中华临床医师杂志(电子版)最新文献

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Thin-section CT characteristics of active and inactive pulmonary tuberculosis 活动性和非活动性肺结核的薄层CT特征
中华临床医师杂志(电子版) Pub Date : 2011-12-17 DOI: 10.3877/706
Dong Xin, Qin Chong, A. Guo-kun
{"title":"Thin-section CT characteristics of active and inactive pulmonary tuberculosis","authors":"Dong Xin, Qin Chong, A. Guo-kun","doi":"10.3877/706","DOIUrl":"https://doi.org/10.3877/706","url":null,"abstract":"Objective To evaluate characteristic of active and inactive pulmonary tuberculosis using thin-section CT. Methods Total of 138 patients were reviewed retrospectively using thin-section CT for suspicion of pulmonary tuberculosis.12 patients were excluded due to sputum smear/culture negative or no follow-up results or final diagnosis of non-tuberculous lesions.The results from 126 patients were used for this study.On the basis of disease activity and inactivity,thin-section CT patterns of micronodules,nodules,masses,consolidation,cavity,ground-glass opacity,and bronchial abnormalities were assessed.Results Of the 138 patients included in this study,91 cases were active and 35 cases were inactive.Most common thin-section CT manifestations of active pulmonary tuberculosis were centrilobular micronodules,bronchiectasis,consolidation,acinar micronodules,ground-glass opacity,nodules,thick-walled cavities,bronchial wall thickening with irregular stenosis or occlusion,masses and miliary micro-nodules.Among this,consolidation,ground-glass opacity,thick-walled cavities,bronchial wall thickening with irregular stenosis or occlusion and miliary micronodules were specific performance.Most common thin-section CT manifestations of inactive pulmonary tuberculosis were calcified nodules,irregular linear,defined-well centrilobular micronodules,traction bronchiectasis,defined-well acinar micronodules,pericicatricial emphysema,parenchyma bands,incompletely calcified nodules and bronchial wall thickening with smooth stenosis,of which irregular linear,pericicatricial emphysema,parenchyma bands,and bronchial wall thickening with smooth stenosis were specific performance.Conclusions Interaction of these thin-section CT signs can be helpful in the distinction of active from inactive pulmonary tuberculosis in most cases.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5919-5924"},"PeriodicalIF":0.0,"publicationDate":"2011-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image fusion of functional magnetic resonance imaging and diffusion tensor imaging:a new method of pretreatment planning for patient with brain tumor 功能磁共振成像与弥散张量成像图像融合:一种脑肿瘤患者预处理方案的新方法
中华临床医师杂志(电子版) Pub Date : 2011-12-17 DOI: 10.3877/725
Wang Zhi, Guo Yue, Chen Min, Cui Zhuang, Gao Hong, Z. Cheng
{"title":"Image fusion of functional magnetic resonance imaging and diffusion tensor imaging:a new method of pretreatment planning for patient with brain tumor","authors":"Wang Zhi, Guo Yue, Chen Min, Cui Zhuang, Gao Hong, Z. Cheng","doi":"10.3877/725","DOIUrl":"https://doi.org/10.3877/725","url":null,"abstract":"Objective To develop and test an image fusion software(fDf,fMRI/DTI fusion) which can overlap the anatomical(T1WI images),functional MRI(fMRI) and diffusion tensor imaging(DTI) simultaneously for preoperational evaluation of patients′ tumor.Methods fMRI with bilateral hands grasp movement and DTI were performed using GE 1.5 T magnetic resonance system on 10 subjects(5 healthy volunteers and 5 patients with brain tumor,of which 3 were metastases,1 was cavernous hemangioma and 1 was glioma).All data were input to the personal computer and off-line postprocessing of fMRI and DTI data was performed using SPM5 and Volume-One software package to visualize the activated functional cortex areas and corticospinal tracts.fDf was used to import the fMRI and structural images to Volume-One to show them simultaneously.Results Brain functional activation maps and diffusion tensor fiber tracking images were obtained in all five healthy volunteers and four patients except one who suffered from left hemiplegia.The functional activation maps and the fiber tracking images were successfully fused by the fDf software,where the activations areas and the white matter fiber were displayed together.The fusion images of healthy volunteers showed the hand motion areas and corresponding corticospinal tracts,while that of the patients display the relationship of the eloquent cortex and peritumoral fiber tracts,which were useful in guiding the treatments for the surgeons and radiotherapists.It only took hours to present the fused images to the neurosurgeons or the radiotherapists.Conclusions All the results confirm that the image fusion software work well for all the data.It is an easy,free and fast way to realize the image fusion.The neurosurgeon and radiotherapist consider the software were very helpful for preoperative planning.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"6021-6026"},"PeriodicalIF":0.0,"publicationDate":"2011-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-input lung perfusion: A new technique and primary outcomes in tuberculosis 双输入肺灌注:一种治疗肺结核的新技术和主要结果
中华临床医师杂志(电子版) Pub Date : 2011-12-17 DOI: 10.3877/705
Y. Xiaodong, A. Guo-kun, Quan Chang-bin, Zhang Jing, Li Hong, Tianhua Yuan, Qin Chong, Liu Zhe, Tian Mei
{"title":"Dual-input lung perfusion: A new technique and primary outcomes in tuberculosis","authors":"Y. Xiaodong, A. Guo-kun, Quan Chang-bin, Zhang Jing, Li Hong, Tianhua Yuan, Qin Chong, Liu Zhe, Tian Mei","doi":"10.3877/705","DOIUrl":"https://doi.org/10.3877/705","url":null,"abstract":"Objective To report a new perfusion CT technique for assessing double blood supply in lung and its primary findings in tuberculosis.Methods After written informed consents were acquired,25 consecutive patients with active tuberculosis underwent volume perfusion using 320-detector row CT.The dual-input CT perfusion (DICTp) based on the maximum slope method was adopted to quantify lung perfusion.Pulmonary trunk,descending aorta (representing bronchial artery) at hilus level were selected as dual-input arteries.Blood flow (BF) and perfusion index (PI) of tuberculosis were measured respectively by two observers.Interobserver reproducibility was evaluated using Bland-Altman statistics.Results Interobserver reproducibility was good according to Bland-Altman analysis.The final hemodynamics of TB were generated by averaging:PF(46.41±19.84)ml·min-1·(100 ml)-1; BF(20.91±11.98)ml·min-1·(100 ml)-1; PI 0.68±0.16.PF was significantly higher than BF (P<0.001).Conclusions A dual-input lung CT perfusion model was established and firstly performed in tuberculosis with good interobserver reproducibility.The primary outcomes suggest that TB is fed by both pulmonary and systemic circulation,among which the former is dominant.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5913-5918"},"PeriodicalIF":0.0,"publicationDate":"2011-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between body fat percentage and body mass index of Huai′an 淮安人体脂率与体质指数的关系
中华临床医师杂志(电子版) Pub Date : 2011-11-30 DOI: 10.3877/669
Shezhen Yang, Zhang Xiao-qing
{"title":"Relationship between body fat percentage and body mass index of Huai′an","authors":"Shezhen Yang, Zhang Xiao-qing","doi":"10.3877/669","DOIUrl":"https://doi.org/10.3877/669","url":null,"abstract":"Objective To survey the actuality of body composition for adults in Huai′an and know the relationship between body fat percentage and body mass index (BMI).Methods A total of 1700 health adults were enrolled in this study.It was measured by bioelectrical impedance for weight,WHR,F%,BMI,visceral fat area, in comparison with the part index of adult in Shanghai,Taiyuan and Tokyo.The obesity diagnosis outpoint was determined for the research object.Results Along with the age,BMI and F% were significantly increased year by year trend, but not balanced.The adult index of BMI or F% in Huai′an was similar to the distribution of Shanghai,Taiyuan and Tokyo,however,there were significant differences between that BMI of 20­30 years old male and F% of 50­60 years old female.As the growth of the age,the visceral fat area distribution was increasing.Men achieve 50% visceral type obesity than women about ten years earlier.The again obese outpoint of male in Huai′an was 24.625 kg/m2,and female was 22.505 kg/m2.Regression equations showed that:F%(male)=WHR×233.241-BMI×0.673-year×0.297-156.3;F%(female)=WHR×43.388+BMI×0.928-year×0.083-25.43.Conclusions There is malconformation between BMI and F%.Along with chronic disease prevention,the outpoint of obese diagnosis should be properly adjusted.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5350-5354"},"PeriodicalIF":0.0,"publicationDate":"2011-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of high­sensitive C­reactive protein with urine microalbumin/creatinine in essential hypertension 高血压患者尿微量白蛋白/肌酐与高敏c反应蛋白的关系
中华临床医师杂志(电子版) Pub Date : 2011-11-30 DOI: 10.3877/667
P. Guo-zhong, Zhao Yan-ye, Fan Yu-dong, X. Hui, Wang Chun-ling, Wu Di, Liu Peng
{"title":"Relationship of high­sensitive C­reactive protein with urine microalbumin/creatinine in essential hypertension","authors":"P. Guo-zhong, Zhao Yan-ye, Fan Yu-dong, X. Hui, Wang Chun-ling, Wu Di, Liu Peng","doi":"10.3877/667","DOIUrl":"https://doi.org/10.3877/667","url":null,"abstract":"Objective To study the relationship between high­sensitive C­reactive protein(hs­CRP) and urine microalbumin/creatinine ratio(ACR) in patients with essential hypertension. Methods Serum hs­CRP,adiponectin and ACR were examined in 166 patients with essential hypertension and in 50 healthy persons(healthy group). According to ACR values, 166 patients were divided into two groups: microalbuminuria group(n=38,ACR ≥30 mg/g) and normal urine protein group (n=128, ACR<30 mg/g). hs­CRP, adiponectin and ACR were compared among microalbuminuria group, normal urine protein group and control group. Linear correlation analysis was used to find the correlation between variables and Logistic binary regression analysis was used to find the independent factor related with high level of ACR. Results (1) The concentration of lg(hs­CRP) was significantly increased in microalbuminuria group compared with normal urine protein group and healthy group[(1.52±0.19)mg/L,(0.16±0.09)mg/L and (0.04±0.14)mg/L, respectively,P<0.05]. (2) Pearson linear correlation analysis showed that the correlation coefficient between CRP and ACR was 0.459, P<0.05. The Logistic multi­factor regression analysis showed that the hs­CRP was an independent predictor of high level of ACR. Conclusions hs­CRP is positively related with ACR. hs­CRP may be an independent predictor of high level of ACR.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5341-5345"},"PeriodicalIF":0.0,"publicationDate":"2011-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Betahistine combined with Donepezil on amnestic mild cognitive impairment 倍他司汀联合多奈哌齐治疗遗忘性轻度认知障碍的疗效观察
中华临床医师杂志(电子版) Pub Date : 2011-11-30 DOI: 10.3877/673
Zhuang Zhiqing, W. Xiaoyan, Chen Zheng-dong, Ju Gui-ping, Ye Xing-rong, Zhu Jun, Chen Xiao-hua, Gu Wei-xia
{"title":"Effect of Betahistine combined with Donepezil on amnestic mild cognitive impairment","authors":"Zhuang Zhiqing, W. Xiaoyan, Chen Zheng-dong, Ju Gui-ping, Ye Xing-rong, Zhu Jun, Chen Xiao-hua, Gu Wei-xia","doi":"10.3877/673","DOIUrl":"https://doi.org/10.3877/673","url":null,"abstract":"Objective To observe the effect of betahistine combined with donepezil on the hypomnesis of amnestic mild cognitive impairment (aMCI).Methods The participants of aMCI were exposed to betahistine + donepezil(combined treatment group)and donepezil(control group)respectively,then neuropsychologic tests such as the Mini­Mental State Examination (MMSE),Auditory Verbal Learning Test (AVLT),Complex Figure Test (CFT),were used to assess the cognitive function before the treatment and after the treatment of 4 weeks and 12 weeks.Results The scores of MMSE increased gradually with the extention of treatment,but had no marked statistically changes at all time points(P>0.05).The scores of delayed recall of AVLT (AVLT­DR)and delayed recall of CFT (CFT­DR)increased obviously(P<0.05), but compared with the control group,the scores of AVLT­DR of combined treatment group increased at both 4 weeks and 12 weeks (P<0.05),and the scores of CFT­DR increased at 12 weeks only(P<0.05).Conclusions Betahistine can increase the effect of donepezil on cognition,maybe resulting from its effect on the cerebral vascular.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5371-5374"},"PeriodicalIF":0.0,"publicationDate":"2011-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic analysis of fibroblast­like synoviocytes from synovial of rheumatoid arthritis 类风湿关节炎滑膜成纤维细胞样滑膜细胞的蛋白质组学分析
中华临床医师杂志(电子版) Pub Date : 2011-11-26 DOI: 10.3877/645
Z. Hui, Qiu Chao-lin, Que Guo-ying, Zong Ming, Sun Li-shan, Fan Lie-ying
{"title":"Proteomic analysis of fibroblast­like synoviocytes from synovial of rheumatoid arthritis","authors":"Z. Hui, Qiu Chao-lin, Que Guo-ying, Zong Ming, Sun Li-shan, Fan Lie-ying","doi":"10.3877/645","DOIUrl":"https://doi.org/10.3877/645","url":null,"abstract":"Objective Studies have found that the fibroblast­like synoviocytes(FLS)play an important role in the hyperplasia of synovium.However,which molecules of FLS caused the hyperplasia remains unclear.This study was performed to separate the differentially expressed proteins of FLS from the patients with rheumatoid arthritis(RA)or osteoarthritis(OA)by two­dimensional electrophoresis(2­DE),and found proteins associated with hyperplasia of FLS by mass spectrometry(MS).Methods Total proteins were extracted and quantified from the primary cultured FLS from patients of RA or OA.Proteins were separated by high­resolution 2­DE,and the differentially expressed proteins were identified by MS.Results There were 1147 protein spots from RA and 1324 protein spots from OA showed on 2­DE graphs,respectively.We had selected 54 protein spots for MS analysis,and 34 protein spots were successfully identified.We had selected the human protein isoaspartate methyltransferase(PIMT)and pirin(iron­binding nuclear protein,PIR)high expressed in FLS of OA,thioredoxin 1(TRX­1)only expressed in FLS of RA.These 3 proteins may be associated with hyperplasia of synovium.Conclusions The decreased expression of PIMT,PIR and increased expression of TRX­1 may be one of the reasons for hyperplasia of FLS in RA.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"5027-5032"},"PeriodicalIF":0.0,"publicationDate":"2011-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement values of the diameters of normal fetal cardiac by fetal echocardiogram in mid­second trimester 妊娠中期胎儿超声心动图对正常胎儿心脏直径的测量值
中华临床医师杂志(电子版) Pub Date : 2011-11-26 DOI: 10.3877/635
L. Yuan, G. Jun, Guo De-ying, Fang Jing-yang, C. Yun, Zhang Gui-zhen
{"title":"Measurement values of the diameters of normal fetal cardiac by fetal echocardiogram in mid­second trimester","authors":"L. Yuan, G. Jun, Guo De-ying, Fang Jing-yang, C. Yun, Zhang Gui-zhen","doi":"10.3877/635","DOIUrl":"https://doi.org/10.3877/635","url":null,"abstract":"Objective To measure the normal fetal cardiac reference values about left atrium,right atrium,left ventricle,right ventricle,aorta,pulmonary artery in mid­second trimester and evaluate the dynamic changes.Methods The diameters of 854 cases of normal fetal cardiac were measured by two­dimensional ultrasound and the parameters were obtained,according to gestational weeks,the cases were divided into five groups:the first group:20­24 weeks;the second group:25­28 weeks;the third group:29­32 weeks;the fourth group:33­36 weeks;the fifth group:37­40 weeks.Calculated the average of the parameters in each groups and then compared the various parameters with each gestational weeks among every groups by regression correlation analysis.Results The size of the atrium and ventricle,the diameter of the aorta and pulmonary artery were enlarged with increasing gestational weeks,and gestational weeks were significantly positive correlated(P<0.05),the interior diameters of fetal right atrium and ventricle were greater than the left,the interior diameters of pulmonary artery were greater than aortic,with statistical significance.Conclusions The diameters of fetal cardiac size are significantly associated with gestational weeks.According to these,we can evaluate the development situations of fetal cardiac. The development of fetal cardiac is dominant in right cardiac.To grasp the normal values diameters of fetal cardiac during this gestational week range is helpful to identify the fetal congenital heart disease.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"4968-4970"},"PeriodicalIF":0.0,"publicationDate":"2011-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70279296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical research of stereotactic conformal body γ-knife and cinobufacini on patients with hepatocellular carcinoma 立体定向适形体γ刀与布法基尼治疗肝癌的临床研究
中华临床医师杂志(电子版) Pub Date : 2011-11-06 DOI: 10.3877/405
Zhang Xiaoyu, Huang Yong-he, Tang Chun-guo, Liang Ying-chun, S. Yi, Qi Zhan-zhong, Chen Jian, Zhong Guocheng
{"title":"Clinical research of stereotactic conformal body γ-knife and cinobufacini on patients with hepatocellular carcinoma","authors":"Zhang Xiaoyu, Huang Yong-he, Tang Chun-guo, Liang Ying-chun, S. Yi, Qi Zhan-zhong, Chen Jian, Zhong Guocheng","doi":"10.3877/405","DOIUrl":"https://doi.org/10.3877/405","url":null,"abstract":"Objective This study aims to investigate the clinical value of stereotactic conformal body gamma(γ)-knife combined with cinobufacini on patients with hepatocellular carcinoma.Methods 60 patients who were diagnosed as hepatocellular carcinoma were divided into two groups randomly.30 patients of the control group were treated by stereotactic conformal body γ-knife only,and 30 patients of joint group were treated by body γ-knife and cinobufacini together.Then the clinical effect of the joint group and control group was compared after different treatment.Results After treatment,the ratio of pain relief,quality of life,survival time and clinical effect in joint group were distinctly better than control group (P<0.05).Conclusions Cinobufacini can reduce adverse reaction of radiotherapy;Stereotactic conformal body γ-knife combined with cinobufacini can be an effective and safe treatment for patients with hepatocellular carcinoma.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"1901-1905"},"PeriodicalIF":0.0,"publicationDate":"2011-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70278511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Value of detection of chromosomally abnormal fetuses by ultrasonographic nuchal translucency 超声颈透检测染色体异常胎儿的价值
中华临床医师杂志(电子版) Pub Date : 2011-11-06 DOI: 10.3877/401
Gao Yan-bing, Cui Guang-he, Qiu Chun-ying, S. Fang
{"title":"Value of detection of chromosomally abnormal fetuses by ultrasonographic nuchal translucency","authors":"Gao Yan-bing, Cui Guang-he, Qiu Chun-ying, S. Fang","doi":"10.3877/401","DOIUrl":"https://doi.org/10.3877/401","url":null,"abstract":"Objective To assess the ultrasonographic detection of nuchal translucency in identifying chromosomally abnormal fetuses,so as to increase the diagnostic rate of fetal disorder in chromosomes.Methods 610 cases of single-fetus pregnant women without any complication from the Affiliated Hospital of Binzhou College of Medicine were included in this study from 2008 to 2009.All subjects without any other fetus abnormality were subject to routine prenatal ultrasonography.The thickness of fetal nuchal translucency in pregnant women with 10-13 weeks of gestation,and that of nuchal fold in those with 14-16 weeks of gestation,was measured.If the thickness of fetal nuchal translucency is higher than 3 mm,or that of nuchal fold is higher than 6 mm,then the pregnant women underwent amniocentesis or chorionic villus biopsy and analysis of fetal karyotype.Data of parents′ behaviour were collected.Results 17 cases of pregnant women were subject to analysis of karyotype.Among of them,8 fetuses were found to be normal karyotype and 9 were aneuploid fetuses.Fetuses with normal karyotype had a significantly thinner nuchal translucency,compared with the fetuses with abnormal karyotype (3.7 mm vs.6.0 mm) in this study.The thickening of most cases of fetus with normal karyotype resolved automatically after the gestation of 14 weeks.Most of the fetus with chromosome abnormalities evolved to nuchal edema or occurrence of other abnormalities in the second trimester.Parents′ behaviour had little correlation with fetus chromosome abnormalities. Conclusions Detection of increased nuchal translucency in the first and second trimester,or observation of changes of nuchal translucency by serial follow-up ultrasound examinations is very important to the finding of fetuses with abnormal karyotype and the detection of high risky fetuses.On the other hand,it is valuable to the differential diagnosis of fetus anomaly and the prognosis.","PeriodicalId":63159,"journal":{"name":"中华临床医师杂志(电子版)","volume":"5 1","pages":"1881-1886"},"PeriodicalIF":0.0,"publicationDate":"2011-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70278434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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