Brain Science Advances最新文献_第2页

Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation 帕金森病的皮层-皮层下时空动力学可以通过经颅交流电刺激进行调节

Brain Science Advances Pub Date : 2023-06-01 DOI: 10.26599/BSA.2023.9050009

Tiantian Liu, Zilong Yan, Ziteng Han, Jian Zhang, Boyan Fang, Tianyi Yan

{"title":"Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation","authors":"Tiantian Liu, Zilong Yan, Ziteng Han, Jian Zhang, Boyan Fang, Tianyi Yan","doi":"10.26599/BSA.2023.9050009","DOIUrl":"https://doi.org/10.26599/BSA.2023.9050009","url":null,"abstract":"Objective: We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms of transcranial alternating current stimulation (tACS) in patients with Parkinson’s disease (PD). Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 20 patients with PD and 20 normal controls (NC). Each patient with PD received successive multidisciplinary intensive rehabilitation treatment and tACS treatment over a one-year interval. Individual functional brain network mapping and co-activation pattern (CAP) analysis were performed to characterize cortico–subcortical dynamics. Results: The same tACS electrode placement stimulated different proportions of functional brain networks across the participants. CAP analysis revealed that the visual network, attentional network, and default mode network co-activated with the thalamus, accumbens, and amygdala, respectively. The pattern characterized by the de-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than in NCs, and this amplitude increased after tACS treatment. Furthermore, the co-occurrence of cortico–subcortical CAPs was significantly higher in patients with PD than in NCs and decreased after tACS treatment. Conclusions: This study investigated cortico–subcortical spatiotemporal dynamics in patients with PD and further revealed the tACS treatment mechanism. These findings contribute to understanding cortico– subcortical dynamics and exploring noninvasive neuromodulation targets of cortico–subcortical circuits in brain diseases, such as PD, Alzheimer’s disease, and depression.","PeriodicalId":67062,"journal":{"name":"Brain Science Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43749822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The altered network complexity of resting-state functional brain activity in schizophrenia and bipolar disorder patients 精神分裂症和双相情感障碍患者静息状态功能性脑活动网络复杂性的改变

Brain Science Advances Pub Date : 2023-06-01 DOI: 10.26599/BSA.2023.9050007

Yan Niu, N. Zhang, Mengni Zhou, Lan Yang, Jie Sun, Xue-Qing Cheng, Yanan Li, Lefan Guo, Jie Xiang, Bin Wang

{"title":"The altered network complexity of resting-state functional brain activity in schizophrenia and bipolar disorder patients","authors":"Yan Niu, N. Zhang, Mengni Zhou, Lan Yang, Jie Sun, Xue-Qing Cheng, Yanan Li, Lefan Guo, Jie Xiang, Bin Wang","doi":"10.26599/BSA.2023.9050007","DOIUrl":"https://doi.org/10.26599/BSA.2023.9050007","url":null,"abstract":"Schizophrenia (SZ) and bipolar disorder (BD) are two of the most frequent mental disorders. These disorders exhibit similar psychotic symptoms, making diagnosis challenging and leading to misdiagnosis. Yet, the network complexity changes driving spontaneous brain activity in SZ and BD patients are still unknown. Functional entropy (FE) is a novel way of measuring the dispersion (or spread) of functional connectivities inside the brain. The FE was utilized in this study to examine the network complexity of the resting-state fMRI data of SZ and BD patients at three levels, including global, modules, and nodes. At three levels, the FE of SZ and BD patients was considerably lower than that of normal control (NC). At the intra-module level, the FE of SZ was substantially higher than that of BD in the cingulo-opercular network. Moreover, a strong negative association between FE and clinical measures was discovered in patient groups. Finally, we classified using the FE features and attained an accuracy of 66.7% (BD vs. SZ vs. NC) and an accuracy of 75.0% (SZ vs. BD). These findings proposed that network connectivity’s complexity analyses using FE can provide important insights for the diagnosis of mental illness.","PeriodicalId":67062,"journal":{"name":"Brain Science Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45530057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

High amplitude high frequency oscillations during posttraumatic epileptogenesis 创伤后癫痫发生时的高振幅高频振荡

Brain Science Advances Pub Date : 2023-03-01 DOI: 10.26599/bsa.2023.9050006

Jagannathan Rangarajan, Udaya Kumar

引用次数: 0

Activatable molecular fluorescence probes for the imaging and detection of ischemic stroke 可激活分子荧光探针用于缺血性脑卒中的成像和检测

Brain Science Advances Pub Date : 2023-02-27 DOI: 10.26599/BSA.2023.9050003

Mengdie Wang, Yan Zhang

引用次数: 1

NMDARs regulate the excitatory-inhibitory balance within neural circuits NMDARs调节神经回路内的兴奋-抑制平衡

Brain Science Advances Pub Date : 2023-02-27 DOI: 10.26599/BSA.2022.9050020

Liang Zhou, Xiaohui Sun, Jingjing Duan

引用次数: 1

Substrate stiffness in nerve cells 神经细胞的基质硬度

Brain Science Advances Pub Date : 2023-02-27 DOI: 10.26599/BSA.2023.9050002

Weijin Si, J. Gong, Xiaofei Yang

引用次数: 3

The regulation of host cytoskeleton during SARS-CoV-2 infection in the nervous system 神经系统感染SARS-CoV-2时宿主细胞骨架的调控

Brain Science Advances Pub Date : 2023-02-27 DOI: 10.26599/BSA.2023.9050004

Qian Zhang, Yaming Jiu

引用次数: 2

Neuronal excitation regulation and beyond 神经元兴奋调节及其他

Brain Science Advances Pub Date : 2023-02-27 DOI: 10.26599/BSA.2023.9050005

Shangbang Gao, Yan Zhang

引用次数: 0

BK channels in microglia 小胶质细胞中的BK通道

Brain Science Advances Pub Date : 2022-12-01 DOI: 10.26599/BSA.2023.9050001

Xiaohui Sun

引用次数: 1

Circadian dysregulation and Alzheimer’s disease: A comprehensive review 昼夜节律失调与阿尔茨海默病:一项全面的综述

Brain Science Advances Pub Date : 2022-11-30 DOI: 10.26599/BSA.2022.9050021

Peter Iacobelli

{"title":"Circadian dysregulation and Alzheimer’s disease: A comprehensive review","authors":"Peter Iacobelli","doi":"10.26599/BSA.2022.9050021","DOIUrl":"https://doi.org/10.26599/BSA.2022.9050021","url":null,"abstract":"Alzheimer’s disease (AD), the foremost variant of dementia, has been associated with a menagerie of risk factors, many of which are considered to be modifiable. Among these modifiable risk factors is circadian rhythm, the chronobiological system that regulates sleep‐wake cycles, food consumption timing, hydration timing, and immune responses amongst many other necessary physiological processes. Circadian rhythm at the level of the suprachiasmatic nucleus (SCN), is tightly regulated in the human body by a host of biomolecular substances, principally the hormones melatonin, cortisol, and serotonin. In addition, photic information projected along afferent pathways to the SCN and peripheral oscillators regulates the synthesis of these hormones and mediates the manner in which they act on the SCN and its substructures. Dysregulation of this cycle, whether induced by environmental changes involving irregular exposure to light, or through endogenous pathology, will have a negative impact on immune system optimization and will heighten the deposition of Aβ and the hyperphosphorylation of the tau protein. Given these correlations, it appears that there is a physiologic association between circadian rhythm dysregulation and AD. This review will explore the physiology of circadian dysregulation in the AD brain, and will propose a basic model for its role in AD‐typical pathology, derived from the literature compiled and referenced throughout.","PeriodicalId":67062,"journal":{"name":"Brain Science Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43910306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0