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Research Progress of Imperata cylindrica var. major 白茅专业研究进展
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.113022
佳佳 李
{"title":"Research Progress of Imperata cylindrica var. major","authors":"佳佳 李","doi":"10.12677/hjmce.2023.113022","DOIUrl":"https://doi.org/10.12677/hjmce.2023.113022","url":null,"abstract":"Imperata cylindrica var. major belongs to Poaceae family, its rhizome is a traditional medicinal and food homologous Chinese medicinal herb,","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress in Nucleoside Antiviral Drugs 核苷类抗病毒药物的研究进展
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.113018
梦瑶 王
{"title":"Research Progress in Nucleoside Antiviral Drugs","authors":"梦瑶 王","doi":"10.12677/hjmce.2023.113018","DOIUrl":"https://doi.org/10.12677/hjmce.2023.113018","url":null,"abstract":"Modified nucleosides are a major class of anti-virus and anti-tumor drugs, which are widely used in the clinic. However, issues including the emergence of drug resistance, toxicity and superinfection have posed new challenges for nucleoside-based antiviral drug discovery. Many research found that chemical manipulation could impact the antiviral potency, safety, and drug resistance","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Quanzhen Yiqi Decoction on Inflammatory Response and Immune Function of COPD Rats Were Analyzed Based on LASP1 and CXCR1 基于LASP1和CXCR1分析全真益气汤对COPD大鼠炎症反应和免疫功能的影响
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.113020
佳佳 赵
{"title":"The Effects of Quanzhen Yiqi Decoction on Inflammatory Response and Immune Function of COPD Rats Were Analyzed Based on LASP1 and CXCR1","authors":"佳佳 赵","doi":"10.12677/hjmce.2023.113020","DOIUrl":"https://doi.org/10.12677/hjmce.2023.113020","url":null,"abstract":"Objective: To observe the effects of Quanzhen Yiqi Decoction on the expression of LASP1 and CXCR1 in lung tissue of chronic obstructive pulmonary disease (COPD) rats, and to explore the effects of Quanzhen Yiqi Decoction on inflammation and immune function of COPD. Methods: Eighteen SD rats were randomly divided into Chinese medicine group and model group, with 9 rats in each group. COPD rat model was established by smoking combined with lipopolysaccharide (LPS). The model group was given 0.9% normal saline daily. The traditional Chinese medicine group was given 40% Quanzhen Yiqi Decoction concentrated decoction every day. The mrna levels of LASP1 and CXCR1 in rat lung tissue were detected by fluorescence quantitative PCR, and the protein levels of LASP1 and CXCr1 in rat lung tissue were detected by Western blot. Results: The mRNA expression abundance of LASP1 in the Chinese medicine group was 0.145 times that in the model group. The mRNA expression abundance of CXCR1 in the TCM group was 0.614 times of that in the model group. Compared with model group, the protein expression levels of LASP1 and CXCR1 in TCM group were significantly decreased. Conclusions: Quanzhen Yiqi Decoction can inhibit airway inflammation in COPD rats by down-regulating the expressions of LASP1 and CXCR1 genes and proteins, which may be one of the potential mechanisms to reduce the risk of lung cancer caused by COPD.","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Adsorption Properties of Active Carbon and Hydroxylated Multi Walled Carbon Nanotubes on the Hydrolysates of Giant Salamander 活性炭与羟基化多壁碳纳米管对大鲵水解液的吸附性能比较
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.112009
莹 纪
{"title":"Comparison of Adsorption Properties of Active Carbon and Hydroxylated Multi Walled Carbon Nanotubes on the Hydrolysates of Giant Salamander","authors":"莹 纪","doi":"10.12677/hjmce.2023.112009","DOIUrl":"https://doi.org/10.12677/hjmce.2023.112009","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66077925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress of Research on Chemical Composition and Pharmacological Effects of Astragalus membranaceus 黄芪化学成分及药理作用的研究进展
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.112010
贵珍 刘
{"title":"Progress of Research on Chemical Composition and Pharmacological Effects of Astragalus membranaceus","authors":"贵珍 刘","doi":"10.12677/hjmce.2023.112010","DOIUrl":"https://doi.org/10.12677/hjmce.2023.112010","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Debittering and Deodoring of Enzymatic Hydrolysates of Andrias davidianus 大卫草酶解物脱臭脱臭的研究
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.112008
莹 纪
{"title":"Study on Debittering and Deodoring of Enzymatic Hydrolysates of Andrias davidianus","authors":"莹 纪","doi":"10.12677/hjmce.2023.112008","DOIUrl":"https://doi.org/10.12677/hjmce.2023.112008","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66077392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress on Main Functional Components and Comprehensive Utilization of Pear Pomace 梨渣主要功能成分及其综合利用研究进展
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.113019
兰兰 何
{"title":"Research Progress on Main Functional Components and Comprehensive Utilization of Pear Pomace","authors":"兰兰 何","doi":"10.12677/hjmce.2023.113019","DOIUrl":"https://doi.org/10.12677/hjmce.2023.113019","url":null,"abstract":"Rosa roxburghii is a kind of ethnic medicine with homology of medicine and food, and has a variety of active ingredients. Rosa roxburghii pomace is a by-product produced after Rosa roxburghii processing. The content of fruit dregs is similar to that of Rosa roxburghii , which has the effects of anti-oxidation, anti-aging, lowering blood sugar and blood lipid. It has high utilization value, but it has not yet been well developed and utilized, causing significant environmental pollution and resource waste. The reasonable development and utilization of Rosa roxburghii pomace is of great","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual Screening of Antitumor Small Molecule Inhibitors Targeting CDK6 靶向CDK6的抗肿瘤小分子抑制剂的虚拟筛选
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.113024
树香 李
{"title":"Virtual Screening of Antitumor Small Molecule Inhibitors Targeting CDK6","authors":"树香 李","doi":"10.12677/hjmce.2023.113024","DOIUrl":"https://doi.org/10.12677/hjmce.2023.113024","url":null,"abstract":"Objective: The abnormal cell cycle caused by Cyclin-dependent kinases 6 (CDK6) overexpression is responsible for excessive proliferation of cancer cells","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66078794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism and Treatment of Drug Resistance in Castration-Resistant Prostate Cancer Caused by Glucocorticoid Receptors 糖皮质激素受体致去势抵抗性前列腺癌耐药机制及治疗
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.111004
晨帆 李
{"title":"Mechanism and Treatment of Drug Resistance in Castration-Resistant Prostate Cancer Caused by Glucocorticoid Receptors","authors":"晨帆 李","doi":"10.12677/hjmce.2023.111004","DOIUrl":"https://doi.org/10.12677/hjmce.2023.111004","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66077416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the HPLC Fingerprint Chromatogram of Xinhui Tangerine Peel in Different Years 新会陈皮不同年份HPLC指纹图谱研究
药物化学 Pub Date : 2023-01-01 DOI: 10.12677/hjmce.2023.111003
晴晴 王
{"title":"Study on the HPLC Fingerprint Chromatogram of Xinhui Tangerine Peel in Different Years","authors":"晴晴 王","doi":"10.12677/hjmce.2023.111003","DOIUrl":"https://doi.org/10.12677/hjmce.2023.111003","url":null,"abstract":"","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66077757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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