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Design, Synthesis and Biological Evaluation of Naphthalene Ring PD-1/PD-L1 Inhibitors 萘环PD-1/PD-L1抑制剂的设计、合成及生物学评价
药物化学 Pub Date : 2021-01-01 DOI: 10.12677/hjmce.2021.92012
磊 赵
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引用次数: 0
Research Progress on Hypoglycemic Effect and Mechanism of Plant Active Ingredients 植物活性成分降血糖作用及机制研究进展
药物化学 Pub Date : 2021-01-01 DOI: 10.12677/hjmce.2021.94017
琛 薛
{"title":"Research Progress on Hypoglycemic Effect and Mechanism of Plant Active Ingredients","authors":"琛 薛","doi":"10.12677/hjmce.2021.94017","DOIUrl":"https://doi.org/10.12677/hjmce.2021.94017","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"120 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66074041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Research of Dihydroartemisinin Derivative 双氢青蒿素衍生物的研究进展
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.83008
洋洋 李
{"title":"Advances in Research of Dihydroartemisinin Derivative","authors":"洋洋 李","doi":"10.12677/hjmce.2020.83008","DOIUrl":"https://doi.org/10.12677/hjmce.2020.83008","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of Ultrasonic Assisted Extraction Process of Total Flavonoids from Pomegranate Peel 超声辅助提取石榴皮总黄酮工艺的优化
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.82004
珍 梁
{"title":"Optimization of Ultrasonic Assisted Extraction Process of Total Flavonoids from Pomegranate Peel","authors":"珍 梁","doi":"10.12677/hjmce.2020.82004","DOIUrl":"https://doi.org/10.12677/hjmce.2020.82004","url":null,"abstract":"Objective: The condition of ultrasonic assisted extraction process of total flavonoids from pomegranate peel was optimized. Methods: Considering the extraction rate of total flavonoids for the evaluation index, the size of particle screen, extraction solvent, extraction solvent percentage, solid-liquid ratio and extraction time were selected as the influencing factors based on the single factor experiment. Results: The optimal conditions are as follows: 100 mesh particle size, 60% ethanol as extraction solvent, 1:60 ratio of material to liquid, 60 minutes of extraction, and 30 minutes of ultrasonic extraction. Under this optimal extraction condition, the extraction rate of total flavonoids from pomegranate peel was 119.5 mg/g, and the degree of its main influencing factors was solid-liquid ratio > extracting time > ethanol concentration > mesh. Conclusions: The simple, reliable, and stable method would provide an experimental basis for the development and utilization of total flavonoids in pomegranate peel.","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Density Functional Theory Calculation Aided Screening of SARS-CoV-2 RNA Polymerase Inhibitors 密度泛函理论计算辅助筛选SARS-CoV-2 RNA聚合酶抑制剂
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.82005
莉芳 张
{"title":"Density Functional Theory Calculation Aided Screening of SARS-CoV-2 RNA Polymerase Inhibitors","authors":"莉芳 张","doi":"10.12677/hjmce.2020.82005","DOIUrl":"https://doi.org/10.12677/hjmce.2020.82005","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biological Evaluation of Benzo[c]heterocyclic Compounds against SHP2 苯并[c]杂环化合物抗SHP2的生物学评价
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.83009
勃 冯
{"title":"Biological Evaluation of Benzo[c]heterocyclic Compounds against SHP2","authors":"勃 冯","doi":"10.12677/hjmce.2020.83009","DOIUrl":"https://doi.org/10.12677/hjmce.2020.83009","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Novel Lipase Mesoporous Composite Microreactor 新型脂肪酶介孔复合微反应器的研究进展
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.84011
佳 王
{"title":"Research Progress of Novel Lipase Mesoporous Composite Microreactor","authors":"佳 王","doi":"10.12677/hjmce.2020.84011","DOIUrl":"https://doi.org/10.12677/hjmce.2020.84011","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 1A and the Advances of Its Inhibitors 双特异性酪氨酸磷酸化调控1A激酶及其抑制剂的研究进展
药物化学 Pub Date : 2020-01-01 DOI: 10.12677/hjmce.2020.82006
勇 王
{"title":"The Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 1A and the Advances of Its Inhibitors","authors":"勇 王","doi":"10.12677/hjmce.2020.82006","DOIUrl":"https://doi.org/10.12677/hjmce.2020.82006","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Hyoscyamine in Hindu Datura by RP-HPLC 反相高效液相色谱法测定曼陀罗中莨菪碱的含量
药物化学 Pub Date : 2019-01-01 DOI: 10.12677/hjmce.2019.72005
宝仪 熊
{"title":"Determination of Hyoscyamine in Hindu Datura by RP-HPLC","authors":"宝仪 熊","doi":"10.12677/hjmce.2019.72005","DOIUrl":"https://doi.org/10.12677/hjmce.2019.72005","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the Recovery of Hyoscyaminefrom the Waste after the Extraction ofScopolamine in Hindu Datura 从印度曼陀罗中提取东莨菪碱后的废液中回收莨菪碱的研究
药物化学 Pub Date : 2019-01-01 DOI: 10.12677/hjmce.2019.72002
黄 徐胜
{"title":"Study on the Recovery of Hyoscyaminefrom the Waste after the Extraction ofScopolamine in Hindu Datura","authors":"黄 徐胜","doi":"10.12677/hjmce.2019.72002","DOIUrl":"https://doi.org/10.12677/hjmce.2019.72002","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66073100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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