Chinese Journal of Plastic and Reconstructive Surgery最新文献

{"title":"Botulinum toxin therapy for androgenetic alopecia: From mechanistic insights to clinical applications","authors":"Baoyi Li ,&nbsp;Changjiang Zhao ,&nbsp;Ruiyu Luo ,&nbsp;He Yan ,&nbsp;Zihan Li ,&nbsp;Lingling Jia ,&nbsp;Hua Jiang ,&nbsp;Yufei Li","doi":"10.1016/j.cjprs.2025.08.006","DOIUrl":"10.1016/j.cjprs.2025.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Androgenetic alopecia (AGA) is a common hair loss disorder that significantly affects patient’s quality of life. Botulinum toxin (BoNT) has emerged as a potential treatment; however, its effectiveness and underlying mechanisms remain unclear. This systematic review aimed to synthesize the existing evidence on BoNT for AGA, analyze its mechanisms, evaluate its efficacy, and explore its potential for precision therapy.</div></div><div><h3>Methods</h3><div>A PubMed search was conducted for studies published between 2020 and 2025. A total of 25 studies, including 11 clinical trials and 7 reviews, were included. The studies were analyzed for BoNT mechanisms in AGA, treatment regimens, efficacy, outcomes, cost-effectiveness, and safety profiles.</div></div><div><h3>Results</h3><div>Experimental evidence suggests that BoNT reduces transforming growth factor-β in dermal papilla cells, a key pathological pathway in AGA. Other hypothetical mechanisms, such as scalp muscle relaxation improving microcirculation or inhibiting androgen conversion require further validation. In clinical trials, most studies used 30–150 U of BoNT via intramuscular (six studies) or intradermal (three studies) injections, with 1–3 sessions and up to 6 months of follow-up. Early open-label trials reported response rates of 70%–79%, but recent high-quality randomized controlled trials (RCTs) showed no significant improvement in hair density compared to placebo. Combination therapy with finasteride or minoxidil enhanced treatment outcomes, though large-scale evidence is lacking. BoNT was less cost-effective than first-line therapies such as minoxidil, with session costs approximately 37 times higher. Intramuscular injection appeared more effective than intradermal injection, possibly due to scalp muscle relaxation and vascular decompression. BoNT generally had a mild safety profile.</div></div><div><h3>Conclusion</h3><div>Currently, BoNT lacks robust evidence to replace traditional treatments for AGA. Future research should focus on establishing standardized dosing protocols, conducting large-scale, long-term RCTs, and integrating molecular biomarkers to improve understanding and optimize the clinical use of BoNT in AGA management.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 3","pages":"Pages 173-178"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric and visual analysis of postburn hand reconstruction","authors":"Shenying Luo ,&nbsp;Hsin Liang ,&nbsp;Bin Gu,&nbsp;Tao Zan,&nbsp;Jieyi Ren","doi":"10.1016/j.cjprs.2025.03.002","DOIUrl":"10.1016/j.cjprs.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Scar contractions caused by hand burns seriously impact both the function and appearance of the hand. Consequently, post-burn hand reconstruction is a primary focus of secondary reconstructive surgery performed within the first 10 years after a burn injury. This study aimed to identify developmental trends and research hotspots in post-burn hand reconstruction, providing insights and recommendations for researchers.</div></div><div><h3>Methods</h3><div>Bibliometric and visualization analyses were conducted using CiteSpace v6.4. R1 (64-bit) and VOS viewer. The Web of Science Core Collection served as the data source. A total of 136 articles between 1997 and 2025 were included based on the following keywords: “postburn hand reconstruction” or “postburn hand” or “scar contraction hand deformity.”</div></div><div><h3>Results</h3><div>The field of post-burn hand reconstruction is advancing, as indicated by the overall and annual increase in publications. The United States leads in number of published papers. However, major institutions show low centrality, indicating weak collaboration between countries and regions, with research still dominated by single-center studies. The top three most prolific authors were Paul P M van Zuijlen, Fatih Uyghur, and Ersin Uyghur. The keywords “double Z-plasty” and the cluster “flap” not only have high emergence intensity but also appear frequently in recent studies, marking them as current research hotspots.</div></div><div><h3>Conclusion</h3><div>The lack of long-term research and consensus limits further advancements in post-burn hand reconstruction. To address this, multi-center and multi-disciplinary collaborations should be encouraged. Additionally, integrating basic medical research with biomedical engineering could enhance the management and outcomes of post-burn hand reconstruction.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 101-110"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solcoseryl-enriched biodegradable diplene membrane for lower eyelid reconstruction: A novel bioactive approach","authors":"Maria Cervatiuc ,&nbsp;Igor Vladimirovich Reshetov ,&nbsp;Eldor Jonnazarov ,&nbsp;Svetlana Vagovna Saakyan ,&nbsp;Dzhakhongir Shavkatdzhonovich Rakhimov ,&nbsp;Abusaid Ibodulloevich Sadulloev ,&nbsp;Mukhammadnazir Mukhamadzokirovich Normatov ,&nbsp;Rustamjon Zoidovich Juraev ,&nbsp;Bahodur Bahtiyorovich Abdurahmonov ,&nbsp;Abduhakim Abdulatifovich Saidov ,&nbsp;Mukhriddin Bahodurovich Mazhitov ,&nbsp;Nekruz Rahimovich Rahmatov ,&nbsp;Fuzliddin Botirdzhonovich Gadoev ,&nbsp;Aminjon Nozimjonovich Shafiev ,&nbsp;Uzak Zholdoshovich Zhumakadyrov","doi":"10.1016/j.cjprs.2025.05.003","DOIUrl":"10.1016/j.cjprs.2025.05.003","url":null,"abstract":"<div><h3>Background</h3><div>The full-thickness excision of malignant lower-eyelid tumors, particularly those with posterior lamellar involvement, presents a reconstructive challenge. Traditional grafts often have limitations, prompting interest in biocompatible alternatives, such as biodegradable diplene membranes. This study introduces a novel modification to the standard protocol: the use of diplene membranes enriched with Solcoseryl, a metabolically active agent that enhances angiogenesis, reduces inflammation, and accelerates epithelialization.</div></div><div><h3>Methods</h3><div>Twenty-seven patients (mean age, 68.96 ​± ​8.09 years) with histologically confirmed malignant lower-eyelid tumors underwent reconstruction using diplene membranes combined with Solcoseryl. The outcomes were compared with those of a previously reported cohort treated with Diplene alone. The follow-up period ranged from 3 to 12 months.</div></div><div><h3>Results</h3><div>All patients achieved successful restoration of eyelid support with high aesthetic satisfaction. The Solcoseryl group demonstrated significantly faster epithelialization (mean 9.8 ​± ​1.2 days), improved microcirculatory parameters, and no serious complications. Minor hematomas occurred in two cases (7.4%).</div></div><div><h3>Conclusion</h3><div>The modified Diplene–Solcoseryl membrane enhanced wound healing and biocompatibility during lower-eyelid reconstruction by transforming the membrane into a bioactive scaffold. This innovation offers superior functional and aesthetic outcomes compared to standard diplene use and represents a significant advancement in oculoplastic and oncological reconstructive surgery.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 66-70"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep inferior epigastric perforator and transverse rectus abdominis musculocutaneous flap breast reconstruction: A comparison of breast mobility outcomes","authors":"Cheng Huang,&nbsp;Xia Fang,&nbsp;Nan Li,&nbsp;Dawei Li,&nbsp;Qi Bao,&nbsp;Chenggang Yi,&nbsp;Xueqing Hu","doi":"10.1016/j.cjprs.2024.11.009","DOIUrl":"10.1016/j.cjprs.2024.11.009","url":null,"abstract":"<div><div>Current breast reconstruction evaluations mostly focus on static cosmetic analysis as a measure of the clinical outcomes. Moreover, it is essential to consider the dynamic changes in the reconstructed breast alongside assessments of aesthetic symmetry, functional restoration, complication rates, and long-term stability of the reconstruction. This study aimed to assess the mobility of the reconstructed breast following various breast reconstruction techniques, specifically by comparing deep inferior epigastric perforator (DIEP) flaps and pedicled transverse rectus abdominis musculocutaneous (TRAM) flaps. We conducted a longitudinal case study to investigate the changes in breast movement resulting from different surgical interventions. The comparison showed that DIEP flap reconstruction was more likely to achieve superior breast mobility outcomes than TRAM flap reconstruction. For a better breast aesthetic outcome, it is fundamental to improve the awareness of the dynamic evaluation of the reconstructed breast at the surgical strategy level.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 89-92"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal osteitis complicated with post-traumatic knife osteonecrosis in sexual assault: A case report","authors":"Lungere Bazibuhe Prosper ,&nbsp;Mongwa Mbikilile Justin ,&nbsp;Kitumaini Munyahali John ,&nbsp;Fataki Rutega Junior ,&nbsp;Bandeke Matabishi Destin ,&nbsp;Kavira Isse-Somo ,&nbsp;Cikwanine Buhendwa ,&nbsp;Alumeti Munyali Désiré","doi":"10.1016/j.cjprs.2024.12.001","DOIUrl":"10.1016/j.cjprs.2024.12.001","url":null,"abstract":"<div><div>Frontal osteitis complicated with bone necrosis is rare. In addition, the condition has various etiologies, such as frontal sinusitis, penetrating head injury, postoperative complications after sinus surgery, and hematogenous spread from distant sites. In frontal osteitis, early diagnosis is important, and fistulization of pus in the scalp or on the traumatized forehead may raise the suspicion of osteitis in one of the skull bones. The exclusion of osteonecrosis is such cases is an emergency; hence, a magnetic resonance imaging and a computed tomography scan are required in the absence of skull radiography. Early administration of the appropriate treatment in the immediate post-trauma period ensures effective prevention of frontal osteitis; however, the treatment of bone necrosis involves debridement and antibiotic therapy to prevent fatal intracranial complications. This report presents the case of a 16-year-old female patient who experienced sexual and physical assault that resulted in undetected frontal trauma complicated with frontal osteonecrosis. Thorough clinical examination of the patient was performed, and follow-up and multidisciplinary management enabled the social integration of the patient.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 97-100"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of myelomeningocele defect reconstruction: Insights and outcomes from a single center","authors":"Ming Chin Lim,&nbsp;Ahmad Sukari Halim","doi":"10.1016/j.cjprs.2025.03.001","DOIUrl":"10.1016/j.cjprs.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Numerous reconstruction methods have been developed for myelomeningocele defects; however, no published reports have been published on the preferred reconstruction method in Malaysia. This study reviewed reconstruction techniques and outcomes in patients with myelomeningocele at our center.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted on reconstruction methods and outcomes in patients with myelomeningocele referred to the Plastic and Reconstructive Unit, Hospital Universiti Sains Malaysia (HUSM), Kelantan, for wound coverage from to 1997–2023. Data on patient demographics, defect size, reconstruction methods, operation duration, flap-related complications, and secondary repairs were collected and analyzed.</div></div><div><h3>Results</h3><div>Thirteen patients were identified in this retrospective study, comprising 5 female patients, 7 male patients, and 1 ambiguous gender patient. Wound closures were performed using primary closure method, local flaps, or regional flap closure. Nine (69.2%) of the thirteen patients underwent soft tissue reconstruction using the local flap, three (23.1%) underwent primary closure, and only one (7.7%) patient underwent wound closure with a regional flap. Flap-related complications were observed in four of the thirteen patients, including wound breakdown in two cases and partial flap necrosis in two cases. Of these four patients, secondary repair was required in three: split-thickness skin grafting was performed in two, and primary closure in one. The remaining patient was managed conservatively with dressings. Patients were followed up for a mean duration of 56.6 (±62.4) months, and complete healing was achieved in all cases.</div></div><div><h3>Conclusion</h3><div>Myelomeningocele repair remains challenging, and a multidisciplinary approach is recommended. We demonstrated various local and regional flap closure methods with good outcomes. Reconstruction techniques should be tailored for individual cases based to the surgeon expertise.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 83-88"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical CT study of lumbar artery perforator flap in women","authors":"Olesya Startseva ,&nbsp;Igor Reshetov ,&nbsp;Jaume Masia ,&nbsp;Alexandra Frolova ,&nbsp;Elena Mershina ,&nbsp;Evgeniya Zhigailova ,&nbsp;Mark Gabriyanchik","doi":"10.1016/j.cjprs.2025.02.001","DOIUrl":"10.1016/j.cjprs.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>The lumbar artery perforator (LAP) flap is an important autologous option in breast reconstruction. As the lumbar perforator flap is relatively new in this field, several questions remain regarding preoperative preparation, especially concerning computed tomography (CT) and magnetic resonance imaging of the donor site. The objective of this study was to aid the surgical approach to the LAP flap in female patients by precisely determining the characteristics of the lumbar perforators.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the computed tomographic angiography images of 20 patients who underwent evaluation of the perforator positions from the four lumbar arteries. Four characteristics were studied: length, diameter, path of the lumbar pedicle, and thickness of the tissues available for transfer.</div></div><div><h3>Results</h3><div>We analyzed 20 CT images, identifying 149 perforating vessels of the lumbar artery. The most suitable perforator for flap harvesting was the L4 perforator, which exhibited a larger diameter, a greater number of perforasomes, and a higher percentage of the cutaneous-septal tract.</div></div><div><h3>Conclusion</h3><div>The LAP flap is a viable option for breast reconstruction and as a free flap in women. The L4 perforator artery is the most suitable for harvesting, owing to its superior perfusion capacity, diameter, and course; however, an interposition graft may be required to lengthen the vascular pedicle.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 78-82"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative resection of giant neurofibromas","authors":"Zhichao Wang ,&nbsp;Xuan Yu ,&nbsp;Yihui Gu ,&nbsp;Wei Wang ,&nbsp;Chengjiang Wei ,&nbsp;Bin Gu ,&nbsp;Jun Yang ,&nbsp;Qingfeng Li","doi":"10.1016/j.cjprs.2025.06.003","DOIUrl":"10.1016/j.cjprs.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Plexiform neurofibromas (PNF) are highly vascular tumors with the potential for significant growth. Surgical removal of giant PNF is often challenging because of intraoperative hemorrhage. This study proposed and evaluated an innovative surgical approach involving FENCY ligation and the role of preoperative embolization in the resection of giant PNF.</div></div><div><h3>Methods</h3><div>This was a retrospective, interventional, and sequential case series conducted in a plastic and reconstructive surgery unit. We summarized all patients with PNF who underwent resection at our center between 2019 and 2024. Surgical case notes from 11 patients with giant PNF who underwent FENCY ligation were reviewed, including three patients who received preoperative embolization. All patients participated in structured telephone interviews. Patient demographics, surgical safety, postoperative recovery, and patient satisfaction were evaluated.</div></div><div><h3>Results</h3><div>Among 456 patients with 494 PNF who underwent surgical resection, we categorized the procedures into median, large, and giant PNF subgroups. To illustrate comprehensive perioperative and surgical approaches, we analyzed seven female and four male patients with giant PNF. The median maximum tumor diameter at the time of surgery was 30.4 ​cm (range, 11.5–55.6 ​cm). Most PNF were located on the face (63.6%), followed by the back (18.2%), buttocks (18.2%), upper limbs (9.1%), and neck (9.1%). The median intraoperative hemorrhage volume was 366 ​mL (range, 10–2 034 ​mL), And the median hospital stay was 17 days (range, 14–33 days). The mean follow-up duration was 2.5 years (range, 0.4–5.5 years). No severe complications were observed, except for one case of infection.</div></div><div><h3>Conclusion</h3><div>PNF resection, particularly giant PNF resection, is a high-risk treatment option. Comprehensive evaluation, perioperative preparation, and surgical techniques are required to ensure efficacy and safety. FENCY ligation and preoperative embolization can be used to resect giant PNF in multiple complex regions with satisfactory outcomes.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 71-77"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous fat transplantation improves dermal adipose dysfunction by regulating autophagy and mitophagy","authors":"Zhijin Li ,&nbsp;Junxian Wen ,&nbsp;Nanze Yu ,&nbsp;Xiaojun Wang","doi":"10.1016/j.cjprs.2025.06.002","DOIUrl":"10.1016/j.cjprs.2025.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Dermal white adipose tissue (dWAT) plays a crucial role in maintaining skin structure and functional homeostasis. Dysfunction of dWAT is closely associated with skin aging and fibrosis, with the impairment of autophagy and mitophagy considered the key mechanisms underlying adipose tissue dysfunction. Autologous fat transplantation (AFT) is widely used in plastic and aesthetic surgeries; however, its effects on dermal adipose function remain unclear.</div></div><div><h3>Methods</h3><div>In this study, a mouse model of dermal adipose dysfunction was established using the PPAR-γ inhibitor GW9662, followed by subcutaneous AFT. Dermal adipose thickness, lipid metabolism, autophagy, and mitophagy-related protein expression (PPAR-γ, PLIN-1, Beclin-1, LC3, Pink-1, and Parkin) were analyzed by H&amp;E staining, immunohistochemistry, and qRT-PCR.</div></div><div><h3>Results</h3><div>GW9662 treatment significantly inhibited lipid metabolism and reduced the expression of autophagy- and mitophagy-related markers, indicating a possible impairment in these pathways. AFT upregulated these markers, suggesting a potential modulatory effect on autophagy and mitophagy.</div></div><div><h3>Conclusion</h3><div>Dermal adipose dysfunction induced by PPAR-γ inhibition may involve dysregulation of autophagy and mitophagy. Subcutaneous fat transplantation appeared to partially reverse these molecular alterations, thereby supporting its potential application in skin aging and adipose tissue restoration.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal leech therapy and grated unripe papaya bandage for the treatment of chronic leg ulcer: A case report","authors":"Nazim Husain ,&nbsp;Md Akhter Hussain Jamali ,&nbsp;Jamal Akhtar ,&nbsp;Usama Akram ,&nbsp;N. Zaheer Ahmed","doi":"10.1016/j.cjprs.2025.02.002","DOIUrl":"10.1016/j.cjprs.2025.02.002","url":null,"abstract":"<div><div>Leg ulcers pose a significant burden on morbidity, healthcare costs, and quality of life, despite rarely resulting in limb loss. This underscores the necessity for safe and effective alternative treatments. Unani medicine offers various therapeutic options for managing ulcers. This case report details the successful treatment of a non-healing venous ulcer using Unani regimens in a 40-year-old male with a history of diabetes mellitus and paralytic polio. The patient sought care at the Regional Research Institute of Unani Medicine, Silchar, Assam, India, for a chronic ulcer in the gaiter region of his right leg, which was associated with mild pain, itching, and hyperpigmentation but notably lacked any signs of varicose veins. Over the years, the patient had undergone various treatments, including topical care and antibiotics; however, frustration with persistent non-healing led him to explore alternative interventions. The Unani treatment included medicinal leech therapy, followed by the application of a grated unripe papaya bandage for 14 days. By the end of this period, the ulcer had completely healed, allowing the discontinuation of the dressing. By the 21st day, symptom resolution was observed, with complete relief from pain and itching and normalization of hyperpigmentation in the surrounding area. This case highlights the potential of Unani therapeutic approaches in effectively managing non-healing venous ulcers.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 2","pages":"Pages 93-96"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}