Green Chemical Engineering最新文献_第8页

Application and progress of techno-economic analysis and life cycle assessment in biomanufacturing of fuels and chemicals 技术经济分析和生命周期评估在燃料和化学品生物制造中的应用与进展

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.09.002

Rongzhan Fu , Lixia Kang , Chenyue Zhang , Qiang Fei

{"title":"Application and progress of techno-economic analysis and life cycle assessment in biomanufacturing of fuels and chemicals","authors":"Rongzhan Fu , Lixia Kang , Chenyue Zhang , Qiang Fei","doi":"10.1016/j.gce.2022.09.002","DOIUrl":"https://doi.org/10.1016/j.gce.2022.09.002","url":null,"abstract":"<div>To reduce the dependency on petroleum-based products and emission of greenhouse gas, renewable biofuels and chemicals play an important role to meet the unmatched energy demands of the rapidly growing population. However, most biofuel and chemical products do not reach the commercialization stage, mainly hindered by incomparable economics to petroproducts. Techno-economic assessment (TEA) is a useful tool to estimate economic performance, and identify bottlenecks for the development of biofuel and chemical production technology, meanwhile, life cycle assessment (LCA) is applied to assess sustainability by reducing the environmental impact of biofuel and chemical production. This present review covers TEA and LCA research progress in the manufacturing of biofuels and biochemical, and discusses the impacts of TEA and LCA results on the development and optimization of biofuel and chemical production. In addition, challenges associated with TEA and LCA of biofuel and biochemical production were briefly overviewed, and potential approaches that may overcome such challenges were discussed enabling viable and sustainable biomanufacturing of fuels and chemicals. Future integrated TEA and LCA studies could significantly promote the economic and sustainable development of the biomanufacturing process.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 189-198"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50178406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Synergistic utilization of carbon sources for efficient biosynthesis of N-acetylglucosamine 协同利用碳源高效生物合成n -乙酰氨基葡萄糖

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.04.001

Yanni Pei, Yuhan Wang, Xiaolin Shen, Jia Wang, Xinxiao Sun, Qipeng Yuan

{"title":"Synergistic utilization of carbon sources for efficient biosynthesis of N-acetylglucosamine","authors":"Yanni Pei, Yuhan Wang, Xiaolin Shen, Jia Wang, Xinxiao Sun, Qipeng Yuan","doi":"10.1016/j.gce.2022.04.001","DOIUrl":"10.1016/j.gce.2022.04.001","url":null,"abstract":"<div>N-acetylglucosamine (GlcNAc) is an amino monosaccharide that has a variety of bioactivities and is widely used in pharmaceutical and food industries. Production of GlcNAc by chitin hydrolysis is limited by the supply of raw materials and encounters the risk of shellfish protein contamination. For efficient biosynthesis of GlcNAc, one challenge is to balance the carbon distribution between growth and production. Here, we applied the strategy of synergistic carbon utilization, in which glycerol supports cell growth and provides the acetyl group of GlcNAc while glucose serves as the precursor to glucosamine. The efficiency of GlcNAc production was stepwise improved by blocking the product re-uptake and degradation, strengthening the biosynthetic pathway and synergistically utilizing two carbon sources. With these efforts, the final strain produced 41.5 g/L GlcNAc with a yield of 0.49 g/g of total carbon sources. In addition, we also explored the feasibility of using acetate as a cheap carbon source to partly replace glycerol. This study provides a promising alternative strategy for sustainable and efficient production of GlcNAc.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 233-238"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44541691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Engineering Escherichia coli for high-yield production of ectoine 工程大肠杆菌高产产异托因

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2021.09.002

Daoan Wang , Jiamin Chen , Yang Wang , Guocheng Du , Zhen Kang

{"title":"Engineering Escherichia coli for high-yield production of ectoine","authors":"Daoan Wang , Jiamin Chen , Yang Wang , Guocheng Du , Zhen Kang","doi":"10.1016/j.gce.2021.09.002","DOIUrl":"10.1016/j.gce.2021.09.002","url":null,"abstract":"<div>Ectoine is a natural macromolecule protector and synthesized by some extremophiles. It provides protections against radiation-mediated oxidative damages and is widely used as a bioactive ingredient in pharmaceutics and cosmetics. To meet its growing commercial demands, we engineered Escherichia coli strains for the high-yield production of ectoine. The ectABC gene cluster from the native ectoine producer Halomonas elongata was introduced into different Escherichia coli (E. Coil) strains via plasmids and 0.8 g L-1 of ectoine was produced in flask cultures by engineered E. coli BL21 (DE3). Subsequently, we designed the ribosome-binding sites of the gene cluster to fine-tune the expressions of genes ectA, ectB, and ectC, which increased the ectoine yield to 1.6 g L-1. After further combinatorial overexpression of Corynebacterium glutamicum aspartate kinase mutant (G1A, C932T) and the H. elongate aspartate-semialdehyde dehydrogenase to increase the supply of the precursor, the titer of ectoine reached to 5.5 g L-1 in flask cultures. Finally, the engineered strain produced 60.7 g L-1 ectoine in fed-batch cultures with a conversion rate of 0.25 g/g glucose.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 217-223"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46731087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Bioconversion of lignocellulosic biomass into bacterial nanocellulose: challenges and perspectives 木质纤维素生物质转化为细菌纳米纤维素:挑战和前景

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.04.007

Wenchao Li , Yuqing Shen , Huan Liu , Xinxin Huang , Bin Xu , Cheng Zhong , Shiru Jia

{"title":"Bioconversion of lignocellulosic biomass into bacterial nanocellulose: challenges and perspectives","authors":"Wenchao Li , Yuqing Shen , Huan Liu , Xinxin Huang , Bin Xu , Cheng Zhong , Shiru Jia","doi":"10.1016/j.gce.2022.04.007","DOIUrl":"10.1016/j.gce.2022.04.007","url":null,"abstract":"<div>Nanocellulose has various outstanding properties and great potential for replacing petrochemical products. The utilization of lignocellulose to produce nanocellulose is of great significance to the sustainable development of the economy and society. However, the direct extraction of nanocellulose from lignocellulose by chemical method is challenged by toxic chemicals utilization, energy and time consumption, and waste water generation. Therefore, this paper addressed the conversion of lignocellulosic biomass into bacterial nanocellulose (BNC) by the biological method. Moreover, this article highlights the recent advances in potentials and challenges of lignocellulosic biomass for BNC production through the bioconversion process, including biomass pretreatment, enzymatic hydrolysis, glucose and xylose fermentation, GA accumulation, and inhibitor tolerant. The development in metabolic and evolutionary engineering to enhance the production capacity of BNC-producing strain is also discussed. It is expected to provide guidance on the effective bioproduction of nanocellulose from lignocellulosic biomass.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 160-172"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48928612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals: current status and future perspectives 甲醇生物转化为增值化学品的天然甲基化营养体工程:现状和未来展望

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.10.005

Jing Wang, Ruirui Qin, Yuanke Guo, Chen Ma, Xin Wang, Kequan Chen, Pingkai Ouyang

引用次数: 5

OFC: Outside Front Cover OFC：外封面

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/S2666-9528(23)00013-4

引用次数: 0

Characterization of glucose isomerase-producing bacteria and optimization of fermentation conditions for producing glucose isomerase using biomass 产糖异构酶细菌的鉴定及生物质产糖异构酶发酵条件的优化

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.05.003

Aristide Laurel Mokale Kognou , Chonlong Chio , Janak Raj Khatiwada , Sarita Shrestha , Xuantong Chen , Hongwei Li , Yuen Zhu , Zi-Hua Jiang , Chunbao (Charles) Xu , Wensheng Qin

{"title":"Characterization of glucose isomerase-producing bacteria and optimization of fermentation conditions for producing glucose isomerase using biomass","authors":"Aristide Laurel Mokale Kognou , Chonlong Chio , Janak Raj Khatiwada , Sarita Shrestha , Xuantong Chen , Hongwei Li , Yuen Zhu , Zi-Hua Jiang , Chunbao (Charles) Xu , Wensheng Qin","doi":"10.1016/j.gce.2022.05.003","DOIUrl":"10.1016/j.gce.2022.05.003","url":null,"abstract":"<div>Glucose isomerase (GI) is an enzyme with high potential applications. Characterization of GI producing bacteria with interesting properties from an industrial point of view is essential. Bacillus sp., Paenarthrobacter sp., Chryseobacterium sp., Hymenobacter sp., Mycobacterium sp., and Stenotrophomonas sp. were isolated from soil samples. Optimization of enzyme production yield was investigated in various fermentation conditions using response surface methodology. All isolates exhibited maximum GI activity at 40 °C, pH 6–8 after 4 days of incubation. A mixture of peptone/yeast extract or tryptone/peptone enhanced higher enzyme production. The same trend was observed in fermentation medium containing 1% xylose or 2%–2.5% wheat straw. This study advanced the knowledge of these bacterial isolates in promoting wheat straw as feedstock for the bio-based industry.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 239-249"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45691911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Biomanufacturing boosts the high-level development of economy and society 生物制造促进了经济社会的高水平发展

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2023.03.004

Chun Li, An-Ping Zeng, Ying-Jin Yuan

引用次数: 0

Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy 用于改善癌症治疗的多功能工程多肽给药系统

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2022.07.010

Xiaobin Li , Junyu Liu , Haihong Chen , Yaxin Chen , Yi Wang , Can Yang Zhang , Xin-Hui Xing

{"title":"Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy","authors":"Xiaobin Li , Junyu Liu , Haihong Chen , Yaxin Chen , Yi Wang , Can Yang Zhang , Xin-Hui Xing","doi":"10.1016/j.gce.2022.07.010","DOIUrl":"10.1016/j.gce.2022.07.010","url":null,"abstract":"<div>With the rapid development of chemical engineering and biotechnology, polypeptide, as a promising candidate in the biomedical field, has been thoroughly investigated and extensively used as the drug delivery vehicle for diseases treatment, especially cancer, owing to the high biocompatibility, good biodegradability, versatile constructions, and diverse functions. Engineered polypeptide-based drug delivery system (so-called EPP-DDS) can deliver the cargos to the target site via a specific recognition effect, followed by overcoming the barriers like blood brain barrier (BBB) and releasing them by responding to the microenvironment cues, to improve the therapeutic efficacy and reduce the side-effect. Herein, it's of great importance to conclude and summarize the updates on EPP-DDS developed by chemical engineering methods. In this review, we first summarized the recent updates in the manufacturing of polypeptide and preparation of EPP-DDS based on green biochemical engineering and/or synthetic processes for cancer therapy, including chemotherapy, immunotherapy, photodynamic therapy (PDT), gene therapy, and combination therapy. Then, we surveyed the research progress of inflammation-mediated cancer treatment strategies based on EPP-DDS with high anti-inflammation activity. Finally, we concluded the discovery and green production process of engineered polypeptide, challenges, and perspectives of EPP-DDS. Overall, the EPP-DDS has great potential for cancer therapy in the clinic with improved therapeutic efficacy and reduced adverse effect, which needs the innovation of green biochemical engineering for customized design and production of polypeptides.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 173-188"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42155772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ionic-microenvironment stabilizes the disulfide engineered lysine decarboxylase for efficient cadaverine production 离子微环境稳定二硫键工程赖氨酸脱羧酶以高效生产尸胺

Green Chemical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.gce.2021.11.010

Zhuang Li , Yaju Xue , Xiuling Ji , Yuhong Huang

{"title":"Ionic-microenvironment stabilizes the disulfide engineered lysine decarboxylase for efficient cadaverine production","authors":"Zhuang Li , Yaju Xue , Xiuling Ji , Yuhong Huang","doi":"10.1016/j.gce.2021.11.010","DOIUrl":"10.1016/j.gce.2021.11.010","url":null,"abstract":"<div>Cadaverine is the key monomer for the synthesis of nylon 5X. Efficient and alkaline stable lysine decarboxylases are highly desirable for cadaverine production as the reaction pH increasing from 6.3 to 8.5. However, the most studied lysine decarboxylase CadA (E. coli) lost almost all activity at pH 8.0, which is the foremost challenge for the industrial-cadaverine production. In this study, we first found that the Na+-microenvironment significantly improved the alkaline stability of the disulfide engineered lysine decarboxylase ΔLdcEt3 (P233C/L628C) (half-life 362 h), compared to the conventional buffer (half-life 0.66 h) at pH 8.0. Meanwhile, the whole-cell conversion efficiency of the industrial-grade l-lysine with ΔLdcEt3 could reach up to 99% in 2 h in the fermenter. Experimental investigation and molecular dynamics confirmed that Na+-microenvironment could improve active-aggregation state and affect secondary structure of ΔLdcEt3. Therefore, Na+-microenvironment stabilizes ΔLdcEt3 providing a great potential industrial application for high-level cadaverine production.</div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":"4 2","pages":"Pages 224-232"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45527480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2