2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)最新文献_第9页

Analysis and understanding of aptamer and peptide molecular interactions: Application to mucin 1 (Muc1) aptasensor 适配体与肽分子相互作用的分析与理解:mucin 1 (Muc1)适配体传感器的应用

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220133

Kristen L Rhinehardt, R. Mohan, G. Srinivas, A. Kelkar

{"title":"Analysis and understanding of aptamer and peptide molecular interactions: Application to mucin 1 (Muc1) aptasensor","authors":"Kristen L Rhinehardt, R. Mohan, G. Srinivas, A. Kelkar","doi":"10.1109/ISPTS.2015.7220133","DOIUrl":"https://doi.org/10.1109/ISPTS.2015.7220133","url":null,"abstract":"Molecular level interactions and accessibility to binding site play a critical role in efficacy of biosensors. Details on the orientation and location of binding of a biomarker to a bioreceptor can be obtained through computational modeling and analysis. In the present paper, Molecular Dynamics (MD) was used to model the and understand the molecular interaction within a aptamer based sensor using a known peptide-aptamer combination of anti-mucin 1 S2.2 aptamer and MUC1-G (ADPTRPAPG) peptide in a 150mM NaCl solution to mirror SPR aptasensor conditions. The modeling analysis was further extended to understand the influence of other solvent environments. In the solvent environment of 150mM NaCl, MUC1-G binding event was found to occur consistently in the loop region of the aptamer, and showed a key role of arginine residue of the peptide in the aptamer-peptide binding. To further emulate relevant biosensor application characteristics, variation in aptamer and peptide structure as well as solvent conditions were studied and analyzed. These illustrated the sensitivity and selectivity of MUC1-G peptide-aptamer binding. Selective changes in the solvent conditions to reflect a variety of physiological conditions that can be experienced in biosensor applications were modeled through modifications in the peptide-aptamer-solvent molecular systems. Results indicate that certain modified solvent conditions did not induce binding, but rather association events. Present results indicate even variations in the solvent conditions for biosensor applications can impact the binding. Insights from modeling and analysis illustrate the selectiveness and sensitivity to solvent environments in the case of Mucin 1, a breast cancer biomarker, which are critical to the development of reliable and repeatable biosensors.","PeriodicalId":6520,"journal":{"name":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","volume":"1 3 1","pages":"297-302"},"PeriodicalIF":0.0,"publicationDate":"2015-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81827133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of odor compass: Source direction detection system 气味罗盘的研制:源方向探测系统

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220099

Mohammed Zahid, Tanishqua Bhute, Manisha D. Shirke, D. Gharpure

引用次数: 3

Self Powered neutron detector based reactor flux estimation using multisensor particle filter 基于自供电中子探测器的多传感器粒子滤波反应堆通量估计

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220093

P. Tamboli, S. Duttagupta, K. Roy

{"title":"Self Powered neutron detector based reactor flux estimation using multisensor particle filter","authors":"P. Tamboli, S. Duttagupta, K. Roy","doi":"10.1109/ISPTS.2015.7220093","DOIUrl":"https://doi.org/10.1109/ISPTS.2015.7220093","url":null,"abstract":"In this paper, we propose an improved method of In-core neutron flux estimation using Inconel Self Powered Neutron Detectors (SPNDs). The method proposed here is based upon multi-sensor based particle filter utilizing a number of uniformly distributed SPNDs along with the out-core ionization chambers which measure the overall flux. The proposed method estimates the neutron flux of large non-linear core volume involving stiff non-linearities with non-Gaussian uncertainties both in the process and sensor model. We propose an improved particle filtering based data fusion algorithm on multi-sensor network for flux estimation under nonlinear non-Gaussian environment. The nonlinear system in our study is a large core nuclear reactor measured through in-core Self Powered Neutron Detectors. Many critical applications such as reactor protection and control rely upon the neutron flux information and thus make the reliability of data an utmost important. The point kinetic model based on neutron transport theory conveniently explains the dynamics of nuclear reactor. The state equation in point kinetic model is stiff nonlinear set of equations. The neutron flux in the large core, loosely coupled reactor are sensed by multiple sensors measuring point fluxes located at various locations inside the reactor core. The flux values are coupled to each other through diffusion equation. The coupling facilitates redundancy in the information. The multiple independent information about the localized flux peaking can be fused together to enhance the estimation accuracy to a great extent. In our work, we establish, observation model for the neutron flux sensor used for large core flux measurement i.e. Self Powered Neutron Detectoric document.","PeriodicalId":6520,"journal":{"name":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","volume":"27 1","pages":"106-112"},"PeriodicalIF":0.0,"publicationDate":"2015-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86195605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Magnetic field sensor based on Zn doped cobalt ferrites synthesized by chemical co-precipitation route 化学共沉淀法合成锌掺杂钴铁氧体磁场传感器

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220103

P. Janrao, J. C. Maurya, S. Bhoraskar, V. Mathe

引用次数: 4

Design and modeling of a ZnO-based MEMS acoustic sensor for aeroacoustic and audio applications 气动声学和音频应用中基于zno的MEMS声学传感器的设计和建模

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220129

D. S. Arya, M. Prasad, C. C. Tripathi

{"title":"Design and modeling of a ZnO-based MEMS acoustic sensor for aeroacoustic and audio applications","authors":"D. S. Arya, M. Prasad, C. C. Tripathi","doi":"10.1109/ISPTS.2015.7220129","DOIUrl":"https://doi.org/10.1109/ISPTS.2015.7220129","url":null,"abstract":"In previous research work related to the acoustic sensors, the researchers had focused on the individuality of the sensors for aeroacoustic application and sensors for audio range application. This paper describes a simple and novel model of acoustic sensor for aeroacoustic and audio applications (microphone). The model of the device presented in this paper shows interoperability. The sensor reported has the bandwidth of~22 KHz, which covers the entire bandwidth of microphone and aeroacoustic sensors. A LEM (Lumped Element Model) is used to determine the characteristics of the device. The device has the square diaphragm of 1.5 × 1.5 mm2 and a nominal thickness of 15 μm to sustain the high SPL (Sound Pressure Level). A piezoelectric ZnO layer 2.4 μm-thick is sandwiched between two Al-top and bottom electrodes. The top electrode is segmented to enhance the sensitivity of the device. Furthermore, a microtunnel of 100 μm wide and 21μm deep is designed to achieve the lower cut-on frequency of ~5 Hz. The theoritical results show that the sensor has sensitivity (RMS) of 126.3μV/Pa and 96.6 μV/Pa in case of central and outer electrodes respectively. The resonant frequency of ~ 85 KHz is obtained from lumped model, simulated using MULTISIM 13.0. The result is verified with MEMS-CAD TOOL COVENTORWARE®.","PeriodicalId":6520,"journal":{"name":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","volume":"61 1","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2015-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85639739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

IT06. "Space odyssey — The journey continues" ….… video presentation IT06。“太空漫游-旅程继续”....视频演示

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220146

Pramod D. Nayate

引用次数: 0

Electronic nose for on-line quality evaluation of black tea using incremental SOM techniques 基于增量SOM技术的红茶质量在线评价电子鼻

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220128

Saptarshi Ghosh, N. Bhattacharyya, B. Tudu, R. Bandyopadhyay

引用次数: 5

AgI1-xClx (x = 0 − 0.025) — Electrolytes for trace level sensing of chlorine ag1 - xclx (x = 0−0.025)-用于痕量氯水平传感的电解质

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-03-07 DOI: 10.1109/ISPTS.2015.7220090

P. C. Clinsha, K. I. Gnanasekar, V. Jayaraman, T. Gnanasekaran

引用次数: 1

Titanium dioxide nanotube based sensing platform for detection of mycobacterium tuberculosis volatile biomarkers methyl nicotinate and p-anisate 基于二氧化钛纳米管的结核分枝杆菌挥发性生物标志物烟酸甲酯和茴香酯检测平台

2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS) Pub Date : 2015-01-01 DOI: 10.1109/ispts.2015.7220138

Younghwan Kim, Jason Young, David C. Robinson, Greg Jones, M. Misra, S. Mohanty

{"title":"Titanium dioxide nanotube based sensing platform for detection of mycobacterium tuberculosis volatile biomarkers methyl nicotinate and p-anisate","authors":"Younghwan Kim, Jason Young, David C. Robinson, Greg Jones, M. Misra, S. Mohanty","doi":"10.1109/ispts.2015.7220138","DOIUrl":"https://doi.org/10.1109/ispts.2015.7220138","url":null,"abstract":"This research presents a metal functionalized titanium dioxide (TiO2) nanotube based sensor developed for detection of volatile biomarkers (methyl p-anisate and methyl nicotinate) associated with tuberculosis (TB). In this work self-aligning TiO2 nanotubes were fabricated, and functionalized with cobalt for specific binding to the volatile biomarkers of interest. Mimics of the volatile biomarkers were dissolved in water at variable concentrations, and nitrogen gas was flowed through the biomarker solutions and delivered to the sensor. A potentiostatic scan was used to measure current across the device under constant potentials ranging from −1.0 volts to 1-volts methyl nicotinate and methyl p-anisate. The sensor response showed a 3 × 105 change in current for methyl nicotinate, and 7.61 × 106 change in current for methyl p-anisate when compared to baseline. The sensor also showed little response to five other VOCs (acetone, ethanol, methanol, benzene, and phenol) which suggest the sensor is functionalized to be specific for the target VOCs associated with TB. Results showed detection of the volatile biomarkers yield orders of magnitude change in current which is detected easily. The sensor is simple to operate, responds in minutes, and has potential applications in non-invasive diagnosis of TB and other diseases that have distinct volatile biomarkers.","PeriodicalId":6520,"journal":{"name":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","volume":"57 1","pages":"317-324"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90691780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1