2009 2nd International Conference on Biomedical Engineering and Informatics最新文献

{"title":"Is that Possible to Design the Versatile Inhibitors for H1N1, H5N1, H5N2, and H5N7?","authors":"Chien-Yu Chen, D. Bau, M. Tsai, Y. Hsu, T. Ho, Hung-Jin Huang, Yea-Huey Chang, F. Tsai, Chang-Hai Tsai, Calvin Yu‐Chian Chen","doi":"10.1109/BMEI.2009.5305805","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305805","url":null,"abstract":"In this study, a QSAR model of neuraminidase (NA) type 1 (N1) was elevated. This map contained two hydrogen bond acceptor features, one hydrogen bond donor features, and one positive ionizable feature. In the second step, we created the interaction maps in the active sites on the neuraminidase type2, and type7 (N2 and N7) protein structures. The structure-based pharmacophore map was showed the features on every amino acid in the active site on the protein structure. The third step was pharmacophore comparison, root-mean-squared error (RMSE) was reported for the matching pharmacophore features. The result showed that the maps of N1, N2, and N7 had subtle differences in distances of each features. We created the combined map for N1, N2, and N7 to resolving the difference in the three NA types. The combined map was employed to NCI database screening, then, the potent versatile inhibitors were elevated in the results.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"35 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82294542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traffic-Adaptive Hybrid Routing Algorithm for Double-Layered Satellite Networks","authors":"D. Yao, Cheng Wang, Jianhui Shen","doi":"10.1109/BMEI.2009.5305476","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305476","url":null,"abstract":"Aiming at QoS routing problems in double-layered LEO/MEO satellite networks, a novel routing algorithm, TAHR, which takes advantage of hierarchical architecture and traffic distribution capacity of double-layered satellite networks, is proposed. An analysis on several performance metrics, such as end-to-end delay, jitter of delay, routing maintenance signaling load and ISL utilization rate in LEO layer, is made. Simulation results show that TAHR can be applied to QoS-guaranteed routing in LEO/MEO double-layered satellite networks effectively while cut down routing maintenance load and improve throughput greatly.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78756336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Human Disease Genes Based on Associations between Phenome and Proteins","authors":"Guangri Quan, Yu Du, Junheng Huang, Yadong Wang","doi":"10.1109/BMEI.2009.5301815","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5301815","url":null,"abstract":"Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical model reflects the regularity of associations between similarities of phenotypes and interactions of proteins. It can discribe the real biological systems better than traditional models, and gives a stronger predictive ability.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"87 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76100114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Imaging of Different Music Sound Duration as Revealed by Standardized Low Resolution Brain Electromagnetic Tomography (sLORETA)","authors":"W. Sittiprapaporn","doi":"10.1109/BMEI.2009.5304915","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5304915","url":null,"abstract":"Mismatch negativity (MMN) was used to investigate the processing of different synthesized music sounds duration in the human auditory perception. Compared to the short sound, the long sound elicited a more prominent MMN occurring later than that of the short one. sLORETA computation of the mismatch responses yielded clear lefthemispheric laterality in both types of sound duration. However, the short sound produced MMN maximum over the middle temporal gyrus (MTG), whereas maximum of the MMN activated by the long sound was observed over the superior temporal gyrus (STG). The results suggest the existence of the long-term memory trace, and housed primarily in the left hemisphere as revealed by sLORETA. Additionally, the spatial and temporal features of the long sound indicate delayed activation of left-lateralized perisylvian cell assemblies that function as cortical memory traces of long music sound in the human auditory cortex.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76216821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfection of Human Embryonic Germ(EG) Cells with Human Cardiac alpha-Actin Promoter Driving pEGFP-N1","authors":"J. Hua, Yuai Yang, Shuzhen Zhuang, Z. Dou","doi":"10.1109/BMEI.2009.5305494","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305494","url":null,"abstract":"In order to purify the cardiomyocytes derived stem cells, we constructed an expression vector, α -actin-pEGFP-N1 which consists of EGFP gene as reporter markers, and driven by human cardiacα-actin promoter, then transfected it into human embryonic germ cells(hEGCs) by Lipofectamine2000. Fluorescent observation and immunocytochemistry staining demonstrated that transfected hEGCs could differentiate into cardiomyocyte like cells and expressed GFP. The results suggest that this system may provide a model for the study of cardiogenesis and differentiation.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"37 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87968765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SurgView-RFT Electromagnetic Navigation System in Trigeminal Ganglion RF Therapy","authors":"T. Xi, Y. Sun, Lixu Gu, Minjie Chen","doi":"10.1109/BMEI.2009.5305668","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305668","url":null,"abstract":"Percutaneous radiofrequency thermocoagulation of the trigeminal ganglion (PRTTG) is demonstrated as the first choice for most patients suffering trigeminal neuralgia (TN). The purpose of this study was to assess the safety and efficacy of SurgView-RFT electromagnetic navigation system in PRTTG therapy of intractable TN. Experiments including head model of human, live goat, cadaver guarantee the accuracy of the system. 3 cases of TN were underwent CT positioning with RFT in our department after a follow up observation of 3-24 months. All the patients got successful procedure with pain relief and without recurrence and complications such as hematoma, tinnitus and corneal palsy. SurgView-RFT electromagnetic navigation system overcomes the disadvantage of traditional positioning method and is a safe and promising method for treatment of intractable TN with better short- and long-term outcomes and lower complication rate. It is proved that the system has significant clinical clinical value.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"68 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87064189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebinning Methods for Cone Beam SPECT Reconstruction with Non-Uniform Attenuation","authors":"Yunbin Chen, Junhai Wen, Li Wang, P. Hu, H. Zhang","doi":"10.1109/BMEI.2009.5305112","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305112","url":null,"abstract":"Single photon emission computed tomography (SPECT) could achieve the functional image of the organ of interest, so the diseases can be found much earlier. Cone-beam SPECT reconstruction can improve the photo density and spatial resolution of the reconstructed image. A simple method for cone beam reconstruction is to rebin the cone-beam projection data into 2D sinograms and use 2D reconstruction method to obtain the 3D reconstructed images. In this paper, we proposed two rebinning methods for cone-beam SPECT reconstruction with non-uniform attenuation, these two algorithms both can obtain good reconstruction results, especially when reconstructed slice is close to the mid-plane.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"165 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88061452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Improved Probabilistic Model for Finding Differential Gene Expression","authors":"Li Zhang, Xuejun Liu","doi":"10.1109/BMEI.2009.5302665","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5302665","url":null,"abstract":"Finding differentially expressed genes is a funda- mental objective of a microarray experiment. Recently proposed method, PPLR, considers the probe-level measurement error and improves accuracy in finding differential gene expression. However, PPLR uses the importance sampling procedure in the E-step of the variational EM algorithm, which leads to less computational efficiency. We modified the original PPLR to obtain an improved model for finding different gene expression. The new model, IPPLR, adds hidden variables to represent the true gene expressions and eliminates the importance sampling in original PPLR. We apply IPPLR on a spike-in data set and a mouse embryo data set. Results show that IPPLR improves accuracy and computational efficiency in finding differential gene expression. I. INTRODUCTION Microarray (1) (2) are currently widely used to obtain large- scale measurements of gene expression. Finding differentially expressed (DE) genes is the most basic objective of a mi- croarray experiment. Due to the notorious noise existing in microarray data, replicates are usually used in the experiments to deal with data variability. Moreover, some microarrays (such as Affymetrix GeneChips) contain multiple probes to interrogate gene expression profiles. This provides rich infor- mation to obtain an estimation of the technical measurement error associated with each gene expression measurement. This error information is especially significant for weakly expressed genes as these genes are often associated with high variability. Probabilistic methods provide a principle way to handle noisy data. Most of the probabilistic methods, such as the widely used methods, Cyber-T (3) and SAM (4), are based on single point estimates of gene expression values, and ignore the associated probe-level measurement error. This wastes rich information in data. Measurement error of data points has received more and more attention in noisy data analysis (5) (6) (7) (8) in recent years. PPLR (5) considers the probe-level measurement error in finding differential gene expression. This method has been proved to be more accurate than other alternatives (5) (9). However, PPLR uses the importance sampling procedure in the E-step of the variational EM algorithm. This leads to bad accuracy and less computational efficiency. Especially, when the experiment involves a large number of chips, PPLR is extremely time-consuming. This makes the application of PPLR difficult in reality. In this contribution, we improve PPLR by adding hidden variables to represent the true gene expression. This eliminates the inefficient importance sampling in original PPLR. Results on a spikes-in data set and a mouse embryo data set show that the improved PPLR, IPPLR, improves accuracy and computational efficiency in finding DE genes.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"28 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86090392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Characteristic of SMA Intravascular Stent in Blood Stream Field","authors":"Zhiwen Zhu, Hai-Chao Zhai, Hongli Wang","doi":"10.1109/BMEI.2009.5305552","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305552","url":null,"abstract":"In this paper, a kind of Shape Memory Alloy (SMA) model based on multivariate statistical analysis was developed and applied in studying the vibration characteristic of SMA intravascular stent in blood stream field. Hysteretic nonlinear theory was introduced to interpret the difference between loading and unloading curve of SMA. Multivariate statistical analysis method was applied in finding the relationship among strain, stress and temperature. Dynamic characteristic of SMA intravascular stent in blood stream field was analyzed in multi- scale method and the first-order approximate solution was obtained. Finally the stability of SMA beam system in blood stream field was analyzed. The new SMA model can describe the strain-stress hysteretic curves of SMA well, which is helpful to research on SMA in theory.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"76 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83885822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Algorithm Combining Self Organizing Map with Simulated Annealing Used in Intrusion Detection","authors":"Huai-bin Wang, Zhijian Xu, Chundong Wang, Zheng Yuan","doi":"10.1109/BMEI.2009.5305521","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305521","url":null,"abstract":"The effect of clustering by Self Organizing Map (SOM) is always effective in intrusion detection (IDS). But there are still some limitations in the algorithm of SOM, such as the algorithm is easy to get into the local minimum, detection accuracy is low, the convergence speed is slow and so on. In this paper, to improve the accuracy and convergence rate, we use Simulated Annealing (SA) algorithm to refine the weight of SOM. SA algorithm find the optimal point by a form of probability, and it is proved that if enough time is given, the SA can certainly find the optimal point. The algorithm is divided into two steps: first, use traditional SOM algorithm to train samples; second, adjust the weight of excited neuron and its neighborhoods by SA algorithm. The simulation experiment results illuminate that the application performs fairly more effective.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"4 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82822804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}