2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)最新文献

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Populating Local Minima in the Protein Conformational Space 填充蛋白质构象空间的局部极小值
Brian S. Olson, Amarda Shehu
{"title":"Populating Local Minima in the Protein Conformational Space","authors":"Brian S. Olson, Amarda Shehu","doi":"10.1109/BIBM.2011.22","DOIUrl":"https://doi.org/10.1109/BIBM.2011.22","url":null,"abstract":"Protein Modeling conceptualizes the protein energy landscape as a funnel with the native structure at the low-energy minimum. Current protein structure prediction algorithms seek the global minimum by searching for low-energy conformations in the hope that some of these reside in local minima near the native structure. The search techniques employed, however, fail to explicitly model these local minima. This work proposes a memetic algorithm which combines methods from evolutionary computation with cutting-edge structure prediction protocols. The Protein Local Optima Walk (PLOW) algorithm proposed here explores the space of local minima by explicitly projecting each move in the conformation space to a nearby local minimum. This allows PLOW to jump over local energy barriers and more effectively sample near-native conformations. Analysis across a broad range of proteins shows that PLOW outperforms an MMC-based method and compares favorably against other published abini to structure prediction algorithms.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"93 1","pages":"114-117"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77205213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Brdicka curve — A new source of biomarkers Brdicka曲线——生物标记物的新来源
Lenka Vyslouzilova, V. Adam, Andrea Szabóová, O. Štěpánková, R. Kizek, Jiří Anýž
{"title":"Brdicka curve — A new source of biomarkers","authors":"Lenka Vyslouzilova, V. Adam, Andrea Szabóová, O. Štěpánková, R. Kizek, Jiří Anýž","doi":"10.1109/BIBMW.2011.6112374","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112374","url":null,"abstract":"This paper is devoted to analysis of voltammograms resulting from Brdicka reaction - the graphs that are currently used for determination of content of metallothioneins (MT) in tissue samples most often. We describe our search for typical patterns in the considered curves that would make it possible to distinguish among voltammograms produced by samples taken from different body parts. We suggest a rather compact representation of information contained in the considered graphs that is based on Haar's Simple Wavelet transformation. The resulting representation is successfully tested for classification of real data obtained from 8 rats and their 9 body parts. The preliminary experiments confirm that the suggested derived attributes of Brdicka curves seem to be good candidates for becoming numerical biomarkers exhibiting an important advantage: the process leading to their calculation can be fully automated.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"11 1","pages":"193-198"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82506842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Detection of lobular carcinoma in situ(LCIS) by image analysis 小叶原位癌(LCIS)的影像学检测
Sujin Kim, Desok Kim, H. Choi, H. Joo
{"title":"Detection of lobular carcinoma in situ(LCIS) by image analysis","authors":"Sujin Kim, Desok Kim, H. Choi, H. Joo","doi":"10.1109/BIBMW.2011.6112440","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112440","url":null,"abstract":"In this study, we aimed to develop a quantitative image analysis method that may enhance the detection of the lobular carcinoma in-situ (LCIS) in breast cancer specimens. Glandular areas were segmented by using mathematical morphology from 5X histologic images of breast cancer cases (n=213). Computational features such as shape, intensity, and texture were extracted from glandular areas. Segmented glandular areas of LCIS were significantly larger, thicker, lower and less variant in intensity, compared to normal areas (Mann-Whitney test, p<0.01). Our models based on data mining algorithms detected LCIS frames at the accuracy rate close to 99%. Our proposed methods may be well incorporated into a further development of computer aided detection (CAD) software for the screening of whole slide images to locate the LCIS areas.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"5 1","pages":"623-624"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80265784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Using genetic algorithms for the inference of motifs that are represented in only a subset of sequences of interest 使用遗传算法对仅在感兴趣的序列子集中表示的基序进行推理
Jeffrey A. Thompson, C. Congdon
{"title":"Using genetic algorithms for the inference of motifs that are represented in only a subset of sequences of interest","authors":"Jeffrey A. Thompson, C. Congdon","doi":"10.1109/BIBMW.2011.6112539","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112539","url":null,"abstract":"In this work, we present GAMID, and extension of GAMI. GAMID is designed to be used for motif inference in noncoding DNA for co-expressed genes or for divergent species. In these cases, we would like to allow the inferred motif to be present in only a subset of the input data. This paper describes the approach and presents preliminary results.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"14 1","pages":"1005-1005"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84363061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach to phylogenomic analysis of bacterial pathogens 细菌性病原体的系统发育分析方法
L. Zaslavsky, V. Chetvernin, D. Dernovoy, B. Fedorov, W. Klimke, A. Souvorov, I. Tolstoy, T. Tatusova, D. Lipman
{"title":"An approach to phylogenomic analysis of bacterial pathogens","authors":"L. Zaslavsky, V. Chetvernin, D. Dernovoy, B. Fedorov, W. Klimke, A. Souvorov, I. Tolstoy, T. Tatusova, D. Lipman","doi":"10.1109/BIBMW.2011.6112529","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112529","url":null,"abstract":"From the beginning of the microbial genome sequencing era, researchers have shown a commendable commitment to phylogenetic diversity. The completion of one genome from each prokaryotic division or phylum is still a frequently articulated community goal. However, largely because of the interest in human pathogens and advances in sequencing technologies, there are also now a number of very closely related genomes whose organization and gene content can be directly compared. Studying genetic variability of pathogenic bacteria using whole-genome sequencing provides a way to understanding the mechanism of bacterial adaptation to rapid environmental changes and can be a source of useful information on virulence mechanisms. The bacterial genome datasets available in public archives represent a large collection of genome at different levels of sequence quality and assembly. A fast and reliable method of phylogenetic classification based on genome sequences provides a necessary foundation for a more detailed comparative analysis. NCBI has developed an approach of grouping bacterial organisms into phylogenetic clades using a genome dissimilarity measure based on the comparison of universally conserved markers. Special adjustments have been made to compensate for data inaccuracy and incompleteness. Tests performed on complete and draft genomes from phylum Proteobacteria demonstrated that the proposed robust genomic distance allows stable and reliable species-level clustering and can be used for forming phylogenetic clades. Since the tradeoff for the increased robustness of the method is its limited sensitivity at a very fine level, a phylogenomic refinement could be done within each constructed clade when file-level phylogenetic resolution of close genomes is necessary.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"16 1","pages":"981-981"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82713220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wavelet and PCA for Metabolic Network Comparison 小波与PCA在代谢网络比较中的应用
Yong Luo, Yan Zhao, Lei Cheng
{"title":"Wavelet and PCA for Metabolic Network Comparison","authors":"Yong Luo, Yan Zhao, Lei Cheng","doi":"10.1109/BIBM.2011.27","DOIUrl":"https://doi.org/10.1109/BIBM.2011.27","url":null,"abstract":"This paper is composed based on principal component analysis and wavelet transform method to compare the metabolic networks. We combine 7 centrality topologies of metabolic network to extract a comprehensive center on principal component analysis and construct the original signal based on statistical method. By using the wavelet tool to describe the metabolic network structure, we build the fuzzy function to compare the metabolic network structure between different species. This method above can effectively analyze the structure similarity of different species' metabolic networks, reveal the species-specific of metabolic networks and lay a mathematical foundation for the evolution of metabolic networks. Also it is the first time to use the wavelet analysis method in studying the metabolic networks, and it makes an attempt on a new research direction.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"23 1","pages":"633-638"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82715697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ontology Graph Based Query Expansion for Biomedical Information Retrieval 基于本体图的生物医学信息检索查询扩展
Liang Dong, P. Srimani, J. Wang
{"title":"Ontology Graph Based Query Expansion for Biomedical Information Retrieval","authors":"Liang Dong, P. Srimani, J. Wang","doi":"10.1109/BIBM.2011.15","DOIUrl":"https://doi.org/10.1109/BIBM.2011.15","url":null,"abstract":"Query expansion based biomedical information retrieval has been studied for over two decades, most of the studies focus only on taking advantage of one vocabulary: MeSH. We propose a completely different approach utilizing an arbitrary number of controlled vocabularies from Metathesaurus. Experiment shows that our ontology based query expansion scheme achieves 8.2% and 17.7% improvement compared with schemes using pseudo relevance feedback query expansion and using no query expansion respectively. The average improvement is 24.8% in comparison to all other existing strategies. Furthermore, we identify that generalized biomedical concepts are the reason for performance degradation.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"11 1","pages":"488-493"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82556887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
A randomized, controlled study of efficacy and safety on mild to moderate insomnia intervened by Chinese medicine in the integrated program 中医药干预综合治疗轻、中度失眠症疗效及安全性的随机对照研究
Yan Li, Biyun Xu, Shuhui Chen, Peng Liu, A. Ou, Yan Xu, Z. Wen, Biyang Ou, Ruiyu Xu, Zhaozhang Wei, Liang Zeng
{"title":"A randomized, controlled study of efficacy and safety on mild to moderate insomnia intervened by Chinese medicine in the integrated program","authors":"Yan Li, Biyun Xu, Shuhui Chen, Peng Liu, A. Ou, Yan Xu, Z. Wen, Biyang Ou, Ruiyu Xu, Zhaozhang Wei, Liang Zeng","doi":"10.1109/BIBMW.2011.6112461","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112461","url":null,"abstract":"To evaluate the effectiveness and safety in mild to moderate insomnia intervened by Chinese Medicine in the integrated program. Methods: Patients(18 to 56 years old) from the Five National Center, who were with mild to moderate insomnia, were randomly divided into two groups according to the central, experimental group: sleep hygiene instruction + balance acupuncture+ Chinese herbal drug; control group: sleep hygiene instruction + minor acupuncture + placebo capsules. PSQI, ISI and PSG were assessed separately after different stages of treatment and follow-up evaluation. Results: (1) Subjective and objective sleep quality: PSQI scores in the 29th days and ISI scores in the 15th days or 29th days of treatment of the experimental group were lower than the control group. PSG parameters of the experimental group were not significantly different before and after treatment. Conclusion: For patients with mild to moderate insomnia, sleep hygiene education, combined with Balance Acupuncture and Bupleurum chinense and fossil fragment and shellfish decoction can improve the subjective sleep.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"38 11 1","pages":"732-739"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82820955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Interaction simulation of Lipoxygenase with arachidonate acid using NAMD 用NAMD模拟脂氧合酶与花生四烯酸的相互作用
Zhongwei Li, E. Khosravi, Shuju Bai
{"title":"Interaction simulation of Lipoxygenase with arachidonate acid using NAMD","authors":"Zhongwei Li, E. Khosravi, Shuju Bai","doi":"10.1109/BIBMW.2011.6112525","DOIUrl":"https://doi.org/10.1109/BIBMW.2011.6112525","url":null,"abstract":"Lipoxygenase (LOX) family is believed as the major cause of pathological symptoms in asthma by biosynthesis of leukotrienes. The physiological function is known as firstly producing 8R-HPETE (derived from arachidonate acid, referred as AA), which is transformed in further enzymatic step into leukotrienes. However, much less detail is known about the role of 5-Lox in the inflammatory reaction. We have used the 1.85Å resolution structure of a wild coral Lipoxygenase (8R-LOX) (with 41% sequence identical to the human arachidonate 5-LOX) as a foundation to model the interactions between 8R-Lox and its substrate AA, and its binding site was identified using ICM. In this research, the 8R-Lox:AA complex obtained was refined and analyzed by molecular dynamic method (NAMD). Parameterization scheme for unknown structure of non-heme iron ligated by a series of residues was developed using VMD paratool plugin. All quantum mechanical calculation were performed by Gaussian03 with the Becke3LYP functional at 6–31G(d) basis set.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"34 1","pages":"973-973"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83635752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automatic Summarization of Results from Clinical Trials 临床试验结果的自动摘要
Rodney L. Summerscales, S. Argamon, Shangda Bai, J. Hupert, A. Schwartz
{"title":"Automatic Summarization of Results from Clinical Trials","authors":"Rodney L. Summerscales, S. Argamon, Shangda Bai, J. Hupert, A. Schwartz","doi":"10.1109/BIBM.2011.72","DOIUrl":"https://doi.org/10.1109/BIBM.2011.72","url":null,"abstract":"A central concern in Evidence Based Medicine (EBM) is how to convey research results effectively to practitioners. One important idea is to summarize results by key summary statistics that describe the effectiveness (or lack thereof) of a given intervention, specifically the absolute risk reduction (ARR) and number needed to treat (NNT). Manual summarization is slow and expensive, thus, with the exponential growth of the biomedical research literature, automated solutions are needed. In this paper, we present a novel method for automatically creating EBM-oriented summaries from research abstracts of randomly-controlled trials (RCTs). The system extracts descriptions of the treatment groups and outcomes, as well as various associated quantities, and then calculates summary statistics. Results on a hand-annotated corpus of research abstracts show promising, and potentially useful, results.","PeriodicalId":6345,"journal":{"name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","volume":"1 1","pages":"372-377"},"PeriodicalIF":0.0,"publicationDate":"2011-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89967859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
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