世界危重病急救学杂志(英文版)最新文献

{"title":"Long-term psychological outcomes among frontline healthcare workers following the COVID-19 pandemic: A systematic review.","authors":"Traci N Adams, Hetal J Patel, Carol S North","doi":"10.5492/wjccm.v15.i2.118885","DOIUrl":"10.5492/wjccm.v15.i2.118885","url":null,"abstract":"<p><strong>Background: </strong>Studies of short-term mental health (MH) outcomes among frontline (FL) healthcare workers (HCWs) during the pandemic have been extensively published and have reached dramatically variable conclusions. Long-term MH outcomes in this population have received less study. A synthesis of available data on long-term MH outcomes among FL HCWs associated with the coronavirus disease 2019 (COVID-19) pandemic is needed to inform efforts for screening, mobilizing psychiatry resources, and preparing for the long-term MH consequences of future pandemics.</p><p><strong>Aim: </strong>To determine the prevalence of MH sequelae of FL HCWs 1-3 years after the COVID-19 pandemic.</p><p><strong>Methods: </strong>All studies published between March 1, 2023, and December 1, 2025, that reported on the post-pandemic MH of FL HCWs affected by the COVID-19 pandemic, such as insomnia, stress, burnout, anxiety, and depression, were identified using PubMed, PsycINFO, Scopus, EMBASE, Cochrane Database of Systematic Reviews, Google Scholar, MEDLINE, and Web of Science. Articles identified in the search were screened using the approaches recommended by the PRISMA 2020.</p><p><strong>Results: </strong>Of the 1819 articles, 1679 were excluded after review of the title and abstract, 140 were reviewed at length, and 19 were included. The available data (entirely based on symptom screening measures) suggest that FL HCWs are at risk for stress-related, anxiety, depressive, and sleep disorders at least 1 year after the end of the pandemic.</p><p><strong>Conclusion: </strong>These results suggest that enhanced access to psychiatry services is warranted in HCW populations exposed to pandemics.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 2","pages":"118885"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Insight into emergency endotracheal intubation in critically ill and strategies beyond equipment.","authors":"Habib Md Reazaul Karim, Anirban Bhattacharjee, Ankur Khandelwal","doi":"10.5492/wjccm.v15.i2.118845","DOIUrl":"10.5492/wjccm.v15.i2.118845","url":null,"abstract":"<p><p>We read the study by Aggarwal <i>et al</i> recently published in <i>World Journal of Critical Care Medicine</i>, assessing the emergency endotracheal intubation (ETI) using two different equipment in critically ill patients and applaud it for choosing a crucial aspect of acute care. ETI remains a high-risk procedure in such patients with significant morbidity. The randomized design and objective outcome measures are notable strengths. Further, the inclusion of operator experience and contextual details enhances understanding of human factors and system-level influences. However, a few aspects warrant further consideration and discussion while adopting the research in clinical practice and future research.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 2","pages":"118845"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-kidney cross-talk: A call for action!","authors":"Susan Paulin, Ratthinam Palaniappan","doi":"10.5492/wjccm.v15.i2.115116","DOIUrl":"10.5492/wjccm.v15.i2.115116","url":null,"abstract":"<p><p>The cascade of events initiated by traumatic brain injury (TBI) has been a major focus of research. Despite significant advances, a deeper understanding of both favorable and unfavorable factors is still needed in this special cohort, especially concerning non-neurological complications - such as respiratory dysfunction, cardiovascular issues, sepsis, and acute kidney injury (AKI). This underscores the need to look beyond the immediate \"what kills first\" approach and address other critical problems that are essential for both patient management and resource utilization. The brain-kidney cross-talk goes both ways. In this context, Wankhade <i>et al</i> recently published a study in <i>World Journal of Critical Care Medicine</i>, investigating the risk factors that predict the development of AKI following TBI, and the most frequently recognized contributors. TBI can lead to AKI through several pathways, while conversely, AKI can worsen brain injury. While the pathophysiology is increasingly understood, there are limited interventions to prevent AKI in TBI patients. So does identification of predictors and risk factors translate to prevention of AKI here? A precise understanding is needed to help develop targeted interventions rather than just reactive treatments. The search for predictive biomarkers is a promising area of research, especially with regard to early identification of non-neurological complications. Future research must shift towards the development of predictive biomarkers and targeted preventive strategies, ensuring extension of clinical focus beyond immediate life threats and addressing the full spectrum of TBI-related pathophysiology.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 2","pages":"115116"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial.","authors":"Chakkaravarthe Anbarasan, Ankur Sharma, Nikhil Kothari, Tanvi M Meshram, Kamlesh Kumari, Shilpa Goyal, Pradeep K Bhatia","doi":"10.5492/wjccm.v15.i2.115389","DOIUrl":"10.5492/wjccm.v15.i2.115389","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is associated with impaired tissue perfusion and elevated serum lactate, a key prognostic marker. Magnesium plays a vital role in cellular energy metabolism and may enhance lactate clearance in sepsis.</p><p><strong>Aim: </strong>To investigate the impact of magnesium on the clearance of lactate in critically sick patients with sepsis.</p><p><strong>Methods: </strong>In this triple-blind, randomized trial, 138 adult patients with a diagnosis of sepsis (according to Sepsis-3 guidelines) and with serum lactate levels > 2 mmol/L were randomized into the magnesium (M) group and the placebo (P) group. Randomization was performed using an online sequence generator. The individuals in group M were administered 2 g of magnesium sulphate infusion diluted in 50 mL of normal saline over 2 hours for 3 days. The individuals in group P were administered an identical volume of normal saline for three days. The primary outcome was to compare the time to lactate clearance (20% decrease from baseline) in both groups. The secondary outcomes included changes in lactate clearance, intensive care unit (ICU) duration, hospital stay, and 28-day mortality in both groups.</p><p><strong>Results: </strong>Time to 20% lactate clearance was considerably lower in the M group (5.73 ± 2.19 hours) when compared to the P group (8.54 ± 2.72 hours), with a mean difference [95% confidence interval (CI)]: -2.81 (-3.65 to -1.99), <i>P</i> < 0.001. Mean rise in lactate clearance was markedly more significant in M group than P group on day 1 [18.88% ± 1.80% <i>vs</i> 12.61% ± 1.94% respectively, with mean difference (95%CI): 6.26 (5.63-6.89), <i>P</i> < 0.001] on day 2 [30.02% ± 4.30 % <i>vs</i> 23.34% ± 4.76% respectively, with mean difference (95%CI): 6.68 (5.15-8.20), <i>P</i> < 0.001] and day 3 [50.74% ± 6.06 % <i>vs</i> 37.94% ± 4.53% respectively, with mean difference (95%CI): 12.80 (11.00-14.60), <i>P</i> < 0.001]. The length of ICU stay was considerably shorter in the M group, 8 (3-15) days, compared to the P group, 12 (5-19) days (<i>P</i> < 0.001). The duration of hospitalization was significantly decreased in the M group, 12 (4-24) days than in the P group, 16 (9-25) days (<i>P</i> < 0.001); however, the 28-day mortality was similar in both groups.</p><p><strong>Conclusion: </strong>Magnesium supplementation was associated with shorter lactate clearance time and reduced ICU and hospital stay duration in patients with sepsis; however, the difference in 28-day mortality between the groups was statistically nonsignificant.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 2","pages":"115389"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of artificial intelligence and point of care ultrasound in management of critically ill patients.","authors":"Arun Muthukumar, Alexander Schreck, Carlos E Guerra-Londono, Abdul Kader Tabbara, Santiago Uribe-Marquez","doi":"10.5492/wjccm.v15.i2.114201","DOIUrl":"10.5492/wjccm.v15.i2.114201","url":null,"abstract":"<p><p>Point of care ultrasound (POCUS) has become an invaluable tool in the management of critically ill patients, offering real-time diagnostic insights into cardiovascular, pulmonary, and abdominal pathophysiology. In the critical care setting, timely diagnosis is essential to manage life-threatening conditions. The integration of artificial intelligence (AI) into POCUS has been a transformative technological advancement in the field. AI-incorporated POCUS can help clinicians of varying experience levels overcome limitations associated with operator dependency and varied image quality. These innovations are valuable, not only in resource-constrained settings, but also during time-sensitive clinical scenarios, profoundly impacting patient outcomes. AI-driven platforms can provide prompt feedback of protocolized exams such as rapid ultrasound in shock and bedside lung ultrasound in emergency. This is especially relevant in situations, where basic imaging such as transthoracic echocardiography is often performed by non-specialized personnel. Most AI tools remain investigational, and the need for robust validation of machine learning in clinical workflows remains a burning question. Despite a promising role in simulation, the effectiveness of these tools in real-world clinical scenarios depends heavily on the quality of training datasets. The integration of AI and POCUS, while reducing diagnostic errors, is also revolutionizing diagnostics with deep learning models, which demonstrate high accuracy. Beyond improving diagnostic precision, AI is optimizing workflows, reducing processing times, and enabling real-time interpretation. Future advancements in AI, integrating imaging with clinical data and predictive modeling, have the potential to significantly enhance prognostic accuracy and patient outcomes, particularly in critical care settings. This narrative review aims to explore the current applications, advancements, and future directions of AI-assisted POCUS in the intensive care unit, with a particular focus on machine learning in critically ill patients.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 2","pages":"114201"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting acute kidney injury outcomes in traumatic brain injury.","authors":"Nupur Karan, Rohit Patnaik","doi":"10.5492/wjccm.v15.i1.114998","DOIUrl":"10.5492/wjccm.v15.i1.114998","url":null,"abstract":"<p><p>Acute kidney injury in traumatic brain injury is a major concern, affecting up to 10% of the patients in intensive care unit due to multifaceted mechanisms, including hemorrhagic shock, rhabdomyolysis, and brain-kidney cross-talk, compounded by hyperosmolar therapies. A significant challenge is that serum creatinine is considered a late and nonspecific marker, often missing the critical early insult phase. Future strategies for early prediction and prevention must focus on emerging factors, such as preventing hyperchloremia and utilizing novel biomarkers, such as neutrophil gelatinase-associated lipocalin and kidney injury molecule 1, which detect subclinical injury and predict the need for renal replacement therapy. Composite risk stratification tools (<i>e.g.</i>, renal angina index) are vital for personalized management. Although over 90% of patients recover renal function, prevention of collateral damage to the kidney must be recognized as a critical priority in traumatic brain injury care.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"114998"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death in patients with immune-mediated inflammatory diseases in the intensive care unit: First week data.","authors":"Ilia S Avrusin, Natalia N Abramova, Liudmila A Firsova, Yury S Aleksandrovich, Dmitry O Ivanov, Mikhail M Kostik","doi":"10.5492/wjccm.v15.i1.112265","DOIUrl":"10.5492/wjccm.v15.i1.112265","url":null,"abstract":"<p><strong>Background: </strong>Systemic immune-mediated diseases can be quite severe in both course and complications, causing multiple organ failure and death. These patients are often required to be hospitalized in an intensive care unit (ICU).</p><p><strong>Aim: </strong>To find early predictors of death in patients with immune-inflammatory diseases hospitalized in the ICU.</p><p><strong>Methods: </strong>The study included 51 patients (23 boys, 28 girls) with immune-inflammatory diseases, including multisystem inflammatory syndrome associated with coronavirus disease 2019 (<i>n</i> = 18), systemic rheumatic diseases (<i>n</i> = 24), and generalized infections (<i>n</i> = 9) aged from 7 months up to 17 years old, admitted to the ICU of the clinic of Saint Petersburg State Pediatric Medical University in the period from 2007 to 2023. All patients were divided into those with a fatal outcome (<i>n</i> = 13) and those who recovered (<i>n</i> = 38). Macrophage activation syndrome (MAS) was diagnosed by the 2016 European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation criteria.</p><p><strong>Results: </strong>First-day predictors were white blood cell ≤ 3.1 × 10⁹/L, platelets ≤ 168 × 10⁹/L, diuresis ≤ 1.5 mL/kg/hour, low saturation, K⁺ > 4.7 mmol/L, albumin ≤ 30 g/L, creatinine > 74 μmol/L, pH ≤ 7.36, HCO3^- ≤ 22.2, Glasgow Coma Scale score ≤ 13, Sequential Organ Failure Assessment (SOFA) score > 2, oxygen therapy, mechanical ventilation (MV), fresh frozen plasma transfusions and biological treatment. The third-day predictors were: White blood cell ≤ 4.0 × 10⁹/L, platelets ≤ 63 × 10⁹/L, hemoglobin ≤ 87 g/L, C-reactive protein (CRP) > 129 mg/L, triglycerides > 2.45 mmol/L, albumin ≤ 28 g/L, creatinine > 83.5 μmol/L, pH ≤ 7.38, Glasgow Coma Scale score ≤ 10, SOFA score > 2 and need in MV, intravenous immunoglobulin, and blood transfusion requirements. On the fifth day, the main predictors were CRP > 28 mg/L, triglycerides > 2.3 mmol/L, creatinine > 58 μmol/L, fibrinogen > 3.3 g/L, compliance with the MAS criteria, Glasgow Coma Scale score ≤ 14, SOFA score > 2, and need for MV, vasopressors, and anticoagulant therapy, as well as blood and fresh frozen plasma transfusions. The seventh-day predictors were CRP > 19.1 mg/L, albumin ≤ 35 g/L, total protein ≤ 55 g/L, compliance with the MAS criteria, Glasgow Coma Scale score ≤ 12, SOFA score > 3, and need for MV and biological and anticoagulant therapy.</p><p><strong>Conclusion: </strong>Hemaphagocytosis (leukopenia, thrombocytopenia, hyperferritinemia, increased histochemistry score), progressive decline in Glasgow Coma Scale, increasing SOFA scores, and persistent high CRP levels were markers of an unfavorable outcome in patients with immune-mediated inflammatory diseases.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"112265"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring.","authors":"Valeria Fraioli, Marco Sanvitti, Federico Bilotta","doi":"10.5492/wjccm.v15.i1.114225","DOIUrl":"10.5492/wjccm.v15.i1.114225","url":null,"abstract":"<p><p>Sepsis and septic shock remain major global health challenges, with persistently high mortality despite advances in critical care. Conventional diagnostic tools, including the Sequential Organ Failure Assessment score and biomarkers such as C-reactive protein and procalcitonin, lack sufficient sensitivity and specificity, particularly in early disease. Circulating microRNAs (miRNAs), small non-coding RNAs regulating gene expression, have emerged as promising biomarkers for early diagnosis, prognostic assessment, and therapeutic monitoring. This narrative review synthesizes clinical studies published after 2022, highlighting the evolving role of circulating and extracellular vesicle-derived miRNAs in sepsis. Diagnostic investigations confirmed the accuracy of miRNA-451a (miR-451a) and miR-9-5p, while expanding evidence supports miR-193b-5p and miR-135a as additional diagnostic candidates. Contrasting results on miR-181a-5p emphasize the need for further validation. Prognostic and therapeutic monitoring studies identified miR-155, miR-182, miR-146b-5p, miR-126-5p, miR-195, and miR-497 as dynamic markers reflecting immune modulation and disease trajectory. Collectively, these findings highlight circulating miRNAs as powerful, versatile biomarkers that advance precision medicine in sepsis, pending multicenter validation and methodological standardization for clinical translation.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"114225"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care ultrasound for evaluating acute dyspnoea in emergency departments: Systematic review and meta-analysis.","authors":"Issam Seyala, Jonathan Soldera","doi":"10.5492/wjccm.v15.i1.113426","DOIUrl":"10.5492/wjccm.v15.i1.113426","url":null,"abstract":"<p><strong>Background: </strong>Acute dyspnoea is a common yet diagnostically complex presentation in emergency departments (EDs), representing approximately 2.4% of all visits. Traditional diagnostic tools-clinical assessment, chest radiography, and laboratory tests-may lack the precision required for timely and accurate diagnosis. Point-of-care ultrasound (POCUS) offers real-time, bedside imaging and has emerged as a promising tool to address these limitations.</p><p><strong>Aim: </strong>To evaluate the diagnostic accuracy and clinical effectiveness of POCUS <i>vs</i> conventional modalities in adults with acute dyspnoea in the ED.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, EBSCO Host, MAG Online Library, Elsevier, and ProQuest without date restrictions. Studies were included if they involved adult ED patients undergoing POCUS for dyspnoea evaluation. Following PRISMA 2020 guidelines and PROSPERO registration (CRD42025649145), eligible studies were assessed using QUADAS-2, and diagnostic performance was analysed using MetaDisc software. Pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), and receiver operating characteristic curves were calculated.</p><p><strong>Results: </strong>Out of 581 identified records, 44 studies met the inclusion criteria, with 19 included in the meta-analysis. The pooled sensitivity of POCUS was 85.6% (95%CI: 84.0%-87.2%) and specificity was 80.8% (95%CI: 79.0%-82.5%). The DOR was 68.09 (95%CI: 27.07-171.28), and the negative likelihood ratio was 0.14 (95%CI: 0.085-0.231), indicating strong potential to rule out serious pathology. Substantial heterogeneity was noted, mainly due to operator variability, study design, and diagnostic protocols.</p><p><strong>Conclusion: </strong>POCUS offers accurate, rapid, and cost-effective evaluation of acute dyspnoea in EDs. Standardised training and further research on outcomes, protocols, and underrepresented populations are essential for consistent, effective implementation.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"113426"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent health complications in COVID-19 hospitalized patients at tertiary care hospital in Western India.","authors":"Ashish Jain, Pushpendra Saraswat, Ayushi Sharma, Vinod Sharma, Ravi Jain","doi":"10.5492/wjccm.v15.i1.114620","DOIUrl":"10.5492/wjccm.v15.i1.114620","url":null,"abstract":"<p><strong>Background: </strong>Long coronavirus disease (COVID) is a condition characterized by persistent health issues following severe acute respiratory syndrome coronavirus 2 infection. The condition remains poorly understood, especially in terms of long-term impact on health and the quality of life. This study hypothesized that majority of the discharged patients experience long-term post-COVID-19 complications.</p><p><strong>Aim: </strong>To evaluate the long-term post-COVID-19 complications and its impact on the patients' quality of life.</p><p><strong>Methods: </strong>This retrospective cohort study, with telephonic interview-based follow-up, was conducted at a tertiary care hospital in western India between March and August 2024. The medical records of the patients hospitalized with COVID-19 during the second wave (between March and June 2021) and discharged, were reviewed. The data were collected from the patients <i>via</i> structured telephonic interviews that focused on post-infection sequelae across various bodily systems and was summarized using percentages and proportions.</p><p><strong>Results: </strong>A total of 1139 patients who met the inclusion criteria, participated in the study with a follow-up period of three years. Amongst the survivors (<i>n</i> = 1052) at the end of three years, 150 (14.25%) developed new or ongoing diseases after recovery from acute COVID-19, while 51 (4.8%) were still under treatment at the time of follow-up. Amongst these 150 long-COVID-19 patients, pulmonary disease (<i>n</i> = 27, 2.57%), body pain (<i>n</i> = 20, 1.90%), coronary artery disease or angioplasty, and diabetes mellitus (<i>n</i> = 17, 1.61% each), hypertension (<i>n</i> = 16, 1.52%), and fatigue (<i>n</i> = 13, 1.24%) were frequently reported. Although statistically insignificant, the patients who received three or more vaccine doses after the second wave of the pandemic reported slightly lower rates of post-COVID-19 morbidity and treatment requirements.</p><p><strong>Conclusion: </strong>The current study highlights the burdens of long-term complications following COVID-19 infection, with a broad spectrum of post-infection sequelae. However, the impact of vaccination on the course of development and treatment of long COVID could not be ascertained. This finding emphasizes the need for continued research and healthcare planning to address the persistent impact of COVID-19 upon the survivors.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"114620"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}