbnb.2021.123004","DOIUrl":"https://doi.org/10.4236/jbnb.2021.123004","url":null,"abstract":"In this study, the effect of silica/calcium phosphate (SiCaP) nanocomposite particles on the properties of a novel chitosan-based thermosensitive hydrogel system was examined. SiCaP nanocomposite powder was fabricated using a sol-gel method and then used to fabricate nanocomposite hydrogels (Ch- β/7.5SiCaP and Ch-β/15SiCaP) including chitosan and β-glycerophosphate (Ch-β) as a matrix. Results revealed that compared to the Ch-β hydrogel without SiCaP, the presence of SiCaP particles in nanocomposite hydrogels maintained pH stability during the sol-gel transition, accelerated the gelation and improved the stiffness of nanocomposite hydrogels. Gelation time at 37℃ was reduced approximately 75% and stiffness was increased approximately 115%. Both of these changes are attributed to chemical and physical interactions of the SiCaP bioactive particles with chitosan. Furthermore, compared to the Ch-β hydrogel, the presence of SiCaP in the Ch-β/7.5SiCaP nanocomposite hydrogel did not affect biocompatibility negatively, but improved osteoblastic cell differentiation. Our studies suggest that these nanocomposite hydrogels may offer an innovative approach to bone regeneration strategies.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46878577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gold Nanoparticles/Thermochromic Composite Film on Screen-Printed Electrodes for Simultaneous Detection of Protein and Temperature 丝网印刷电极上的金纳米粒子/热致变色复合膜同时检测蛋白质和温度

生物材料与纳米技术(英文) Pub Date : 2021-04-22 DOI: 10.4236/JBNB.2021.122002

Dorothy Araba Yakoba Agyapong, Hanjia Jiang, Xin-Ye Ni, Jingwen Wu, Hong-juan Zeng

引用次数: 1

Skin Cancer Treatment by Nanoskin Cellulose: Future Cancer Wound Healing 纳米皮肤纤维素治疗皮肤癌:未来癌症伤口愈合

生物材料与纳米技术(英文) Pub Date : 2021-01-01 DOI: 10.4236/jbnb.2021.121001

P. Basmaji, Gabriel Molina de Olyveira, Mohamed M. Kanjou

引用次数: 3

Insightful Understanding of the Role of the Mechanical Properties in Defining the Reliability of All-Ceramic Dental Restorations: A Review 力学性能在确定全陶瓷修复体可靠性中的作用的深刻理解:综述

生物材料与纳米技术(英文) Pub Date : 2021-01-01 DOI: 10.4236/jbnb.2021.124006

M. Albakry

引用次数: 3

Gold Nanoparticles Incorporated with Cyclodextrins and Its Applications 含环糊精的金纳米颗粒及其应用

生物材料与纳米技术(英文) Pub Date : 2021-01-01 DOI: 10.4236/jbnb.2021.124007

Fahad Alanazi, D. Salah

引用次数: 2

In-Silico Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders 用于靶向神经退行性疾病的负载绿原酸（CGA）的聚合物纳米颗粒的硅内验证和开发

生物材料与纳米技术(英文) Pub Date : 2020-08-20 DOI: 10.4236/jbnb.2020.114018

V. Agarwal, S. Agarwal, R. Kaur, Pranav Pancham, Harleen Kaur, Siddhi Bhardwaj, Manisha Singh

{"title":"In-Silico Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders","authors":"V. Agarwal, S. Agarwal, R. Kaur, Pranav Pancham, Harleen Kaur, Siddhi Bhardwaj, Manisha Singh","doi":"10.4236/jbnb.2020.114018","DOIUrl":"https://doi.org/10.4236/jbnb.2020.114018","url":null,"abstract":"Background: Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. Objective: The current study is aimed at the in-silico validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. Methods: A successful in-silico validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis. Results & Conclusion: The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of −17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48030138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Molecular Dynamics Study of Collagen Fibrils: Relation between Mechanical Properties and Molecular Chirality 胶原原纤维的分子动力学研究:力学性能与分子手性的关系

生物材料与纳米技术(英文) Pub Date : 2020-08-20 DOI: 10.4236/jbnb.2020.114017

K. Saitoh, Tomohiro Sato, M. Takuma, Y. Takahashi

{"title":"Molecular Dynamics Study of Collagen Fibrils: Relation between Mechanical Properties and Molecular Chirality","authors":"K. Saitoh, Tomohiro Sato, M. Takuma, Y. Takahashi","doi":"10.4236/jbnb.2020.114017","DOIUrl":"https://doi.org/10.4236/jbnb.2020.114017","url":null,"abstract":"Collagen is a basic biopolymer usually found in animal bodies, but its mechanical property and behavior are not sufficiently understood so as to apply to effective regenerative medicine and so on. Since the collagen material is composed of many hierarchical structures from atomistic level to tissue or organ level, we need to well understand fundamental and atomistic mechanism of the collagen in mechanical response. First, we approach at exactly atomistic level by using all-atom modeling of tropocollagen (TC) molecule, which is a basic structural unit of the collagen. We perform molecular dynamics (MD) simulations concerning tensile loading of a single TC model. The main nature of elastic (often superelastic) behavior and the dependency on temperature and size are discussed. Then, to aim at coarse-graining of atomic configuration into some bundle structure of TC molecules (TC fibril), as a model of higher collagen structure, we construct a kind of mesoscopic model by adopting a simulation framework of beads-spring model which is ordinarily used in polymer simulation. Tensile or compression simulation to the fibril model reveals that the dependency of yield or buckling limit on the number of TCs in the model. Also, we compare the models with various molecular orientations in winding process of initial spiral of TC. The results are analyzed geometrically and it shows that characteristic orientational change of molecules increases or decreases depending on the direction and magnitude of longitudinal strain.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45460771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Development of the Heparin Monitoring System Based on Microfluidics Technology 基于微流体技术的肝素监测系统的研制

生物材料与纳米技术(英文) Pub Date : 2020-05-11 DOI: 10.4236/jbnb.2020.113013

Jingwen Zhou

引用次数: 0

Ultrastructural Characterization of the Titanium Surface Degree IV in Dental Implant Aluminum Free (Acid Attack) 无铝（酸蚀）种植体钛表面Ⅳ度的超微结构表征

生物材料与纳米技术(英文) Pub Date : 2020-05-11 DOI: 10.4236/jbnb.2020.113009

I. Brum, M. A. Carvalho, P. Santos, R. Devita, J. Pires, J. J. Carvalho

引用次数: 5

Natural Nanoskin ACT Management of the Rare Disease as Burnt Patient with Epidermolysis Bullosa and Stevens-Johnson 天然纳米皮肤ACT治疗烧伤大疱性表皮松解症和Stevens-Johnson罕见病

生物材料与纳米技术(英文) Pub Date : 2020-05-11 DOI: 10.4236/jbnb.2020.113012

P. Basmaji, nia Martins, M. Kanjo

引用次数: 1